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Volumn 34, Issue 26, 2009, Pages 2843-2847

Direct single injection of p38 mitogen-activated protein kinase inhibitor does not affect calcitonin gene-related peptide expression in dorsal root ganglion neurons innervating punctured discs in rats

Author keywords

Calcitonin gene related peptide; Dorsal root ganglion; Intervertebral disc; Lumbar; P38 mitogen activated protein kinase

Indexed keywords

1 [7 (4 FLUOROPHENYL) 1,2,3,4 TETRAHYDRO 8 (4 PYRIDYL)PYRAZOLO[5,1 C][1,2,4]TRIAZIN 2 YL] 2 PHENYLETHANEDIONE; CALCITONIN GENE RELATED PEPTIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 74249103747     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3181b8db15     Document Type: Article
Times cited : (10)

References (32)
  • 2
    • 84944360083 scopus 로고
    • Innervation of annulus fibrosus and posterior longitudinal ligament
    • Roofe PG. Innervation of annulus fibrosus and posterior longitudinal ligament. Arch Neurol Psychiatry 1940;44:100-103
    • (1940) Arch Neurol Psychiatry , vol.44 , pp. 100-103
    • Roofe, P.G.1
  • 3
    • 0026410084 scopus 로고
    • Immunohistochemical observations on spinal tissue innervation
    • Gronblad M, Weinstein JN, Santavirta S. Immunohistochemical observations on spinal tissue innervation. Acta Orthop Scand 1991;62:614-622
    • (1991) Acta Orthop Scand , vol.62 , pp. 614-622
    • Gronblad, M.1    Weinstein, J.N.2    Santavirta, S.3
  • 4
    • 0014828339 scopus 로고
    • Lumbar disc lesion, with special reference to the histological significance of nerve endings of the lumbar discs
    • Shinohara H. Lumbar disc lesion, with special reference to the histological significance of nerve endings of the lumbar discs. J Jpn Orthop Assoc 1970; 44:553-570
    • (1970) J Jpn Orthop Assoc , vol.44 , pp. 553-570
    • Shinohara, H.1
  • 5
    • 0030790455 scopus 로고    scopus 로고
    • Nerve ingrowth into diseased intervertebral disc in chronic back pain
    • Freemont AJ, Peacock TE, Goupille P, et al. Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet 1997;350:178-181
    • (1997) Lancet , vol.350 , pp. 178-181
    • Freemont, A.J.1    Peacock, T.E.2    Goupille, P.3
  • 6
    • 14844356611 scopus 로고    scopus 로고
    • Disc inflammation potentially promotes axonal regeneration of dorsal root ganglion neurons innervating lumbar intervertebral disc in rats
    • DOI 10.1097/01.brs.0000146051.11574.b4
    • Aoki Y, Ohtori S, Ino H, et al. Disc inflammation potentially promotes axonal regeneration of dorsal root ganglion neurons innervating lumbar intervertebral disc in rats. Spine 2004;29:2621-2626 (Pubitemid 40353247)
    • (2004) Spine , vol.29 , Issue.23 , pp. 2621-2626
    • Aoki, Y.1    Ohtori, S.2    Ino, H.3    Douya, H.4    Ozawa, T.5    Saito, T.6    Moriya, H.7    Takahashi, K.8
  • 7
    • 33745067505 scopus 로고    scopus 로고
    • Exposure of the nucleus pulposus to the outside of the anulus fibrosus induces nerve injury and regeneration of the afferent fibers innervating the lumbar intervertebral discs in rats
    • Inoue G, Ohtori S, Aoki Y, et al. Exposure of the nucleus pulposus to the outside of the anulus fibrosus induces nerve injury and regeneration of the afferent fibers innervating the lumbar intervertebral discs in rats. Spine 2006; 31:1433-1438
    • (2006) Spine , vol.31 , pp. 1433-1438
    • Inoue, G.1    Ohtori, S.2    Aoki, Y.3
  • 8
    • 0030253909 scopus 로고    scopus 로고
    • Pain mechanisms involved in musculoskeletal disorders [review]
    • Sluka KA. Pain mechanisms involved in musculoskeletal disorders [review]. J Orthop Sports Phys Ther 1996;24:240-254
    • (1996) J Orthop Sports Phys Ther , vol.24 , pp. 240-254
    • Sluka, K.A.1
  • 9
    • 33749516681 scopus 로고    scopus 로고
    • The degenerated lumbar intervertebral disc is innervated primarily by peptide-containing sensory nerve fibers in humans
    • Ozawa T, Ohtori S, Inoue G, et al. The degenerated lumbar intervertebral disc is innervated primarily by peptide-containing sensory nerve fibers in humans. Spine 2006;31:2418-2422
    • (2006) Spine , vol.31 , pp. 2418-2422
    • Ozawa, T.1    Ohtori, S.2    Inoue, G.3
  • 10
    • 22144434056 scopus 로고    scopus 로고
    • Expression and co-expression of VR1, CGRP, and IB4-binding glycoprotein in dorsal root ganglion neurons in rats: Differences between the disc afferents and the cutaneous afferents
    • Aoki Y, Ohtori S, Takahashi K, et al. Expression and co-expression of VR1, CGRP, and IB4-binding glycoprotein in dorsal root ganglion neurons in rats: differences between the disc afferents and the cutaneous afferents. Spine 2005;30:1496-1500
    • (2005) Spine , vol.30 , pp. 1496-1500
    • Aoki, Y.1    Ohtori, S.2    Takahashi, K.3
  • 11
    • 1642360758 scopus 로고    scopus 로고
    • Distribution and immunocytochemical characterization of dorsal root ganglion neurons innervating the lumbar intervertebral disc in rats: A review
    • DOI 10.1016/j.lfs.2004.01.008, PII S0024320504000190
    • Aoki Y, Takahashi Y, Ohtori S, et al. Distribution and immunocytochemical characterization of dorsal root ganglion neurons innervating the lumbar intervertebral disc in rats: a review. Life Sci 2004;74:2627-2642 (Pubitemid 38369360)
    • (2004) Life Sciences , vol.74 , Issue.21 , pp. 2627-2642
    • Aoki, Y.1    Takahashi, Y.2    Ohtori, S.3    Moriya, H.4    Takahashi, K.5
  • 12
    • 0036097591 scopus 로고    scopus 로고
    • Substance P and calcitonin gene-related peptide immunoreactive sensory DRG neurons innervating the lumbar intervertebral discs in rats
    • Ohtori S, Takahashi K, Chiba T, et al. Substance P and calcitonin generelated peptide immunoreactive sensory DRG neurons innervating the lumbar intervertebral discs in rats. Ann Anat 2002;184:235-240 (Pubitemid 34520900)
    • (2002) Annals of Anatomy , vol.184 , Issue.3 , pp. 235-240
    • Ohtori, S.1    Takahashi, K.2    Chiba, T.3    Yamagata, M.4    Sameda, H.5    Moriya, H.6
  • 13
    • 0036201899 scopus 로고    scopus 로고
    • Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators
    • Burke JG, Watson RW, McCormack D, et al. Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. J Bone Joint Surg Br 2002;84:196-201.
    • (2002) J Bone Joint Surg Br , vol.84 , pp. 196-201
    • Burke, J.G.1    Watson, R.W.2    McCormack, D.3
  • 14
    • 13444268945 scopus 로고    scopus 로고
    • Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: A study in surgical specimen and autopsy controls
    • Weiler C, Nerlich AG, Bachmeier BE, et al. Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls. Spine 2005;30:44-53.
    • (2005) Spine , vol.30 , pp. 44-53
    • Weiler, C.1    Nerlich, A.G.2    Bachmeier, B.E.3
  • 15
    • 22144496084 scopus 로고    scopus 로고
    • Neovascularization and neoinnervation of subcutaneously placed nucleus pulposus and the inhibitory effects of certain drugs
    • Olmarker K. Neovascularization and neoinnervation of subcutaneously placed nucleus pulposus and the inhibitory effects of certain drugs. Spine 2005;30:1501-1504
    • (2005) Spine , vol.30 , pp. 1501-1504
    • Olmarker, K.1
  • 16
    • 34247225562 scopus 로고    scopus 로고
    • Axonal growth potential of lumbar dorsal root ganglion neurons in an organ culture system: Response of nerve growth factor-sensitive neurons to neuronal injury and an inflammatory cytokine
    • Aoki Y, An HS, Takahashi K, et al. Axonal growth potential of lumbar dorsal root ganglion neurons in an organ culture system: response of nerve growth factor-sensitive neurons to neuronal injury and an inflammatory cytokine. Spine 2007;32:857-863
    • (2007) Spine , vol.32 , pp. 857-863
    • Aoki, Y.1    An, H.S.2    Takahashi, K.3
  • 17
    • 50649084851 scopus 로고    scopus 로고
    • TNF-alpha in nucleus pulposus induces sensory nerve growth: A study of the mechanism of discogenic low back pain using TNF-alpha-deficient mice
    • Hayashi S, Taira A, Inoue G, et al. TNF-alpha in nucleus pulposus induces sensory nerve growth: a study of the mechanism of discogenic low back pain using TNF-alpha-deficient mice. Spine 2008;33:1542-1546
    • (2008) Spine , vol.33 , pp. 1542-1546
    • Hayashi, S.1    Taira, A.2    Inoue, G.3
  • 18
    • 0032928614 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human
    • Widmann C, Gibson S, Jarpe MB, et al. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev 1999;79:143-180
    • (1999) Physiol Rev , vol.79 , pp. 143-180
    • Widmann, C.1    Gibson, S.2    Jarpe, M.B.3
  • 19
    • 0032032424 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin- stimulated primary glial cultures
    • Bhat NR, Zhang P, Lee JC, et al. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin- stimulated primary glial cultures. J Neurosci 1998;18:1633-1641
    • (1998) J Neurosci , vol.18 , pp. 1633-1641
    • Bhat, N.R.1    Zhang, P.2    Lee, J.C.3
  • 20
    • 0032515186 scopus 로고    scopus 로고
    • A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA
    • Ridley SH, Dean JL, Sarsfield SJ, et al. A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA. FEBS Lett 1998;439:75-80.
    • (1998) FEBS Lett , vol.439 , pp. 75-80
    • Ridley, S.H.1    Dean, J.L.2    Sarsfield, S.J.3
  • 21
    • 33846232608 scopus 로고    scopus 로고
    • Glial phosphorylated p38 MAP kinase mediates pain in a rat model of lumbar disc herniation and induces motor dysfunction in a rat model of lumbar spinal canal stenosis
    • Ito T, Ohtori S, Inoue G, et al. Glial phosphorylated p38 MAP kinase mediates pain in a rat model of lumbar disc herniation and induces motor dysfunction in a rat model of lumbar spinal canal stenosis. Spine 2007; 32:159-167
    • (2007) Spine , vol.32 , pp. 159-167
    • Ito, T.1    Ohtori, S.2    Inoue, G.3
  • 22
    • 28244497107 scopus 로고    scopus 로고
    • Animal models for human disc degeneration
    • review
    • Singh K, Masuda K, An HS. Animal models for human disc degeneration [review]. Spine J 2005;5:267-279
    • (2005) Spine J , vol.5 , pp. 267-279
    • Singh, K.1    Masuda, K.2    An, H.S.3
  • 23
    • 39049144760 scopus 로고    scopus 로고
    • ISSLS prize winner: Repeated disc injury causes persistent inflammation
    • Ulrich JA, Liebenberg EC, Thuillier DU, et al. ISSLS prize winner: repeated disc injury causes persistent inflammation. Spine 2007;32:2812-2819
    • (2007) Spine , vol.32 , pp. 2812-2819
    • Ulrich, J.A.1    Liebenberg, E.C.2    Thuillier, D.U.3
  • 24
    • 0032707474 scopus 로고    scopus 로고
    • Sensory innervation of the dorsal portion of the lumbar intervertebral disc in rats
    • Ohtori S, Takahashi Y, Takahashi K, et al. Sensory innervation of the dorsal portion of the lumbar intervertebral disc in rats. Spine 1999;24:2295-2299
    • (1999) Spine , vol.24 , pp. 2295-2299
    • Ohtori, S.1    Takahashi, Y.2    Takahashi, K.3
  • 25
    • 0029894021 scopus 로고    scopus 로고
    • Involvement of cytokines in lipopolysaccharide- induced facilitation of CGRP release from capsaicin-sensitive nerves in the trachea: Studies with interleukin-1beta and tumor necrosis factor-alpha
    • Hua XY, Chen P, Fox A, et al. Involvement of cytokines in lipopolysaccharide- induced facilitation of CGRP release from capsaicin-sensitive nerves in the trachea: studies with interleukin-1beta and tumor necrosis factor-alpha. J Neurosci 1996;16:4742-4748
    • (1996) J Neurosci , vol.16 , pp. 4742-4748
    • Hua, X.Y.1    Chen, P.2    Fox, A.3
  • 26
    • 0034663315 scopus 로고    scopus 로고
    • Involvement of the proinflammatory cytokines tumor necrosis factor-alpha, IL-1 beta, and IL-6 but not IL-8 in the development of heat hyperalgesia: Effects on heat-evoked calcitonin gene-related peptide release from rat skin
    • Opree A, Kress M. Involvement of the proinflammatory cytokines tumor necrosis factor-alpha, IL-1 beta, and IL-6 but not IL-8 in the development of heat hyperalgesia: effects on heat-evoked calcitonin gene-related peptide release from rat skin. J Neurosci 2000;20:6289-6293
    • (2000) J Neurosci , vol.20 , pp. 6289-6293
    • Opree, A.1    Kress, M.2
  • 27
    • 0037179755 scopus 로고    scopus 로고
    • P38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
    • Ji RR, Samad TA, Jin SX, et al. p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 2002;36:57-68.
    • (2002) Neuron , vol.36 , pp. 57-68
    • Ji, R.R.1    Samad, T.A.2    Jin, S.X.3
  • 28
    • 0037147689 scopus 로고    scopus 로고
    • Activation of p38MAPkinase in the rat dorsal root ganglia and spinal cord following peripheral inflammation and nerve injury
    • Kim SY, Bae JC, Kim JY, et al. Activation of p38MAPkinase in the rat dorsal root ganglia and spinal cord following peripheral inflammation and nerve injury. Neuroreport 2002;13:2483-2486
    • (2002) Neuroreport , vol.13 , pp. 2483-2486
    • Kim, S.Y.1    Bae, J.C.2    Kim, J.Y.3
  • 29
    • 11144338758 scopus 로고    scopus 로고
    • Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia
    • Mizushima T, Obata K, Yamanaka H, et al. Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia. Pain 2005;113:51-60.
    • (2005) Pain , vol.113 , pp. 51-60
    • Mizushima, T.1    Obata, K.2    Yamanaka, H.3
  • 30
    • 0141767048 scopus 로고    scopus 로고
    • Activation of p38 mitogenactivated protein kinase in spinal microglia is a critical link in inflammationinduced spinal pain processing
    • Svensson CI, Marsala M, Westerlund A, et al. Activation of p38 mitogenactivated protein kinase in spinal microglia is a critical link in inflammationinduced spinal pain processing. J Neurochem 2003;86:1534-1544
    • (2003) J Neurochem , vol.86 , pp. 1534-1544
    • Svensson, C.I.1    Marsala, M.2    Westerlund, A.3
  • 31
    • 39049119345 scopus 로고    scopus 로고
    • P38 MAPK inhibition in nucleus pulposus cells: A potential target for treating intervertebral disc degeneration
    • Studer RK, Aboka AM, Gilbertson LG, et al. p38 MAPK inhibition in nucleus pulposus cells: a potential target for treating intervertebral disc degeneration. Spine 2007;32:2827-2833
    • (2007) Spine , vol.32 , pp. 2827-2833
    • Studer, R.K.1    Aboka, A.M.2    Gilbertson, L.G.3
  • 32
    • 33749445416 scopus 로고    scopus 로고
    • Differential regulation of matrix degrading enzymes in a TNFalpha-induced model of nucleus pulposus tissue degeneration
    • Séguin CA, Bojarski M, Pilliar RM, et al. Differential regulation of matrix degrading enzymes in a TNFalpha-induced model of nucleus pulposus tissue degeneration. Matrix Biol 2006;25:409-418
    • (2006) Matrix Biol , vol.25 , pp. 409-418
    • Séguin, C.A.1    Bojarski, M.2    Pilliar, R.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.