Basophil models of homeopathy: a sceptical view

Homeopathy

Volumn 99, Issue 1, 2010, Pages 51-56

  Ennis, Madeleine ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD63 ANTIGEN; CIMETIDINE; HISTAMINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY;

ARTICLE; BASOPHIL; CELL ACTIVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DILUTION; FLOW CYTOMETRY; HOMEOPATHY; HUMAN; HUMAN CELL; INHIBITION KINETICS; NEGATIVE FEEDBACK; STANDARDIZATION; STATISTICAL SIGNIFICANCE;

ANTIGENS, CD; BASOPHILS; FLOW CYTOMETRY; HISTAMINE; HOMEOPATHY; HUMANS; PHOSPHORIC DIESTER HYDROLASES; PLATELET MEMBRANE GLYCOPROTEINS; PYROPHOSPHATASES;

EID: 73949102369     PISSN: 14754916     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.homp.2009.11.005     Document Type: Article

References (41)

1. Davenas E., Beauvais F., Amara J., et al. Human basophil degranulation triggered by very dilute antiserum against IgE. Nature 333 (1988) 816-818
2. Ovelgonne J.H., Bol A.W., Hop W.C., and van Wijk R. Mechanical agitation of very dilute antiserum against IgE has no effect on basophil staining properties. Experientia 48 (1992) 504-508
3. Hirst S.J., Hayes N.A., Burridge J., Pearce F.L., and Foreman J.C. Human basophil degranulation is not triggered by very dilute antiserum against human IgE. Nature 366 (1993) 525-527
4. Witt C.M., Bluth M., Albrecht H., Weisshuhn T.E., Baumgartner S., and Willich S.N. The in vitro evidence for an effect of high homeopathic potencies-a systematic review of the literature. Complement Ther Med 15 (2007) 128-138
5. Karl and Veronica Carstens-Foundation. The HomBRex-database (2008). www.carstens-stiftung.de/hombrex
6. Lichtenstein L.M., and Gillespie E. Inhibition of histamine release by histamine controlled by H2 receptor. Nature 244 (1973) 287-288
7. Sainte-Laudy J., Sambucy J.L., and Belon P. Biological activity of ultra low doses: I/ effect of ultra low doses of histamine on human basophil degranulation triggered by D. Pteronyssinus extract ultra low doses (1991), Taylor & Francis 127-138
8. Bellavite P., Ortolani R., Pontarollo F., Conforti A., and Pitari G. Immunology and homeopathy. 5. The rationale of the 'Simile'. Evid Based Complement Alternat Med 4 (2007) 149-163
9. Gilbert H.S., and Ornstein L. Basophil counting with a new staining method using alcian blue. Blood 46 (1975) 279-286
10. Lichtenstein L.M., Norman P.S., and Connell J.T. Comparison between skin-sensitizing antibody titers and leukocyte sensitivity measurements as an index of the severity of ragweed hay fever. J Allergy 40 (1967) 160-167
11. Crockard A.D., and Ennis M. Laboratory-based allergy diagnosis; should we go with the flow?. Clin Exp Allergy 31 (2001) 957-977
12. Brown V., and Ennis M. In: Pawankar R., Holgate S.T., and Rosenwasser L.J. (Eds). CD203c for Allergy Diagnosis. Allergy Frontiers:Diagnosis and Health Economics Series: Allergy Frontiers Vol 4 (2009) 183-199
13. Crockard A.D., and Ennis M. Basophil histamine release tests in the diagnosis of allergy and asthma. Clin Exp Allergy 31 (2001) 345-350
14. Bochner B.S., and Sterbinsky S.A. Altered surface expression of CD11 and Leu 8 during human basophil degranulation. J Immunol 146 (1991) 2367-2373
15. Michova A., Abugalia M., Ivanova T., Nikolov G., Taskov H., and Petrunov B. Comparision of two-flow cytometry methods for basophil degranulation in patients sensitized to grass pollen. Allergy 61 (2006) 1078-1083
16. Bühring H.J., Simmons P.J., Pudney M., et al. The monoclonal antibody 97A6 defines a novel surface antigen expressed on human basophils and their multipotent and unipotent progenitors. Blood 94 (1999) 2343-2356
17. Hennersdorf F., Florian S., Jakob A., et al. Identification of CD13, CD107a, and CD164 as novel basophil activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation. Cell Res 15 (2005) 325-335
18. Hauswirth A.W., Sonneck K., Florian S., et al. Interleukin-3 promotes the expression of E-NPP3/CD203C on human blood basophils in healthy subjects and in patients with birch pollen allergy. Int J Immunopathol Pharmacol 20 (2007) 267-278
19. De Week A.L., Sanz M.L., Gamboa P.M., et al. Diagnostic tests based on human basophils: more potentials and perspectives than pitfalls. II. Technical issues. J Investig Allergol Clin Immunol 18 (2008) 143-155
20. Kleine-Tebbe J., Erdmann S., Knol E.F., MacGlashan Jr. D.W., Poulsen L.K., and Gibbs B.F. Diagnostic tests based on human basophils: potentials, pitfalls and perspectives. Int Arch Allergy Immunol 141 (2006) 79-90
21. Poitevin B., Davenas E., and Benveniste J. In vitro immunological degranulation of human basophils is modulated by lung histamine and Apis mellifica. Br J Clin Pharmacol 25 (1988) 439-444
22. Poitevin B., Aubin M.J., and Benveniste J. Approach to a quantitative analysis of the effect of Apis mellifica on the in vitro human basophil degranulation. J Innov Tech. Biol Med 7 (1986) 64-68
23. 'High-dilution' experiments a delusion. Nature 334 (1988) 287-290
24. Benveniste J., Davenas E., Ducot B., Cornillet B., Poitevin B., and Spira A. L'agitation de solutions hautement diluées n'induit pas d'activité biologique spécifique. C.R Acad Sci Paris, Série II 312 (1991) 461-466
25. Knol E.F., Mul F.P., Kuijpers T.W., Verhoeven A.J., and Roos D. Intracellular events in anti-IgE nonreleasing human basophils. J Allergy Clin Immunol 90 (1992) 92-103
26. Sainte-Laudy J. Standardization of basophil degranulation for pharmacological studies. J Immunol Methods 98 (1987) 279-282
27. Sainte-Laudy J., and Belon P. Biological activity of ultra low doses: II/ Effect of ultra low doses of histamine on human basophil degranulation triggered by anti-IgE. Ultra low doses (1991), Taylor & Francis 139-143
28. Belon P., Cumps J., Ennis M., Mannaioni P.F., Roberfroid M., Sainte-Laudy J., et al. Histamine dilutions modulate basophil activation. Inflamm Res. 53 (2004) 181-188
29. Sainte-Laudy J., and Belon P. Analysis of immunosuppressive activity of serial dilutions of histamine on human basophil activation by flow cytometry. Inflamm Res 45 Suppl 1 (1996) S33-S34
30. Sainte-Laudy J., Boudjedaini N., and Belon P. Differential effect of storage on molecular and ultra-molecular dilutions of histamine. Inflamm Res 58 Suppl 1 (2009) 30-31
31. Sainte-Laudy J., Boujenaini N., and Belon P. Confirmation of biological effects of high dilutions. Effects of submolecular concentrations of histamine and 1-, 3-and 4-methylhistamines on human basophil activation. Inflamm Res 57 Suppl 1 (2008) S27-S28
32. Sainte-Laudy J., Boumediene A., Touraine F., Orsel I., Brianchon C., Bonnaud F., et al. Use of both CD63 up regulation and IgE down regulation for the flow cytometric analysis of allergen induced basophil activation. Definition of an activation index. Inflamm Res 56 (2007) 291-296
33. Sainte-Laudy J., and Belon P. Use of four different flow cytometric protocols for the analysis of human basophil activation. Application to the study of the biological activity of high dilutions of histamine. Inflamm Res 55 Suppl 1 (2006) S23-S24
34. Sainte-Laudy J., and Belon P. Improvement of flow cytometric analysis of basophil activation inhibition by high histamine dilutions. A novel basophil specific marker: CD 203c. Homeopathy 95 (2006) 3-8
35. Hadjaj B., Cherruault Y., and Sainte Laudy J. Control of basophil degranulation. Int J Biomed Comput 32 (1993) 151-159
36. Sainte-Laudy J. Modulation of allergen and anti-IgE induced human basophil activation by serial histamine dilutions. Inflamm Res 49 Suppl 1 (2000) S5-S6
37. Brown V., and Ennis M. Flow-cytometric analysis of basophil activation: inhibition by histamine at conventional and homeopathic concentrations. Inflamm Res 50 Suppl 2 (2001) S47-S48
38. Lorenz I., Schneider E.M., Stolz P., Brack A., and Strube J. Sensitive flow cytometric method to test basophil activation influenced by homeopathic histamine dilutions. Forsch Komplementarmed Klass Naturheilkd 10 (2003) 316-324
39. Lorenz I., Schneider E.M., Stolz P., Brack A., and Strube J. Influence of the diluent on the effect of highly diluted histamine on basophil activation. Homeopathy 92 (2003) 11-18
40. Guggisberg A.G., Baumgartner S.M., Tschopp C.M., and Heusser P. Replication study concerning the effects of homeopathic dilutions of histamine on human basophil degranulation in vitro. Complement Ther Med 13 (2005) 91-100
41. Chirumbolo S., Brizzi M., Ortolani R., Vella A., and Bellavite P. Inhibition of CD203c membrane up-regulation in human basophils by high dilutions of histamine: a controlled replication study. Inflamm Res 58 (2009) 755-764