Synthesis and antifungal activities in vitro of novel pyrazino [2,1-a] isoquinolin derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 3, 2010, Pages 979-982

  Tang, Hui ^a   Zheng, Canhui ^a   Lv, Jiaguo ^a   Wu, Juan ^b   Li, Yanan ^a   Yang, Hui ^a   Fu, Bingyue ^a   Li, Chuntong ^a   Zhou, Youjun ^a   Zhu, Ju ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b Chengdu General Hospital   (China)

Author keywords

Antifungal; Lanosterol 14 demethylase(CYP51); Pyrazino 2,1 a isoquinoline; Synthesis

Indexed keywords

FLUCONAZOLE; ISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; [2,1 ALPHA] ISOQUINOLIN DERIVATIVE; ANTIFUNGAL AGENT; PYRAZINE DERIVATIVE;

ANTIFUNGAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; COMPARATIVE STUDY; DRUG EFFECTS; PHYSIOLOGY; SYNTHESIS;

FUNGI;

ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; ISOQUINOLINES; PYRAZINES;

EID: 74349121749     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.12.050     Document Type: Article

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