An update on Shankhpushpi, a cognition-boosting Ayurvedic medicine

Journal of Chinese Integrative Medicine

Volumn 7, Issue 11, 2009, Pages 1001-1022

  Sethiya, Neeraj Kumar ^a   Nahata, Alok ^b   Mishra, Sri Hari ^a   Dixit, Vinod Kumar ^b  

^a M S UNIVERSITY OF BARODA   (India)

^b DR H S GOUR UNIVERSITY   (India)

Author keywords

Canscora decussata; Clitorea ternatea; Cognition disorders; Convulvulus pluricaulis; Evolvulus alsinoides; Medicine, ayurvedic

Indexed keywords

AYURVEDIC DRUG; BR 16A; CANSCORA DECUSSATA EXTRACT; CLITORIA TERNATEA EXTRACT; CONVOLVINE; CONVULVULUS PLURICAULIS EXTRACT; DIAZEPAM; EVOLVULUS ALSINOIDES EXTRACT; FLUMAZENIL; MAHARISHI AMRIT KALASH; MANGIFERIN; N METHYL BETA CARBOLINE 3 CARBOXAMIDE; PHENYTOIN; PIRACETAM; SHANKHPUSHPI; THYROCAP; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE;

ALZHEIMER DISEASE; ANALGESIC ACTIVITY; ANTEROGRADE AMNESIA; ANTHELMINTIC ACTIVITY; ANTIBACTERIAL ACTIVITY; ANTICONVULSANT ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIPYRETIC ACTIVITY; AYURVEDA; CANSCORA DECUSSATA; CLITORIA TERNATEA; COGNITION; CONVOLVULACEAE; CONVULVULUS PLURICAULIS; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG STRUCTURE; ELECTROMYOGRAM; EVOLVULUS ALSINOIDES; GENTIANACEAE; GOITER; HUMAN; IMMUNOMODULATION; INSECTICIDAL ACTIVITY; LEARNING; LEGUME; LIVER PROTECTION; MEMORY; NONHUMAN; PARKINSONISM; PHYTOCHEMISTRY; PRESCRIPTION; RETROGRADE AMNESIA; REVIEW; SEIZURE; SMOOTH MUSCLE RELAXATION; SYMPATHETIC TONE; THYROTOXICOSIS; TRADITIONAL MEDICINE; TRANQUILIZING ACTIVITY;

COGNITION; HUMANS; MATERIA MEDICA; MEDICINE, AYURVEDIC; MEMORY; PHARMACOGNOSY;

EID: 74049131025     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20091101     Document Type: Review

References (236)

1. Patwardhan B, Warude N, Pushpangadan P, Bhatt N. Ayurveda and traditional Chinese medicine: a comparative overview. Evid Based Complement Alternat Med. 2005; 2(4): 465-473.
2. Mason JW. A historical view of the stress field. J Hum Stress. 1975; 1(2): 22-36.
3. Bhattacharya SK, Muruganandam AV. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav. 2003; 75(3): 547-555.
4. Carlini EA. Plants and the central nervous system. Pharmacol Biochem Behav. 2003; 75(3): 501-512.
5. Bharkatiya M, Goyal A, Gupta GD, Gaud RS. Memory enhancers. Indian Pharmacist. 2006; 5(8): 32-36.
6. Suba V, Murugesan T, Rao RB, Pal M, Mandal SC, Saha BP. Neuropharmacological profile of Barleria lupulina Lindl. Extract in animal models. J Ethnopharmacol. 2002; 81(2): 251-255.
7. Johnson N, Davis T, Bosanquet N. The epidemic of Alzheimer's disease. How can we manage the costs? Pharmacoeconomics. 2000; 18(3): 215-223.
8. Nordberg A, Sevensson AL. Cholinesterase inhibitors in the treatment of Alzheimer's disease, a comparison of tolerability and pharmacology. Drug Saf. 1998; 19(6): 465-480.
9. Mukherjee PK, Kumar V, Mal M, Houghton PJ. Acetylcholinesterase inhibitors from plants. Phytomedicine. 2007; 14(4): 289-300.
10. Tully T, Bourtchouladze R, Scott R, Tallman J. Targeting the CREB pathway for memory enhancers. Nat Rev Drug Discov. 2003; 2(4): 267-277.
11. Kumar DC. Pharmacognosy can help minimize accidental misuse of herbal medicine. Curr Sci. 2007; 93(10): 1356-1358.
12. Anonymous Ministry of Health and Family Welfare, Department of Indian Systems of Medicine and Homeopathy. The Ayurvedic pharmacopoeia of India. New Delhi: Controller of Publications. 2001: 147-149.
13. Goyal PR, Singh KP. Shankhpuspi (Evolvulus alsinoides Linn.): a medicinal herb. Int J Mendel. 2005; 22(3-4): 124-125.
14. Shah V, Bole PV. Botanical identity of Shankapushpi. Indian J Pharm. 1961; 23(8): 223-224.
15. Shah VC, Bole PV. Further pharmacognostic studies on the drug 'Shankhpushpi'. J Univers Bombay. 1960; 29: 154-165.
16. Austuin DF. Evolvulus alsinoides (Convolvulaceae): an American herb in the Old World. J Ethnopharmacol. 2008; 117(2): 185-198.
17. Dubey NK, Kumar R, Tripathi P. Global promotion of herbal medicine: India's opportunity. Curr Sci. 2004; 86(1): 37-41.
18. Unnikrishnan E. Materia medica of the local health traditions of Payyannur. Thiruvananthapuram: Kerala Research Programme on Local Level Development, Center for Development Studies. 2004.
19. Gupta AK, Tandon N, Sharma M. Quality standards of Indian medicinal plants. New Delhi: Indian Council of Medical Research. 2005: 70.
20. Chatterjee A. Treatise of Indian medicinal plants. New Delhi: India Council for Scientific and Industrial Research. 1990: 327.
21. Upadhya AS, Kambhojkar MS. Studies on Ayurvedic drug Shankhpushpi from Western maharastra medicobotanical reported aspects. Bullet Med Ethanob Res. 1993; 14(1-2): 64-69.
22. Shah Y, Tangalas EG, Petersseen RC. Mild cognitive impairments. When is it a precursor to Alzheimer disease? Geriatrics. 2000; 55(9): 62, 65-68.
23. Chunekar KC. Bhavaprakasa nighantu (Commentary). Varanasi: Chowkhamba Vidyabhawan. 1969: 454-455.
24. Fantz PR. Nomenclatural notes on the genus Clitorea for the Flora North American Project. Castanea. 2000; 65(2): 89-92.
25. Cramer LH. Gentianaceae. In: Dassenayake MD, Fosberg FR. A revised handbook to the flora of ceylon. New Delhi: Amarind Publishing Co. 1981: 55-78.
26. Sàad F. The convulvulus species of the Canary Isles, the Mediterranean region and the Near and Middle East. Rotterdam: Bronder-ofset. 1967: 281-288.
27. Dandiya PC, Chopra YM. CNS-active drugs from plants indigenous to India. Indian J Pharm. 1970; 2(3): 67-90.
28. Woodson Jr RE, Schery RW, Dwyer JD. Flora of Panama. Ann Missouri Bot Gard. 1980; 67: 582-593.
29. Rajaqkaruna N, Harris CS, Towers GHN. Antimicrobial activity of plants collected from serpentine outcrops in Sri Lanka. Pharm Biol. 2002; 40(3): 235-244.
30. Ayyanar M, Ignacimuthu S. Traditional knowledge of Kani tribals in Kouthalai of Tirunelveli hills, Tamil Nadu, India. J Ethnopharmacol. 2005; 102(2): 246-255.
31. Hegde HV, Hegde GR, Kholkute SD. Herbal care for reproductive health: ethnomedicobotany from Uttara Kannada district in Karnataka, India. Complement Ther Clin Pract. 2007; 13(1): 38-45.
32. Sandhya B, Thomas S, Isabel W, Shenbagarathai R. Ethanomedicinal plants used by the Valaiyan community of Piranmalai hills (Reserved forest), Tamilnadu, India: a pilot study. Afr J Trad CAM. 2006; 3(1): 101-114.
33. Burkill HM. The useful plants of west tropical Africa. Royal Botanic Gardens. 1985; 5: 33.
34. Bussmann RW, Gilbreath GG, Solio J, Lutura M, Lutuluo R, Kunguru K, Wood N, Mathenge SG. Plant use of the Maasai of Sekenani Valley, Maasai Mara, Kenya. J Ethnobiol Ethnomed. 2006; 2: 22-25.
35. Sinha PA, Kumar SP, Wahi A. Comparative pharmacognostic study on Shankhpushpi: Canscora decussata Schult, Convulvulus pleuricaulis Chios and Evolvulus alsinoides Linn. Bull Med Ethnobot Res. 1986; 10(1): 62-73.
36. Kirtikar KR, Basu BD. Indian medicinal plants. 2nd ed. Periodical experts, New Delhi: Indian Council of Medical Research. 1993: 1774.
37. Varadan KSS, Vaidyanathan TS, Rama Rao MV. Phytochemistry of Evolvulus alsinoides Linn. Indian J Pharm. 1958; 20: 100-105.
38. Karandikar GK, Satakopan S. Shankhpushpi-{A} pharmacognostic study-{I}. Evolvulus alsinoides Linn. Indian J Pharm. 1959; 21(7): 200-203.
39. Karandikar GK, Satakopan S. Shankhpushpi-{A} pharmacognostic study-{II}.Convulvulus microphyllus Sieb. Indian J Pharm. 1959; 21(7): 204-207.
40. Karandikar GK, Satakopan S. Shankhpushpi-{A} pharmacognostic study-{III}. Clitorea ternatea Linn. Indian J Pharm. 1959; 21(12): 327-331.
41. Kapadia NS, Acharya NS, Suhagia BN. A pharmacognostical study on Convulvulus prostratus Forssk. J Nat Rem. 2005; 5(2): 108-114.
42. Devi BP, Boominathan R, Mandai SC. Studies on pharmacognostical profiles of Clitorea ternatea root (blue flowered variety). India J Nat Prod. 2002; 18: 2-15.
43. Shah SC, Quadry SJ. A textbook of pharmacognosy. 7th ed. New Delhi: CBS Publishers. 1990: 388-389.
44. Bisht NPS, Singh R. Chemical studies of Convulvulus microphyllus Sieb. Planta Med. 1978; 34(2): 222-223.
45. Deshpande SM, Srivastava DN. Chemical studies of Convulvulus pluricaulis Choisy. J Indian Chem Soc. 1969; 46(8): 759-760.
46. Macedo MLR, Xavier-Filho J. Purification and partial characterization of trypsin inhibitors from seeds of Clitorea ternatea. J Sci Food Agr. 1992; 58(1): 55-58.
47. Revilleza MJ, Mendoza EM, Raymundo LC. Oligosaccharides in several Philippine indigenous food legumes: determination, localization and removal. Plant Foods Hum Nutr. 1990; 40(1): 83-93.
48. Sinha A. Mucilage from the leaves of Clitorea ternatea? India: Proceedings of the Institution of Chemists. 1960: 228-231.
49. Nambiar GR, Mehta AR. Influence of sugars on ergot alkaloid production by cell suspensions of Evolvulus alsinoides L. Indian J Exp Biol. 1981; 19: 535-537.
50. Nair GG, Daniel M, Sabnis SD. Ergolines in the seeds of some Indian Convolvulaceae. Indian J Pharm Sci. 1987; 49(3): 100-102.
51. Rajagopalan N. Free amino acids and amides in legume root nodules. Curr Sci. 1964; 33: 454-456.
52. Joshi SS, Shrivastava RK, Shrivastava DK. Chemical examination of Clitoria ternatea seeds. J Am Oil Chem Soc. 1981; 58(6): 714-715.
53. Kelemu S, Cardona C, Segura G. Antimicrobial and insecticidal protein isolated from seeds of Clitorea ternatea, a tropical forage legume. Plant Physiol Biochem. 2004, 42(11): 867-873.
54. Guruswamy MN, Krishnamurthy TR, Vaidyanathan TS. A preliminary note on the pharmacology of evolvine. Curr Sci. 1956; 25: 119-120.
55. Krishnamurthy TR. Some pharmacological actions of evolvine hydrochloride. Curr Sci. 1959; 28: 64-65.
56. Aulakh GS, Narayanan S, Ma G. Phytochemistry and pharmacology of Shankhpushpi -four varieties. Anc Sci Life. 1988; 7(3-4): 149-156.
57. Baveja SK, Singla RD. Investigation of Evolvulus alsinoides Linn (Shankhpushpi). Indian J Pharm. 1969; 31(4): 108-110.
58. Encyclopedia Britannica Online [2007-04-05]. http://www.britannica.com.
59. Basu NK, Dandiya PC. Chemical investigation of Convulvulus pluricaulis. J Am Pharm Assoc Am Pharm Assoc. 1948; 37(1): 27.
60. Lounasmaa M. The tropane alkaloids. In: Brossi A. The alkaloids: Chemistry and pharmcology. New York: Academic Press. 1988: 72-74.
61. Prasad GC, Gupta RC, Srivastava DN, Tandon AK, Wahi RS, Udupa KN. Effect of Shankhpushpi on experimental stress. J Res Indian Med. 1974; 9(2): 19-27.
62. Singh GK, Bhandari A. Text book of pharmacognosy. New Delhi: CBS Publishers. 2000: 193-194.
63. Mirzaev YR, Aripova SF. Neuro- and psychopharmacological investigations of the alkaloids convolvine and atropine. Chem Natural Comp. 1998; 34(1): 56-58.
64. Razzakov NA, Aripova SF. Confolidine, a new alkaloid from the aerial part of Convolvulus subhirsutus. Chem Natural Comp. 2004; 40(1): 54-55.
65. Gapparov AM, Razzakov NA, Aripova SF. Alkaloids of Convolvulus subhirsutus from Uzbekistan. Chem Natural Comp. 2007; 43(3): 291-292.
66. Gapparov AM, Aripova SF, Razzakov NA, Khuzhaev VU. Conpropine, a new alkaloid from the aerial part of Convolvulus subhirsutus from Uzbekistan. Chem Natural Comp. 2008; 44(6): 743-744.
67. Malabadi RB, Nataraja K. Alkaloid biosynthesis influenced by Agrobacterium rhizogenes mediated transformation and bioreactor in Clitorea ternatea (Linn.). Plant Cell Biotechnol Mol Biol. 2003; 4: 169-178.
68. Ghosal S, Chaudhary RK, Nath A. Chemical constituents of the roots of Canscora decussata . Part II. J Indian Chem Soc. 1971; 48(6): 589-592.
69. Červenka F, Řeháková Z, Brojerová E, Kolečkář V, Vytlačilová J, Jahodář L. Evolvulus alsinoides L. - phytochemical analysis. Conference Proceedings, DPhG Jahrestagung - Joint Meeting, Marburg, Germany, October 5-7, 2006: 106.
70. Deshpande SM, Srivastava DN. Chemical examination of the fatty acids of Convulvulus pluricaulis. Indian Oil Soap J. 1969; 34(2): 217-218.
71. Srivastava DN, Deshpande SM. Gas chromatographic identification of fatty acids, fatty alcohols, and hydrocarbons of Convulvulus pluricaulis (Choisy). J Am Oil Chem Soc. 1975; 52(8): 318-319.
72. Vianni R, Souto SM. Oil content and fatty acid composition of Clitorea ternatea seeds. Arquivos da Universidade Federal Rural do Rio de Janeiro. 1971; 1: 47-50.
73. Debnath NB, Chakravarti D, Ghosh A. Fatty acids of Clitorea ternatea seed oils. J Ins Chemists. 1975; 47: 253-255.
74. Joshi SS, Shrivastava RK, Shrivastava DK. Chemical examination of Clitorea ternatea seeds. J Am Oil Chem Soc. 1981; 58(6): 714-715.
75. Husain S, Devi KS. Fatty acid composition of three plant species: Clitorea ternatea, Mandulea suberosa and Ruta chalapensis. J Oil Technol Assoc India. 1998; 30: 162-164.
76. Cervenka F, Jahodár L. Plant metabolites as nootropics and cognitives. Ceska Slov Farm. 2006; 55(5): 219-229.
77. Gupta P, Akanksha, Siripurapu KB, Ahmad A, Palit G, Arora A, Maurya R. Anti-stress constituents of Evolvulus alsinoides: an Ayurvedic crude drug. Chem Pharm Bull (Tokyo). 2007; 55(5): 771-775.
78. Mehta CR, Shah NB. Chemical examination of Evolvulus alsinoides. Sci Cult. 1958; 24: 180-181.
79. Kapoor A, Mahoor R, Viashampayan N, Gautam N. Antifungal spectrum of some petal extracts. Geobios. 1981; 8(2): 66-67.
80. van Valkenburg JLCH, Bunyapraphatsara N. Plant resources in South-East Asia. Medicinal and poisonous plants 2. Leiden: Prosea Foundation. 2001.
81. Patil UK, Dixit VK. Densitometric standardization of herbal medical products containing Evolvulus alsinoides by quantification of a marker compound. J Planar Chromatogr. 2005; 18(3): 234-239.
82. Kapadia NS, Acharya NS, Acharya SA, Shah MB. Use of HPTLC to establish a distinct chemical profile for Shankhpushpi and for quantification of scopoletin in Convulvulus pluricaulis choisy and in commercial formulations of Shankhpushpi. J Planar Chromatogr. 2006; 19(109): 195-199.
83. Zafar R, Ahmad S, Mujeeb M. Estimation of scopoletin in leaf and leaf callus of Convolvulus microphyllus Sieb. Indian J Pharm Sci. 2005; 67(5): 600-603.
84. Nahata A, Dixit VK. Spectrofluorimetric estimation of scopoletin in Evolvulus alsinoides Linn. and Convulvulus pluricaulis Choisy. Indian J Pharm Sci. 2008; 70(6): 834-837.
85. Sinha A. β-sitosterol from the seeds of Clitorea ternatea . Curr Sci. 1960; 29: 180-181.
86. Kulshrestha DK, Khare MP. Chemical investigation of the seeds of Clitorea ternatea. Curr Sci. 1967; 36: 124-125.
87. Kulshrestha DK, Khare MP. Chemical study of Clitorea ternatea seeds. Chem Ber. 1968; 101: 2096-2105.
88. Gupta RK, Lal LB. Chemical components of the seeds of Clitorea ternatea . Indian J Pharm. 1968; 30: 167-169.
89. Srivastava BK, Pande ES. Anthocyanins from the flowers of Clitorea ternatea. Planta Med. 1977; 32: 138-140.
90. Terahara N, Oda M, Matsui T, Osajima Y, Saito N, Toki K, Honda T. Five new anthocyanins, ternatins A3, B4, B3, B2, and D2, from Clitorea ternatea flowers. J Nat Prod. 1996; 59(2): 139-144.
91. Terahara N, Saito N, Honda H. Structures of Clitorea ternatea pigments. Tennen Yuki Kagobutsu Toronkai Koen Yoshishu. 1989; 31: 324-331.
92. Terahara N, Saito N, Honda T, Toki K, Osajima Y. Structure of ternatin A1, the largest ternatin in the major blue anthocyanins from Clitorea ternatea flower. Tetrahed Lett. 1990; 31(20): 2921-2924.
93. Terahara N, Saito N, Honda T, Toki K, Osajima Y. Structure of ternatin D1, an acylated anthocyanin from Clitorea ternatea flowers. Tetrahed Lett. 1989; 30(39): 5305-5308.
94. Terahara N, Saito N, Honda T, Toki K, Osajima Y. Acylated anthocyanins of Clitorea ternatea flowers and their acyl moieties. Phytochemistry. 1990; 29(3): 949-953.
95. Terahara N, Saito N, Honda T, Toki K, Osajima Y. Further structural elucidation of the anthocyanin, deacyl ternatin, from Clitorea ternatea . Phytochemistry. 1990; 29(11): 3686-3687.
96. Terahara N, Saito N, Honda T, Toki K, Osajima Y. Structure of ternatin A2, one of Clitorea ternatea flower anthocyanins having unsymmetrical side chains. Heterocycles. 1990; 31(10): 1773-1776.
97. Terahara N, Toki K, Saito N, Honda T, Matsui T. Eight new anthocyanins, ternatins C1-C5 and D3 and preternatins A3 and C4 from young Clitorea ternatea flowers. J Nat Prod. 1998; 61(11): 1361-1367.
98. Kondo T, Ueda M, Goto T. Structure of ternatin B1, a pentaacylated anthocyanin substituted on the B-ring asymmetrically with two long chains. Tetrahedron. 1990; 46(13-14): 4749-4756.
99. Tiwari RD, Gupta RK. Chemical examination of the leaves of Clitorea ternatea. J Indian Chem Soc. 1959; 36: 243-246.
100. Morita N, Arisawa M, Nagase M, Hsu HT, Chen YP. Studies on the constituents of Formosan Leguminosae. I. The constituents in the leaves of Clitorea ternatea L (author' s transl) . Yakugaku Zasshi. 1977; 97(6): 649-653.
101. Ripperger H. Isolation of stigmast-4-ene-3, 6-dione from Hamelia patens and Clitorea ternatea. Pharmazie. 1978; 33(1): 82-83.
102. Ranaganayaki S, Singh AK. Isolation and identification of pigments of the flowers of Clitorea ternatea. J Indian Chem Soc. 1979; 56: 1037-1038.
103. Saito N, Abe K, Honda T, Timberlake CF, Bridle P. Acylated delphinidin glucosides and flavonols from Clitorea ternatea. Phytochemistry. 1985; 24(7): 1583-1586.
104. Kazuma K, Kogawa K, Noda N, Kato N, Suzuki M. Identification of delphinidin 3-O-(6′-O-malonyl)-β-glucoside-3′-O-β- glucoside, a postulated intermediate in the biosynthesis of ternatin C5 in the blue petals of Clitorea ternatea (butterfly pea). Chem Biodivers. 2004; 1(11): 1762-1770.
105. Kazuma K, Noda N, Suzuki M. Malonylated flavonol glycosides from the petals of Clitorea ternatea. Phytochemistry. 2003; 62(2): 229-237.
106. Kazuma K, Noda N, Suzuki M. Flavonoid composition related to petal color in different lines of Clitorea ternatea. Phytochemistry. 2003; 64(6): 1133-1139.
107. Yadava RN, Verma V. Antimicrobial activity of a novel flavonol glycoside isolated from the roots of Clitorea ternatea Linn. Asian J Chem. 2003; 15: 842-846.
108. Banerjee SK, Chakravarti RN. Taraxerol from Clitorea ternatea. Bull Calcutta Sch Trop Med. 1963; 11: 106-107.
109. Banerjee SK, Chakravarti RN. Taraxerone from Clitorea ternatea. Bull Calcutta Sch Trop Med. 1964; 12: 23.
110. Kumar V, Mukherjee K, Kumar S, Mal M, Mukherjee PK. Validation of HPTLC method for the analysis of taraxerol in Clitorea ternatea. Phytochem Anal. 2008; 19(3): 244-250.
111. Ghosal S, Chaudhary RK, Nath A. Chemical constituents of gentianaceae. IV. New xanthone of Canscora decussata. J Pharm Sci. 1973; 62(1): 137-139.
112. Madam BR. Phytochemical and pharmacological investigation of Canscora decussata: an Indian indigenous drug. Arch Int Pharmacodyn Ther. 1960; 124: 358-367.
113. Ghosal S, Singh AK, Chaudhary RK. Chemical constituents of gentianaceae XX: natural occurrence of (-)-loliolide in Canscora decussata. J Pharm Sci. 1976; 65(10): 1549-1551.
114. Ghosal S, Biswas K, Chaudhary RK. Chemical constituents of gentianaceae part 22, structure of new 1, 3, 5-tri and 1, 3, 5, 6, 7-penta oxygenated xanthone Canscora decussata Schult. J Chem Soc Perkin 1. 1977; 14: 1597-1605.
115. Chintalwar GJ, Chattopadhyay S. Structural conformation of deccusatin: Swertia deccusata xanthone. Nat Prod Res. 2006; 20(1): 53-56.
116. Ghosal S, Chaudhuri RK, Nath A. Lanostane triterpenes of Canscora decussata. Phytochemistry. 1973; 12: 1763-1766.
117. Sethiya NK, Nahata A, Dixit VK. Simultaneous spectrofluorimetric determination of scopoletin and mangiferin in a methanolic extract of Canscora decussata Schult. Asian J Trad Med. 2008; 3(6): 224-229.
118. Ahmad MH, Rafique UM, McLaughlin W. Characterization of indigenous rhizobia from wild legumes. FEMS Microbiol Lett. 1984; 24(2-3): 197-203.
119. Roy M, Basu PS. Contents of hormones and indole acetic acid metabolism in root nodules of Clitorea ternatea L. Indian J Exp Biol. 1992; 30(9): 835-838.
120. Mukherjee PK, Kumar V, Kumar NS, Heinrich M. The Ayurvedic medicine Clitorea ternatea: from traditional use to scientific assessment. J Ethnopharmacol. 2008; 120(3): 291-301.
121. Agarwal N, Dey CD. Behavioral and lethal effects of alcoholic extracts of Evolvulus alsinoides in albino mice. J Physiol Allied Sci. 1997; 31(2): 81.
122. Nahata A, Patil UK, Dixit VK. Effect of Convulvulus pluricaulis Choisy. on learning behavior and memory enhancement activity in rodents. Nat Prod Res. 2008; 22(16): 1472-1482.
123. Pawar SA, Dhuley JN, Naik SR. Neuropharmacology of an extract derived from Convulvulus micro phyllus. Pharmaceut Biol. 2001; 39(4): 253-258.
124. Taranalli AD, Cheeramkuczhi TC. Influence of Clitorea ternatea on memory and central cholinergic activity in rats. Pharmaceut Biol. 2000; 38(1): 51-56.
125. Kulkarni C, Pattanshetty JR, Amruthraj G. Effect of alcoholic extract of Clitorea ternatea Linn on central nervous system in rodents. Indian J Exp Biol. 1988; 26(12): 957-960.
126. Parimaladevi B, Boominathan R, Mandai SC. Evaluation of antipyretic potential of Clitorea ternatea L. extract in rats. Phytomedicine. 2004; 11(4): 323-326.
127. Bhattacharya SK, Ghosal S, Chaudhuri RK, Sanyal AK. Canscora decussata (Gentianaceae) xanthones. 3. Pharmacological studies. J Pharm Sci. 1972; 61(11): 1838-1849.
128. Misra R. Modern drug development from traditional medicinal plants using radio legend receptor-binding assays. Med Res Rev. 1998; 18(6): 383-402.
129. Andrade C, Sudha S, Venkataraman BV. Herbal treatments for ESC induced memory deficits: a review of research and a discussion on animal models. J ECT. 2000; 16(2): 144-156.
130. Siripurapu KB, Gupta P, Bhatia G, Maurya R, Nath C, Palit G. Adaptogenic and anti-amnesiac properties of Evolvulus alsinoides in rodents. Pharmacol Biochem Behav. 2005; 81(3): 424-432.
131. Nahata A, Patil UK, Dixit VK. Effect of Evolvulus alsinoides Linn. on learning behavior and memory enhancement activity in rodents. Phytother Res. 2009; [Epub ahead of print]. DOI: 10.1002/ptr.2932.
132. Sinha SN, Dixit VP, Madnawat AVS, Sharma OP. The possible potentiation of cognitive processing on administration of Convulvulus microphyllus in rats. Indian Med. 1989; 1(3): 1-6.
133. Rai KS, Rao MS, Karanth KS. Clitorea ternatea enhances learning and memory - an experimental study on rats. International Congress on Frontiers in Pharmacology and Therapeutics in 21st Century. New Delhi, India. Indian J Pharmacol. 2000; 32: 150.
134. Rai KS, Murthy KD, Rao MS. Clitorea ternatea (Linn) root extract treatment in rats during growth spurt period affects dendritic morphology of hippocampal CA3 neurons. Calcutta: Third Congress. Federation of Indian Physiological Societies (FIPS), Calcutta (Abstract No. 45). 2000: 45.
135. Rai KS, Murthy KD, Karanth KS, Nalini K, Rao MS, Srinivasan KK. Clitorea ternatea root extract enhances acetylcholine content in rat hippocampus. Fitoterapia. 2002; 73(7-8): 685-689.
136. Rai KS, Murthy KD, Karanth KS, Rao MS. Clitorea ternatea Linn. root extract treatment during growth spurt period enhances learning and memory in rats. Indian J Physiol Pharmacol. 2001; 45(3): 305-313.
137. Rai KS, Murthy KD, Rao MS, Karanth KS. Altered dendritic arborization of amygdala neurons in young adult rats orally incubated with Clitorea ternatea aqueous root extract. Phytother Res. 2005; 19(7): 592-598.
138. Ng TB, Wang HX, Liu F, Xia LX. Plants beneficial to the aging brain. Neuroembryol Aging. 2006; 3(3): 136-141.
139. Anis M, Sharma MP, Iqbal M. Herbal ethnomedicine of the Gwalior forest division in Madhya Pradesh. India Pharmaceut Biol. 2000; 38(4): 241-253.
140. Bhatnagar M, Shukla SD, Jain S, Mundra A. Cytoprotective effects of Shankhpushpi an E. alsenoids preparation on hippocampal cells in mice. Indian Drugs. 2000; 37(6): 280-285.
141. Auddy B, Ferreira M, Blasina F, Lafon L, Arredondo F, Dajas F, Tripathi PC, Seal T, Mukherjee B. Screening of antioxidant activity of three Indian medicinal plants, traditionally used for the management of neurodegerative diseases. J Ethnopharmacol. 2003; 84(2-3): 31-138.
142. Cervenka F, Jahodár L. Plant metabolites as nootropics and cognitives. Ceska Slov Farm. 2006; 55(5): 219-229.
143. Allimuthu M, Venilla M. Catalogue of siddha antimalarial herbs [2009-05-23]. http://openmed.nic.in/1141.
144. Upadhyay VP. Therapeutic role of Ayurvedic herb in mental disorders. Vedic Path. 1986; 69(1): 24-29.
145. Kumar V. Potential medicinal plants for CNS disorders: an overview. Phytother Res. 2006; 20(12): 1023-1035.
146. Mudgal V. Studies on medicinal properties of Convulvulus pluricaulis and Boerhaavia diffusa. Planta Med. 1975; 28(1): 62-68.
147. Barar FS, Sharma VN. Preliminary pharmacological studies on Convulvulus pluricaulis Chois: an Indian indigenous herb. Indian J Physiol Pharmacol. 1965; 9(2): 99-102.
148. Dandiya PC. The pharmacological basis of herbal drugs acting on CNS. East Pharm. 1990; 33: 39-47.
149. Handa SS. Rasayana drugs, part II. Pharma Times. 1994; 26(3): 17-25.
150. Sharma VN, Barar FS, Khanna NK. Some pharmacological actions of Convulvulus pluricaulis Chois: an Indian indigenous herb. II. Indian J Med Res. 1965; 53(9): 871-876.
151. Dhingra D, Valecha R. Evaluation of the antidepressant-like activity of Convolvulus pluricaulis Choisy in the mouse forced swim and tail suspension tests. Med Sci Monit. 2007; 13(7): 155-161.
152. Dhingra D, Valecha R. Screening for antidepressant-like activity of Convolvulus pluricaulis Choisy in mice. Pharmacologyonline. 2007; 1: 262-278.
153. Boominathan R, Parimaladevi B, Mandal SC. Studies on neuropharmacological effects of Clitorea ternatea Linn. root extract in rats and mice. Nat Prod Sci. 2003; 9(4): 260-263.
154. Jain NN, Ohal CC, Shroff SK, Bhutada RH, Somani RS, Kasture VS, Kasture SB. Clitorea ternatea and the CNS. Pharmacol Biochem Behav. 2003; 75(3): 529-536.
155. Shukla SP. Anti-anxiety agents of plant origin. Probe. 1981; 30(3): 201-208.
156. Dikshit SK, Tewari PV, Dixit SP. Anticonvulsant activity of Canscora decussata Roem. & Sch. Indian J Physiol Pharmacol. 1972; 16(1): 81-83.
157. Dixit SP. Effect of certain indigenous drugs in convulsion in children. JRIM. 1971; 6(2): 214-224.
158. Bhattacharya SK, Ghosal S, Sanyal AK. Monoamine oxidase-inhibiting activity of mangiferin isolated from Canscora decussata. Naturwissenschaften. 1972; 59(12): 651.
159. Cervenka F, Koleckar V, Rehakova Z. Evaluation of natural substances from Evolvulus alsinoides L. with the purpose of determining their antioxidant potency. J Enzym Inhib Med Chem. 2008; 23(4): 574-578.
160. Rice Evans CA, Miller NJ, Paganga J. Antioxidant properties of phenolic compounds. Trends Plant Sci. 1977; 2: 152-159.
161. Chaturvedi M, Mali PC, Dixit VP. Hypolipidaemic effect of Convulvulus microphyllus in cholesterol fed gerbils. J Phytological Res. 1995; 8(2): 153-155.
162. Ganju L, Karan D, Chanda S, Srivastava KK, Sawhney RC, Selvamurthy W. Immunomodulatory effects of agents of plant origin. Biomed Pharmacother. 2003; 57(7): 296-300.
163. Panda S, Kar A. Inhibition of T3 production in levothyroxine-treated female mice by the root extract of Convulvulus pluricaulis. Horm Metab Res. 2001; 33(1): 16-18.
164. Daisy P, Priya N, Rajathi M. Immunomodulatory activity of Eugenia jambolana, Clitorea ternatea and Phyllanthus emblica on alloxon induced diabetic rats. J Exp Zool. 2004; 7(2): 269-278.
165. Madan B, Ghosh B. Canscora decussata promotes adhesion of neutrophils to human umbilical vein endothelial cells. J Ethnopharmacol. 2002; 79(2): 229-235.
166. Honda T, Saito N, Kusano T. Isolation of anthocyanins (Ternatin A1, A2, B1, B2, D1, and D2) from Clitorea ternatea (double blue) having blood platelet aggregation-inhibiting and vascular smooth muscle relaxing activities. Japan Kokai Tokyo Koho. 1991: 7.
167. Thenmozhi V, Elango V, Sadique J. Anti-inflammatory activity of some Indian medicinalplants. Anc Sci Life. 1989; 8(3-4): 258-261.
168. Parimaladevi B, Boominathan R, Mandai SC. Anti-inflammatory, analgesic and antipyretic properties of Clitorea ternatea root. Fitoterapia. 2003; 74(4): 345-349.
169. 4 liver injury in rats. Mediscope. 1979; 22(3): 65-68.
170. Madan B, Mandai BC, Kumar S, Ghosh B. Canscora decussata (Roxb.) Schult (Gentianaceae) inhibits LPS-induced expression of ICAM-1 and E-selectin on endothelial cells and carageenan-induced paw-edema in rats. J Ethnopharmacol. 2003; 89(2-3): 211-216.
171. Dey D, Das MN, Pharmacognosy of antidysenteric drugs of Indian medicine. Acta Bot Indica. 1988; 16(2): 216-226.
172. Purohit MG, Shanthaveerappa GK, Badami S. Antiulcer and anticatatonic activity of alcoholic extract of Evolvulus alsinoides (Convolvulaceae). Indian J Pharm Sci. 1996; 58(3): 110-112.
173. Purohit MG, Shanthaveerappa GK, Badami S. Antimicrobial activity of various extracts of Evolvulus alsinoides (Convolvulaceae). Indian J Microbiology. 1995; 35: 77-78.
174. Kamanzi AK, KonéM, Terreaux C, Traore D, Hostettmann K, Dosso M. Evaluation of the antimicrobial potential of medicinal plants from the Ivory Coast. Phytother Res. 2002; 16(5): 497-502.
175. Dash GK, Suresh P, Sahu SK, Kar DM, Ganapaty S, Panda SB. Evaluation of Evolvulus alsinoides Linn. for anthelmintic and antimicrobial activities. J Nat Rem. 2002; 2(2): 19-22.
176. Tharan NT, Vadivu R, Palanisamy M. Antibacterial activity of Evolvulus alsinoides. Indian Drugs. 2003; 40(10): 585-586.
177. Gupta RC, Mudgal V. Anti-fungal effect of Convulvulus pluricaulis (Shankapushpi). J Res Indian Med. 1974; 9(2): 67.
178. Bhakuni RS, Tripathi AK, Shukla YN. Insect antifeedant constituent from Convulvulus microphyllus (L.) Sieb. Phytother Res. 1996; 10(2): 170-171.
179. Osborn RW, De Samblanx GW, Thevissen K, Goderis I, Torrekens S, Van Leuven F, Attenborough S, Rees SB, Broekaert WF. Isolation and characterization of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanaceae and Saxifragaceae. FEBS Lett. 1995; 368(2): 257-262.
180. Alam MM, Siddiqui MB, Hussain W. Treatment of diabetes through herbal drugs in rural India. Fitoterpia. 1990; 61(3): 240-242.
181. Sharma AK, Majumdar M. Some observations on the effect of Clitorea ternatea Linn. on changes in serum sugar level and small intestinal mucosal carbohydrase activities in alloxan diabetes. Calcut Med J. 1990; 87(11-12): 168-171.
182. Sairam K, Rao CV, Goel RK. Effect of Convulvulus pluricaulis Chois on gastric ulceration and secretion in rats. Indian J Exp Biol. 2001; 39(4): 350-354.
183. Piala JJ, Madissoo H, Rubin B. Diuretic activity of roots of Clitorea ternatea L. in dogs. Experientia. 1962; 18: 89.
184. Madan BR. Spermicidal activity of Canscora decussata - an Indian indigenous drug. Arch Int Pharmacodyn Ther. 1960; 20(1): 88-94.
185. Tyagi SD, Singh N, Joneja S, Agarwal SC. Crude powder of Canscora decussata Roem et Sch: as spermicidal agent in albino rats. Acta Bot Indica. 1990; 18(1): 139-140.
186. Ratnasooriya WD, Hewageegana HGSP, Jayakody JRAC. Gastroprotective activity of Evolvulus alsinoides L. powder. Aust J Med Herbalism. 2005; 17: 55-60.
187. De S, Ravishankar B, Bhaskar GC. Plants with hepatoprotective activity: a review. Indian Drugs. 1998; 80(8): 355-363.
188. Rakhit S, Basu NK. Investigation on Convulvulus pluricaulis Choisy. Indian J Pharm. 1958; 20: 357-359.
189. Chaturvedi GN, Sharma RK, Sen SP. Hypotensive effect of certain indigenous drugs with special reference to Shankhapuspi (C. pluricaulis) in anaesthetised dogs. J Res Indian Med. 1966; 1(1): 57-67.
190. Ghosal S, Biswas K, Chaudhuri RK. Chemical constituents of gentianaceae XXIV: anti-mycobacterium tuberculosis activity of naturally occurring xanthones and synthetic analogs. J Pharm Sci. 1978; 67(5): 721-722.
191. Ghosal S, Chaudhuri RK. Chemical constituents of gentianaceae XIV: antitubercular activity of xanthones of Canscora decussata Schult. J Pharm Sci. 1975; 64(5): 888-889.
192. Singh KK, Prakash A. National seminar on the use of traditional medicinal plants in skin care. Lucknow: CMAP. 1994: 30.
193. Upadhye AS, Vartak VD, Kumbhojkar MS. Ethnomedico-botanical studies in Western Maharashtra, India. Ethnobotany. 1994; 6(1 &. 2): 25-31.
194. Dandekar UP, Chandra RS, Dalvi SS, Joshi MV, Gokhale PC, Sharma AV, Shah PU, Kshirsagar NA. Analysis of a clinically important interaction between Phenytoin and Shankhapushpi, an Ayurvedic preparation. J Ethnopharmacol. 1992; 35(3): 285-288.
195. Moharana D, Moharana S. A clinical trial of Mentat in patients with various types of epilepsy. Probe. 1994; 33(2): 160-162.
196. Sharan V, Khare M. A clinical trial of Mentat in children with behavioral problem. Probe. 1991; 31(1): 12-22.
197. Kulkarni SK, Verma A. BR-16A (Mentat), a herbal preparation improves learning and memory performance in mice. Indian Drugs. 1993; 30: 97-107.
198. Kulkarni SK, Sharma A. Reversal of diazepam withdrawal induced hyperactivity in mice by BR-16A (Mentat), a herbal preparation. Indian J Exp Biol. 1994; 32(12): 886-888.
199. Agrawal A, Dubey ML, Dubey GP. Effects of "Mentat" on memory anxiety scores of normal subjects in three age groups. Pharmacopsychologia. 1990; 3: 43-45.
200. Kulkarni SK, Verma A. Prevention of development of tolerance and dependence to opiate in mice by BR-16A (Mentat), a herbal psychotropic preparation. Indian J Exp Biol. 1992; 30(10): 885-888.
201. Kulkarni SK, Verma A. Protective effect of BR-16A (Mentat), a herbal preparation on alcohol abstinence-induced anxiety. Indian J Exp Biol. 1993; 31(5): 435-439.
202. Verma A, Kulkarni SK, Effect of a herbal psychotropic preparation, BR-16A (Mentat), on performance of mice on elevated plus maze. Indian J Exp Biol. 1991; 29(12): 1120-1123.
203. Kulkarni SK, George B. Pentylenetetrazol-induced kindling in animals: protective effect of BR-16A. Indian J Exp Biol. 1995; 33(6): 424-427.
204. Bhattacharya SK. Behavioural studies on BR-16A (Mentat), a herbal psychotropic formulation. Indian J Exp Biol. 1994; 32(1): 37-43.
205. Kulkarni SK, Verma A. Evidence for nootropic effect of BR-16A (Mentat), a herbal psychotropic preparation in mice. Indian J Physiol Pharmacol. 1992; 36(1): 28-34.
206. Sharma KP, Kushwaha HK, Sharma SS. A placebo-controlled trial on the efficacy of mentat in managing depressive disorders. Probe. 1993; 33(1): 26-31.
207. Bhattacharya SK, Nootropic effect of BR-16A (Mentat), a psychotropic herbal formulation, on cognitive deficits induced by prenatal undernutrition, postnatal environmental impoverishment and hypoxia in rats. Indian J Exp Biol. 1994; 32(1): 31-36.
208. Bhardwaj SK, Srivastava KK. Effect of a composite Indian herbal
209. Tripathi M, Sundaram R, Rafiq MD, Venkataranganna MV, Gopumadhavan S, Mitra SK. Pharmacokinetic interactions of Mentat with carbamazepine and Phenytoin. Eur J Drug Metab Pharmacokinet. 2000; 25(3-4): 223-226.
210. Singh RH, Mehta AK. Studies on the psychotropic effect of the Medhya Rasayana drug. J Res Indian Med Yoga Homeopath. 1977; 12(3): 18.
211. Shukla SP. A comparative study on the barbiturate hypnosis potentiation effect of medhya rasayana drugs - Shankhapushpi (Convulvulus pluricaulis). Bull Medico-Ethno-Bot Res. 1980; 1(4): 554-560.
212. Pandit RK, Prasad GC. Role of thyrocap in the treatment of simple diffuse goitre: a case report. JREIM. 1992; 11(3): 21-24.
213. Juma HK, Abdulrazak SA, Muinga RW, Ambula MK. Evaluation of Clitorea, Gliricidia and Mucuna as nitrogen supplements to Napier grass basal diet in relation to the performance of lactating Jersey cows. Livestock Sci. 2006; 103(1-2): 23-29.
214. Devi UK, Swarup A. Evaluation of clinical efficacy of Menotab in alleviating symptoms of menopausal syndrome: phase III open clinical trial. Antiseptic. 2000; 98(3): 87-89.
215. Singh A. Review of ethnomedicinal uses and pharmacology of Evolvulus alsinoides Linn. Ethnobot Leafl. 2008; 12: 734-740.
216. Nahata A, Patil UK, Dixit VK. Anxiolytic activity of Evolvulus alsinoides and Convulvulus pluricaulis in rodents. Pharmaceut Biol. 2009; 47(5): 444-451.
217. Mehta CR, Shah NB. Studies on Evolvulus alsinoides Linn. Indian J Appllied Chem. 1959; 22(1): 6.
218. Palpu P, Rawat AKS, Rao CV, Srivastava SK, Govindarajan R. Health promoting functional foods fortified with herbs. USA: Council of Scientific and Industrial Research. 2008.
219. Andrade C. ECT-induced anterograde amnesia: can the deficits be minimized? Conv Ther. 1994; 10(1): 59.
220. Andrade C, Udaya HB, Chandra JS. BR-16A (Mentat) restricts development of ECS-induced retrograde amnesia. Biol Psychiat. 1995; 37: 820.
221. Joseph J, Venkataraman BV, Rani MA, Andrade C. BR-16A (Mentat) protects against ECS-induced anterograde amnesia. Biol Psychiat. 1994; 36(7): 478-481.
222. Faruqi S, Chittaranjan A, Ramteke S, Joseph J, Venkataraman BV, Naga Rani MA. Herbal pharmacotherapy for the attenuation of ECS-induced anterograde and retrograde amnesic deficits. Conv Ther. 1995; 11(4): 241.
223. Ramteke S, Andrade C, Faruqi S, Joseph Jerry, Venkataraman BV, Nagarani MA. BR-16A (Mentat) attenuates anterograde amnesia induced by electroconvulsive shocks in slow learning rats. Indian J Pharmacol. 1995; 27(3): 186-188.
224. Andrade C, Raj T, Udaya HB, Suresh Chandra J. Effect of BR-16A (Mentat) on α-2 adrenergic, dopamine autoreceptor and dopamine post-synaptic receptor functioning. Indian J Pharmacol. 1994; 26: 292-295.
225. Andrade C. The herbal treatment of Parkinson's disease: a possible role for BR-16A (Mentat). Indian J Psychol Med. 1996; 19(2): 82.
226. Agarwal U, Dixit SP, Dubey GP. The management of post-stroke functional disability by an indigenous formulation Mentat. Indian Pract. 1994; 47(9): 759-761.
227. Kumar A, Kulkarni SK. Protective effect of BR-16A, a polyherbal preparation against social isolation stress: possible GABAergic mechanism. Phytother Res. 2006; 20(7): 538-541.
228. Ahmad S, Zafar RU, Sahid M. Anticonvulsant potential of callus cultures of Convolvulus microphyllus Sieb. OPEM. 2007; 7(1): 46-50.
229. Gupta RC, Singh PM, Prasad GC, Udupa KN. Probable mode of action of Shankhpushpi in the management of thyrotoxicosis. Anc Sci Life. 1981; 1(1): 46-54.
230. Asthana S, Greig NH, Holloway HW, Raffaele KC, Berardi A, Schapiro MB, Rapoport SI, Soncrant TT. Clinical pharmacokinetics of arecoline in subjects with Alzheimer's disease. Clin Pharmacol Therap. 1996; 60(3): 276-282.
231. Mirzaev YR, Aripova SF. Neuro- and psychopharmacological investigation of the alkaloids convolvine and atropine. Chem Nat Comp. 1998; 34(1): 56-58.
232. Penza M, Montant C, Jeremic M, Mazzoleni G, Wendy Hsiao WL, Marra M, Sharma H, Di Lorenzo D. MAK-4 and -5 supplemented diets inhibit liver carcinogenesis in mice. BMC Complement Altern Med. 2007; 7: 19.
233. Marin A, Carias D, Cioccia AM, Hevia P. Nutritional value of Musa paradisiaca and Clitorea ternatea leaves as diluents for chicken rations. Interciencia. 2003; 28(1): 51-57.
234. Nag G, De B. Antioxidant and acetylcholinesterase inhibitory properties of the Indian medicinal plant "Shankhapushpi" used for enhancing memory function. J Complement Integr Med. 2008; 5(1): 26.
235. Rajagopalan V. Seminar on research in Ayurveda and Siddha. New Delhi: CCRAS. 1995: 20-22, 34.
236. Singh HB, Viswanathan MV. Need for authentication of market samples of crude drug Shankhpushpi Convolvulus microphyllus. J Med Arom Plant Sci. 2000; 22(4a), 23(1a): 612-618.