Sensitive flow cytometric method to test basophil activation influenced by homeopathic histamine dilutions

Forschende Komplementarmedizin und Klassische Naturheilkunde

Volumn 10, Issue 6, 2003, Pages 316-324

  Lorenz, I ^a   Schneider, E M ^a   Stolz, P ^a   Brack, A ^a   Strube, J ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Basophil activation; CD123; Dendritic cells; Flow cytometry; Histamine, highly diluted

Indexed keywords

CD123 ANTIGEN; CD14 ANTIGEN; CD16 ANTIGEN; CD19 ANTIGEN; CD2 ANTIGEN; CD63 ANTIGEN; HISTAMINE; HLA DR ANTIGEN; IMMUNOGLOBULIN E ANTIBODY;

ANALYTICAL EQUIPMENT; ARTICLE; BASOPHIL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DILUTION; FLOW CYTOMETRY; HOMEOPATHY; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; LEUKOCYTE FUNCTION; LIGHT SCATTERING; MONONUCLEAR CELL;

ANTIBODIES, ANTI-IDIOTYPIC; BASOPHILS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FLOW CYTOMETRY; HISTAMINE; HISTAMINE RELEASE; HUMANS; IMMUNOGLOBULIN E; SENSITIVITY AND SPECIFICITY;

EID: 1642453568     PISSN: 14247364     EISSN: None     Source Type: Journal    
DOI: 10.1159/000075885     Document Type: Article

References (51)

1. Benveniste J: The human basophil degranulation test as an in vitro method for the diagnosis of allergies. Clin Allergy 1981;11:1-11.
2. Davenas E, Beauvais F, Amara J, Oberbaum M, Robinzon B, Miadonna A, Tedeschi A, Pomeranz B, Fortner P, Belon P, Sainte Laudy J, Piotevin B, Benveniste J: Human basophil degranulation triggered by very dilute antiserum against IgE. Nature 1988;333:816-818.
3. Hirst SJ, Hayes NA, Burridge J, Pearce FL, Foreman JC: Human basophil degranulation is not triggered by very dilute antiserum against human IgE. Nature 1993;366:525-527.
4. Ovelgonne JH, Bol AW, Hop WC, van Wijk R: Mechanical agitation of very dilute antiserum against IgE has no effect on basophil staining properties. Experientia 1992;48:504-508.
5. Sainte-Laudy J, Belon P: Inhibition of human basophil activation by high dilutions of histamine. Agents Actions 1993;38:C245-C247.
6. Belon P, Cumps J, Ennis M, Mannaioni PF, Sainte-Laudy J, Roberfroid M, Wiegant FA: Inhibition of human basophil degranulation by successive histamine dilutions: Results of a European multi-centre trial. Inflamm Res 1999;48:S17-18.
7. Poitevin B, Davenas E, Benveniste J: In vitro immunological degranulation of human basophils is modulated by lung histamine and Apis mellifica. Br J Clin Pharmacol 1988;25:439-444.
8. Lichtenstein LM, Gillespie E: Inhibition of histamine release by histamine controlled by H2 receptor. Nature 1973;244:287-288.
9. Sainte-Laudy J, Belon P: Analysis of immunosuppressive activity of serial dilutions of histamine on human basophil activation by flow cytometry. Inflamm Res 1996;45:S33-34.
10. Brown V, Ennis M: Flow-cytometric analysis of basophil activation: Inhibition by histamine at conventional and homeopathic concentrations. Inflamm Res 2001;50:S47-48.
11. Gilbert HS, Ornstein L: Basophil counting with a new staining method using alcian blue. Blood 1975; 42:279-286.
12. Sainte-Laudy J, Vallon C, Guerin JC: [Analysis of membrane expression of the CD63 human basophil activation marker. Applications to allergologic diagnosis]. Allerg Immunol (Paris) 1994;26:211-214.
13. Knol EF, Mul FP, Jansen H, Calafat J, Roos D: Monitoring human basophil activation via CD63 monoclonal antibody 435. J Allergy Clin Immunol 1991;88:328-338.
14. Falcone FH, Haas H, Gibbs BF: The human basophil: A new appreciation of its role in immune responses. Blood 2000;96:4028-4038.
15. Nadler MJ, Matthews SA, Turner H, Kinet JP: Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: Coupling form to function. Adv Immunol 2000;76:325-355.
16. Kepley CL, Wilson BS, Oliver JM: Identification of the Fc epsilonRI-activated tyrosine kinases Lyn, Syk, and Zap-70 in human basophils. J Allergy Clin Immunol 1998;102:304-315.
17. Amano T, Furuno T, Hirashima N, Ohyama N, Nakanishi M: Dynamics of intracellular granules with CD63-GFP in rat basophilic leukemia cells. J Biochem (Tokyo) 2001;129:739-744.
18. Metzelaar MJ, Wijngaard PL, Peters PJ, Sixma JJ, Nieuwenhuis HK, Clevers HC: CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. J Biol Chem 1991;266:3239-3245.
19. Sainte-Laudy J, Sabbah A, Vallon C, Guerin JC: Analysis of anti-IgE and allergen induced human basophil activation by flow cytometry. Comparison with histamine release. Inflamm Res 1998;47:401-408.
20. Sainte-Laudy J, Sabbah A, Drouet M, Lauret MG, Loiry M: Diagnosis of venom allergy by flow cytometry. Correlation with clinical history, skin tests, specific IgE, histamine and leukotriene C4 release. Clin Exp Allergy 2000;30:1166-1171.
21. Kinet JP: The high-affinity IgE receptor (Fc epsilon RI): From physiology to pathology. Annu Rev Immunol 1999;17:931-972.
22. Oliver JM, Kepley CL, Ortega E, Wilson BS: Immunologically mediated signaling in basophils and mast cells: Finding therapeutic targets for allergic diseases in the human FcvarepsilonR1 signaling pathway. Immunopharmacology 2000;48:269-281.
23. Richards ML, Katz DH: Biology and chemistry of low affinity IgE receptor (Fc epsilon RII/CD23). Crit Rev Immunol 1991;11:65-86.
24. Abuaf N, Rajoely B, Ghazouani E, Levy DA, Pecquet C, Chabane H, Leynadier F: Validation of a flow cytometric assay detecting in vitro basophil activation for the diagnosis of muscle relaxant allergy. J Allergy Clin Immunol 1999;104:411-418.
25. Monneret G, Gutowski MC, Bienvenu J: Detection of allergen-induced basophil activation by expression of CD63 antigen using a tricolour flow cytometric method. Clin Exp Immunol 1999;115:393-396.
26. Sanz ML, Sanchez G, Gamboa PM, Vila L, Uasuf C, Chazot M, Dieguez I, De Weck AL: Allergen-induced basophil activation: CD63 cell expression detected by flow cytometry in patients allergic to Dermatophagoides pteronyssinus and Lolium perenne. Clin Exp Allergy 2001;31:1007-1013.
27. Hamamoto K, Ohga S, Nomura S, Yasunaga K: Cellular distribution of CD63 antigen in platelets and in three megakaryocytic cell lines. Histochem J 1994;26:367-375.
28. Koyama Y, Suzuki M, Yoshida T: CD63, a member of tetraspan transmembrane protein family, induces cellular spreading by reaction with monoclonal antibody on substrata. Biochem Biophys Res Commun 1998;246:841-846.
29. Woodhead VE, Binks MH, Chain BM, Katz DR: From sentinel to messenger: An extended phenotypic analysis of the monocyte to dendritic cell transition. Immunology 1998;94:552-559.
30. Beinert T, Munzing S, Possinger K, Krombach F: Increased expression of the tetraspanins CD53 and CD63 on apoptotic human neutrophils. J Leukoc Biol 2000;67:369-373.
31. Matsumoto K, Bochner BS, Wakiguchi H, Kurashige T: Functional expression of transmembrane 4 superfamily molecules on human eosinophils. Int Arch Allergy Immunol 1999;120:38-44.
32. Mahmudi-Azer S, Downey GP, Moqbel R: Translocation of the tetraspanin CD63 in association with human eosinophil mediator release. Blood 2002;99:4039-4047.
33. Kepley CL, Youssef L, Andrews RP, Wilson BS, Oliver JM: Syk deficiency in nonreleaser basophils. J Allergy Clin Immunol 1999;104:279-284.
34. Knol EF, Mul FP, Kuijpers TW, Verhoeven AJ, Roos D: Intracellular events in anti-IgE nonreleasing human basophils. J Allergy Clin Immunol 1992; 90:92-103.
35. Maddox J: Maddox on the 'Benveniste affair'. Science 1988;241:1585-1586.
36. Kepley CL, Youssef L, Andrews RP, Wilson BS, Oliver JM: Multiple defects in Fc epsilon RI signaling in Syk-deficient nonreleaser basophils and IL-3-induced recovery of Syk expression and secretion. J Immunol 2000;165:5913-5920.
37. Lavens-Phillips SE, MacGlashan DW Jr: The tyrosine kinases p53/56lyn and p72syk are differentially expressed at the protein level but not at the messenger RNA level in nonreleasing human basophils. Am J Respir Cell Mol Biol 2000;23:566-571.
38. Nakagawa T, Stadler BM, de Weck AL: Flow-cytometric analysis of human basophil degranulation. I. Quantification of human basophils and their degranulation by flow-cytometry. Allergy 1981;36:39-47.
39. MacGlashan DW Jr: Graded changes in the response of individual human basophils to stimulation: Distributional behavior of events temporally coincident with degranulation. J Leukoc Biol 1995;58:177-188.
40. Baumgartner S, Heusser P, Thurneysen S: Methodological standards and problems in preclinical homoeopathic potency research. Forsch Komplementärmed 1998;5:27-32.
41. Linde K, Melchart D, Jonas WB, Hornung J: Ways to enhance the quality and acceptance of clinical and laboratory studies in homoeopathy. Br Hom J 1994;83:3-7.
42. Pearce FL: Biological effects of histamine: An overview. Agents Actions 1991;33:4-7.
43. Clough GF, Church MK: Histamine synthesis, action and inactivation: Is the balance disturbed in allergy? Clin Exp Allergy 1999;29:9-11.
44. Lichtenstein LM, Gillespie E: Inhibition of histamine release by histamine controlled by H2 receptor. Nature 1973;244:287-288.
45. Lichtenstein LM, Gillespie E: The effects of the H1 and H2 antihistamines on 'allergic' histamine release and its inhibition by histamine. J Pharmacol Exp Ther 1975;192:441-450.
46. Tedeschi A, Lorini M, Arquati M, Miadonna A: Regulation of histamine release from human basophil leucocytes: Role of H1, H2 and H3 receptors. Allergy 1991;46:626-631.
47. Sainte-Laudy J: Modulation of allergen and anti-igE induced human basophil activation by serial histamine dilutions. Inflamm Res 2000;49:S5-6.
48. Drobis JD, Siraganian RP: Histamine release from cultured human basophils: Lack of histamine resynthesis after antigenic release. J Immunol 1976;117: 1049-1053.
49. MacGlashan D Jr, McKenzie-White J, Chichester K, Bochner BS, Davis FM, Schroeder JT, Lichtenstein LM: In vitro regulation of FcepsilonRIalpha expression on human basophils by IgE antibody. Blood 1998;91:1633-1643.
50. Yamaguchi M, Hirai K, Morita Y, Takaishi T, Ohta K, Suzuki S, Motoyoshi K, Kawanami O, Ito K: Hemopoietic growth factors regulate the survival of human basophils in vitro. Int Arch Allergy Immunol 1992;97:322-329.
51. Lorenz I, Schneider EM, Stolz P, Brack A, Strube J: Influence of the diluent on the effect of highly diluted histamine on basophil activation. Homeopathy 2003;92:11-18.