Possible physiological roles of acetone metabolism in humans

Medical Hypotheses

Volumn 53, Issue 3, 1999, Pages 236-242

  Kalapos, M P ^a  

^a Theoretical Biology Research Group Budapest   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE;

ARTICLE; HUMAN; LIVER; METABOLISM; MODEL; PH; PHYSIOLOGY; PRIORITY JOURNAL;

EID: 0032830469     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1054/mehy.1998.0752     Document Type: Article

References (47)

1. Argiles J. M. Has acetone a role in the conversion of fat to carbohydrate in mammals. Trends Biochem Sci. 11:1986;61-63.
2. Pedersen K. J. The ketonic decomposition of beta-keto carboxylic acids. J Am Chem Soc. 51:1929;2098-2107.
3. Kalapos M. P. Acetone metabolism. Biochemistry, toxicology and clinical implications (Hungarian with English abstract) Orv Hetil. 138:1997;1187-1193.
4. Casazza J. P., Felver M. E., Veech R. L. The metabolism of acetone in rats. J Biol Chem. 259:1984;231-236.
5. Landau B. R., Brunengraber H. The role of acetone in the conversion of fat to carbohydrate. Trends Biochem Sci. 12:1987;113-114.
6. Coleman D. L. Acetone metabolism in mice. Increased activity in mice heterozygous for obesity genes. Proc Natl Acad Sci USA. 77:1980;290-293.
7. Koop D. R., Casazza J. P. Identification of ethanol-inducible P-450 isozyme 3a as the acetone and acetol monooxygenase of rabbit microsomes. J Biol Chem. 260:1985;13607-13612.
8. Koop D. R., Crump B. L., Nordblom G. D., Coon M. J. Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: Ethanol, imidazole, trichloroethylene, acetone, pyrazole, and isoniazid. Proc Natl Acad Sci USA. 82:1985;4065-4069.
9. Kato R., Onoda K. I., Takanaka A. Species difference in drug metabolism by liver microsomes in alloxan diabetic or fasted animals. Jap J Pharmac. 20:1970;546-553.
10. Reinke L. A., Stohs S. J., Rosenberg H. Altered activity of hepatic mixed-function monooxigenase enzymes in streptozotocin-induced diabetic rats. Xenobiotica. 8:1978;611-619.
11. Gonzalez F. J. The molecular biology of cytochrome P450s. Pharmacol Rev. 40:1989;243-288.
12. Kosugi K., Chandramouli V., Kumaran K., Schumann W. C., Landau B. R. Determinants in the pathways followed by the carbons of acetone in their conversion to glucose. J Biol Chem. 261:1986;13179-13181.
13. Rudney H. Propanediol phosphate as a possible intermediate in the metabolism of acetone. J Biol Chem. 210:1954;361-371.
14. Sellinger O. Z., Miller O. N. Phosphorylation of acetol by homogenates of rat liver. Federation Proc. 16:1958;245-246.
15. Sellinger O. Z., Miller O. N. The metabolism of acetol phosphate. J Biol Chem. 234:1959;1641-1646.
16. Ray M., Ray S. Purification and partial characterization of methylglyoxal reductase from goat liver. Biochim Biophys Acta. 802:1984;119-127.
17. Ruddick J. A. Toxicology, metabolism, and biochemistry of 1,2-propanediol. Toxicol Appl Pharmacol. 21:1972;102-111.
18. Vander Jagt D. L., Robinson B., Taylor K. K., Hunsaker L. A. Reduction of trioses by NADPH-dependent aldo-keto reductases. J Biol Chem. 267:1992;4364-4369.
19. Vander Jagt D. L., Hunsaker L. A. Substrate specificity of reduced and oxidized forms of human aldose reductase. Weiner H. Enzymology and Molecular Biology of Carbonyl Metabolism. 4. 1993;279-288 Plenum Press, New York.
20. Lopes-Cardozo M., Klein W. Ketone body utilization by homogenates of adult rat brain. Neurochem Res. 7:1982;687-703.
21. Owen O. E., Trapp V. E., Skutches C. L. Acetone metabolism during diabetic ketoacidosis. Diabetes. 31:1982;242-248.
22. Reichard G. A., Haff A. C., Skutches C. L., Paul P, Holroyde R. D., Owen O. E. Plasma acetone metabolism in fasting human. J Clin Invest. 63:1979;619-626.
23. Kalapos M. P., Mandl J., Bánhegyi G., Antoni F., Garzó T. Net glucose production from acetone in isolated murine hepatocytes. The effect of different pretreatments. Int J Biochem. 26:1994;1069-1079.
24. Hetényi G., Byers M., Ferrarotto C. Gluconeogenesis from acetone in diabetic rats. Horm Metabol Res. 19:1987;143-145.
25. Klingenberg M., von Hafen H. Wege des Wasserstoffs in Mitochondrien. Biochem Zeitschr. 337:1963;120-145.
26. Fagan J. M., Satarug S., Cook P., Tischler M. E. Rat muscle protein turnover and redox state in progressive diabetes. Life Sci. 40:1985;783-790.
27. Tischler M. E., Fagan J. M. Relationship of the reduction-oxidation state to protein degradation in skeletal and atrial muscle. Arch Biochem Biophys. 217:1982;191-201.
28. Hawkins R. A., Williamson D. H., Krebs H. A. Ketone-body utilization by adult and suckling rat brain in vivo. Biochem J. 122:1971;13-18.
29. Kammula R. J. Metabolism of ketone bodies by ovine brain in vivo. Am J Physiol. 231:1976;1490-1494.
30. Ruderman N. B., Ross P. S., Berger M., Goodman M. N. Regulation of glucose and ketone body metabolism in brain of anesthetized rats. Biochem J. 138:1974;1-10.
31. Owen O. E., Morgan A. P., Kemp H. G., Sullivan J. M., Herrera M. G., Cahill G. F. Brain metabolism during fasting. J Clin Invest. 46:1967;1589-1595.
32. Granner D., Pilkis S. J. The genes of hepatic glucose metabolism. J Biol Chem. 265:1990;10173-10176.
33. Bidlack W. R., Brown R. C., Mohan C. Nutritional parameters that alter hepatic drug metabolism, conjugation, and toxicity. Federation Proc. 45:1986;142-148.
34. Thurman R. G., Kauffman F. C. Factors regulating drug metabolism in intact hepatocytes. Pharmacol Rev. 31:1980;229-251.
35. Ueng T. H., Friedman F. K., Miller H., Park S. S., Gelboin H. V., Alvares A. P. Studies on ethanol-inducible cytochrome P-450 in rabbit liver, lungs, and kidneys. Biochem Pharmacol. 36:1988;2689-2691.
36. Ueng T. H., Tsai J. N., Ju M., Ueng Y. F., Iwasaki M., Guengrich F. P. Effects of acetone administration on cytochrome P-450-dependent monooxygenases in hamster liver, kidney, and lung. Arch Toxicol. 65:1991;45-51.
37. Sulway M. J., Malins J. M. Acetone in diabetic ketoacidosis. Lancet. ii:1970;736-740.
38. Wahren J., Sato Y., Ostman J., Hagenfeldt L., Felig P. Turnover and splanchnic metabolism of free fatty acids and ketones in insulin-dependent diabetics at rest and in response to exercise. J Clin Invest. 73:1984;1367-1376.
39. Reichard G. A., Skutches C. L., Hoeldtke R. D., Owen O. E. Acetone metabolism in humans during diabetic ketoacidosis. Diabetes. 35:1986;668-674.
40. Casazza J. P., Fu J. Measurement of acetol in serum. Anal Biochem. 148:1985;344-348.
41. Casazza J. P., Song B. J., Veech R. L. Short chain diol metabolism in human disease states. Trends Biochem Sci. 15:1990;26-30.
42. Keller U., Schnell H., Girard J., Stauffacher W. Effect of physiological elevation of plasma growth hormone levels on ketone body kinetics and lipolysis in normal and acutely insulin-deficient man. Diabetologia. 26:1984;103-108.
43. McLellan A. C., Phillips S. A., Thornalley P. J. Fluorimetric assay of D-lactate. Anal Biochem. 206:1992;12-16.
44. Thornalley P. J., Hooper N. I., Jennings P. E. The human red blood cell glyoxalase system in diabetes mellitus. Diab Res Clin Pract. 7:1989;115-120.
45. Skutches C. L., Owen O. E., Reichard G. A. Acetone and acetol inhibition on insulin-stimulated glucose oxidation in adipose tissue and isolated adipocytes. Diabetes. 39:1990;450-455.
46. Kalapos M. P. Methylglyoxal toxicity in mammals. Toxicol Lett. 73:1994;3-24.
47. Vander Jagt, D. L. The glyoxalase system, Dolphin, D.Poulson, R.Avramovic, O. Glutathione: Chemical, Biochemical, and Medical Aspects - Part A, John Wiley and Sons, 1989, 598, 641.