Interaction of the human plasma membrane monoamine transporter (hPMAT) with antidepressants and antipsychotics

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 381, Issue 1, 2010, Pages 33-39

  Haenisch, Britta ^a   Bönisch, Heinz ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Antidepressants; Antipsychotics; MPP +; Organic cation transporter; PMAT

Indexed keywords

AMFEBUTAMONE; AMITRIPTYLINE; ANTIDEPRESSANT AGENT; CARRIER PROTEIN; CLOZAPINE; DESIPRAMINE; FLUOXETINE; HALOPERIDOL; IMIPRAMINE; LEVOMEPROMAZINE; NEUROLEPTIC AGENT; OLANZAPINE; PAROXETINE; PLASMA MEMBRANE MONOAMINE TRANSPORT PROTEIN; REBOXETINE; RISPERIDONE; SERTRALINE; TIANEPTINE; TRIMIPRAMINE; UNCLASSIFIED DRUG; VENLAFAXINE;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS;

ANTIDEPRESSIVE AGENTS; ANTIPSYCHOTIC AGENTS; BRAIN; CELL LINE; CELL LINE, TRANSFORMED; EQUILIBRATIVE NUCLEOSIDE TRANSPORT PROTEINS; HUMANS; MEMBRANE TRANSPORT PROTEINS; PROTEIN BINDING;

EID: 74349116697     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-009-0479-8     Document Type: Article

References (37)

1. Y Acimovic IR Coe 2002 Molecular evolution of the equilibrative nucleoside transporter family: identification of novel family members in prokaryotes and eukaryotes Mol Biol Evol 19 2199 2210 1:CAS:528: DC%2BD38XpslCntbk%3D 12446811
2. A Amphoux V Vialou E Drescher M Brüss C Mannoury La Cour C Rochat MJ Millan B Giros H Bönisch S Gautron 2006 Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain Neuropharmacology 50 941 952 10.1016/j.neuropharm.2006.01.005 1:CAS:528:DC%2BD28XltlKrtb8%3D 16581093 (Pubitemid 43810126)
3. P Baumann C Hiemke S Ulrich G Eckermann I Gaertner M Gerlach HJ Kuss G Laux B Müller-oerlinghausen ML Rao P Riederer G Zernig 2004 The AGNP-TDM expert group consensus guidelines: therapeutic drug monitoring in psychiatry Pharmacopsychiatry 37 243 265 10.1055/s-2004-832687 1:CAS:528: DC%2BD2MXpslCksw%3D%3D 15551191 (Pubitemid 39587052)
4. H Bönisch M Brüss 2006 The norepinephrine transporter in physiology and disease Handb Exp Pharmacol 175 485 524 10.1007/3-540-29784-7-20 16722247
5. Y Cheng WH Prusoff 1973 Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction Biochem Pharmacol 22 3099 3108 10.1016/0006-2952(73) 90196-2 1:CAS:528:DyaE2cXhtVGgs7c%3D 4202581
6. A Dahlin L Xia W Kong R Heyner J Wang 2007 Expression and immunolocalization of the plasma membrane monoamine transporter in the brain Neuroscience 146 1193 1211 10.1016/j.neuroscience.2007.01.072 1:CAS:528:DC%2BD2sXlt1Sjtr8%3D 17408864 (Pubitemid 46694120)
7. LC Daws 2009 Unfaithful neurotransmitter transporters: focus on serotonin uptake and implications for antidepressant efficacy Pharmacol Therapeut 121 89 99 10.1016/j.pharmthera.2008.10.004 1:CAS:528:DC%2BD1cXhsFagtrrL
8. A Doran RS Obach BJ Smith NA Hosea S Becker E Callegari C Chen X Chen E Choo J Cianfrogna LM Cox JP Gibbs MA Gibbs H Hatch CE Hop IN Kasman J Laperle J Liu X Liu M Logman D Maclin FM Nedza F Nelson E Olson S Rahematpura D Raunig S Rogers K Schmidt DK Spracklin M Szewc M Troutman E Tseng M Tu JW Van Deusen K Venkatakrishnan G Walens EQ Wang D Wong AS Yasgar C Zhang 2005 The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model Drug Metab Dispos 33 165 174 10.1124/dmd.104.001230 1:CAS:528:DC%2BD2MXltlentw%3D%3D 15502009 (Pubitemid 40023528)
9. K Engel J Wang 2005 Interaction of organic cations with a newly identified plasma membrane monoamine transporter Mol Pharmacol 68 1397 1407 10.1124/mol.105.016832 1:CAS:528:DC%2BD2MXhtF2it7jN 16099839 (Pubitemid 41539995)
10. K Engel M Zhou J Wang 2004 Identification and characterization of a novel monoamine transporter in the human brain J Biol Chem 279 50042 50049 10.1074/jbc.M407913200 1:CAS:528:DC%2BD2cXhtVWjs7rF 15448143 (Pubitemid 39577815)
11. TH Grasela JB Fiedler-Kelly C Salvadori C Marey R Jochemsen 1993 Development of a population pharmacokinetic databasefor tianeptine Eur J Clin Pharmacol 45 173 179 10.1007/BF00315502 1:CAS:528:DyaK2cXitlSisQ%3D%3D 8223841
12. D Gründemann V Gorboulev S Gambaryan M Veyhl H Koepsell 1994 Drug excretion mediated by a new prototype of polyspecific transporter Nature 372 549 552 10.1038/372549a0 7990927 (Pubitemid 24368536)
13. D Gründemann B Schechinger GA Rappold E Schömig 1998 Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter Nat Neurosci 1 349 351 10.1038/1557 10196521
14. C Haag R Berkels D Gründemann A Lazar D Taubert E Schömig 2004 The localisation of the extraneuronal monoamine transporter (EMT) in rat brain J Neurochem 88 291 297 1:CAS:528:DC%2BD2cXntlSrug%3D%3D 14690517
15. M Hayer-Zillgen M Brüss H Bönisch 2002 Expression and comparison of the pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3 Br J Pharmacol 136 829 836 10.1038/sj.bjp.0704785 1:CAS:528:DC%2BD38XlvV2rurk%3D 12110607 (Pubitemid 34836857)
16. ED Hendley KM Taylor SH Snyder 1970 3H-Normetanephrine uptake in rat brain slices. Relationship to extraneuronal accumulation of norepinephrine Eur J Pharmacol 12 167 179 10.1016/0014-2999(70)90062-2 1:CAS:528:DyaE3MXpvF2i 4394372
17. C Hiemke H Weigmann S Härtter K Mann 2000 Therapeutisches drug monitoring von psychopharmaka NeuroTransmitter 11 52 55
18. LL Iversen J Glowinski J Axelrod 1965 The uptake and storage of H3-norepinephrine in the reserpine-pretreated rat heart J Pharmacol Exp Ther 150 173 183 1:CAS:528:DyaF28Xht1OitA%3D%3D 4379176
19. J Kornhuber J Wiltfang P Riederer S Bleich 2006 Neuroleptic drugs in the human brain: clinical impact of persistence and region-specific distribution Eur Arch Psychiatry Clin Neurosci 256 274 280 10.1007/s00406-006-0661-7 16788768 (Pubitemid 44285050)
20. OH Lowry NJ Rosebrough AL Farr RJ Randall 1951 Protein measurement with the Folin phenol reagent J Biol Chem 193 265 275 1:CAS:528:DyaG38XhsVyrsw%3D%3D 14907713
21. JA Moron A Brockington RA Wise BA Rocha BT Hope 2002 Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mice lines J Neurosci 22 389 395 1:CAS:528:DC%2BD38XmsVKnuw%3D%3D 11784783
22. B Olivier W Soudijn I von Wijngaarden 2000 Serotonin, dopamine and norepinephrine transporters in the central nervous system and their inhibitors Prog Drug Res 54 61 119
23. G Pineyro L Deveault P Blier T Dennis C de Montigny 1995 Effect of acute and prolonged tianeptine administration on the 5-HT transporter: electrophysiological, biochemical and radioligand binding studies in the rat brain Naunyn Schmiedebergs Arch Pharmacol 351 111 118 1:CAS:528: DyaK2MXktV2ksbY%3D 7770093
24. A Randrup C Braestrup 1977 Uptake inhibition of biogenic amines by newer antidepressant drugs: relevance to the dopamine hypothesis of depression Psychopharmacology 53 309 314 10.1007/BF00492370 1:CAS:528:DyaE2sXlslOnu7s%3D 408861
25. H Russ K Staust F Martel M Gliese E Schömig 1996 The extraneuronal transporter for monoamine transmitters exists in cells derived from human central nervous system glia Eur J Neurosci 8 1256 1264 10.1111/j.1460-9568.1996. tb01294.x 1:STN:280:DyaK28zisFGlug%3D%3D 8752596 (Pubitemid 26174651)
26. MA Saracino M Amore E Baioni C Petio MA Raggi 2008 Determination of selected phenothiazines in human plasma by solid-phase extraction and liquid chromatography with coulometric detection Anal Chim Acta 624 308 316 10.1016/j.aca.2008.06.040 1:CAS:528:DC%2BD1cXhtVWksr%2FF 18706338
27. I Sora FS Hall AM Andrews M Itokawa XF Li HB Wei C Wichems KP Lesch DL Murphy GR Uhl 2001 Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference Proc Natl Acad Sci U S A 98 5300 5305 10.1073/pnas.091039298 1:CAS:528: DC%2BD3MXjt1Ontr0%3D 11320258 (Pubitemid 32397123)
28. DH Sweet DS Miller JB Pritchard 2001 Ventricular choline transport: a role for organic cation transporter 2 expressed in choroid plexus J Biol Chem 276 41611 41619 10.1074/jbc.M108472200 1:CAS:528:DC%2BD3MXosVGnsLs%3D 11553644 (Pubitemid 37371052)
29. M Tatsumi K Groshan RD Blakely E Richelson 1997 Pharmacological profile of antidepressants and related compounds at human monoamine transporters Eur J Pharmacol 340 249 258 10.1016/S0014-2999(97)01393-9 1:CAS:528:DyaK2sXotVyjsbo%3D 9537821 (Pubitemid 28022649)
30. M Uhr MT Grauer F Holsboer 2003 Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption Biol Psychiatry 54 840 846 10.1016/S0006-3223(03) 00074-X 1:CAS:528:DC%2BD3sXnvFWisb8%3D 14550684 (Pubitemid 37205136)
31. V Vialou L Balasse S Dumas B Giros S Gautron 2007 Neurochemical characterization of pathways expressing plasma membrane monoamine transporter in the rat brain Neuroscience 144 616 622 10.1016/j.neuroscience.2006.09.058 1:CAS:528:DC%2BD28Xht12qs7bP 17110048 (Pubitemid 44873040)
32. HK Wayment JO Schenk BA Sorg 2001 Characterization of extra-cellular dopamine clearance in the medial prefrontal cortex: role of monoamine uptake and monoamine oxidase inhibition J Neurosci 21 35 44 1:CAS:528: DC%2BD3MXmtVOiug%3D%3D 11150317
33. VG Wilson M Grohmann U Trendelenburg 1988 The uptake and O-methylation of 3H-(+/-)-isoprenaline in rat cerebral cortex slices Naunyn Schmiedebergs Arch Pharmacol 377 397 405
34. X Wu R Kekuda W Huang YJ Fei FH Leibach J Chen SJ Conway V Ganapathy 1998 Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain J Biol Chem 273 32776 32786 10.1074/jbc.273.49.32776 1:CAS:528: DyaK1cXnvFOnurg%3D 9830022 (Pubitemid 28557664)
35. L Xia K Engel M Zhou J Wang 2007 Membrane localization and pH-dependent transport of a newly cloned organic cation transporter (PMAT) in kidney cells Am J Physiol Renal Physiol 292 F682 F690 10.1152/ajprenal.00302.2006 1:CAS:528:DC%2BD2sXjt1Gmtrs%3D 17018840 (Pubitemid 46220537)
36. M Zhou K Engel J Wang 2007 Evidence for significant contribution of a newly identified monoamine transporter (PMAT) to serotonin uptake in the human brain Biochem Pharmacol 73 147 154 10.1016/j.bcp.2006.09.008 1:CAS:528:DC%2BD28Xht12rsbbE 17046718 (Pubitemid 44853932)
37. M Zhou L Xia J Wang 2007 Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine Drug Metab Dispos 35 1956 1962 10.1124/dmd.107.015495 1:CAS:528:DC%2BD2sXhtFantr7N 17600084 (Pubitemid 47481592)