Antiplatelet autoantibodies elicited by dengue virus non-structural protein 1 cause thrombocytopenia and mortality in mice

Journal of Thrombosis and Haemostasis

Volumn 5, Issue 11, 2007, Pages 2291-2299

  Sun, D S ^a   King, C C ^b   Huang, H S ^a   Shih, Y L ^c   Lee, C C ^c   Tsai, W J ^d   Yu, C C ^e   Chang, H H ^a  

^a TZU CHI UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^d NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^e Hui Te Hospital   (Taiwan)

Author keywords

Autoimmunity; Dengue; Hemorrhage fever; Platelet; Warfarin

Indexed keywords

ANTITHROMBIN III; AUTOANTIBODY; CROSS REACTING ANTIBODY; D DIMER; FIBRIN; IMMUNOGLOBULIN; NONSTRUCTURAL PROTEIN 1; PROTEIN C; PROTEIN S; THROMBOCYTE ANTIBODY; UNCLASSIFIED DRUG; VIRUS PROTEIN; WARFARIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DENGUE; DISEASE ASSOCIATION; FIBRIN DEPOSITION; HEMORRHAGIC FEVER; HUMAN; HUMAN CELL; HYPERCOAGULABILITY; IN VITRO STUDY; MACROPHAGE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK FACTOR; THROMBOCYTE ACTIVATION; THROMBOCYTOPENIA;

ANIMALS; ANTIBODIES, VIRAL; AUTOANTIBODIES; BLOOD PLATELETS; DENGUE; DENGUE VIRUS; HUMANS; MICE; MICE, INBRED C57BL; RABBITS; THROMBOCYTOPENIA; VIRAL NONSTRUCTURAL PROTEINS;

EID: 35448932885     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2007.02754.x     Document Type: Article

References (32)

1. Gubler DJ. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 1998; 11: 480-96.
2. Halstead SB, O'Rourke EJ. Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody. J Exp Med 1977; 146: 201-17.
3. Porterfield JS. Antibody-dependent enhancement of viral infectivity. Adv Virus Res 1986; 31: 335-55.
4. Halstead SB. Antibody, macrophages, dengue virus infection, shock, and hemorrhage: A pathogenetic cascade. Rev Infect Dis 1989; 11(Suppl. 4): S830-9.
5. Suhrbier A, La Linn M. Suppression of antiviral responses by antibody-dependent enhancement of macrophage infection. Trends Immunol 2003; 24: 165-8.
6. Wallace MJ, Smith DW, Broom AK, Mackenzie JS, Hall RA, Shellam GR, McMinn PC. Antibody-dependent enhancement of Murray Valley encephalitis virus virulence in mice. J Gen Virol 2003; 84: 1723-8.
7. Lin CF, Lei HY, Shiau AL, Liu HS, Yeh TM, Chen SH, Liu CC, Chiu SC, Lin YS. Endothelial cell apoptosis induced by antibodies against dengue virus nonstructural protein 1 via production of nitric oxide. J Immunol 2002; 169: 657-64.
8. Lin CF, Lei HY, Liu CC, Liu HS, Yeh TM, Wang ST, Yang TI, Sheu FC, Kuo CF, Lin YS. Generation of IgM anti-platelet autoantibody in dengue patients. J Med Virol 2001; 63: 143-9.
9. Chang HH, Shyu HF, Wang YM, Sun DS, Shyu RH, Tang SS, Huang YS. Facilitation of cell adhesion by immobilized dengue viral nonstructural protein 1 (NS1): Arginine-glycine-aspartic acid structural mimicry within the dengue viral NS1 Antigen. J Infect Dis 2002; 186: 743-51.
10. Rand ML, Wright JF. Virus-associated idiopathic thrombocytopenic purpura. Transfus Sci 1998; 19: 253-9.
11. Porta C, Caporali R, Montecucco C. Thrombotic thrombocytopenic purpura and autoimmunity: A tale of shadows and suspects. Haematologica 1999; 84: 260-9.
12. Oishi K, Inoue S, Cinco MT, Dimaano EM, Alera MT, Alfon JA, Abanes F, Cruz DJ, Matias RR, Matsuura H, Hasebe F, Tanimura S, Kumatori A, Morita K, Natividad FF, Nagatake T. Correlation between increased platelet-associated IgG and thrombocytopenia in secondary dengue virus infections. J Med Virol 2003; 71: 259-64.
13. Saito M, Oishi K, Inoue S, Dimaano EM, Alera MT, Robles AM, Estrella BD Jr, Kumatori A, Moji K, Alonzo MT, Buerano CC, Matias RR, Morita K, Natividad FF, Nagatake T. Association of increased platelet-associated immunoglobulins with thrombocytopenia and the severity of disease in secondary dengue virus infections. Clin Exp Immunol 2004; 138: 299-303.
14. Song S, Crow AR, Freedman J, Lazarus AH. Monoclonal IgG can ameliorate immune thrombocytopenia in a murine model of ITP: An alternative to IVIG. Blood 2003; 101: 3708-13.
15. O'Reilly RA. Drugs used in disorders of coagulation. In: Katzung BG, ed. Basic and Clinical Pharmacology, 7th edn. San Francisco: Prentice Hall, 1998: 547-62.
16. Lin YL, Liao CL, Chen LK, Yeh CT, Liu CI, Ma SH, Huang YY, Huang YL, Kao CL, King CC. Study of Dengue virus infection in SCID mice engrafted with human K562 cells. J Virol 1998; 72: 9729-37.
17. Chao DY, Lin TH, Hwang KP, Huang JH, Liu CC, King CC. 1998 dengue hemorrhagic fever epidemic in Taiwan. Emerg Infect Dis 2004; 10: 552-4.
18. Harlow E, Lane D. Antobodies: A Laboratory Manual. New York: Cold Spring Harbor Laboratory, 1988.
19. Karpatkin S, Nardi M, Lennette ET, Byrne B, Poiesz B. Anti-human immunodeficiency virus type 1 antibody complexes on platelets of seropositive thrombocytopenic homosexuals and narcotic addicts. Proc Natl Acad Sci USA 1988; 85: 9763-7.
20. Court WS, Christensen AK, Sacks RW, LoBuglio AF. Human monocyte interaction with antibody-coated platelets. I. General characteristics. Am J Hematol 1984; 17: 225-36.
21. Nardi M, Feinmark SJ, Hu L, Li Z, Karpatkin S. Complement-independent Ab-induced peroxide lysis of platelets requires 12-lipoxygenase and a platelet NADPH oxidase pathway. J Clin Invest 2004; 113: 973-80.
22. Li Z, Nardi MA, Karpatkin S. Role of molecular mimicry to HIV-1 peptides in HIV-1-related immunologic thrombocytopenia. Blood 2005; 106: 572-6.
23. Inoue H, Aizawa H, Matsumoto K, Shigyo M, Takata S, Hara M, Hara N. Effect of beta 2-agonists on histamine-induced airway microvascular leakage in ozone-exposed guinea pigs. Am J Respir Crit Care Med 1997; 156: 723-7.
24. Horan JT, Francis CW. Fibrin degradation products, fibrin monomer and soluble fibrin in disseminated intravascular coagulation. Semin Thromb Hemost 2001; 27: 657-66.
25. Wills BA, Oragui EE, Stephens AC, Daramola OA, Dung NM, Loan HT, Chau NV, Chambers M, Stepniewska K, Farrar JJ, Levin M. Coagulation abnormalities in dengue hemorrhagic fever: Serial investigations in 167 Vietnamese children with dengue shock syndrome. Clin Infect Dis 2002; 35: 277-85.
26. Zeerleder S, Hack CE, Wuillemin WA. Disseminated intravascular coagulation in sepsis. Chest 2005; 128: 2864-75.
27. Nishioka K. Serum complement level in dengue hemorrhagic fever. Allerg Immunol 1974; 20-21: 385-92.
28. Bas de Laat H, Derksen RH, de Groot PG. beta2-glycoprotein I, the playmaker of the antiphospholipid syndrome. Clin Immunol 2004; 112: 161-8.
29. McKenzie SE, Reilly MP. Heparin-induced thrombocytopenia and other immune thrombocytopenias: Lessons from mouse models. Semin Thromb Hemost 2004; 30: 559-68.
30. Kelton JG. Heparin-induced thrombocytopenia: An overview. Blood Rev 2002; 16: 77-80.
31. Kelton JG. Platelet and red cell clearance is determined by the interaction of the IgG and complement on the cells and the activity of the reticuloendothelial system. Transfus Med Rev 1987; 1: 75-84.
32. Van Gorp EC, Setiati TE, Mairuhu AT, Suharti C, Cate Ht H, Dolmans WM, Van Der Meer JW, Hack CE, Brandjes DP. Impaired fibrinolysis in the pathogenesis of dengue hemorrhagic fever. J Med Virol 2002; 67: 549-54.