Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: Synthesis, in vitro pharmacology, and modeling

Journal of Medicinal Chemistry

Volumn 47, Issue 23, 2004, Pages 5620-5629

  Héja, László ^a,b   Kovács, Ilona ^a,b   Szárics, Éva ^a,b   Incze, Maria ^a,b   Temesváriné Major, Eszter ^a,b   Dörnyei, Gábor ^a,b   Peredy Kajtár, Mária ^a,b   Gács Baitz, Eszter ^a,b   Szántay, Csaba ^a,b   Kardos, Julianna ^a,b  

^a CHEMICAL RESEARCH CENTER   (Hungary)

^b BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

1,6 DIMETHYL 5BETA HYDROXY 5ALPHA PHENYLPIPERIDIN 3ALPHA,4BETA DICARBOXYLIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ERGOLINE DERIVATIVE; ETHYL 1 METHYL 2 OXO 2 PHENYLETHYLAMINOACETATE; ETHYL 1,6 DIMETHYL 3 OXO 5 PHENYL 1,2,3,6 TETRAHYDROPYRIDIN 2 CARBOXYLATE; ETHYL 1,6 DIMETHYL 5BETA HYDROXY 5ALPHA PHENYL 3ALPHA CARBOXYPIPERIDIN 4BETA CARBOXYLATE; ETHYL 4 [(ETHOXYCARBONYLMETHYL)METHYLAMINO] 2 METHYL 3 PHENYLPENT 2 ENOATE; ETHYL [METHYL (1 METHYL 2 OXO 2 PHENYLETHYL)AMINO]ACETATE; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; METHYL 4 [(METHOXYCARBONYLMETHYL)METHYLAMINO] 2 METHYL 3 PHENYLPENT 2 ENOATE; METHYL [METHYL (1 METHYL 2 OXO 2 PHENYLETHYL)AMINO]ACETATE; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID UPTAKE; AMINO ACID SEQUENCE; AMINO ACID TRANSPORT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN MEMBRANE; CIS TRANS ISOMERISM; CONTROLLED STUDY; DRUG BINDING; DRUG MECHANISM; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MALE; MOLECULAR MODEL; NONHUMAN; RAT;

AMINO ACIDS; ANIMALS; BIOLOGICAL TRANSPORT; BRAIN; ERGOLINES; EXCITATORY AMINO ACID ANTAGONISTS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; MALE; MODELS, MOLECULAR; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 7444245552     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040809c     Document Type: Article

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