Supercritical carbon dioxide extraction of tagitinin C from Tithonia diversifolia

Journal of Supercritical Fluids

Volumn 33, Issue 1, 2005, Pages 53-59

  Ziemons E ^a   Goffin, E ^a   Lejeune, R ^a   Proenca Da Cunha A ^b   Angenot, L ^a   Thunus, L ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Sesquiterpene lactone; Supercritical fluid extraction; Tagitinin C; Tithonia diversifolia

Indexed keywords

HIGH TEMPERATURE EFFECTS; OPTIMIZATION; PARTICLE SIZE ANALYSIS; PRESSURE EFFECTS; SOLVENTS; SUPERCRITICAL FLUIDS;

AERIAL PARTS; EXTRACTION KINETIC CURVES; EXTRACTION YIELDS; SOLVENT MASS;

CARBON DIOXIDE;

CARBON DIOXIDE; DICHLOROMETHANE; ETHER; PLANT EXTRACT; SOLVENT; TAGITININ C; TITHIONIA DIVERSIFOLIA EXTRACT; UNCLASSIFIED DRUG;

ARTICLE; DRUG ISOLATION; DRUG STRUCTURE; HIGH TEMPERATURE PROCEDURES; LEACHING; MEDICINAL PLANT; PARTICLE SIZE; PLANT LEAF; PRESSURE; QUANTITATIVE ANALYSIS; SOXHLET EXTRACTION; SUPERCRITICAL FLUID EXTRACTION; TITHIONIA DIVERSIFOLIA;

EID: 7444268609     PISSN: 08968446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.supflu.2004.04.001     Document Type: Article

References (15)

1. Goffin E., Ziemons E., De Mol P., de Ceu de Madureira M., Martins A.P., Proenca da Cunha A., Philippe G., Tits M., Angenot L., Frederich M. In vitro antiplasmodial activity of Tithonia diversifolia and identification of its main active constituent: tagitinin C. Planta Med. 68:2002;543
2. Pal R., Kulshreshtha D.K., Rastogi R.P. Chemical constituents of Tithonia tagitiflora Desf: part IV. Tagitinin C, D & F. Indian J. Chem. 15:1977;208
3. Baruah N.C., Sharma R.P., Madhusudanan K.P., Thyagarajan G. Sesquiterpene lactones of Tithonia diversifolia. Stereochemistry of the tagitinins and related compounds. J. Org. Chem. 44:1979;1831
4. Gu J.-Q., Gills J.J., Park E.J., Mata-Greenwood E., Hawthorne M.E., Axelrod F., Chavez P.I., Fong H.H.S., Mehta R.G., Pezzuto J.M., Kinghorn A.D. Sesquiterpenoids from Tithonia diversifolia with potential cancer chemopreventive activity. J. Nat. Prod. 65:2002;532
5. M. Mukhopadhyay, Natural Extracts using Supercritical Carbon Dioxide, CRC Press, Boca Raton, 2000, p. 339.
6. L.T. Taylor, Supercritical Fluid Extraction, Wiley-Interscience, New York, 1996, p. 181.
7. Smith R.M., Burford M.D. Optimization of supercritical fluid extraction of volatile constituents from a model plant matrix. J. Chromatogr. 600:1992;175
8. Smith R.M., Burford M.D. Supercritical fluid extraction and gas chromatographic determination of the sesquiterpene lactone parthenolide in the medicinal herb feverfew (Tanacetum parthenium). J. Chromatogr. 627:1992;255
9. Chen S.L., You J., Wang G.J. Supercritical fluid extraction of essential oil from Rhizoma Atractylodes Macrocephalae. Fenxi Ceshi Xuebao. 19:2000;59
10. Kohler M., Haerdi W., Christen P., Veuthey J.L. Extraction of artemisinin and artemisinic acid from Artemisia annua L. using supercritical carbon dioxide. J. Chromatogr. A. 785:1997;353
11. Kohler M., Haerdi W., Christen P., Veuthey J.L. Supercritical fluid extraction and chromatography of artemisinin and artemisinic acid. An improved method for the analysis of Artemisia annua samples. Phytochem. Anal. 8:1997;223
12. Goffin E., Proença da Cunha A., Ziemons E., Tits M., Angenot L., Frederich M. High performance liquid chromatographic quantification of tagitinin C in Tithonia diversifolia (Hemsley) A. Gray. Phytochem. Anal. 14:2003;378
13. Ziémons E., Goffin E., Lejeune R., Angenot L., Thunus L. FTIR Measurement of Tagitinin C after Solvent Extraction from Tithonia diversifolia. Talanta. 62:2004;383
14. ICH, Guidance for industry, Q2B Validation of Analytical Procedures: Methodology, Federal Register 62 (1996) 27463.
15. Drake B., Smith R. Measurement of static dielectric constants of supercritical fluid solvents and cosolvents. J. Supercrit. Fluids. 3:1990;162