Adenovirus vector-specific t cells demonstrate a unique memory phenotype with high proliferative potential and coexpression of ccr5 and integrin α4β7

AIDS

Volumn 24, Issue 2, 2010, Pages 205-210

  Chakupurakal, Geothy ^a   Onion, David ^a   Cobbold, Mark ^b   Mautner, Vivien ^a   Moss, Paul Ah ^a  

^a School of Cancer Sciences   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Adenovirus; CD4 T lymphocytes; HIV; Immunophenotype; Vaccination

Indexed keywords

ADENOVIRUS VECTOR; BIOLOGICAL MARKER; CD4 ANTIGEN; CD45RA ANTIGEN; CD45RO ANTIGEN; CHEMOKINE RECEPTOR CCR5; GLYCOPROTEIN GP 120; INTEGRIN; INTEGRIN ALPHA 4 BETA 7; UNCLASSIFIED DRUG;

ADENOVIRUS 5; ARTICLE; BIOASSAY; CELL EXPANSION; CELL LABELING; CELL SPECIFICITY; EFFECTOR CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MEMORY CELL; MEMORY T LYMPHOCYTE; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; VIRUS REPLICATION;

ADENOVIRUSES, HUMAN; CD4-POSITIVE T-LYMPHOCYTES; GENETIC VECTORS; HIV INFECTIONS; HIV SEROPOSITIVITY; HIV-1; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; INTEGRINS; PHENOTYPE; RECEPTORS, CCR5;

EID: 74249092994     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e328333addf     Document Type: Article

References (29)

1. Lasaro MO, Ertl HC. New Insights on Adenovirus as vaccine vectors. Mol Ther 2009; 17:1333-1339.
2. Tatsis N, Lasaro MO, Lin SW, Xiang ZQ, Zhou D, Dimenna L, et al. Adenovirus vector-induced immune responses in nonhu-man primates: responses to prime boost regimens. J Immunol 2009; 182:6587-6599.
3. Buchbinder SP, Mehrotra DV, Duerr A, Fitzgerald DW, Mogg R, Li D, et al. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet 2008; 372:1881-1893.
4. McElrath MJ, De Rosa SC, Moodie Z, Dubey S, Kierstead L, Janes H, et al. HIV-1 vaccine-induced immunity in the test-of-con-cept Step Study: a case-cohort analysis. Lancet 2008; 372:1894-1905.
5. Perreau M, Pantaleo G, Kremer EJ. Activation of a dendritic cell-T cell axis by Ad5 immune complexes creates an improved environment for replication of HIV in T cells. J Exp Med 2008; 205:2717-2725.
6. Koup RA, Lamoreaux L, Zarkowsky D, Bailer RT, King CR, Gall JG, et al. Multiply-deleted replication-defective adenovirus vectors do not induce measurable vector-specific T cells in human trials. J Virol 2009; 83:6318-6322.
7. Weedon SJ, Green NK, McNeish IA, Gilligan MG, Mautner V, Wrighton CJ, et al. Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase. Int J Cancer 2000; 86:848-854.
8. Campbell JD. Detection and enrichment of antigen-specific CD4R and CD8R T cells basedon cytokine secretion. Methods 2003; 31:150-159.
9. Onion D, Patel P, Pineda RG, James ND, Mautner V. Anti-vector and tumor immune responses following adenovirus directed enzyme pro-drug therapy for the treatment of prostate cancer. Hum Gene Ther 2009 [Epub ahead of print].
10. Stallwood Y, Fisher KD, Gallimore PH, Mautner V. Neutralisation of adenovirus infectivity by ascitic fluid from ovarian cancer patients. Gene Ther 2000; 7:637-643.
11. O'Brien KL, Liu J, King SL, Sun YH, Schmitz JE, Lifton MA, et al. Adenovirus-specific immunity after immunization with an Ad5 HIV- 1vaccinecandidateinhumans.NatMed2009;15:873-875.
12. Okada R, Kondo T, Matsuki F, Takata H, Takiguchi M. Pheno-typic classification of human CD4R T cell subsets and their differentiation. Int Immunol 2008; 20:1189-1199.
13. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401:708-712.
14. Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 2004; 22:745-763.
15. Appay V, Zaunders JJ, Papagno L, Sutton J, Jaramillo A, Waters A, et al. Characterization of CD4(R) CTLs ex vivo. J Immunol 2002; 168:5954-5958.
16. Crompton L, Khan N, Khanna R, Nayak L, Moss PA. CD4R T cells specific for glycoprotein B from cytomegalovirus exhibit extreme conservation of T-cell receptor usage between different individuals. Blood 2008; 111:2053-2061.
17. Pourgheysari B, Khan N, Best D, Bruton R, Nayak L, Moss PA. The cytomegalovirus-specific CD4R T-cell response expands with age and markedly alters the CD4R T-cell repertoire. J Virol 2007; 81:7759-7765.
18. Stubbe M, Vanderheyde N, Pircher H, Goldman M, Marchant A. Characterization of a subset of antigen-specific human central memory CD4R T lymphocytes producing effector cytokines. Eur J Immunol 2008; 38:273-282.
19. Arthos J, Cicala C, Martinelli E, Macleod K, Van Ryk D, Wei D, et al. HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells. Nat Immunol 2008; 9:301-309.
20. Vogels R, Zuijdgeest D, van Rijnsoever R, Hartkoorn E, Damen I, de Bethune MP, et al. Replication-deficient human adeno-virus type 35 vectors for gene transfer and vaccination: efficient human cell infection and bypass of preexisting adenovirus immunity. J Virol 2003; 77:8263-8271.
21. Smith CA, Woodruff LS, Rooney C, Kitchingman GR. Extensive cross-reactivity of adenovirus-specific cytotoxic T cells. Hum Gene Ther 1998; 9:1419-1427.
22. Olive M, Eisenlohr LC, Flomenberg P. Quantitative analysis of adenovirus-specific CD4R T-cell responses from healthy adults. Viral Immunol 2001; 14:403-413.
23. Onion D, Crompton LJ, Milligan DW, Moss PA, Lee SP, Mautner V. The CD4R T-cell response to adenovirus is focused against conserved residues within the hexon protein. J Gen Virol 2007; 88 (Pt 9):2417-2425.
24. Smith CA, Woodruff LS, Kitchingman GR, Rooney CM. Ade-novirus-pulsed dendritic cells stimulate human virus-specific T-cell responses in vitro. J Virol 1996; 70:6733-6740.
25. Sester M, Sester U, Alarcon SS, Heine G, Lipfert S, Girndt M, et al. Age-related decrease in adenovirus-specific T cell responses. J Infect Dis 2002; 185:1379-1387.
26. Feuchtinger T, Richard C, Joachim S, Scheible MH, Schumm M, Hamprecht K, et al. Clinical grade generation of hexon-specific T cells for adoptive T-cell transfer as a treatment of adenovirus infection after allogeneic stem cell transplantation. J Immun-other 2008; 31:199-206.
27. Pauls E, Ballana E, Moncunill G, Bofill M, Clotet B, Ramo-Tello C, et al. Evaluation of the anti-HIV activity of natalizumab, an antibody against integrin alpha4. AIDS 2009; 23:266-268.
28. Kader M, Wang X, Piatak M, Lifson J, Roederer M, Veazey R, et al. alpha4(R)beta7(hi)CD4(R) memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection. Mucosal Immunol 2009; 2:439-449.
29. Tang J, Olive M, Champagne K, Flomenberg N, Eisenlohr L, Hsu S, et al. Adenovirus hexon T-cell epitope is recognized by most adults and is restricted by HLA DP4, the most common class II allele. Gene Ther 2004; 11:1408-1415.