Analysis of [2H7]methionine, [2H4]methionine, methionine, [2H4]homocysteine and homocysteine in plasma by gas chromatography-mass spectrometry to follow the fate of administered [2H7]methionine

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 3-4, 2010, Pages 417-422

  Shinohara, Yoshihiko ^a   Hasegawa, Hiroshi ^a   Kaneko, Tomoyoshi ^a   Tamura, Yuka ^a   Hashimoto, Takao ^a   Ichida, Kimiyoshi ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

GC MS; Homocysteine; Methionine; Pharmacokinetics; Stable isotope

Indexed keywords

CATION EXCHANGE CHROMATOGRAPHY; CHEMICAL IONIZATION MODES; DERIVATIZATIONS; DISULFIDE BONDS; DITHIOTHREITOL; ETHYL ESTER DERIVATIVES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GC-MS; HOMOCYSTEINES; INTERNAL STANDARDS; ISOBUTYL; PATHOPHYSIOLOGICAL; QUANTIFICATION METHODS; RAT PLASMA; SELECTED ION MONITORING; STABLE ISOTOPES; WATER-ETHANOL;

CHROMATOGRAPHIC ANALYSIS; ESTERS; ETHANOL; IONIZATION OF GASES; IONIZATION OF LIQUIDS; ISOTOPES; MASS SPECTROMETERS; MASS SPECTROMETRY; PHARMACOKINETICS;

GAS CHROMATOGRAPHY;

2 H 4 HOMOCYSTEINE; 2 H 4 METHIONINE; 2 H 7 METHIONINE; DITHIOTHREITOL; ESTER DERIVATIVE; HOMOCYSTEINE; METHIONINE DERIVATIVE; N ISOBUTYLOXYCARBONYL ETHYL ESTER DERIVATIVE; UNCLASSIFIED DRUG; DEUTERIUM; ESTER; METHIONINE;

ACCURACY; AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; ION EXCHANGE CHROMATOGRAPHY; MALE; MASS FRAGMENTOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BLOOD; CHEMISTRY; METHODOLOGY; TIME;

RATTUS;

ANIMALS; DEUTERIUM; ESTERS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HOMOCYSTEINE; METHIONINE; RATS; TIME FACTORS;

EID: 74049125003     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.12.020     Document Type: Article

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