The function of the pleckstrin homology domain in BCR-ABL-mediated leukemogenesis

Leukemia

Volumn 24, Issue 1, 2010, Pages 226-229

  Demehri, S ^a   O'Hare, T ^a,b   Eide, C A ^a,b   Smith, C A ^a   Tyner, J W ^a   Druker, B J ^a,b   Deininger, M W N ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; PLECKSTRIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; AUTOPHOSPHORYLATION; CHRONIC MYELOID LEUKEMIA; ENZYME ACTIVITY; FLUORESCENCE ACTIVATED CELL SORTING; GENE DELETION; HUMAN; IMMUNOBLOTTING; LETTER; LEUKEMOGENESIS; LYMPHOID CELL; MALIGNANT TRANSFORMATION; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DOMAIN; PROTEIN FUNCTION;

EID: 74249102001     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2009.196     Document Type: Letter

References (10)

1. Deininger MW, Goldman JM, Melo JV. The molecular biology of chronic myeloid leukemia. Blood 2000; 96: 3343-3356.
2. Li S, Ilaria Jr RL, Million RP, Daley GQ, Van Etten RA. The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity. J Exp Med 1999; 189: 1399-1412.
3. Lugo TG, Pendergast AM, Muller AJ, Witte ON. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science 1990; 247: 1079-1082.
4. Kin Y, Li G, Shibuya M, Maru Y. The Dbl homology domain of BCR is not a simple spacer in P210BCR-ABL of the Philadelphia chromosome. J Biol Chem 2001; 276: 39462-39468.
5. Ilaria Jr RL, Van Etten RA. P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members. J Biol Chem 1996; 271: 31704-31710.
6. Benekli M, Baer MR, Baumann H, Wetzler M. Signal transducer and activator of transcription proteins in leukemias. Blood 2003; 101: 2940-2954.
7. Melo JV. The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype. Blood 1996; 88: 2375-2384.
8. Russo C, Gao Y, Mancini P, Vanni C, Porotto M, Falasca M et al. Modulation of oncogenic DBL activity by phosphoinositol phosphate binding to pleckstrin homology domain. J Biol Chem 2001; 276: 19524-19531.
9. Han J, Luby-Phelps K, Das B, Shu X, Xia Y, Mosteller RD et al. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 1998; 279: 558-560.
10. Rossman KL, Worthylake DK, Snyder JT, Siderovski DP, Campbell SL, Sondek J. A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. Embo J 2002; 21: 1315-1326.