Proteomic analysis of the protective effects of Platycodi Radix in liver of chronically alcoholic rats

Journal of Medicinal Food

Volumn 12, Issue 6, 2009, Pages 1190-1198

  An, Jeung Hee ^a   Kim, Dong Sub ^b   Lee, Yoo Hyun ^b   Ho, Jin Nyoung ^b   Kim, Hye Kyung ^c   Kang, Ok Ja ^d   Shin, Il Shik ^d   Cho, Hong Yon ^b  

^a Sogang University   (South Korea)

^b Korea University   (South Korea)

^c Hanseo University   (South Korea)

^d Gangneung Wonju National University   (South Korea)

Author keywords

Alcohol; Antioxidant; Liver disease; Platycodi Radix diet; Proteomics

Indexed keywords

3ALPHA HYDROXYSTEROID DEHYDROGENASE; CYTOCHROME P450 2D; CYTOCHROME P450 2E1; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE MU; PEROXIREDOXIN; PEROXIREDOXIN 4; PLATYCODON GRANDIFLORUM EXTRACT; PROTEIN BCL 2; SMOOTH MUSCLE ACTIN; STRESS ACTIVATED PROTEIN KINASE 1; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL LIVER DISEASE; ALCOHOLISM; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DEFENSE MECHANISM; DRUG ISOLATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INDUCTION; ENZYME REGULATION; LIVER PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; PLATYCODON; PLATYCODON GRANDIFLORUM ROOT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEOMICS; RAT; SUPPLEMENTATION;

ALANINE TRANSAMINASE; ALCOHOLISM; ANIMALS; ASPARTATE AMINOTRANSFERASES; CYTOCHROME P-450 CYP2E1; DISEASE MODELS, ANIMAL; GENE EXPRESSION; GLUTATHIONE TRANSFERASE; HUMANS; LIVER; MALE; PLATYCODON; PROTECTIVE AGENTS; PROTEOMICS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS;

RATTUS;

EID: 74349086844     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2009.0017     Document Type: Article

References (33)

1. Lieber CS: Alcohol and the liver. Gastroenterology 1994;106: 1085-1105.
2. Dey A, Cederbaum AI: Alcohol and oxidative liver injury. Hepatology 2006;43(2 Suppl 1):S63-S74.
3. Koch OR, Pani G, Borrello S, Colavitti R, Cravero A, Farrè S, Galeotti T: Oxidative stress and antioxidant defenses in ethanolinduced cell injury. Mol Aspects Med 2004;25:191-198.
4. McDonough KH: Antioxidant nutrients and alcohol. Toxicology 2003:189:89-97.
5. Loguercio C, Federico A: Oxidative stress in viral and alcoholic hepatitis. Free Radic Biol Med 2003;34:1-10.
6. Yu BP: Cellular defenses against damage from reactive oxygen species. Physiol Rev 1994;1:139-162.
7. Vanhaecke T, Lindros KO, Oinonen T, Vercruysse A, Roqiers V: Effect of long-term ethanol exposure on the acinar distribution of hepatic glutathione S-transferase. Drug Metab Dispos 2000;28: 1470-1474.
8. Venkatraman A, Landar A, Davis AJ, Ulasova E, Page G, Murphy MP, Darley-Usmar V, Bailey SM: Oxidative modification of hepatic mitochondria protein thiols: effect of chronic alcohol consumption. Am J Physiol Gastrointest Liver Physiol 2004;286:G521-G527.
9. Lee EB: Pharmacological studies on Platycodon grandiflorum A. DC. IV. A comparison of experimental pharmacological effects of crude platycodin with clinical indications of platycodi radix [in Japanese]. Yakugaku Zasshi 1973;93:1188-1194.
10. Lee JY, Hwang WI, Lim ST: Antioxidant and anticancer activities of organic extracts from Platycodon grandiflorum A. De Candolle roots. J Ethnopharmacol 2004;93:409-415.
11. Lee KJ, Kim JY, Choi JH, Kim HG, Chung YC, Roh SH, Jeong HG: Inhibition of tumor invasion and metastasis by aqueous extract of the radix of Platycodon grandiflorum. Food Chem Toxicol 2006;44:1890-1896.
12. Reininger EA, Bauer R: Prostaglandin-H-synthase (PGHS)-1 and -2 microtiter assays for the testing of herbal drugs and in vitro inhibition of PGHS-isoenzyms by polyunsaturated fatty acids from Platycodi radix. Phytomedicine 2006;13:164-169.
13. Reitman S, Frankel S: A colorimetric method for the determination of serum glutamic oxaloacetic determination and glutamic pyruvic transaminase. Am J Clin Pathol 1957;28:56-63.
14. Dai Y, Rashba-Step, Cederbaum AI: Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates. Biochemistry 1993;32:6928-6937.
15. An JH, Kim J, Seong J: Redox signaling by ionizing radiation in mouse liver. Ann N Y Acad Sci 2004;1030:86-94.
16. Lands WE: Cellular signals in alcohol-induced liver injury: a review. Alcohol Clin Exp Res 1995;19:928-938.
17. Xu Y, Leo MA, Lieber CS: Lycopene attenuates alcoholic apoptosis in HepG2 cells expressing CYP2E1. Biochem Biophys Res Commun 2003;29:614-618. (Pubitemid 36945537)
18. Kim BJ, Hood BL, Aragon RA, Hardwick JP, Conrads TP, Veenstra TD, Song BJ: Increased oxidation and degradation of cytosolic proteins in alcohol-exposed mouse liver and hepatoma cells. Proteomics 2006;6:1250-1260.
19. Roede JR, Stewart BJ, Petersen DR: Decreased expression of peroxiredoxin 6 in a mouse model of ethanol consumption. Free Radic Biol Med 2008;45:1551-1558.
20. Tsutsumi M, Lasker JM, Shimizu M, Rosman AS, Lieber CS: The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver. Hepatology 1989;10:437-446.
21. Sakurai K, Cederbaum AI: Oxidative stress and cytotoxicity induced by ferric-nitrilotriacetate in HepG2 cells that express cytochrome P450 2E1. Mol Pharmacol 1989;54:1024-1035.
22. Cardin R, D'Errico A, Fiorentino M, Cecchetto A, Naccarato R, Farinati F: Hepatocyte proliferation and apoptosis in relation to oxidative damage in alcohol-related liver disease. Alcohol Alcohol 2002;37:43-48.
23. Reed DJ: Mitochondrial glutathione and chemically induced stress including ethanol. Drug Metab Rev 2004;36:569-582.
24. Rouach H, Fataccioli V, Gentil M, French SW, Morimoto M, Nordmann R: Effect of chronic ethanol feeding on lipid peroxidation and protein oxidation in relation to liver pathology. Hepatology 1997;25:351-355.
25. Ghibelli L, Coppola S, Fanelli C, Rotilio G, Civitareale P, Scovassi AI, Cirido MR: Glutathione depletion causes cytochrome c release even in the absence of cell commitment to apoptosis. FASEB J 1999;13:2031-2036.
26. Gonzalez FJ:Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. Mutat Res 2005;569:101-110.
27. Caro AA, Cederbaum AI: Oxidative stress, toxicology, and pharmacology of CYP2E1. Annu Rev Pharmacol Toxicol 2004; 44:27-42.
28. Nishitani Y, Matsumoto H: Ethanol rapidly activation of JNK associated with ER stress under inhibition of ADH. FEBS Lett 2006;580:9-14.
29. Verlaan M, te Morsche RH, Roelofs HM, Laheij RJ, Jansen JB, Peters WH, Drenth JP: Glutathione S-transferase Mu null genotype affords protection against alcohol induced chronic pancreatitis. Am J Med Genet A 2003;120:34-39.
30. Klouckova I, Hrncirova P, Mechref Y, Randy J, Arnold RJ, Li TK, McBride WJ, Novotny MV: Changes in liver protein abundance in inbred alcohol-preferring rats due to chronic alcohol exposure, as measured through a proteomics approach. Proteomics 2006;6:3060-3074.
31. Yang KS, Kang SW, Woo HA, Hwang SC, Chae HZ, Kim K, Rhee SG: Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid. J Biol Chem 2002;277:38029-38036.
32. Dickinson DA, Forman HJ: Cellular glutathione and thiols metabolism. Biochem Pharmacol 2002;64:1019-1026.
33. Dierick JF, Wenders F, Chainiaux F, Remacle J, Fischer AB, Toussaint O: Retrovirally mediated overexpression of peroxiredoxin VI increases the survival of WI-38 human diploid fibroblasts exposed to cytotoxic doses of tert-butylhydroperoxide and UVB. Biogerontology 2003;4:125-131.