Direct substitution of propargylic alcohol with oxygen, nitrogen, and carbon nucleophiles catalyzed by molybdenum(VI)

Tetrahedron Letters

Volumn 51, Issue 8, 2010, Pages 1176-1179

  Zhang, Ming ^a   Yang, Hongwei ^a   Cheng, Yixiang ^a   Zhu, Yuhua ^a   Zhu, Chengjian ^a,b  

^a NANJING UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

Alcohols; Molybdenum; Nucleophilic substitution; Propargylation

Indexed keywords

1,3 DIPHENYL PROP 2 YN 1 OL; ALCOHOL; ALKYNE DERIVATIVE; CARBON; MOLYBDENUM; NITROGEN; NUCLEOPHILE; OXYGEN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; EPOXIDATION; POLYMERIZATION;

EID: 74049110509     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.12.128     Document Type: Article

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32. 6 (9 mg, 0.05 mmol) in acetonitrile (2 ml) at 65 °C, and the resulting mixture was stirred for 5 min before the addition of propargylic alcohol (0.5 mmol). The mixture was stirred at this temperature and the reaction was monitored by TLC analysis. After the reaction was complete, the mixture was then cooled to room temperature and directly purified by flash chromatography on silica gel to afford the corresponding product.
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