Slower clearance of intravenous metformin in rats with acute renal failure induced by uranyl nitrate: Contribution of slower renal and non-renal clearances

European Journal of Pharmaceutical Sciences

Volumn 39, Issue 1-3, 2010, Pages 1-7

  Choi, Young H ^a   Lee, Inchul ^b   Lee, Myung G ^a  

^a Seoul National University   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

Author keywords

Hepatic CYP2C11 and 2D subfamily; Metformin; Pharmacokinetics; Rats; U ARF

Indexed keywords

CYTOCHROME P450 2C11; CYTOCHROME P450 2D; IPRIFLAVONE; METFORMIN; OCTAMER TRANSCRIPTION FACTOR 2; URANYL NITRATE;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG CLEARANCE; DRUG PROTEIN BINDING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY CLEARANCE; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; LIVER FUNCTION; MALE; MAXIMUM PLASMA CONCENTRATION; MICHAELIS MENTEN KINETICS; NONHUMAN; PRIORITY JOURNAL; RAT; URINE FLOW RATE;

ANIMALS; DISEASE MODELS, ANIMAL; INJECTIONS, INTRAVENOUS; KIDNEY FAILURE, ACUTE; KIDNEY FUNCTION TESTS; LIVER FUNCTION TESTS; MALE; METABOLIC CLEARANCE RATE; METFORMIN; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; URANYL NITRATE;

EID: 74149090100     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2009.05.006     Document Type: Article

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