Clonal relationships between thyroid-stimulating hormone receptor-stimulating antibodies illustrate the effect of hypermutation on antibody function

Immunology

Volumn 129, Issue 2, 2010, Pages 300-308

  Padoa, Carolyn J ^a,b   Larsen, Sanne L ^a   Hampe, Christiane S ^c   Gilbert, Jacqueline A ^a   Dagdan, Elif ^a   Hegedus, Laszlo ^d   Dunn Walters, Deborah ^a   Banga, J Paul ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c UNIVERSITY OF WASHINGTON   (United States)

^d ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Antibodies; Autoimmunity; Graves' disease; V region genes

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY KSAB1; MONOCLONAL ANTIBODY KSAB2; THYROTROPIN RECEPTOR; THYROTROPIN RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLONE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; GENE SEQUENCE; GRAVES DISEASE; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOPATHOGENESIS; MOLECULAR EVOLUTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SOMATIC HYPERMUTATION; SOMATIC MUTATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY DIVERSITY; AUTOIMMUNITY; COMPLEMENTARITY DETERMINING REGIONS; DNA MUTATIONAL ANALYSIS; DNA SHUFFLING; GENETIC ENGINEERING; GRAVES DISEASE; HYBRIDOMAS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; IMMUNOGLOBULINS, THYROID-STIMULATING; MICE; RECEPTORS, THYROTROPIN; RECOMBINANT FUSION PROTEINS; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 73949144106     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2009.03184.x     Document Type: Article

References (31)

1. Davies TF, Ando T, Lin RY, Tomer Y, Latif R. Thyrotropin receptor-associated diseases: from adenomata to Graves' diease. J Clin Invest 2005 115 : 1972 1983.
2. Rees Smith B, McLachlan SM, Furmaniak J. Autoantibodies to the thyrotropin receptor. Endocr Rev 1988 9 : 106 121.
3. De Forteza R, Smith CU, Amin J, McKenzie JM, Zakarija M. Visualisation of the thyrotropin receptor on the cell surface by potent autoantibodies. J Clin Endocrinol Metab 1994 78 : 1271 1273.
4. Banga JP, Nielsen CH, Gilbert JA, El Fassi D, Hegedus L. Application of new therapies in Graves' disease and thyroid associated ophthalmopathy: animal models and translation to human clinical trials. Thyroid 2008 18 : 973 981.
5. Weetman AP, Yateman ME, Ealey PA, Black CM, Reimer CB, Williams RC, Shine B, Marshall NJ. Thyroid stimulating antibody activity between different immunoglobulin G subclasses. J Clin Invest 1990 86 : 723 727.
6. Zakarija M. Immunochemical characterization of the thyroid stimulating antibody (TSAb) of Graves' disease: evidence for restricted heterogeneity. J Clin Lab Immunol 1983 10 : 77 85.
7. Williams RC, Marshall NJ, Kilpatrick K et al. Kappa/lambda immunoglobulin distribution in Graves' thyroid stimulating antibodies. Simultaneous analysis of C lambda gene polymorphisms. J Clin Invest 1988 82 : 1306 1312.
8. Smith BR, Sanders J, Furmaniak J. TSH receptor antibodies. Thyroid 2007 17 : 923 938.
9. Allen CD, Okada T, Cyster J. Germinal-center organization and cellular dynamics. Immunity 2007 27 : 190 202.
10. McIntosh R, Watson P, Weetman AP. Somatic hypermutation in autoimmune thyroid disease. Immunol Rev 1988 162 : 219 231.
11. Ando TR, Latif A, Pritsher T, Moran Y, Nagayama Y, Davies TF. A monoclonal thyroid stimulating antibody. J Clin Invest 2002 110 : 1667 1674.
12. Sanders J, Jeffreys J, Depraetere H et al. Thyroid stimulating monoclonal antibodies. Thyroid 2002 12 : 1043 1050.
13. Costagliola S, Bonomi M, Morgenthaler N, Van Durme J, Panneels V, Refetoff S, Vassart G. Delineation of the discontinuous conformational epitope of a monoclonal antibody displaying full in vitro and in vivo thyrotropin activity. Mol Endocrinol 2004 18 : 3020 3034.
14. Gilbert JA, Gianoukakis AG, Salehi S et al. Monoclonal pathogenic antibodies to the TSH receptor in Graves' disease with potent thyroid stimulating activity, but differential blocking activity activate multiple signaling pathways. J Immunol 2006 176 : 5084 5092.
15. Sanders J, Jeffreys J, Depraetere H et al. Characteristics of a human monoclonal autoantibody to the thyrotropin receptor: sequence structure and function. Thyroid 2004 14 : 560 570.
16. Sanders J, Evans M, Betterle C et al. A human monoclonal autoantibody to the thyrotropin receptor with thyroid-stimulating blocking activity. Thyroid 2008 18 : 735 746.
17. Flynn JC, Glibert JA, Meroueh C, Snower DP, David CS, Kong YC, Banga JP. Chronic exposure in vivo to TSH receptor stimulating monoclonal antibodies sustains high thyroxine levels and thyroid hyperplasia in thyroid autoimmunity prone HLA-DRB1*0301 transgenic mice. Immunology 2007 122 : 261 267.
18. Padoa CJ, Banga JP, Madec AM et al. A Fab fragment of a human monoclonal antibody specifically inhibits type 1 diabetes associated GAD65 antibody. Diabetes 2003 52 : 2689 2695.
19. Carter P, Kelley RF, Rodrigues ML et al. High level Escherichia coli expression and production of a bivalent humanized antibody fragment. Biotechnology 1992 10 : 163 167.
20. Neidhardt FC, Bloch PL, Smith DF. Culture medium for enterobacteria. J Bacteriol 1974 119 : 736 747.
21. Ajjan RA, Weetman AP. Techniques to quantify TSH receptor antibodies. Nat Clin Pract Endocrinol Metab 2008 4 : 461 468.
22. Vidarsson G, van de Winkel JGJ, van Dijk MA. Multiplex screening for functionally rearranged immunoglobulin variable region reveals expression of hybridoma-specific aberrant V-genes. J Immunol Methods 2001 249 : 245 252.
23. Chang B, Casali P. The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement. Immunol Today 1994 15 : 367 373.
24. Spencer J, Dunn M, Dunn-Walters DK. Characteristics of sequences around individual nucleotide substitutions in IGHV genes suggests different GC and AT mutators. J Immunol 1999 162 : 6596 6601.
25. Dunn-Walters DK, Spencer J. Strong intrinsic biases towards mutation and conservation of bases in human IgVH genes during somatic hypermutation prevent statistical analysis of antigen selection. Immunology 1998 95 : 339 344.
26. Hershberg U, Mohamed U, Shlomchik MJ, Steven H, Kleinstein J. Improved methods for detecting selection by mutation analysis of Ig V region sequences. Int Immunol 2008 20 : 683 694.
27. Weller S, Mamani-Matsuda M, Picard C, Cordier C, Lecoeuche D, Gauthier F, Weil JC, Reynaud CA. Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+IgD+CD27+ B cell repertoire in the infants. J Exp Med 2008 205 : 1331 1342.
28. McCann KJ, Ottensmeier CH, Callard A et al. Remarkable selective glycosylation of the immunoglobulin variable region in follicular lymphoma. Mol Immunol 2008 45 : 1567 1572.
29. Martinez O, Gangi E, Mordi D, Gupta S, Dorevitch S, Lefranc M-P, Prabhakar BS. Diversity in the complementarity-determining region 3 (CDR3) of antibodies from mice with evolving anti-thyroid-stimulating hormone receptor antibody responses. Endocrinology 2007 148 : 752 761.
30. Prummel MF, Strieder T, Wiersinga W. The environment and autoimmune thyroid disease. Eur J Endocrinol 2004 150 : 605 618.
31. Luo G, Seetharamiah GS, Niesel DW, Zhang H, Peterson JW, Prabhakar BS, Klimpel GR. Purification and characterisation of Yersinia enterocolitica envelope proteins which induce antibodies that react with human thyrotropin receptor. J Immunol 1994 152 : 2555 2561.