Glutamine attenuates hyperoxia-induced acute lung injury in mice

Clinical and Experimental Pharmacology and Physiology

Volumn 37, Issue 1, 2010, Pages 56-61

  Perng, Wann Cherng ^a   Huang, Kun Lun ^a   Li, Min Hui ^a   Hsu, Ching Wang ^a   Tsai, Shih Hung ^a   Chu, Shi Jye ^a   Chang, Deh Ming ^a  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

Acute lung injury; Glutamine; Hyperoxia

Indexed keywords

GLUTAMINE; HEAT SHOCK PROTEIN 70; INTERLEUKIN 6; MALONALDEHYDE; MYELOPEROXIDASE; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPEROXIA; LUNG EDEMA; LUNG INJURY; LUNG LAVAGE; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; SURVIVAL;

ACUTE LUNG INJURY; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DISEASE MODELS, ANIMAL; EDEMA; GLUTAMINE; HEAT-SHOCK PROTEINS; HYPEROXIA; LUNG; MALE; MALONDIALDEHYDE; MICE; MICE, INBRED C57BL; NEUTROPHIL INFILTRATION; ORGAN SIZE; PEROXIDASE; RANDOM ALLOCATION; SURVIVAL ANALYSIS;

EID: 74049126635     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2009.05239.x     Document Type: Article

References (36)

1. Altemeier WA, Sinclair SE. Hyperoxia in the intensive care unit: Why more is not always better. Curr. Opin. Crit. Care 2007 13 : 73 8.
2. Crapo JD. Morphologic changes in pulmonary oxygen toxicity. Annu. Rev. Physiol. 1986 48 : 721 731.
3. Calfee CS, Matthay MA. Nonventilatory treatments for acute lung injury and ARDS. Chest 2007 131 : 913 920.
4. Labow BI, Souba WW. Glutamine. World J. Surg. 2000 24 : 1503 1513.
5. Flaring UB, Rooyackers OE, Wernerman J, Hammarqvist F. Glutamine attenuates post-traumatic glutathione depletion in human muscle. Clin. Sci. 2003 104 : 275 282.
6. Parry-Billings M, Evans J, Calder PC, Newsholme EA. Does glutamine contribute to immunosuppression after major burns? Lancet 1990 336 : 523 525.
7. Planas M, Schwartz S, Arbos MA, Farriol M. Plasma glutamine levels in septic patients. JPEN J. Parenter. Enteral Nutr. 1993 17 : 299 300.
8. Singleton KD, Wischmeyer PE. Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression. Am. J. Physiol. Regul. Intergr. Comp. Physiol. 2007 292 : R1839 45.
9. Curi R, Lagranha CJ, Doi SQ et al. Molecular mechanisms of glutamine action. J. Cell. Physiol. 2005 204 : 392 401.
10. Ahmad S, White CW, Chang LY, Schneider BK, Allen CB. Glutamine protects mitochondrial structure and function in oxygen toxicity. Am. J. Physiol. Lung Cell. Mol. Physiol. 2001 280 : L779 91.
11. Ogunlesi F, Cho C, McGrath-Morrow SA. The effect of glutamine on A549 cells exposed to moderate hyperoxia. Biochim. Biophys. Acta 2004 1688 : 112 120.
12. US National Institutes of Health. Guide for the Care and Use of Laboratory Animals, NIH Publication No. 85-23. National Academy Press, 1996.
13. Ward NS, Waxman AB, Homer RJ et al. Interleukin-6-induced protection in hyperoxic acute lung injury. Am. J. Respir. Cell Mol. Biol. 2000 22 : 535 542.
14. Chang H, Li MH, Chen CW, Yan HC, Huang KL, Chu SJ. Intravascular FC-77 attenuates phorbol myristate acetate-induced acute lung injury in isolated rat lungs. Crit. Care Med. 2008 36 : 1222 1229.
15. Chen HI, Yeh DY, Liou HL, Kao SJ. Insulin attenuates endotoxin-induced acute lung injury in conscious rats. Crit. Care Med. 2006 34 : 758 764.
16. Nakamura T, Yamakawa M, Maeda J et al. Effect of glutamine on acute lung injury in rats with endotoxemia. Clin. Nutr. 1997 16 : 79 83.
17. Hayashi Y, Sawa Y, Fukuyama N, Nakazawa H, Matsuda H. Preoperative glutamine administration induces heat-shock protein 70 expression and attenuates cardiopulmonary bypass-induced inflammatory response by regulating nitric oxide synthase activity. Circulation 2002 106 : 2601 2607.
18. Singleton KD, Beckey VE, Wischmeyer PE. Glutamine prevents activation of NF-kappaB and stress kinase pathways, attenuates inflammaory cytokine release, and prevents acute respiratory distress syndrome (ARDS) following sepsis. Shock 2005 24 : 583 589.
19. Jain D, Atochina-Vasserman E, Kadire H et al. SP-D-deficient mice are resistant to hyperoxia. Am. J. Physiol. Lung Cell. Mol. Physiol. 2007 292 : L861 71.
20. Kobayashi H, Sakashita N, Okuma T et al. Class A scavenger receptor (CD204) attenuates hyperoxia-induced lung injury by reducing oxidative stress. J. Pathol. 2007 212 : 38 46.
21. George CL, Fantuzzi G, Bursten S, Leer L, Abraham E. Effects of lisofylline on hyperoxia-induced lung injury. Am. J. Physiol. 1999 276 : L776 85.
22. Mukhopadhyay S, Hoidal JR, Mukherjee TK. Role of TNFalpha in pulmonary pathophysiology. Respir. Res. 2006 7 : 125.
23. Martin TR. Lung cytokines and ARDS. Roger S. Mitchell Lecture. Chest 1999 116 (Suppl. S2 8.
24. Wischmeyer PE, Kahana M, Wolfson R, Ren H, Musch MM, Chang EB. Glutamine induces heat shock protein and protects against endotoxin shock in the rat. J. Appl. Physiol. 2001 90 : 2403 2410.
25. Wheeler DS, Wong HR. Heat shock response and acute lung injury. Free Radic. Biol. Med. 2007 42 : 1 14.
26. Huang KL, Wu CP, Chen YL, Kang BH, Lin YC. Heat stress attenuates air bubble-induced acute lung injury: A novel mechanism of diving acclimatization. J. Appl. Physiol. 2003 94 : 1485 1490.
27. Villar J, Edelson JD, Post M, Mullen JB, Slutsky AS. Induction of heat stress proteins is associated with decreased mortality in an animal model of acute lung injury. Am. Rev. Respir. Dis. 1993 147 : 177 181.
28. Hiratsuka M, Yano M, Mora BN, Nagahiro I, Cooper JD, Patterson GA. Heat shock pretreatment protects pulmonary isografts from subsequent ischemia-reperfusion injury. J. Heart Lung Transplant. 1998 17 : 1238 1246.
29. Wischmeyer PE. Glutamine and heat shock protein expression. Nutrition 2002 18 : 225 228.
30. Olivera WG, Ridge KM, Sznajder JI. Lung liquid clearance and Na,K-ATPase during acute hyperoxia and recovery in rats. Am. J. Respir. Crit. Care Med. 1995 152 : 1229 1234.
31. +-ATPase beta1 subunit gene improves alveolar fluid clearance and survival in hyperoxic rats. Hum. Gene Ther. 2000 11 : 2231 2242.
32. Perkowski S, Scherpereel A, Murciano JC et al. Dissociation between alveolar transmigration of neutrophils and lung injury in hyperoxia. Am. J. Physiol. Lung Cell. Mol. Physiol. 2006 291 : L1050 8.
33. Shasby DM, Fox RB, Harada RN, Repine JE. Reduction of the edema of acute hyperoxic lung injury by granulocyte depletion. J. Appl. Physiol. 1982 52 : 1237 1244.
34. Lagranha CJ, Levada-Pires AC, Sellitti DF, Procopio J, Curi R, Pithon-Curi TC. The effect of glutamine supplementation and physical exercise on neutrophil function. Amino Acids 2008 34 : 337 346. (Pubitemid 351569769)
35. Pithon-Curi TC, Trezena AG, Tavares-Lima W, Curi R. Evidence that glutamine is involved in neutrophil function. Cell Biochem. Funct. 2002 20 : 81 6.
36. Wang Y, Phelan SA, Manevich Y, Feinstein SI, Fisher AB. Transgenic mice overexpressing peroxiredoxin 6 show increased resistance to lung injury in hyperoxia. Am. J. Respir. Cell Mol. Biol. 2006 34 : 481 486.