The future role of a molecular approach to pulp-dentinal regeneration

Caries Research

Volumn 38, Issue 3, 2004, Pages 314-320

  Tziafas, D ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Dentin; Growth factors; Odontoblast like cells; Odontoblasts; Pulp; Reactionary dentin; Reparative dentin; TGF ; Vital pulp therapy

Indexed keywords

GROWTH FACTOR;

CONFERENCE PAPER; DENTIN; EXTRACELLULAR MATRIX; HUMAN; MOLECULAR BIOLOGY; NONHUMAN; ODONTOBLAST; SIGNAL TRANSDUCTION; TISSUE REGENERATION; TOOTH DEVELOPMENT; TOOTH PULP;

ANIMALS; BONE MORPHOGENETIC PROTEINS; DENTAL PULP; DENTAL PULP CAPPING; DENTIN; DENTIN, SECONDARY; HUMANS; ODONTOBLASTS; REGENERATION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 2642547127     PISSN: 00086568     EISSN: None     Source Type: Journal    
DOI: 10.1159/000077771     Document Type: Conference Paper

References (62)

1. Baume LJ: The biology of pulp and dentine; in Myers HM (ed): Monographs in Oral Science. Basel, Karger, 1980, vol 8, pp 67-182.
2. Begue-Kirn C, Smith AJ, Ruch JV, Wozney JM, Purchio AF, Hartmann D, Lesot H: Effects of dentin proteins, transforming growth factor beta 1 (TGF beta 1) and bone morphogenetic protein 2 (BMP2) on the differentiation of odontoblast in vitro. Int J Dev Biol 1992;36:491-503.
3. Bergenholtz G: Factors in pulpal repair after oral exposure. Adv Dent Res 2001;15:84.
4. Bjørndal L, Darvann T: A light microscopic study of odontoblastic and non-odontoblastc cells involved in tertiary dentinogenesis in well-defined cavitated carious lesions. Caries Res 1999;33:50-60.
5. Bjørndal L, Mjör IA: Pulp-dentin biology in restorative dentistry. 4. Dental caries - Characteristics of lesions and pulpal reactions. Quintessence Int 2001;32:717-736.
6. Chiego DJ: An ultrastructural and autoradiographic analysis of primary and replacement odontoblasts following cavity preparation and wound healing in the rat molar. Proc Finn Dent Soc 1992;88:243-256.
7. Cox CF, Bergenholtz G, Heys DR, Syed A, Fitzgerald M, Heys RJ: Pulp capping of the dental pulp mechanically exposed to the oral microflora: A 1-2 year observation of wound healing in the monkey. J Oral Pathol 1985;14:156-168.
8. Cox CF, Keall CL, Ostro E, Bergenholtz G: Biocompatibility of surface-sealed dental materials against exposed pulps. J Prosthet Dent 1987;57:1-8.
9. Cox CF, Subay RK, Ostro E, Suzulli S, Suzulli SH: Tunnel defects in dentin bridges: Their formation following direct pulp capping. Oper Dent 1996;21:4-11.
10. Cvek M, Granath L, Cleaton-Jones P, Austin J: Hard tissue barrier formation in pulpotomized monkey teeth capped with cyanoacrylate or calcium hydroxide for 10 and 60 minutes. J Dent Res 1987;66:1166-1174.
11. Decup F, Six N, Palmier B, Buch D, Lasfargues JJ, Salih E, Goldberg M: Bone sialoprotein-induced reparative dentinogenesis in the pulp of rat's molar. Clin Oral Investig 2000;4:110-119.
12. Finkelman RD, Mohan S, Jennings JC, Taylor AK, Jepsen S, Baylink DJ: Quantitation of growth factors IGF-I, SGF/IGF-II and TGF-beta in human dentin. J Bone Miner Res 1990;5:717-723.
13. 3H-thymidine. J Dent Res 1979;58:2198-2206.
14. Fitzgerald M, Ghiego JD Jr, Heys R: Autoradiographic analysis of odontoblast replacement following pulp exposure in primate teeth. Arch Oral Biol 1990;35:707-715.
15. Frank RM: Ultrastructural relationship between the odontoblast, its process and the nerve fibre; in Symons NBB (ed): Dentine and Pulp: Their Structure and Reactions. London, Livingstone, 1968, pp 115-145.
16. Heritier MD, D'Angleterre M, Baillez Y: Differentiation of odontoblasts in mouse dental papillae recombined with normal or chemically-treated dentinal matrices. Arch Oral Biol 1990;35:917-924.
17. Heys DR, Cox CF, Heys RJ, Avery JK: Histological considerations of direct pulp capping agents. J Dent Res 1981;60:1371-1379.
18. Heys DR, Fitzgerald M, Heys RJ, Chiego DJ: Healing of primate dental pulps capped with Teflon. Oral Surg Oral Med Oral Pathol 1990;69:227-237.
19. Higashi T, Okamoto H: Characteristics and effects of calcified degenerative zones on the formation of hard tissue barriers in amputated canine dental pulp. J Endod 1996;22:168-172.
20. Horsted-Bindslev P, Bergenholtz G: Vital pulp therapies; in Bergenholtz G, Horsted-Bindslev P, Reit C (eds): Textbook of Endodontology. London, Blackwell Munksgaard, 2003.
21. Horsted P, Sondeergard B, Thylstrup A, Attar K, Fejerskov O: A restrospective study of direct pulp capping with calcium hydroxide compounds. Endod Dent Traumatol 1985;1:29-34.
22. Kakehashi S, Stanley HR, Fitzgerald RJ: The effects of surgical exposure on dental pulps in germ-free and conventional laboratory rats. Oral Surg Oral Med Oral Pathol 1965;20:340-349.
23. Kim S: Neurovascular interactions in the dental pulp in health and inflammation. J Endod 1990;16:48-57.
24. Kitamura C, Kimura K, Nakayama T, Toyoshima K, Terashita M: Primary and secondary induction of apoptosis in odontoblasts after cavity preparation of rat molars. J Dent Res 2001;80:1530-1534.
25. Jepsen S, Hans-Karl A, Fleiner B, Tucker M, Rueger D: Recombinant human osteogenic protein-1 induces dentin formation: An experimental study in miniature swine. J Endod 1997;23:378-382.
26. Lesot H, Smith AJ, Tziafas D, Begue-Kirn C, Cassidy N, Ruch JV: Biologically active molecules and dental tissue repair: A comparative review of reactionary and reparative dentinogenesis with the induction of odontoblast differentiation in vitro. Cells Mater 1994;4:199-218.
27. Lovschall H, Fejerskov O, Flyvbjerg A: Pulp capping with recombinant human insulin growth factor-I (rhIGF-I) in rat molars. Adv Dent Res 2001;15:108-112.
28. Magloire H, Joffre A Bleicher F: An in vitro model of human dental pulp repair. J Dent Res 1996;75:1971-1978.
29. Magloire H, Romeas A, Melin M, Couble M-L, Bleicher F, Farges J-C: Molecular regulation of odontoblast activity under dentin injury. Adv Dent Res 2001;15:46-50.
30. Mjör IA: Dentin-predentin complex and its permeability: Pathology and treatment overview. J Dent Res 1985;64:621-627.
31. Mjör IA: Pulp-dentin biology in restorative dentistry. 7. The exposed pulp. Quintessence Int 2002;33:113-135.
32. Mjör IA, Dahl E, Cox CF: Healing of pulp exposures: An ultrastructural study. J Oral Pathol Med 1991;20:496-501.
33. Murray PE, Smith AJ: Saving pulps - A biological basis. An overview. Prim Dent Care 2002;9:21-26.
34. Nakamura Y, Hammarström L, Lundberg E, Ekdahl H, Matsumoto K, Gestrelius S, Lyngstadaas SP: Enamel matrix derivative promotes reparative processes in the dental pulp. Adv Dent Res 2001;15:105-107.
35. Nakashima M: Induction of dentin formation on canine amputated pulp by recombinant human bone morphogenetic proteins (BMP)-2 and -4. J Dent Res 1994a;73:1515-1522.
36. Nakashima M: Induction of dentine in amputated pulp of dogs by recombinant human bone morphogenetic proteins -2 and -4 with collagen matrix. Arch Oral Biol 1994b;39:1085-1089.
37. Nyborg H: Healing processes in the dental pulp on capping. A morphologic study. Experiments on surgical lesions of the pulp in dog and man. Acta Odontol Scand 1955;13(suppl 16):1-130.
38. Ruch JV: Odontoblast differentiation and the formation of odontoblast layer. J Dent Res 1985;64:489-498.
39. Rutherford BR: Regeneration of the pulp-dentin complex; in Lynch SE, Genco RJ, Marx RE (eds): Tissue Engineering. Applications in Maxillofacial Surgery and Periodontics. Chicago, Quintessence Publishing Co, Inc, 1999, pp 185-199.
40. Rutherford B, Spangberg L, Tucker M, Charette M: Transdentinal stimulation of reparative dentine formation by osteogenic protein-1 in monkeys. Arch Oral Biol 1995;40:681-683.
41. Rutherford RB, Wahle J, Tucker M, Rueger D, Charette M: Induction of reparative dentine formation in monkeys by recombinant human osteogenic protein-1. Arch Oral Biol 1993;38:571-576.
42. Schroder U: Effects of calcium hydroxide-containing agent on pulp cell migration, proliferation and differentiation. J Dent Res 1985;64:541-548.
43. Sloan AJ, Smith AJ: Stimulation of the dentine-pulp complex of rat incisor teeth by TGFbeta isoforms 1-3 in vitro. Arch Oral Biol 1999;44:149-156.
44. Smith AJ: Pulpal responses to caries and dental repair. Caries Res 2002;36:223-232.
45. Smith AJ, Cassidy N, Perry H, Begue-Kirn C, Ruch JV, Lesot H: Reactionary dentinogenesis. Int J Dev Biol 1995;39:273-280.
46. Smith AJ, Murray PE, Sloan AJ, Matthews JB, Zhao S: Transdentinal stimulation of tertiary dentinogenesis. Adv Dent Res 2001;15:51-54.
47. Smith AJ, Sloan AJ, Matthews JB, Murray PE, Lumley P: Reparative processes in dentine and pulp; in Addy M, Embery G, Edgar WM, Orchardson R (eds): Tooth Wear and Sensitivity. London, Dunitz, 2002, pp 53-66.
48. Smith AJ, Tobias RS, Cassidy N, Plant CG, Browne RM, Begue-Kirn C, Ruch JV, Lesot H: Odontoblast stimulation in ferrets by dentine matrix components. Arch Oral Biol 1994;39:13-22.
49. Stanley HR: Pulp capping: Conserving the dental pulp - Can it be done? Is it worth it? Oral Surg Oral Med Oral Pathol 1989;68:628-639.
50. Stanley HR, Pereira JC, Spiegel E, Broom C, Schultz M: The detection and prevalence of reactive and physiologic sclerotic dentin, reparative dentin and dead tracts beneath various types of dental lesions according to tooth surface and age. J Pathol 1983;12:257-289.
51. Trowbridge HO: Pathogenesis of pulpitis resulting from dental caries. J Endod 1981;7:52-60.
52. Tziafas D: Induction of reparative dentinogenesis in vivo: A synthesis of experimental observations. Connect Tissue Res 1995;32:297-301.
53. Tziafas D: Reparative Dentinogenesis: A Monograph on the Dentinogenic Potential of Dental Pulp. Thessaloniki, University Studio Press, 1997.
54. Tziafas, D, Alvanou A, Komnenou A, Gasic J, Papadimitriou S: Effects of basic fibroblast growth factor, insulin-like growth factor-II and transforming growth factor beta1 on dental pulp cells after implantation in dog teeth. Arch Oral Biol 1998;43:431-444.
55. Tziafas D, Alvanou A, Panagiotakopoulos N, Smith AJ, Lesot H, Komnenou A, Ruch JV: Induction of odontoblast-like cell differentiation in dog dental pulps after in vivo implantation of dentine matrix components. Arch Oral Biol 1995a;40:883-893.
56. Tziafas D, Belibasakis G, Veis A, Papadimitriou S: Dentin regeneration in vital pulp therapy: Design principles. Adv Dent Res 2001;15:96-100.
57. Tziafas D, Kolokuris I, Alvanou A, Kaidoglou K: Short-term dentinogenic response of dog dental pulp tissue after its induction by demineralized or native dentine or predentine. Arch Oral Biol 1992;37:119-128.
58. Tziafas D, Panagiotakopoulos N, Komnenou A: Immunolocalization of fibronectin during the early response of dog dental pulp to demineralized dentine or calcium hydroxide-containing cement. Arch Oral Biol 1995b;40:23-31.
59. Tziafas D, Smith AJ, Lesot H: Designing new treatment strategies in vital pulp therapy. J Dentist 2000;28:77-92.
60. Yamamura T: Differentiation of pulpal cells and inductive influences of various matrices with reference to pulpal wound healing. J Dent Res 1985;64:530-540.
61. Yoshiba K, Yoshiba N, Nakamura H, Iwaku M, Ozawa H: Immunolocalization of fibronectin during reparative dentinogenesis in human teeth after pulp capping with calcium hydroxide. J Dent Res 1996;75:1590-1597.
62. Zhao S, Sloan AJ, Murray PE, Lumley PJ, Smith AJ: Ultrastructural localization of TGF-β exposure in dentine by chemical treatment. Histochem J 2000;32:489-494.