-
1
-
-
0001530451
-
-
ed. by R. A. Abramovitch, Wiley, New York
-
(a) R. T. Coutts, A. F. Casy, "Pyridines and its Derivatives" ed. by R. A. Abramovitch, Wiley, New York, 1975, p 445;
-
(1975)
Pyridines and its Derivatives
, pp. 445
-
-
Coutts, R.T.1
Casy, A.F.2
-
2
-
-
0021176774
-
-
(b) P. Krogsgaadd-Lassen, E. Falch, V. Christensen, Drugs Future, 9, 597 (1984);
-
(1984)
Drugs Future
, vol.9
, pp. 597
-
-
Krogsgaadd-Lassen, P.1
Falch, E.2
Christensen, V.3
-
3
-
-
73949147557
-
-
P. Lindberg, A. Branstrbm, B
-
(c) P. Lindberg, A. Branstrbm, B.
-
-
-
-
4
-
-
73949150081
-
-
Wallmark, H. Mattsson, L. Rikner, K.-J. Hoffman, Med. Res. Rev., 10, 1 (1990);
-
(1990)
Med. Res. Rev
, vol.10
, pp. 1
-
-
Wallmark, H.1
Mattsson, L.2
Rikner, K.-J.H.3
-
6
-
-
0034845023
-
-
(e) M. Uchida, T. Izumizawa, T. Nakano, S. Yamaguchi, K. Tamao, K. Furukawa, Chem. Mater., 13, 2680 (2001);
-
(2001)
Chem. Mater
, vol.13
, pp. 2680
-
-
Uchida, M.1
Izumizawa, T.2
Nakano, T.3
Yamaguchi, S.4
Tamao, K.5
Furukawa, K.6
-
7
-
-
1842577519
-
-
(f) G. Bringmann, Y. Reichert, V. V. Kane, Tetrahedron, 60, 3539 (2004)
-
(2004)
Tetrahedron
, vol.60
, pp. 3539
-
-
Bringmann, G.1
Reichert, Y.2
Kane, V.V.3
-
8
-
-
73949141181
-
-
Biologically Active Organofluorine Compounds ed. by N. Ishikawa, CMC, Tokyo, 1990;
-
(a) "Biologically Active Organofluorine Compounds" ed. by N. Ishikawa, CMC, Tokyo, 1990;
-
-
-
-
9
-
-
73949113605
-
-
Fluorine in Organic Chemistry ed. by R. D. Chambers, Blackwell Publishing, Oxford, UK (2004)
-
(b) "Fluorine in Organic Chemistry" ed. by R. D. Chambers, Blackwell Publishing, Oxford, UK (2004)
-
-
-
-
10
-
-
0039607736
-
-
Fluazinam: T. Akagi, S. Mitani, T. Komyoji, K. Nagatani, J. Pesticide Sci., 21, 23 (1996);
-
(1996)
J. Pesticide Sci
, vol.21
, pp. 23
-
-
Fluazinam, T.1
Akagi, S.2
Mitani, T.3
Komyoji, K.N.4
-
11
-
-
13444266910
-
-
Celecoxib: T. D. Penning, J. J. Talley, S. R. Bertenshaw, J. S. Carter, P. W. Collins, S. Docter, M. J. Graneto, L. F. Lee, J. W. Malecha, J. M. Miyashiro, R. S. Rogers, D. J. Rogier, S. S. Yu, G. D. Anderson, C. M. Koboldt, W. E. Perkins, K. Seibert, A. W. Veen- huizen, Y. Y. Zhang, P. C. Isakson, J. Med. Chem., 40, 1347 (1997);
-
Celecoxib: T. D. Penning, J. J. Talley, S. R. Bertenshaw, J. S. Carter, P. W. Collins, S. Docter, M. J. Graneto, L. F. Lee, J. W. Malecha, J. M. Miyashiro, R. S. Rogers, D. J. Rogier, S. S. Yu, G. D. Anderson, C. M. Koboldt, W. E. Perkins, K. Seibert, A. W. Veen- huizen, Y. Y. Zhang, P. C. Isakson, J. Med. Chem., 40, 1347 (1997);
-
-
-
-
12
-
-
34250202592
-
-
TRPVl-antagonists: (a) L. A. Roberts, M. Connor, Recent Patents on CNS Drug Discovery, 1, 65 (2006); Ob) S. R. Fletcher, E. Mclver, S. Lewis, F. Burkamp, C. Leech, G. Mason, S. Boyce, D. Morrison, G. Richards, K. Sutton, A. B. Jones, Bioorg. Med. Chem. Lett., 16, 2872 (2006) and references therein; 11-ß-HSD-1 inhibitors: B. Sorensen, J. Rohde, J. Wang, S. Fung, K. Monzon, W. Chiou, L. Pan, X. Deng, D. Stolarik, E. U. Frevert, P. Jacobson, J. T. Link, Bioorg. Med. Chem. Lett., 16, 5958 (2006) and references therein
-
TRPVl-antagonists: (a) L. A. Roberts, M. Connor, Recent Patents on CNS Drug Discovery, 1, 65 (2006); Ob) S. R. Fletcher, E. Mclver, S. Lewis, F. Burkamp, C. Leech, G. Mason, S. Boyce, D. Morrison, G. Richards, K. Sutton, A. B. Jones, Bioorg. Med. Chem. Lett., 16, 2872 (2006) and references therein; 11-ß-HSD-1 inhibitors: B. Sorensen, J. Rohde, J. Wang, S. Fung, K. Monzon, W. Chiou, L. Pan, X. Deng, D. Stolarik, E. U. Frevert, P. Jacobson, J. T. Link, Bioorg. Med. Chem. Lett., 16, 5958 (2006) and references therein
-
-
-
-
13
-
-
84949805957
-
-
Fluorine in Organic Chemistry ed. by R. D. Chambers, Wiley, New York, 1973;
-
(a) "Fluorine in Organic Chemistry" ed. by R. D. Chambers, Wiley, New York, 1973;
-
-
-
-
14
-
-
50849150452
-
-
(b) J. A. MacPhee, A. Panaye, J.-E. Dubois, Tetrahedron, 34, 3553 (1978);
-
(1978)
Tetrahedron
, vol.34
, pp. 3553
-
-
MacPhee, J.A.1
Panaye, A.2
Dubois, J.-E.3
-
15
-
-
73949151285
-
-
Biomedical Frontiers of Fluorine Chemistry eds. by I. Ojima, J. R. McCarthy, J. T. Welch, American Chemical Society, Washington DC, 1996
-
(c) "Biomedical Frontiers of Fluorine Chemistry" eds. by I. Ojima, J. R. McCarthy, J. T. Welch, American Chemical Society, Washington DC, 1996
-
-
-
-
17
-
-
73949147005
-
-
J. H. Simons, C. J. Lewis, J. Am. Chem. Soc., 60, 92 (1938);(c) W. R. Hasek, W. C. Smith, V. A. Engelhardt, ibid., 82, 543 (I960);
-
(b) J. H. Simons, C. J. Lewis, J. Am. Chem. Soc., 60, 92 (1938);(c) W. R. Hasek, W. C. Smith, V. A. Engelhardt, ibid., 82, 543 (I960);
-
-
-
-
21
-
-
73949130421
-
-
(b) R. Nishiyama, K. Fujikawa, I. Yokomichi, Y. Tsuji, S. Nishimura, EP 42696 (1981);
-
(1981)
, vol.EP 42696
-
-
Nishiyama, R.1
Fujikawa, K.2
Yokomichi, I.3
Tsuji, Y.4
Nishimura, S.5
-
23
-
-
73949142573
-
-
32, 246 (1990); (e) L. D. Shustov, L. N. Nikolenko, T. M. Senchenkova, Zh. Obshch. Khim., 53, 103 (1983)
-
(d) 32, 246 (1990); (e) L. D. Shustov, L. N. Nikolenko, T. M. Senchenkova, Zh. Obshch. Khim., 53, 103 (1983)
-
-
-
-
24
-
-
0035537555
-
-
B. Jiang, W. Xiong, X. Zhang, F. Zhang, Org. Process Res. Dev., 5, 531 (2001)
-
(2001)
Org. Process Res. Dev
, vol.5
, pp. 531
-
-
Jiang, B.1
Xiong, W.2
Zhang, X.3
Zhang, F.4
-
25
-
-
0034932097
-
-
W.-N. Xiong, C.-G. Yang, B. Jiang, Bioorg. Med. Chem., 9, 1773(2001)
-
(2001)
Bioorg. Med. Chem
, vol.9
, pp. 1773
-
-
Xiong, W.-N.1
Yang, C.-G.2
Jiang, B.3
-
26
-
-
58149269533
-
-
M. A. Gonzalez, D. B. Gorman, C. T. Hamilton, G. A. Roth, Org. Process Res. Dev., 12, 301 (2008)
-
(2008)
Org. Process Res. Dev
, vol.12
, pp. 301
-
-
Gonzalez, M.A.1
Gorman, D.B.2
Hamilton, C.T.3
Roth, G.A.4
-
27
-
-
73949095967
-
-
WO 2002036595
-
T. C. Johnson, J. C. Vanheertum, D. G. Ouse, M. A. Pobanz, K. E. Arndt, D. K. Walker, WO 2002036595 (2002)
-
(2002)
-
-
Johnson, T.C.1
Vanheertum, J.C.2
Ouse, D.G.3
Pobanz, M.A.4
Arndt, K.E.5
Walker, D.K.6
-
28
-
-
0033522949
-
-
M. T. Cocco, C. Congiu, V. Onnis, Tetrahedron Lett., 40, 4407 (1999)
-
(1999)
Tetrahedron Lett
, vol.40
, pp. 4407
-
-
Cocco, M.T.1
Congiu, C.2
Onnis, V.3
-
29
-
-
0001773607
-
-
T. Konakahara, M. Hojahmat, S. Tamura, J. Chem. Soc, Perkin Trans. 1, 1999, 2803
-
(1999)
J. Chem. Soc, Perkin Trans. 1
, pp. 2803
-
-
Konakahara, T.1
Hojahmat, M.2
Tamura, S.3
-
30
-
-
48849112208
-
-
L. E. Kiss, H. S. Ferreira, D. A. Learmonth, Org. Lett., 10, 1835 (2008)
-
(2008)
Org. Lett
, vol.10
, pp. 1835
-
-
Kiss, L.E.1
Ferreira, H.S.2
Learmonth, D.A.3
-
31
-
-
73949139973
-
-
WO 2007013830
-
D. Learmonth, L. Kiss, P. L. Palma, H. D. S. Ferreira, P. A. S. D. Silva, WO 2007013830 (2007)
-
(2007)
-
-
Learmonth, D.1
Kiss, L.2
Palma, P.L.3
Ferreira, H.D.S.4
Silva, P.A.S.D.5
-
32
-
-
39149099951
-
-
V. Y. Sosnovskikh, R. A. Irgashev, M. I. Kodess, Tetrahedron, 64, 2997 (2008)
-
(2008)
Tetrahedron
, vol.64
, pp. 2997
-
-
Sosnovskikh, V.Y.1
Irgashev, R.A.2
Kodess, M.I.3
-
33
-
-
0030729427
-
-
(a) I. Katsuyama, S. Ogawa, Y. Yamaguchi, K. Funabiki, M. Matsui, H. Muramatsu, K. Shibata, Synthesis, 1997, 1321;
-
(1997)
Synthesis
, pp. 1321
-
-
Katsuyama, I.1
Ogawa, S.2
Yamaguchi, Y.3
Funabiki, K.4
Matsui, M.5
Muramatsu, H.6
Shibata, K.7
-
34
-
-
0031721109
-
-
(b) Y. Yamaguchi, I. Katsuyama, K. Funabiki, M. Matsui, K. Shibata, J. Heterocycl. Chem., 35, 805 (1998)
-
(1998)
J. Heterocycl. Chem
, vol.35
, pp. 805
-
-
Yamaguchi, Y.1
Katsuyama, I.2
Funabiki, K.3
Matsui, M.4
Shibata, K.5
-
35
-
-
0029975542
-
-
(a) I. Katsuyama, K. Funabiki, M. Matsui, H. Muramatsu, K. Shibata, Tetrahedron Lett., 37, 4177 (1996);
-
(1996)
Tetrahedron Lett
, vol.37
, pp. 4177
-
-
Katsuyama, I.1
Funabiki, K.2
Matsui, M.3
Muramatsu, H.4
Shibata, K.5
-
36
-
-
33846622079
-
-
(b) idem, Heterocycles, 68, 2097 (2006)
-
(2006)
Heterocycles
, vol.68
, pp. 2097
-
-
Katsuyama, I.1
Funabiki, K.2
Matsui, M.3
Muramatsu, H.4
Shibata, K.5
-
37
-
-
0000376885
-
-
(a) I. Katsuyama, S. Ogawa, H. Nakamura, Y. Yamaguchi, K. Funabiki, M. Matsui, H. Muramatsu, K. Shibata, Heterocycles, 48, 779 (1998);
-
(1998)
Heterocycles
, vol.48
, pp. 779
-
-
Katsuyama, I.1
Ogawa, S.2
Nakamura, H.3
Yamaguchi, Y.4
Funabiki, K.5
Matsui, M.6
Muramatsu, H.7
Shibata, K.8
-
40
-
-
73949150082
-
-
CF3-CH3PyH, CH3Py ⇄ 4-CF3-CH3Py, CH3PyH+ 2-CF 3-CH3PyH, CH3py ⇄ 2-CF 3-CH3Py, CH3PyH+ 4-CF 3CH3Py δH°, 13.2 kcal/mol; 2-CF 3CH3Py δ H°, 16.0 kcal/mol PM 3 2-CF3
-
3
-
-
-
-
41
-
-
84986500421
-
-
(a) K. Shibata, I. Katsuyama, M. Matsui, H. Muramatsu, J. Heterocycl. Chem., 28, 161 (1991);
-
(1991)
J. Heterocycl. Chem
, vol.28
, pp. 161
-
-
Shibata, K.1
Katsuyama, I.2
Matsui, M.3
Muramatsu, H.4
-
42
-
-
73949149217
-
-
(b) I. Katsuyama, M. Matsui, H. Muramatsu, K. Shibata, ITE Lett., on Batteries, New Technologies &Medicine, 4, 55 (2003)
-
(2003)
ITE Lett., on Batteries, New Technologies &Medicine
, vol.4
, pp. 55
-
-
Katsuyama, I.1
Matsui, M.2
Muramatsu, H.3
Shibata, K.4
-
44
-
-
33846525992
-
-
(b) I. Kieltsch, P. Eisenberger, A. Togni, Angew. Chem. Int. Ed., 46, 754 (2007);
-
(2007)
Angew. Chem. Int. Ed
, vol.46
, pp. 754
-
-
Kieltsch, I.1
Eisenberger, P.2
Togni, A.3
-
45
-
-
73949132583
-
-
2008-214281
-
(c) 2008-214281
-
-
-
-
46
-
-
0000266968
-
-
(a) H. Sawada, M. Yoshida, H. Hagii, K. Aoshima, M. Kobayashi, Bull. Chem. Soc. Jpn., 59, 215 (1986);
-
(1986)
Bull. Chem. Soc. Jpn
, vol.59
, pp. 215
-
-
Sawada, H.1
Yoshida, M.2
Hagii, H.3
Aoshima, K.4
Kobayashi, M.5
-
47
-
-
0000078270
-
-
(b) T. Akiyama, K. Kato, M. Kajitani, Y. Sakaguchi, J. Nakamura, H. Hayashi, A. Sugimori, ibid, 61, 3531 (1988);
-
(1988)
Bull. Chem. Soc. Jpn
, vol.61
, pp. 3531
-
-
Akiyama, T.1
Kato, K.2
Kajitani, M.3
Sakaguchi, Y.4
Nakamura, J.5
Hayashi, H.6
Sugimori, A.7
-
48
-
-
0000859590
-
-
(c) Y. Tanabe, N. Matsuo, N. Ohono, J. Org. Chem., 53, 4582 (1988)
-
(1988)
J. Org. Chem
, vol.53
, pp. 4582
-
-
Tanabe, Y.1
Matsuo, N.2
Ohono, N.3
-
52
-
-
85008525652
-
-
(a) Y. Kobayashi, I. Kumadaki, S. Sato, N. Hara, E. Chikami, Chem. Pharm. Bull., 18, 2334 (1970);
-
(1970)
Chem. Pharm. Bull
, vol.18
, pp. 2334
-
-
Kobayashi, Y.1
Kumadaki, I.2
Sato, S.3
Hara, N.4
Chikami, E.5
-
53
-
-
37049099522
-
-
(b) Y. Kobayashi, I. Kumadaki, K. Yamamoto, J. Chem. Soc, Chem. Commum., 1977, 536
-
(1977)
J. Chem. Soc, Chem. Commum
, pp. 536
-
-
Kobayashi, Y.1
Kumadaki, I.2
Yamamoto, K.3
-
54
-
-
37049108761
-
-
(c) Y. Kobayashi, K. Yamamoto, I. Kumadaki, J. Chem. Soc, Perkin Trans. 1, 1980, 2755
-
(1980)
J. Chem. Soc, Perkin Trans. 1
, pp. 2755
-
-
Kobayashi, Y.1
Yamamoto, K.2
Kumadaki, I.3
-
55
-
-
0006598557
-
-
(a) I. Ruppert, K. Schlich, W. Volbach, Tetrahedron Lett., 25, 2195 (1984);
-
(1984)
Tetrahedron Lett
, vol.25
, pp. 2195
-
-
Ruppert, I.1
Schlich, K.2
Volbach, W.3
-
59
-
-
46949094149
-
-
G. G. Dubinina, H. Furutachi, D. A. Vicic, J. Am. Chem. Soc., 130, 8600(2008)
-
(2008)
J. Am. Chem. Soc
, vol.130
, pp. 8600
-
-
Dubinina, G.G.1
Furutachi, H.2
Vicic, D.A.3
-
61
-
-
33748661487
-
-
M. Schlosser, Angew. Chem. Int. Ed., 45, 5432 (2006); (b) K. Uneyama, Organofluorine Chemistry, Blackwell Publishing, Oxford, UK (2006)
-
(a) M. Schlosser, Angew. Chem. Int. Ed., 45, 5432 (2006); (b) K. Uneyama, "Organofluorine Chemistry", Blackwell Publishing, Oxford, UK (2006)
-
-
-
-
63
-
-
0343070655
-
-
(b) K. Miyashita, K. Kondoh, K. Tsuchiya, H. Miyabe, T. Imanishi, J. Chem. Soc, Perkin Trans. 1, 1996, 1261;
-
(1996)
J. Chem. Soc, Perkin Trans. 1
, pp. 1261
-
-
Miyashita, K.1
Kondoh, K.2
Tsuchiya, K.3
Miyabe, H.4
Imanishi, T.5
-
64
-
-
0029873426
-
-
(c) H. Yamanaka, T. Takekawa, K. Morita, T. Ishihara, J. T. Gupton, Tetrahedron Lett., 37, 1829 (1996);
-
(1996)
Tetrahedron Lett
, vol.37
, pp. 1829
-
-
Yamanaka, H.1
Takekawa, T.2
Morita, K.3
Ishihara, T.4
Gupton, J.T.5
-
66
-
-
0001372567
-
-
(e) E. Okada, T. Kinomura, H. Takeuchi, M. Hojo, Heterocycles, 44, 349 (1997);
-
(1997)
Heterocycles
, vol.44
, pp. 349
-
-
Okada, E.1
Kinomura, T.2
Takeuchi, H.3
Hojo, M.4
-
68
-
-
0033000464
-
-
(g) K. Funabiki, H. Nakamura, M. Matsui, K. Shibata, SynLett, 1999, 756;
-
(1999)
SynLett
, pp. 756
-
-
Funabiki, K.1
Nakamura, H.2
Matsui, M.3
Shibata, K.4
-
70
-
-
0035799153
-
-
(i) V. I. Tyvorskii, D. N. Bobrov, O. G. Kulinkovich, K. A. Tehrani, N. de Kimpe, Tetrahedron, 57, 2051 (2001);
-
(2001)
Tetrahedron
, vol.57
, pp. 2051
-
-
Tyvorskii, V.I.1
Bobrov, D.N.2
Kulinkovich, O.G.3
Tehrani, K.A.4
de Kimpe, N.5
-
71
-
-
0242660834
-
-
(j) S. Gille, A. Ferry, T. Billard, B. R. Langlois, J. Org. Chem., 68, 8932 (2003);
-
(2003)
J. Org. Chem
, vol.68
, pp. 8932
-
-
Gille, S.1
Ferry, A.2
Billard, T.3
Langlois, B.R.4
-
72
-
-
2342466231
-
-
(k) F. Palacios, C. Alonso, G. Lubiales, M. Villegas, Tetrahedron Lett., 45, 4031 (2004);
-
(2004)
Tetrahedron Lett
, vol.45
, pp. 4031
-
-
Palacios, F.1
Alonso, C.2
Lubiales, G.3
Villegas, M.4
-
73
-
-
23944453893
-
-
T. Mori, Y. Iwai, J. Ichikawa, Chem. Lett., 34, 778 (2005);
-
(2005)
Chem. Lett
, vol.34
, pp. 778
-
-
Mori, T.1
Iwai, Y.2
Ichikawa, J.3
-
76
-
-
30944441071
-
-
C. Brule, J.-P. Bouillon, E. Nicola!, C. Portella, Synthesis, 2006, 103;
-
(o) C. Brule, J.-P. Bouillon, E. Nicola!, C. Portella, Synthesis, 2006, 103;
-
-
-
-
77
-
-
34547096469
-
-
(p) H. Suzuki, N. Sakai, R. Iwahara, T. Fujiwaka, M. Satoh, A. Kakehi, T. Konakahara, J. Org. Chem., 72, 5878 (2007);
-
(2007)
J. Org. Chem
, vol.72
, pp. 5878
-
-
Suzuki, H.1
Sakai, N.2
Iwahara, R.3
Fujiwaka, T.4
Satoh, M.5
Kakehi, A.6
Konakahara, T.7
-
78
-
-
51649100808
-
-
(q) B. I. Usachev, D. L. Obydennov, G.-V. Röschenthaler, V. Y. Sos- novskikh, Org. Lett., 10, 2857 (2008)
-
(2008)
Org. Lett
, vol.10
, pp. 2857
-
-
Usachev, B.I.1
Obydennov, D.L.2
Röschenthaler, G.-V.3
Sos- novskikh, V.Y.4
|