Bioluminescence analysis of smad-dependent TGF-β signaling in live mice

Methods in Molecular Biology

Volumn 574, Issue , 2009, Pages 193-202

  Luo, Jian ^a   Wyss Coray, Tony ^a  

^a NONE

Author keywords

bioluminescence imaging; immunofluorescence; in vivo; luciferase; Smad; TGF

Indexed keywords

SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ARTICLE; FLUORESCENCE MICROSCOPY; LUMINESCENCE; METABOLISM; MOUSE; SIGNAL TRANSDUCTION;

ANIMALS; LUMINESCENCE; MICE; MICROSCOPY, FLUORESCENCE; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 74049140469     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60327-321-3_16     Document Type: Article

References (16)

1. Dennler, S., Goumans, M. J., and ten Dijke, P. (2002) Transforming growth factor beta signal transduction. J Leukoc Biol 71, 731-740.
2. Massague, J., Blain, S. W., and Lo, R. S. (2000) TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 103, 295-309.
3. Shi, Y., and Massague, J. (2003) Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113, 685-700.
4. Mazerbourg, S., Klein, C., Roh, J., Kaivo- Oja, N., Mottershead, D. G., Korchynskyi, O., Ritvos, O., and Hsueh, A. J. (2004) Growth differentiation factor-9 signaling is mediated by the type I receptor, activin receptor-like kinase 5. Mol Endocrinol 18, 653-665.
5. Oh, S. P., Yeo, C. Y., Lee, Y., Schrewe, H., Whitman, M., and Li, E. (2002) Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning. Genes Dev 16, 2749-2754.
6. Rebbapragada, A., Benchabane, H., Wrana, J. L., Celeste, A. J., and Attisano, L. (2003) Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Mol Cell Biol 23, 7230-7242.
7. Reissmann, E., Jornvall, H., Blokzijl, A., Andersson, O., Chang, C., Minchiotti, G., Persico, M. G., Ibanez, C. F., and Brivanlou, A. H. (2001) The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. Genes Dev 15, 2010-2022.
8. Unsicker, K., Flanders, K. C., Cissel, D. S., Lafyatis, R., and Sporn, M. B. (1991) Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system. Neuroscience 44, 613-625.
9. Kim, J. S., Yoon, S. S., Kim, Y. H., and Ryu, J. S. (1996) Serial measurement of interleukin- 6, transforming growth factor-beta, and S-100 protein in patients with acute stroke. Stroke 27, 1553-1557.
10. Mogi, M., Harada, M., Kondo, T., Narabayashi, H., Riederer, P., and Nagatsu, T. (1995) Transforming growth factor-beta 1 levels are elevated in the striatum and in ventricular cerebrospinal fluid in Parkinson's disease. Neurosci Lett 193, 129-132.
11. van der Wal, E. A., Gomez-Pinilla, F., and Cotman, C. W. (1993) Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies. Neuroreport 4, 69-72.
12. Platten, M., Wick, W., and Weller, M. (2001) Malignant glioma biology: role for TGF-beta in growth, motility, angiogenesis, and immune escape. Microsc Res Tech 52, 401-410.
13. Lin, A. H., Luo, J., Mondshein, L. H., ten Dijke, P., Vivien, D., Contag, C. H., and Wyss-Coray, T. (2005) Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury. J Immunol 175, 547-554.
14. Luo, J., Lin, A. H., Masliah, E., and Wyss- Coray, T. (2006) Bioluminescence imaging of Smad signaling in living mice shows correlation with excitotoxic neurodegeneration. Proc Natl Acad Sci USA 103, 18326-18331.
15. Luo, J., Ho, P. P., Buckwalter, M. S., Hsu, T., Lee, L. Y., Zhang, H., Kim, D. K., Kim, S. J., Gambhir, S. S., Steinman, L., and Wyss-Coray, T. (2007) Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis. J Clin Invest 117, 3306-3315.
16. Ray, P., De, A., Min, J. J., Tsien, R. Y., and Gambhir, S. S. (2004) Imaging tri-fusion multimodality reporter gene expression in living subjects. Cancer Res 64, 1323-1330.