Effect of oxygen affinity on systemic perfusion and brain tissue oxygen tension after extreme hemodilution with hemoglobin-starch conjugates in rats

Intensive Care Medicine

Volumn 35, Issue 11, 2009, Pages 1925-1933

  Hare, Gregory M T ^a,b   Liu, Elaine ^a   Baker, Andrew J ^a   Mazer, C David ^a,b  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cerebral hypoxia; Hemodilution; Hemoglobin based oxygen carrier; Lactate

Indexed keywords

HEMOGLOBIN; HETASTARCH; HRC 101; LACTIC ACID; OXYGEN;

ANALYSIS OF VARIANCE; ANEMIA; ANIMAL; ARTICLE; BLOOD; BLOOD GAS ANALYSIS; CHEMISTRY; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECT; DRUG SCREENING; HEMATOCRIT; HEMODILUTION; HIPPOCAMPUS; MALE; METABOLISM; METHODOLOGY; MOLECULAR WEIGHT; OXYGEN CONSUMPTION; RAT; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION; VASCULARIZATION;

ANALYSIS OF VARIANCE; ANEMIA; ANIMALS; BLOOD GAS ANALYSIS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; HEMATOCRIT; HEMODILUTION; HEMOGLOBINS; HETASTARCH; HIPPOCAMPUS; LACTIC ACID; MALE; MOLECULAR WEIGHT; OXYGEN; OXYGEN CONSUMPTION; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 73949122750     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-009-1532-2     Document Type: Article

References (39)

1. Dunne JR, Malone D, Tracy JK, Gannon C, Napolitano LM (2002) Perioperative anemia: an independent risk factor for infection, mortality, and resource utilization in surgery. J Surg Res 102:237-244
2. Habib RH, Zacharias A, Schwann TA, Riordan CJ, Durham SJ, Shah A (2003) Adverse effects of low hematocrit during cardiopulmonary bypass in the adult: should current practice be changed? J Thorac Cardiovasc Surg 125:1438-1450
3. Karkouti K, Wijeysundera DN, Beattie WS (2008) Risk associated with preoperative anemia in cardiac surgery: a multicenter cohort study. Circulation 117:478-484
4. Rao SV, Jollis JG, Harrington RA, Granger CB, Newby LK, Armstrong PW, Moliterno DJ, Lindblad L, Pieper K, Topol EJ, Stamler JS, Califf RM (2004) Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes. JAMA 292:1555-1562
5. Wu WC, Schifftner TL, Henderson WG, Eaton CB, Poses RM, Uttley G, Sharma SC, Vezeridis M, Khuri SF, Friedmann PD (2007) Preoperative hematocrit levels and postoperative outcomes in older patients undergoing noncardiac surgery. JAMA 297:2481-2488
6. Zilberberg MD, Stern LS, Wiederkehr DP, Doyle JJ, Shorr AF (2008) Anemia, transfusions and hospital outcomes among critically ill patients on prolonged acute mechanical ventilation: a retrospective cohort study. Crit Care 12(R60):1-8
7. Carson JL, Poses RM, Spence RK, Bonavita G (1988) Severity of anaemia and operative mortality and morbidity. Lancet 1:727-729
8. Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E (1999) A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 340:409-417
9. Karkouti K, Wijeysundera DN, Yau TM, McCluskey SA, van RA, Beattie WS (2008) The influence of baseline hemoglobin concentration on tolerance of anemia in cardiac surgery. Transfusion 48:666-672
10. Kulier A, Levin J, Moser R, Rumpold-Seitlinger G, Tudor IC, Snyder-Ramos SA, Moehnle P, Mangano DT, Investigators of the Multicenter Study of Perioperative Ischemia Research Group; Ischemia Research, Education Foundation (2007) Impact of preoperative anemia on outcome in patients undergoing coronary artery bypass graft surgery. Circulation 116:471-479
11. Al FN, Lawrence-Nelson J, Kostis JB, Lacy CR, Ranjan R, Wilson AC (2002) Effect of anemia on 1-year mortality in patients with acute myocardial infarction. Am Heart J 144:636-641
12. Sabatine MS, Morrow DA, Giugliano RP, Burton PB, Murphy SA, McCabe CH, Gibson CM, Braunwald E (2005) Association of hemoglobin levels with clinical outcomes in acute coronary syndromes. Circulation 111:2042-2049
13. Nikolsky E, Aymong ED, Halkin A, Grines CL, Cox DA, Garcia E, Mehran R, Tcheng JE, Griffin JJ, Guagliumi G, Stuckey T, Turco M, Cohen DA, Negoita M, Lansky AJ, Stone GW (2004) Impact of anemia in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: analysis from the controlled abciximab and device investigation to lower late angioplasty complications (CADILLAC) trial. J Am Coll Cardiol 44:547-553
14. Steyerberg EW, Mushkudiani N, Perel P, Butcher I, Lu J, McHugh GS, Murray GD, Marmarou A, Roberts I, Habbema JD, Maas AI (2008) Predicting outcome after traumatic brain injury: development and international validation of prognostic scores based on admission characteristics. PLoS Med 5(e165):1251-1261
15. McIntyre LA, Fergusson DA, Hutchison JS, Pagliarello G, Marshall JC, Yetisir E, Hare GM, Hébert PC (2006) Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury. Neurocrit Care 5:4-9
16. Swaminathan M, Phillips-Bute BG, Conlon PJ, Smith PK, Newman MF, Stafford-Smith M (2003) The association of lowest hematocrit during cardiopulmonary bypass with acute renal injury after coronary artery bypass surgery. Ann Thorac Surg 76:784-791
17. Surgenor SD, DeFoe GR, Fillinger MP, Likosky DS, Groom RC, Clark C, Helm RE, Kramer RS, Leavitt BJ, Klemperer JD, Krumholz CF, Westbrook BM, Galatis DJ, Frumiento C, Ross CS, Olmstead EM, O'Connor GT (2006) Intraoperative red blood cell transfusion during coronary artery bypass graft surgery increases the risk of postoperative low-output heart failure. Circulation 114(1 Suppl):I43-I48
18. Silverberg DS, Wexler D, Iaina A (2002) The importance of anemia and its correction in the management of severe congestive heart failure. Eur J Heart Fail 4:681-686
19. Bateman ST, Lacroix J, Boven K, Forbes P, Barton R, Thomas NJ, Jacobs B, Markovitz B, Goldstein B, Hanson JH, Li HA, Randolph AG, Pediatric Acute Lung Injury, Sepsis Investigators Network (2008) Anemia, blood loss, and blood transfusions in North American children in the intensive care unit. Am J Respir Crit Care Med 178:26-33
20. Jani SM, Smith DE, Share D, Kline-Rogers E, Khanal S, O'Donnell MJ, Gardin J, Moscucci M (2007) Blood transfusion and in-hospital outcomes in anemic patients with myocardial infarction undergoing percutaneous coronary intervention. Clin Cardiol 30:II49-II56
21. Koch CG, Li L, Duncan AI, Mihaljevic T, Cosgrove DM, Loop FD, Starr NJ, Blackstone EH (2006) Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting. Crit Care Med 34:1608-1616
22. Murphy GJ, Reeves BC, Rogers CA, Rizvi SI, Culliford L, Angelini GD (2007) Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery. Circulation 116:2544-2552
23. Natanson C, Kern SJ, Lurie P, Banks SM, Wolfe SM (2008) Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysis. JAMA 299:2304-2312
24. Kavdia M, Pittman RN, Popel AS (2002) Theoretical analysis of effects of blood substitute affinity and cooperativity on organ oxygen transport. J Appl Physiol 93:2122-2128
25. 2 affinity. Am J Physiol 276:H553-H562
26. Cabrales P, Sakai H, Tsai AG, Takeoka S, Tsuchida E, Intaglietta M (2005) Oxygen transport by low and normal oxygen affinity hemoglobin vesicles in extreme hemodilution. Am J Physiol 288:H1885-H1892
27. Sakai H, Cabrales P, Tsai AG, Tsuchida E, Intaglietta M (2005) Oxygen release from low and normal P50 Hb vesicles in transiently occluded arterioles of the hamster window model. Am J Physiol 288:H2897-H2903
28. Rosen AL, Gould S, Sehgal LR, Noud G, Sehgal HL, Rice CL, Moss GS (1979) Cardiac output response to extreme hemodilution with hemoglobin solutions of various P50 values. Crit Care Med 7:380-384
29. Pittman RN, Miller KB, Tait PH (2003) Effect of hemoglobin solutions as hemodiluents on capillary oxygen tension. Adv Exp Med Biol 510:83-88
30. Vaslef SN, Kaminski BJ, Talarico TL (2001) Oxygen transport dynamics of acellular hemoglobin solutions in an isovolemic hemodilution model in swine. J Trauma 51:1153-1160
31. 2 carriers on microvascular pressure. Am J Physiol 288:H2146-H2153
32. Khandelwal SR, Randad RS, Lin PS, Meng H, Pittman RN, Kontos HA, Choi SC, Abraham DJ, Schmidt-Ullrich R (1993) Enhanced oxygenation in vivo by allosteric inhibitors of hemoglobin saturation. Am J Physiol 265:H1450-H1453
33. 2 delivery in dog muscle in situ. J Appl Physiol 84:995-1002
34. Hare GM, Harrington A, Liu E, Wang JL, Baker AJ, Mazer CD (2006) Effect of oxygen affinity and molecular weight of HBOCs on cerebral oxygenation and blood pressure in rats. Can J Anesth 53:1030-1038
35. Tsai AG, Friesenecker B, McCarthy M, Sakai H, Intaglietta M (1998) Plasma viscosity regulates capillary perfusion during extreme hemodilution in hamster skinfold model. Am J Physiol 275:H2170-H2180
36. Tsai AG, Acero C, Nance PR (2005) Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion. Am J Physiol 288:H1730-H1739
37. Cabrales P, Intaglietta M, Tsai AG (2005) Increase plasma viscosity sustains microcirculation after resuscitation from hemorrhagic shock and continuous bleeding. Shock 23:549-555
38. Cabrales P, Tsai AG (2006) Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions. Am J Physiol 291:H2445-H2452
39. Cabrales P, Martini J, Intaglietta M, Tsai AG (2006) Blood viscosity maintains microvascular conditions during normovolemic anemia independent of blood oxygen-carrying capacity. Am J Physiol 291:H581-H590