CD4+ T-cell localization to the large intestinal mucosa during Trichuris muris infection is mediated by Gαi-coupled receptors but is CCR6- and CXCR3-independent

Immunology

Volumn 129, Issue 2, 2010, Pages 257-267

  Svensson, Marcus ^a   Russell, Karen ^a   MacK, Matthias ^b   Else, Kathryn J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

CD4 helper T cells (Th cells, Th0, Th1, Th2, Th3, Th17); Chemokine receptors; Helminths; Mucosal immunity; Trafficking

Indexed keywords

CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CXCR3; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; L SELECTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DOWN REGULATION; INTESTINE MUCOSA; LYMPHOCYTE MIGRATION; MALE; MESENTERIC LYMPHADENITIS; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRICHURIASIS; TRICHURIS; TRICHURIS MURIS;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, BLOCKING; CD4-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; CELLS, CULTURED; GTP-BINDING PROTEIN ALPHA SUBUNITS; IMMUNITY, MUCOSAL; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED BALB C; MICE, SCID; PERTUSSIS TOXIN; RECEPTORS, CCR6; RECEPTORS, CXCR3; TRICHURIASIS; TRICHURIS;

EID: 73949129043     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2009.03178.x     Document Type: Article

References (25)

1. Cliffe LJ, Grencis RK. The Trichuris muris system: a paradigm of resistance and susceptibility to intestinal nematode infection. Adv Parasitol 2004 57 : 255 307.
2. Cliffe LJ, Humphreys NE, Lane TE, Potten CS, Booth C, Grencis RK. Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion. Science 2005 308 : 1463 1465.
3. Little MC, Bell LV, Cliffe LJ, Else KJ. The characterization of intraepithelial lymphocytes, lamina propria leukocytes, and isolated lymphoid follicles in the large intestine of mice infected with the intestinal nematode parasite Trichuris muris. J Immunol 2005 175 : 6713 6722.
4. + T cells in protective immunity to the murine nematode parasite Trichuris muris. Parasite Immunol 1995 17 : 161 165.
5. + T cell-mediated protection in reconstituted SCID mice. Parasitology 2000 121 (Pt 6 631 637.
6. Butcher EC, Picker LJ. Lymphocyte homing and homeostasis. Science 1996 272 : 60 6.
7. Else KJ, Wakelin D, Wassom DL, Hauda KM. The influence of genes mapping within the major histocompatibility complex on resistance to Trichuris muris infections in mice. Parasitology 1990 101 (Pt 1 61 7.
8. Wakelin D. Acquired immunity to Trichuris muris in the albino laboratory mouse. Parasitology 1967 57 : 515 524.
9. Mack M, Cihak J, Simonis C et al. Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice. J Immunol 2001 166 : 4697 4704.
10. Svensson M, Marsal J, Ericsson A, Carramolino L, Broden T, Marquez G, Agace WW. CCL25 mediates the localization of recently activated CD8αβ(+) lymphocytes to the small-intestinal mucosa. J Clin Invest 2002 110 : 1113 1121.
11. Offermanns S. G-proteins as transducers in transmembrane signalling. Prog Biophys Mol Biol 2003 83 : 101 130.
12. Chen Y, Jiang G, Yang HR et al. Distinct response of liver myeloid dendritic cells to endotoxin is mediated by IL-27. J Hepatol 2009 51 : 510 519.
13. deSchoolmeester ML, Martinez-Pomares L, Gordon S, Else KJ. The mannose receptor binds Trichuris muris excretory/secretory proteins but is not essential for protective immunity. Immunology 2009 126 : 246 255.
14. Gilliver SC, Ruckshanthi JP, Hardman MJ, Nakayama T, Ashcroft GS. Sex dimorphism in wound healing: the roles of sex steroids and macrophage migration inhibitory factor. Endocrinology 2008 149 : 5747 5757.
15. Hamann A, Andrew DP, Jablonski-Westrich D, Holzmann B, Butcher EC. Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo. J Immunol 1994 152 : 3282 3293.
16. Lefrancois L, Parker CM, Olson S, Muller W, Wagner N, Schon MP, Puddington L. The role of β7 integrins in CD8 T cell trafficking during an antiviral immune response. J Exp Med 1999 189 : 1631 1638. (Pubitemid 29240888)
17. Fahmy MA. An investigation on the life cycle of Trichuris muris. Parasitology 1954 44 : 50 7.
18. Campbell DJ, Butcher EC. Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues. J Exp Med 2002 195 : 135 141.
19. + T cells display CCR9-dependent and -independent homing to the small intestine. Blood 2006 107 : 3447 3454.
20. Bell LV, Else KJ. Mechanisms of leucocyte recruitment to the inflamed large intestine: redundancy in integrin and addressin usage. Parasite Immunol 2008 30 : 163 170.
21. Kelly EA, Cruz ES, Hauda KM, Wassom DL. IFN-γ- and IL-5-producing cells compartmentalize to different lymphoid organs in Trichinella spiralis-infected mice. J Immunol 1991 147 : 306 311.
22. Johansson-Lindbom B, Svensson M, Wurbel MA, Malissen B, Marquez G, Agace W. Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant. J Exp Med 2003 198 : 963 969.
23. Kunkel EJ, Campbell JJ, Haraldsen G et al. Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. J Exp Med 2000 192 : 761 768.
24. Oyama T, Miura S, Watanabe C et al. CXCL12 and CCL20 play a significant role in mucosal T-lymphocyte adherence to intestinal microvessels in mice. Microcirculation 2007 14 : 753 766.
25. Hieshima K, Kawasaki Y, Hanamoto H, Nakayama T, Nagakubo D, Kanamaru A, Yoshie O. CC chemokine ligands 25 and 28 play essential roles in intestinal extravasation of IgA antibody-secreting cells. J Immunol 2004 173 : 3668 3675.