Sensitive liquid chromatography assay with ultraviolet detection for a new phosphodiesterase V inhibitor, DA-8159, in human plasma and urine

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 795, Issue 2, 2003, Pages 179-186

  Cho, Joo Youn ^a   Lim, Hyeong Seok ^a   Yu, Kyung Sang ^a   Shim, Hyun Joo ^b   Jang, In Jin ^a   Shin, Sang Goo ^a  

^a Seoul National University   (South Korea)

^b Dong A Pharmaceutical Company   (South Korea)

Author keywords

DA 8159; Phosphodiesterase inhibitor

Indexed keywords

BIOASSAY; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHARMACOKINETICS; ULTRAVIOLET RADIATION;

BIOLOGICAL MATRICES;

ENZYME INHIBITION;

5 [2 PROPYLOXY 5 (1 METHYL 2 PYRROLIDINYLETHYLAMIDOSULFONYL)PHENYL] 1 METHYL 3 PROPYL 1,6 DIHYDRO 7H PYRAZOLO[4,3 D]PYRIMIDIN 7 ONE; ACETONITRILE; BUFFER; ETHER; PHOSPHODIESTERASE INHIBITOR; POTASSIUM DIHYDROGEN PHOSPHATE; SILDENAFIL; SODIUM CARBONATE; UDENAFIL; UNCLASSIFIED DRUG;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIGHT ABSORPTION; LIQUID LIQUID EXTRACTION; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; URINALYSIS;

EID: 0141538028     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(03)00565-8     Document Type: Article

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