Methylene tetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms related to overweight/obesity among Saudi subjects from Qassim Region

Disease Markers

Volumn 27, Issue 2, 2009, Pages 97-102

  Settin, Ahmad A ^a   Algasham, Abdullah ^a   Dowaidar, Moataz ^a   Ismail, Hisham ^a  

^a QASSIM UNIVERSITY   (Saudi Arabia)

Author keywords

ACE; Gene polymorphism; MTHFR; Obesity; Qassim Region; Saudi population

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); DIPEPTIDYL CARBOXYPEPTIDASE; DNA; ACE PROTEIN, HUMAN; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ADULT; ALLELE; ARTICLE; BODY MASS; CONTROLLED STUDY; DNA DETERMINATION; DNA POLYMORPHISM; GENE FREQUENCY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; OBESITY; PRIORITY JOURNAL; SAUDI ARABIA; CASE CONTROL STUDY; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; FEMALE; GENETIC POLYMORPHISM; GENETICS; MALE; POLYMERASE CHAIN REACTION; RISK FACTOR;

ADULT; BODY MASS INDEX; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); OBESITY; OVERWEIGHT; PEPTIDYL-DIPEPTIDASE A; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RISK FACTORS; YOUNG ADULT;

EID: 74049117582     PISSN: 02780240     EISSN: None     Source Type: Journal    
DOI: 10.1155/2009/384718     Document Type: Article

References (36)

1. H. Shigeta, M. Shigeta, N. Atsuko, N. Nakamura and T. Yoshikawa, Lifestyle, obesity, and insulin resistance, Am Diabetes Assoc 24 (2001), 608-611.
2. P.S. Powers, Obesity and the regulation of weight, The Williams and Wilkins Co.: London, 1980.
3. E. Lara-Pantin, Obesity in developing countries, in: Recent Advances in Obesity Research, E. Berry, S.H. Blondheim, H.E. Eliahou et al., V. London: John Libbey & Co., 1987, pp. 5-8.
4. G.A. Bray, Obesity, Lippincott Company: Philadelphia, 1992.
5. B.A. Reeder, Y. Chen, S.M. Macdonald, A. Angel, L. Sweet and Y. Chen, Regional and rural-urban differences in obesity in Canada, Can Med Assoc J 157 (1997), 10-16.
6. D.S.Wald, M. Lawand J.K. Morris, Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis, BMJ 325(7374) (23 Nov 2002), 1202.
7. L.D. Botto and Q. Yang, 5, 10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review, Am J Epidemiol 151(9) (1 May 2000), 862-877.
8. N.M. van der Put, F. Gabrëels, E.M. Stevens, J.A. Smeitink, F.J.Trijbels, T.K. Eskes, L.P. van den Heuvel and H.J. Blom, A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects, Am J Hum Genet 62(5) (May 1998), 1044-1051. (Pubitemid 28199004)
9. R. Rozen, Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR), Thromb Haemost, 78(1) (Jul 1997), 523-526.
10. J.E. Kimmons, H.M. Blanck, B.C. Tohill, J. Zhang and L.K. Khan, Associations between body mass index and the prevalence of low micronutrient levels among US adults, MedGen- Med 8(4) (19 Dec 2006), 59.
11. S.J. Lewis, D.A. Lawlor, B.G. Nordestgaard, A. Tybjaerg- Hansen, S. Ebrahim, J. Zacho, A. Ness, S. Leary and G.D. Smith, The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts, Eur J Endocrinol 159(1) (159 Jul 2008), 35-40. Epub 2008 Apr 21.
12. C.G. Bell, D. Meyre, E. Petretto, C. Levy-Marchal, S. Hercberg, M.A. Charles, C. Boyle, J.Weill, M. Tauber, C.A. Mein, T.J. Aitman, P. Froguel and A.J. Walley, No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases, Eur J Hum Genet, 15(3) (15 Mar 2007), 320-327. Epub 2006 Dec 13.
13. M.J. Wacker, M.P. Godard, E.H. McCabe, J.E. Donnelly and J.K. Kelly, Sex difference in the association of the angiotensin converting enzyme I/D polymorphism and body mass index, Med Sci Monit 14(7) (14 Jul 2008), CR353-CR357.
14. G. Baslaim, J. Bashore and K. Alhoroub, Impact of obesity on early outcomes after cardiac surgery: experience in a Saudi Arabian center, Ann Thorac Cardiovasc Surg 14(6) (Dec 2008), 369-375.
15. N.A. Al-Baghli, A.J. Al-Ghamdi, K.A. Al-Turki, A.G. El- Zubaier, M.M. Al-Ameer and F.A. Al-Baghli, Overweight and obesity in the eastern province of Saudi Arabia, Saudi Med J 29(9) (Sep 2008), 1319-1325.
16. H. Khalid Mel, Is high-altitude environment a risk factor for childhood overweight and obesity in Saudi Arabia? it Wilderness Environ Med 19(3) (2008 Fall), 157-163.
17. A.A. Alam, Obesity among female school children in North West Riyadh in relation to affluent lifestyle, Saudi Med J 29(8) (Aug 2008), 1139-1144.
18. T.T. Amin, A.I. Al-Sultan and A. Ali, Overweight and obesity and their relation to dietary habits and socio-demographic characteristics among male primary school children in Al- Hassa, Kingdom of Saudi Arabia, Eur J Nutr 47(6) (Sep 2008), 310-318. Epub 2008 Aug 1.
19. M.A. Soyannwo, N.Y. Kurashi, M. Gadallah, J. Hams, O. el- Essawi, N.A. Khan, R.G. Singh, A. Alamri and T.H. Beyari, Blood pressure pattern in Saudi population of Gassim, Afr J Med Med Sci 27(1-2) (Mar-Jun 1998), 107-116.
20. WHO Expert Committee. Obesity: preventing and managing the global epidemic: report of a WHO Consultation on Obesity. WHO Tech Rep Ser 2000; 894.
21. C.H. Tseng, C.P. Tseng, C.K. Chong, J.J. Sheu and J.C. Cheng, Angiotensin-converting enzyme gene polymorphism and stroke in type 2 diabetic patients in Taiwan, Eur J Clin Invest 37(6) (Jun 2007), 483-491.
22. A. Muthumala, D.R. Gable, J. Palmen, J.A. Cooper, J.W. Stephens, G.J. Miller and S.E. Humphries, Is the influence of variation in the ACE gene on the prospective risk of Type 2 diabetes in middle-aged men modified by obesity? Clin Sci (Lond) 113(12) (Dec 2007), 467-472.
23. Y. Hashimoto, A. Futamura, H. Nakarai, H. Yokota, M. Omura, K. Tsukamoto, M. Togo, H. Sato, M. Hara, N. Isoo, J. Taguchi and K. Nakahara, Association between Deletion Polymorphism of Angiotensin Converting Enzyme Gene and Proteinuria in Japanese Overweight Men, J Occup Health 43 (2001), 80-84.
24. A. Bitigen, C. Cevik, D. Demir, A.C. Tanalp, C. Dundar, K. Tigen, B. Mutlu and Y. Basaran, The frequency of angiotensinconverting enzyme genotype and left ventricular functions in the obese population, Congest Heart Fail 13(6) (Nov-Dec 2007), 323-327.
25. C. Riera-Fortuny, J.T. Real, F.J. Chaves, M. Morales-Súarez- Varela, M.L. Mart́inez-Triguero, C. Morillas-Arĩno and A. Herńandez-Mijares, The relation between obesity, abdominal fat deposit and the angiotensin-converting enzyme gene I/D polymorphism and its association with coronary heart disease, Int J Obes (Lond) 29(1) (Jan 2005), 78-84.
26. M.A. El-Hazmi and A.S. Warsy, Increased frequency of angiotensin- converting enzyme DD genotype in Saudi overweight and obese patients, Ann Saudi Med 23(1-2) (Jan-Mar 2003), 24-27.
27. H. Kramer, X. Wu, D. Kan, A. Luke, X. Zhu, A. Adeyemo, C. McKenzie and R. Cooper, Angiotensin-converting enzyme gene polymorphisms and obesity: an examination of three black populations, Obes Res 13(5) (May 2005), 823-828.
28. K. Kim, Association of angiotensin-converting enzyme insertion/ deletion polymorphism with obesity, cardiovascular risk factors and exercise-mediated changes in Korean women, Eur J Appl Physiol 6 (Jan 2009) [Epub ahead of print].
29. L. Di Renzo, M. Bigioni, F.G. Bottini, V. Del Gobbo, M.G. Premrov, R. Cianci and A. De Lorenzo, NormalWeight Obese syndrome: role of single nucleotide polymorphism of IL-1 5 R alpha and MTHFR 677C → T genes in the relationship between body composition and resting metabolic rate, Eur Rev Med Pharmacol Sci 10(5) (Sep-Oct 2006), 235-245.
30. I. Lambrinoudaki, G. Kaparos, D. Papadimitriou, T.N. Sergentanis, M. Creatsa, A. Alexandrou, E. Logothetis, G. Christodoulakos and E. Kouskouni, Methylenetetrahydrofolate reductase C677T polymorphism is associated with central adiposity and increased androgenicity in healthy postmenopausal women, Eur J Endocrinol 159(3) (Sep 2008), 233-241.
31. I. Terruzzi, P. Senesi, I. Fermo, G. Lattuada and L. Luzi, Are genetic variants of the methyl group metabolism enzymes risk factors predisposing to obesity? J Endocrinol Invest 30(9) (Oct 2007), 747-753.
32. O. Fridman, R. Porcile, V. Vanasco, M.N. Junco, L. Gariglio, M.A. Potenzoni, I. Bãnes and A. Morales, Study on homocysteine levels and methylenetetrahydrofolate reductase gene variant (C677T) in a population of Buenos Aires City, Clin Exp Hypertens 30(7) (Oct 2008), 574-584.
33. H.S. Koo, H.S. Lee and Y.M. Hong, Methylenetetrahydrofolate reductase TT genotype as a predictor of cardiovascular risk in hypertensive adolescents, Pediatr Cardiol 29(1) (Jan 2008), 136-141. Epub 2007 Oct 5.
34. M.L. Frelut, N. Emery-Fillon, J.C. Guilland, H.H. Dao and G.P. de Courcy, Alanine amino transferase concentrations are linked to folate intakes and methylenetetrahydrofolate reductase polymorphism in obese adolescent girls, J Pediatr Gastroenterol Nutr 43(2) (Aug 2006), 234-239.
35. K. Thawnashom, R. Tungtrongchitr, S. Petmitr, P. Pongpaew, B. Phonrat, A. Tungtrongchitr and F.P. Schelp, Methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) in relation to homocysteine concentration in overweight and obese Thais, Southeast Asian J Trop Med Public Health 36(2) (Mar 2005), 459-466.
36. X. Liu, L.J. Zhao, Y.J. Liu, D.H. Xiong, R.R. Recker and H.W. Deng, The MTHFR gene polymorphism is associated with lean body mass but not fat body mass, Hum Genet 123(2) (Mar 2008), 189-196. Epub 2008 Jan 8.