Ethanol enhances hepatitis C virus replication through lipid metabolism and elevated NADH/NAD+

Journal of Biological Chemistry

Volumn 285, Issue 2, 2010, Pages 845-854

  Seronello, Scott ^a   Ito, Chieri ^a   Wakita, Takaji ^b   Choi, Jinah ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE; CERULENIN; FATTY ACID SYNTHESIS; FLUVASTATIN; HCV RNA; HEPATITIS C VIRUS; HUMAN HEPATOMA CELLS; HUMAN LIVER; INTRACELLULAR CHOLESTEROL; ISOPROPYL ALCOHOLS; LIPID METABOLISMS; LOVASTATIN; MERCAPTOPROPIONIC ACID; MEVALONATE PATHWAY; PHYSIOLOGICAL CONCENTRATIONS; VIRAL REPLICATION; VIRAL RNA;

ACETONE; ACIDS; ALDEHYDES; FATTY ACIDS; METABOLISM; RNA; VIRUSES;

ETHANOL;

3 MERCAPTOPROPIONIC ACID; ACETALDEHYDE; ACETIC ACID; ACETONE; ALCOHOL; ALDEHYDE DEHYDROGENASE; CHOLESTEROL; CYTOCHROME P450 2E1; FLUINDOSTATIN; MEVINOLIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE NUCLEOSIDASE; REACTIVE OXYGEN METABOLITE; VIRUS RNA;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME INHIBITION; FATTY ACID OXIDATION; GENOTYPE; HEPATITIS C VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; LIPID METABOLISM; NONHUMAN; PRIORITY JOURNAL; VIRUS REPLICATION;

ACETALDEHYDE; ACETONE; ALDEHYDE DEHYDROGENASE; ANTICHOLESTEREMIC AGENTS; CELL LINE, TUMOR; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHOLESTEROL; CYTOCHROME P-450 CYP2E1; ETHANOL; GENOME, VIRAL; HEPACIVIRUS; HEPATITIS C; HUMANS; LIPID METABOLISM; NAD; REACTIVE OXYGEN SPECIES; RNA, VIRAL; SOLVENTS; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 74049115063     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.045740     Document Type: Article

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