Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 288, Issue 5 57-5, 2005, Pages

  Cabrales, Pedro ^a   Tsai, Amy G ^a   Winslow, Robert M ^a   Intaglietta, Marcos ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Blood pressure; Blood substitutes; Perfusion; Plasma expander; Shear stress

Indexed keywords

ALPHA,ALPHA CROSS LINKED HUMAN HEMOGLOBIN; HEMOGLOBIN DERIVATIVE; MACROGOL; MP 4; OXYGEN; PLASMA SUBSTITUTE; POLYETHYLENE GLYCOL CONJUGATED HUMAN HEMOGLOBIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTERIOLE; ARTERY RESISTANCE; ARTICLE; BLOOD FLOW; BLOOD PRESSURE; CAPILLARY PRESSURE; CONTROLLED STUDY; HEMATOCRIT; HEMODILUTION; MEAN ARTERIAL PRESSURE; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; SYRIAN HAMSTER;

ANIMALS; ARTERIOLES; BLOOD PRESSURE; BLOOD SUBSTITUTES; CAPILLARIES; CRICETINAE; HEMODILUTION; HEMOGLOBINS; MALEIMIDES; MESOCRICETUS; MICROCIRCULATION; POLYETHYLENE GLYCOLS; SKIN; VASOCONSTRICTION; VENULES;

EID: 18044363491     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00749.2004     Document Type: Article

References (34)

1. Alayash AI. Effects of intra- and intermolecular crosslinking on the free radical reactions of bovine hemoglobins. Free Radic Biol Med 18: 295-301, 1995.
2. 2 during extreme hemodilution with hemoglobin site specifically PEGylated at Cys-93(β) in hamster window chamber. Am J Physiol Heart Circ Physiol 287: H1609-H1617, 2004.
3. Cabrales P, Tsai AG, Frangos JA, Briceno JC, and Intaglietta M. Oxygen delivery and consumption in the microcirculation after extreme hemodilution with perfluorocarbons. Am J Physiol Heart Circ Physiol 287: H320-H330, 2004.
4. Cabrales P, Tsai AG, and Intaglietta M. Microvascular pressure and functional capillary density in extreme hemodilution with low and high plasma viscosity expanders. Am J Physiol Heart Circ Physiol 287: H363-H373, 2004.
5. Colantuoni A, Bertuglia S, and Intaglietta M. Effects of anesthesia on the spontaneous activity of the microvasculature. Int J Microcirc Clin Exp 3: 13-28, 1984.
6. Davis MJ. Microvascular control of capillary pressure during increases in local arterial and venous pressure. Am J Physiol Heart Circ Physiol 254: H772-H784, 1988.
7. Doherty DH, Doyle MP, Curry SR, Vali RJ, Fattor TJ, Olson JS, and Lemon DD. Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin. Nat Biotechnol 16: 672-676, 1998.
8. Drobin D, Kjellstrom BT, Malm E, Malavalli A, Lohman L, Vandegriff KD, Young MA, and Winslow RM. Hemodynamic response and oxygen transport in pigs resuscitated with maleimide-polyethylene glycol-modified hemoglobin (MP4). J Appl Physiol 96: 1843-1853, 2004.
9. Endrich B, Asaishi K, Götz A, and Messmer K. Technical report: a new chamber technique for microvascular studies in unanaesthetized hamsters. Res Exp Med (Berl) 177: 125-134, 1980.
10. Hess J, Macdonald V, Murray A, Coppes V, and Gomez C. Pulmonary and systemic hypertension after hemoglobin administration (Abstract). Blood 78: 356A, 1991.
11. Hess JR, MacDonald VW, and Brinkley WW, Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin. J Appl Physiol 74: 1769-1778, 1993.
12. Intaglietta M, Silverman NR, and Tompkins WR. Capillary flow velocity measurements in vivo and in situ by television methods. Microvasc Res 10: 165-179, 1975.
13. Intaglietta M and Tompkins WR. Microvascular measurements by video image shearing and splitting. Microvasc Res 5: 309-312, 1973.
14. Intaglietta M and Tompkins WR. Simplified micropressure measurements via bridge current feedback. Microvasc Res 39: 386-389, 1990.
15. 2 dissociation during 4-h hemorrhagic shock in conscious hamsters. Am J Physiol Heart Circ Physiol 270: H827-H836, 1996.
16. Lindbom L, Tuma R, and Arfors KE. Influence of oxygen on perfused capillary density and capillary red cell velocity in rabbit skeletal muscle. Microvasc Res 19: 197-208, 1980.
17. Lipowsky HH and Firrell JC. Microvascular hemodynamics during systemic hemodilution and hemoconcentration. Am J Physiol Heart Circ Physiol 250: H908-H922, 1986.
18. Lipowsky HH and Zweifach BW. Application of the "two-slit" photometric technique to the measurement of microvascular volumetric flow rates. Microvasc Res 15: 93-101, 1978.
19. McCarthy MR, Vandegriff KD, and Winslow RM. The role of facilitated diffusion in oxygen transport by cell-free hemoglobins: implications for the design of hemoglobin-based oxygen carriers. Biophys Chem 92: 103-117, 2001.
20. 2 carriers determine constriction of resistance arteries and hypertension. Am J Physiol Heart Circ Physiol 279: H908-H915, 2000.
21. Sakai H, Tsai AG, Intaglietta M, and Tsuchida E. Hemoglobin encapsulation with polyethylene glycol-modified and unmodified vesicles: systemic and microvascular hemodynamics at 80% blood substitution. In: Advances in Blood Substitutes. Industrial Opportunities and Medical Challenges, edited by Winslow RM, Vandegriff KD, and Intaglietta M. Boston, MA: Birkhäuser, 1997, p. 151-166.
22. Sarelius IH. Cell flow path influences transit time through striated muscle capillaries. Am J Physiol Heart Circ Physiol 250: H899-H907, 1986.
23. Sarelius IH, Maxwell LC, Gray SD, and Duling BR. Capillarity and fiber types in the cremaster muscle of rat and hamster. Am J Physiol Heart Circ Physiol 245: H368-H374, 1983.
24. Tsai AG. Influence of cell-free hemoglobin on local tissue perfusion and oxygenation after acute anemia after isovolemic hemodilution. Transfusion 41: 1290-1298, 2001.
25. Tsai AG, Friesenecker B, Mazzoni MC, Kerger H, Buerk DG, Johnson PC, and Intaglietta M. Microvascular and tissue oxygen gradients in the rat mesentery. Proc Natl Acad Sci USA 95: 6590-6595, 1998.
26. Tsai AG, Friesenecker B, McCarthy M, Sakai H, and Intaglietta M. Plasma viscosity regulates capillary perfusion during extreme hemodilution in hamster skin fold model. Am J Physiol Heart Circ Physiol 275: H2170-H2180, 1998.
27. Tsai AG, Sakai H, Wettstein R, Kerger H, and Intaglietta M. An effective blood replacement fluid that targets oxygen delivery, increases plasma viscosity and has high oxygen affinity. NATA 5: 507-514, 2004.
28. 2 therapeutics. Am J Physiol Heart Circ Physiol 285: H1411-H1419, 2003.
29. Vandegriff KD, Malavalli A, Woodridge J, Lohman J, and Winslow RM. MP4, a new nonvasoactive PEG-Hb conjugate. Transfusion 43: 509-516, 2003.
30. Webb AR, Barclay SA, and Bennett ED. In vitro colloid osmotic pressure of commonly used plasma expanders and substitutes: a study of the diffusibility of colloid molecules. Intensive Care Med 15: 116-120, 1989.
31. Wiederhielm CA, Woodbury JW, Kirk S, and Rushmer RF. Pulsatile pressure in the microcirculation of the frog's mesentery. Am J Physiol 207: 173-176, 1964.
32. Winslow RM. Alternative oxygen therapeutics: products, status of cunicai trials, and future prospects. Curr Hemat Reports 2: 503-510, 2003.
33. Winslow RM. Current status of blood substitute research: towards a new paradigm. J Intern Med 253: 508-517, 2003.
34. Winslow RM and Chapman KW. Pilot-scale preparation of hemoglobin solutions. Methods Enzymol 231: 3-16, 1994.