Itraconazole-enhanced vincristine neurotoxicity in a child with acute lymphoblastic leukemia

Pediatric Hematology and Oncology

Volumn 18, Issue 2, 2001, Pages 137-142

  Jeng, M R ^a   Feusner, J ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Cytochrome P 450; Drug interaction; Itraconazole; MDR; Neurologic toxicity; Vincristine

Indexed keywords

CYTOCHROME P450; DAUNORUBICIN; ITRACONAZOLE; VINBLASTINE; VINCA ALKALOID; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CASE REPORT; CHEMOPROPHYLAXIS; CHILD; DRUG INDUCED DISEASE; DRUG POTENTIATION; HUMAN; MALE; MULTIDRUG RESISTANCE; MYCOSIS; NEUROTOXICITY;

ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AZOLES; CHILD, PRESCHOOL; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; HUMANS; ITRACONAZOLE; LEUKEMIA, LYMPHOCYTIC, ACUTE; MALE; NERVOUS SYSTEM DISEASES; VINCRISTINE;

EID: 0035112762     PISSN: 08880018     EISSN: None     Source Type: Journal    
DOI: 10.1080/088800101300002973     Document Type: Article

References (10)

1. Efficacy of itraconazole in the prevention of fungal infections among neutropenic patients with hematologic malignancies and intensive chemotherapy: A double blind, placebo controlled study
2. Severe vincristine toxicity in combination with itraconazole
3. Aggravation of vincristine-induced neurotoxicity by itraconazole in the treatment of adult ALL
4. Vincristine toxicity in five children with acute lymphoblastic leukaemia
5. The neuromyopathy of vincristine in man: Clinical, electrophysiological and pathological studies
6. Acute vincristine neurotoxicity in the presence of hereditary motor and sensory neuropathy type I
7. Involvement of human liver cytochrome P450 3A in vinblastine metabolism: Drug interactions
8. Reversal of daunorubicin resistance in P388/ADR cells by itraconazole
9. Itraconazole and multidrug resistance: Possible effects on remission rate and disease-free survival in acute leukemia