The 27-bp repeat polymorphism in intron 4 (27 bp-VNTR) of endothelial nitric oxide synthase (eNOS) gene is associated with albumin to creatinine ratio in Mexican Americans

Molecular and Cellular Biochemistry

Volumn 331, Issue 1-2, 2009, Pages 201-205

  Nath, Subrata D ^a   He, Xin ^a   Voruganti, V Saroja ^c   Blangero, John ^c   MacCluer, Jean W ^c   Comuzzie, Anthony G ^c   Arar, Nedal H ^a,b   Abboud, Hanna E ^a,b   Thameem, Farook ^a  

^a University of Texas Health Science Center   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^c SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

ACR; Association analyses; ENOS; Genetic polymorphisms; Mexican Americans; Triglycerides

Indexed keywords

ALBUMIN; CREATININE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; ALBUMINOID; NOS3 PROTEIN, HUMAN;

ADULT; ALBUMINURIA; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE PHENOTYPE CORRELATION; GLOMERULUS FILTRATION RATE; HISPANIC; HUMAN; HYPERTENSION; INTRON; INTRON 4; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; RISK ASSESSMENT; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; VARIABLE NUMBER OF TANDEM REPEAT; WAIST CIRCUMFERENCE; BASE PAIRING; FAMILY; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MIDDLE AGED;

ALBUMINS; BASE PAIRING; CREATININE; FAMILY; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTRONS; MALE; MEXICAN AMERICANS; MIDDLE AGED; MINISATELLITE REPEATS; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, GENETIC;

EID: 74049134415     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-009-0159-5     Document Type: Article

References (29)

1. An P, Freedman BI, Hanis CL, Chen YD, Weder AB, Schork NJ et al (2005) Genome-wide linkage scans for fasting glucose, insulin, and insulin resistance in the national heart, lung, and blood institute family blood pressure program: evidence of linkages to chromosome 7q36 and 19q13 from meta-analysis. Diabetes 54(3):909-914. doi:10.2337/diabetes.54.3.909 (Pubitemid 40322098)
2. Love-Gregory L, Sherva R, Sun L, Wasson J, Schappe T, Doria A et al (2008) Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol. Hum Mol Genet 17:1695-1704. doi:10.1093/hmg/ddn060 (Pubitemid 351737173)
3. Schelling JR, Abboud HE, Nicholas SB, Pahl MV, Sedor JR, Adler SG et al (2008) Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the family investigation of nephropathy and diabetes (FIND). Diabetes 57:235-243. doi:10.2337/db07-0313
4. Mount PF, Power DA (2006) Nitric oxide in the kidney: functions and regulation of synthesis. Acta Physiol (Oxf) 187:433-146. doi: 10.1111/j.1748-1716.2006.01582.x
5. Moncada S, Higgs EA (2006) Nitric oxide and the vascular endothelium. Handb Exp Pharmacol 176:213-254. doi:10.1007/3-540-32967-6-7
6. Tsukada T, Yokoyama K, Arai T, Takemoto F, Hara S, Yamada A et al (1998) Evidence of association of the ecNOS gene polymorphism with plasma NO metabolite levels in humans. Biochem Biophys Res Commun 245:190-193. doi:10.1006/bbrc. 1998.8267 (Pubitemid 28414268)
7. Nakayama M, Yasue H, Yoshimura M, Shimasaki Y, Kugiyama K, Ogawa H et al (1999) T-786→C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 99:2864-2870
8. Tesauro M, Thompson WC, Rogliani P, Qi L, Chaudhary PP, Moss J (2000) Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298. Proc Natl Acad Sci USA 97:2832-2835. doi:10.1073/pnas.97.6.2832 (Pubitemid 30159257)
9. Casas JP, Cavalleri GL, Bautista LE, Smeeth L, Humphries SE, Hingorani AD (2006) Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review. Am J Epidemiol 164:921-935. doi:10.1093/aje/kwj302 (Pubitemid 44729832)
10. MacCluer JW, Stern MP, Almasy L, Atwood LA, Blangero J, Comuzzie AG et al (1999) Genetics of atherosclerosis risk factors in Mexican Americans. Nutr Rev 57:S59-S65
11. Arar NH, Voruganti VS, Nath SD, Thameem F, Bauer R, Cole SA et al (2008) A genome-wide search for linkage to chronic kidney disease in a community-based sample: the SAFHS. Nephrol Dial Transplant 23:3184-3191
12. Dyke B (1994) PEDSYS, a Pedigree Data Management System. User's manual. Population genetics laboratory technical report No. 2, 2nd edn. Southwest Foundation for Biomedical Research, San Antonio, TX 78245, 226 pp
13. Almasy L, Blangero J (2004) Exploring positional candidate genes: linkage conditional on measured genotype. Behav Genet 34:173-177. doi:10.1023/B:BEGE. 0000013731.03827.69 (Pubitemid 38268934)
14. Abecasis GR, Cookson WO, Cardon LR (2000) Pedigree tests of transmission disequilibrium. Eur J Hum Genet 8:545-551. doi: 10.1038/sj.ejhg.5200494 (Pubitemid 30447129)
15. Havill LM, Dyer TD, Richardson DK, Mahaney MC, Blangero J (2005) The quantitative trait linkage disequilibrium test: a more powerful alternative to the quantitative transmission disequilibrium test for use in the absence of population stratification. BMC Genet 6:S91. doi:10.1186/1471-2156-6-S1-S91 (Pubitemid 46443059)
16. Burg M, Menne J, Ostendorf T, Kliem V, Floege J (1997) Genepolymorphisms of angiotensin converting enzyme and endothelial nitric oxide synthase in patients with primary glomerulonephritis. Clin Nephrol 48:205-211
17. Yokoyama K, Tsukada T, Matsuoka H et al (1998) High accumulation of endothelial nitric oxide synthase (ecNOS): a gene polymorphism in patients with end-stage renal disease. Nephron 79:360-361. doi:10.1159/000045069 (Pubitemid 28310351)
18. Wang Y, Kikuchi S, Suzuki H, Nagase S, Koyama A (1999) Endothelial nitric oxide synthase gene polymorphism in intron 4 affects the progression of renal failure in non-diabetic renal diseases. Nephrol Dial Transplant 14:2898-2902. doi:10.1093/ndt/14.12.2898
19. Morita T, Ito H, Suehiro T, Tahara K, Matsumori A, Chikazawa H (1999) Effect of a polymorphism of endothelial nitric oxide synthase gene in Japanese patients with IgA nephropathy. Clin Nephrol 52:203-209
20. Fujita H, Narita T, Meguro H, Ishii T, Hanyu O, Suzuki K (2000) Lack of association between an ecNOS gene polymorphism and diabetic nephropathy in type 2 diabetic patients with proliferative diabetic retinopathy. Horm Metab Res 32:80-83. doi:10.1055/s-2007-978594 (Pubitemid 30143614)
21. Zanchi A, Moczulski DK, Hanna LS, Wantman M, Warram JH, Krolewski AS (2000) Risk of advanced diabetic nephropathy in type 1 diabetes is associated with endothelial nitric oxide synthase gene polymorphism. Kidney Int 57:405-413. doi:10.1046/j.1523-1755.2000.00860.x
22. Majid DS, Navar LG (2001) Nitric oxide in the control of renal hemodynamics and excretory function. Am J Hypertens 14:74S-82S. doi:10.1016/S0895-7061(01)02073-8
23. Majid DS, Williams A, Navar LG (1993) Inhibition of nitric oxide synthesis attenuates pressure-induced natriuretic responses in anaesthetized dogs. Am J Physiol Renal Physiol 262:F718-F722
24. Ochodnicky P, Henning RH, van Dokkum RP, de Zeeuw D (2006) Microalbuminuria and endothelial dysfunction: emerging targets for primary prevention of end-organ damage. J Cardiovasc Pharmacol 47:S151-S162. doi:10.1097/00005344-200606001-00009 (Pubitemid 44620205)
25. Kone BC, Baylis C (1997) Biosynthesis and homeostatic roles of nitric oxide in the normal kidney. Am J Physiol 272:F561-F578
26. Thameem F, Puppala S, Arar NH et al (2008) Endothelial nitric oxide synthase (eNOS) gene polymorphisms and theirassociation with type 2 diabetes-related traits in Mexican Americans. Diab Vasc Dis Res 5:109-113. doi:10.3132/dvdr.2008.018 (Pubitemid 351839282)
27. Hoffmann IS, Tavares-Mordwinkin R, Castejon AM, Alfieri AB, Cubeddu LX (2005) Endothelial nitric oxide synthase polymorphism, nitric oxide production, salt sensitivity and cardiovascular risk factors in Hispanics. J Hum Hypertens 19:233-240
28. Puppala S, Arya R, Thameem F, Arar NH, Bhandari K, Lehman DM (2007) Genotype by diabetes interaction effects on the detection of linkage of glomerular filtration rate to a region on chromosome 2q in Mexican Americans. Diabetes 56:2818-2828. doi:10.2337/db06-0984 (Pubitemid 350044926)
29. Freedman BI, Bowden DW, Rich SS, Xu J, Wagenknecht LE, Ziegler J et al (2008) Genome-wide linkage scans for renal function and albuminuria in Type 2 diabetes mellitus: the diabetes heart study. Diabet Med 25:268-276. doi:10.1111/j.1464-5491.2007.02361.x (Pubitemid 351322699)