Activated platelets increase proliferation and protein synthesis of human dental pulp-derived cells

International Endodontic Journal

Volumn 43, Issue 2, 2010, Pages 115-124

  Agis, H ^a,b   Stampfl, B ^a,b   Watzek, G ^a,b   Gruber, R ^a,b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Austrian Cluster for Tissue Regeneration   (Austria)

Author keywords

AKT MAPK pathways; Cell proliferation; Human dental pulp derived cells; Inflammatory cytokines; LPS; Protein synthesis

Indexed keywords

BIOLOGICAL FACTOR; CALCIUM HYDROXIDE; CYTOKINE; LIPOPOLYSACCHARIDE; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; ROOT CANAL FILLING MATERIAL;

ARTICLE; CELL CULTURE; CELL PROLIFERATION; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; HUMAN; METABOLISM; NONPARAMETRIC TEST; PHYSIOLOGY; SECOND MESSENGER; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ACTIVATION; TOOTH PULP;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BIOLOGICAL FACTORS; BLOOD PLATELETS; CALCIUM HYDROXIDE; CELL PROLIFERATION; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYTOKINES; DENTAL PULP; HUMANS; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; PLATELET ACTIVATION; PROTO-ONCOGENE PROTEINS C-AKT; ROOT CANAL FILLING MATERIALS; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC;

EID: 74349105465     PISSN: 01432885     EISSN: 13652591     Source Type: Journal    
DOI: 10.1111/j.1365-2591.2009.01650.x     Document Type: Article

References (43)

1. Agis H, Bauer M, Knebl G, Watzek G, Gruber R (2008) Effects of platelet-derived growth factor isoforms on plasminogen activation by periodontal ligament and gingival fibroblasts. Journal of Periodontal Research 43, 334 342.
2. Agis H, Kandler B, Fischer MB, Watzek G, Gruber R (2009) Activated platelets increase fibrinolysis of mesenchymal progenitor cells. Journal of Orthopaedic Research 27, 972 980.
3. Bletsa A, Berggreen E, Fristad I, Tenstad O, Wiig H (2006) Cytokine signalling in rat pulp interstitial fluid and transcapillary fluid exchange during lipopolysaccharide-induced acute inflammation. The Journal of Physiology 573, 225 236.
4. Cavalcanti BN, Rode SM, Marques MM (2005) Cytotoxicity of substances leached or dissolved from pulp capping materials. International Endodontic Journal 38, 505 509.
5. Chan CP, Lan WH, Chang MC et al. (2005) Effects of TGF-beta on the growth, collagen synthesis and collagen lattice contraction of human dental pulp fibroblasts in vitro. Archives of Oral Biology 50, 469 479.
6. D'Souza RN, Bachman T, Baumgardner KR, Butler WT, Litz M (1995) Characterization of cellular responses involved in reparative dentinogenesis in rat molars. Journal of Dental Research 74, 702 709.
7. Denholm IA, Moule AJ, Bartold PM (1998) The behaviour and proliferation of human dental pulp cell strains in vitro, and their response to the application of platelet-derived growth factor-BB and insulin-like growth factor-1. International Endodontic Journal 31, 251 258.
8. Feit J, Metelova M, Sindelka Z (1970) Incorporation of 3H thymidine into damaged pulp of rat incisors. Journal of Dental Research 49, 783 786.
9. Gomes BP, Ferraz CC, Vianna ME et al. (2002) In vitro antimicrobial activity of calcium hydroxide pastes and their vehicles against selected microorganisms. Brazilian Dental Journal 13, 155 161.
10. Gruber R, Varga F, Fischer MB, Watzek G (2002) Platelets stimulate proliferation of bone cells: involvement of platelet-derived growth factor, microparticles and membranes. Clinical Oral Implants Research 13, 529 535.
11. Gruber R, Karreth F, Frommlet F, Fischer MB, Watzek G (2003) Platelets are mitogenic for periosteum-derived cells. Journal of Orthopaedic Research 21, 941 948.
12. Gruber R, Jindra C, Kandler B, Watzak G, Fischer MB, Watzek G (2004a) Proliferation of dental pulp fibroblasts in response to thrombin involves mitogen-activated protein kinase signalling. International Endodontic Journal 37, 145 150.
13. Gruber R, Kandler B, Jindra C, Watzak G, Watzek G (2004b) Dental pulp fibroblasts contain target cells for lysophosphatidic Acid. Journal of Dental Research 83, 491 495.
14. Gruber R, Karreth F, Kandler B et al. (2004c) Platelet-released supernatants increase migration and proliferation, and decrease osteogenic differentiation of bone marrow-derived mesenchymal progenitor cells under in vitro conditions. Platelets 15, 29 35.
15. Hanks CT, Bergenholtz G, Kim JS (1983) Protein synthesis in vitro, in the presence of Ca(OH)2-containing pulp-capping medicaments. Journal of Oral Pathology 12, 356 365.
16. Hill SJ, Ebersole JL (1996) The effect of lipopolysaccharide on growth factor-induced mitogenesis in human gingival fibroblasts. Journal of Periodontology 67, 1274 1280.
17. Hu VW, Black GE, Torres-Duarte A, Abramson FP (2002) 3H-thymidine is a defective tool with which to measure rates of DNA synthesis. Journal of the Federation of American Societies for Experimental Biology 16, 1456 1457.
18. Iohara K, Zheng L, Ito M, Tomokiyo A, Matsushita K, Nakashima M (2006) Side population cells isolated from porcine dental pulp tissue with self-renewal and multipotency for dentinogenesis, chondrogenesis, adipogenesis, and neurogenesis. Stem Cells 24, 2493 2503.
19. Jurk K, Kehrel BE (2005) Platelets: physiology and biochemistry. Seminars in thrombosis and hemostasis 31, 381 392.
20. Kalaskar RR, Damle SG (2004) Comparative evaluation of lyophilized freeze dried platelet derived preparation with calcium hydroxide as pulpotomy agents in primary molars. Journal of the Indian Society of Pedodontics and Preventive Dentistry 22, 24 9.
21. Kitamura C, Ogawa Y, Nishihara T, Morotomi T, Terashita M (2003) Transient co-localization of c-Jun N-terminal kinase and c-Jun with heat shock protein 70 in pulp cells during apoptosis. Journal of Dental Research 82, 91 5.
22. Kitamura C, Nishihara T, Ueno Y et al. (2006) Effects of sequential exposure to lipopolysaccharide and heat stress on dental pulp cells. Journal of Cellular Biochemistry 99, 797 806.
23. Kumkumian GK, Lafyatis R, Remmers EF, Case JP, Kim SJ, Wilder RL (1989) Platelet-derived growth factor and IL-1 interactions in rheumatoid arthritis. Regulation of synoviocyte proliferation, prostaglandin production, and collagenase transcription. The Journal of Immunology 143, 833 837.
24. Laino G, d'Aquino R, Graziano A et al. (2005) A new population of human adult dental pulp stem cells: a useful source of living autologous fibrous bone tissue (LAB). Journal of Bone and Mineral Research 20, 1394 1402.
25. Lertchirakarn V, Birner R, Messer HH (1998) Effects of interleukin-1 beta on human pulpal fibroblast proliferation and collagen synthesis. Journal of Endodontics 24, 409 413.
26. Mailland M, Waelchli R, Ruat M, Boddeke HG, Seuwen K (1997) Stimulation of cell proliferation by calcium and a calcimimetic compound. Endocrinology 138, 3601 3605.
27. Marx RE (2004) Platelet-rich plasma: evidence to support its use. International Journal of Oral and Maxillofacial Surgery 62, 489 496.
28. Mirabet V, Solves P, Miñana MD et al. (2008) Human platelet lysate enhances the proliferative activity of cultured human fibroblast-like cells from different tissues. Cell Tissue Bank 9, 1 10.
29. Mjör IA, Dahl E, Cox CF (1991) Healing of pulp exposures: an ultrastructural study. Journal of Oral Pathology & Medicine 20, 496 501.
30. Nakashima M (1992) The effects of growth factors on DNA synthesis, proteoglycan synthesis and alkaline phosphatase activity in bovine dental pulp cells. Archives of Oral Biology 37, 231 236.
31. Raslan N, Wetzel WE (2006) Exposed human pulp caused by trauma and/or caries in primary dentition: a histological evaluation. Dental Traumatology 22, 145 153.
32. Schröder U (1985) Effects of calcium hydroxide-containing pulp-capping agents on pulp cell migration, proliferation, and differentiation. Journal of Dental Research 64 Spec No, 541 548.
33. Shiba H, Fujita T, Doi N et al. (1998) Differential effects of various growth factors and cytokines on the syntheses of DNA, type I collagen, laminin, fibronectin, osteonectin/secreted protein, acidic and rich in cysteine (SPARC), and alkaline phosphatase by human pulp cells in culture. Journal of Cellular Physiology 174, 194 205.
34. de Souza Costa CA, Duarte PT, de Souza PP, Giro EM, Hebling J (2008) Cytotoxic effects and pulpal response caused by a mineral trioxide aggregate formulation and calcium hydroxide. The American Journal of Dentistry 21, 255 261.
35. Spagnuolo G, Galler K, Schmalz G, Cosentino C, Rengo S, Schweikl H (2004) Inhibition of phosphatidylinositol 3-kinase amplifies TEGDMA-induced apoptosis in primary human pulp cells. Journal of Dental Research 83, 703 707.
36. Spagnuolo G, D'Anto V, Valletta R et al. (2008) Effect of 2-hydroxyethyl methacrylate on human pulp cell survival pathways ERK and AKT. Journal of endodontics 34, 684 688.
37. Suchanek J, Soukup T, Visek B, Ivancakova R, Kucerova L, Mokry J (2009) Dental pulp stem cells and their characterization. Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 153, 31 5.
38. Sundqvist G, Rosenquist JB, Lerner UH (1995) Effects of bradykinin and thrombin on prostaglandin formation, cell proliferation and collagen biosynthesis in human dental-pulp fibroblasts. Archives of Oral Biology 40, 247 256.
39. Tziafas D (2004) The future role of a molecular approach to pulp-dentinal regeneration. Caries research 38, 314 320.
40. Wang FM, Hu T, Zhou X (2006) p38 mitogen-activated protein kinase and alkaline phosphatase in human dental pulp cells. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 102, 114 118.
41. Ye L, Peng L, Tan H, Zhou X (2006) HGF enhanced proliferation and differentiation of dental pulp cells. Journal of Endodontics 32, 736 741.
42. Yongchaitrakul T, Pavasant P (2007) Transforming growth factor-beta1 up-regulates the expression of nerve growth factor through mitogen-activated protein kinase signaling pathways in dental pulp cells. European Journal of Oral Sciences 115, 57 63.
43. Zhang W, Walboomers XF, Jansen JA (2008) The formation of tertiary dentin after pulp capping with a calcium phosphate cement, loaded with PLGA microparticles containing TGF-beta1. Journal of Biomedical Materials Research. Part A 85, 439 444.