메뉴 건너뛰기




Volumn 95, Issue 1, 2010, Pages 12-15

Genetic lesions in chronic lymphocytic leukemia: What's ready for prime time use?

Author keywords

[No Author keywords available]

Indexed keywords

FLUDARABINE; PROTEIN IVGH; PROTEIN P53; TUMOR PROTEIN; UNCLASSIFIED DRUG;

EID: 73949101232     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2009.016873     Document Type: Editorial
Times cited : (15)

References (31)
  • 1
    • 73949119178 scopus 로고    scopus 로고
    • Kienle D, Benner A, Läufle C, Winkler D, Schneider C, Bühler A, et al. Gene expression factors as predictors of genetic risk and survival in chronic lymphocytic leukemia. Haematologica. 2010;95(1):102-9.
    • Kienle D, Benner A, Läufle C, Winkler D, Schneider C, Bühler A, et al. Gene expression factors as predictors of genetic risk and survival in chronic lymphocytic leukemia. Haematologica. 2010;95(1):102-9.
  • 2
    • 73949119120 scopus 로고    scopus 로고
    • Zhuang J, Hawkins SF, Glenn MA, Lin K, Johnson GG, Carter A, et al. Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition. Haematologica. 2010;95(1):110-8.
    • Zhuang J, Hawkins SF, Glenn MA, Lin K, Johnson GG, Carter A, et al. Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition. Haematologica. 2010;95(1):110-8.
  • 3
    • 0033567907 scopus 로고    scopus 로고
    • Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94(6):1848-54.
    • Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94(6):1848-54.
  • 4
    • 0033567968 scopus 로고    scopus 로고
    • Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle RN, Wasil T, Fais F, Ghiotto F, Valetto A, Allen SL, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 1999; 94(6):1840-7.
    • (1999) Blood , vol.94 , Issue.6 , pp. 1840-1847
    • Damle, R.N.1    Wasil, T.2    Fais, F.3    Ghiotto, F.4    Valetto, A.5    Allen, S.L.6
  • 5
    • 0037085801 scopus 로고    scopus 로고
    • Somatically mutated IgV(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia
    • Tobin G, Thunberg U, Johnson A, Thorn I, Sodeberg O, Hultdin M, et al. Somatically mutated IgV(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia. Blood 2002;99(6):2262-4.
    • (2002) Blood , vol.99 , Issue.6 , pp. 2262-2264
    • Tobin, G.1    Thunberg, U.2    Johnson, A.3    Thorn, I.4    Sodeberg, O.5    Hultdin, M.6
  • 6
    • 33645507226 scopus 로고    scopus 로고
    • Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status
    • Thorselius M, Kröber A, Murray F, Thunberg U, Tobin G, Bühler A, et al. Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status. Blood. 2006;107(7):2889-94.
    • (2006) Blood , vol.107 , Issue.7 , pp. 2889-2894
    • Thorselius, M.1    Kröber, A.2    Murray, F.3    Thunberg, U.4    Tobin, G.5    Bühler, A.6
  • 7
    • 0037406968 scopus 로고    scopus 로고
    • ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia
    • Crespo M, Bosch F, Villamor N, Bellosillo B, Colomer D, Rozman M, et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med. 2003;348(18):1764-75.
    • (2003) N Engl J Med , vol.348 , Issue.18 , pp. 1764-1775
    • Crespo, M.1    Bosch, F.2    Villamor, N.3    Bellosillo, B.4    Colomer, D.5    Rozman, M.6
  • 8
    • 4143105617 scopus 로고    scopus 로고
    • ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia
    • Rassenti LZ, Huynh L, Toy TL, Chen L, Keating MJ, Gribben JG, et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med. 2004;351(9):893-901.
    • (2004) N Engl J Med , vol.351 , Issue.9 , pp. 893-901
    • Rassenti, L.Z.1    Huynh, L.2    Toy, T.L.3    Chen, L.4    Keating, M.J.5    Gribben, J.G.6
  • 11
    • 0032845683 scopus 로고    scopus 로고
    • Incidence and clinical significance of 6q deletions in B cell chronic lymphocytic leukemia
    • Stilgenbauer S, Bullinger L, Benner A, Benner A, Leupolt E, Winkler D, et al. Incidence and clinical significance of 6q deletions in B cell chronic lymphocytic leukemia. Leukemia. 1999:13(9):1331-41.
    • (1999) Leukemia , vol.13 , Issue.9 , pp. 1331-1341
    • Stilgenbauer, S.1    Bullinger, L.2    Benner, A.3    Benner, A.4    Leupolt, E.5    Winkler, D.6
  • 12
    • 0030706137 scopus 로고    scopus 로고
    • Deletions at 11q identify a subgroup of patients with typical CLL who show consistent disease progression and reduced survival
    • Neilson JR, Auer R, White D, Bienz N, Waters JJ, Whittaker JA, et al. Deletions at 11q identify a subgroup of patients with typical CLL who show consistent disease progression and reduced survival. Leukemia. 1997;11(11):1229-32.
    • (1997) Leukemia , vol.11 , Issue.11 , pp. 1229-1232
    • Neilson, J.R.1    Auer, R.2    White, D.3    Bienz, N.4    Waters, J.J.5    Whittaker, J.A.6
  • 13
    • 46749108058 scopus 로고    scopus 로고
    • Molecular diagnostics in chronic lymphocytic leukemia - pathogenetic and clinical implications
    • Zenz T, Meterns D, Döhner H, Stingelbauer S. Molecular diagnostics in chronic lymphocytic leukemia - pathogenetic and clinical implications. Leuk Lymphoma. 2008; 49(5):864-73.
    • (2008) Leuk Lymphoma , vol.49 , Issue.5 , pp. 864-873
    • Zenz, T.1    Meterns, D.2    Döhner, H.3    Stingelbauer, S.4
  • 14
    • 34447530283 scopus 로고    scopus 로고
    • Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 trial): A randomized controlled trial
    • Catovsky D, Richards S, Oscier D, Dyer MJS, Bezares RF, Pettit AR, et al. Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 trial): a randomized controlled trial. Lancet 2007;370(9583):230-9.
    • (2007) Lancet , vol.370 , Issue.9583 , pp. 230-239
    • Catovsky, D.1    Richards, S.2    Oscier, D.3    Dyer, M.J.S.4    Bezares, R.F.5    Pettit, A.R.6
  • 15
    • 59449110380 scopus 로고    scopus 로고
    • Chemoimmunotherapy may overcome the adverse prognostic significance of 11q deletion in previously untreated patients with chronic lymphocytic leukemia
    • Tsimberidou AM, Tam, C, Abruzzo LV, O'Brien S, Wierda WG, Lerner S, et al. Chemoimmunotherapy may overcome the adverse prognostic significance of 11q deletion in previously untreated patients with chronic lymphocytic leukemia. Cancer. 2009;115(2):373-80.
    • (2009) Cancer , vol.115 , Issue.2 , pp. 373-380
    • Tsimberidou, A.M.1    Tam, C.2    Abruzzo, L.V.3    O'Brien, S.4    Wierda, W.G.5    Lerner, S.6
  • 16
    • 30444451801 scopus 로고    scopus 로고
    • Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia
    • Mayr C, Speicher MR, Kofler DM, Buhmann R, Strehl J, Busch R, et al. Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia. Blood 2006;107(2):742-51.
    • (2006) Blood , vol.107 , Issue.2 , pp. 742-751
    • Mayr, C.1    Speicher, M.R.2    Kofler, D.M.3    Buhmann, R.4    Strehl, J.5    Busch, R.6
  • 17
    • 47649125809 scopus 로고    scopus 로고
    • Chromosome 14q32 translocations involving the immunoglobulin heavy chain locus in chronic lymphocytic leukaemia identify a disease subset with poor prognosis
    • Cavazzini F, Hernandez JA, Gozzetti A, Russo Rossi A, De Angeli C, Tiseo R, et al. Chromosome 14q32 translocations involving the immunoglobulin heavy chain locus in chronic lymphocytic leukaemia identify a disease subset with poor prognosis. Br J Haematol. 2008;142(4): 529-37.
    • (2008) Br J Haematol , vol.142 , Issue.4 , pp. 529-537
    • Cavazzini, F.1    Hernandez, J.A.2    Gozzetti, A.3    Russo Rossi, A.4    De Angeli, C.5    Tiseo, R.6
  • 18
    • 36349025291 scopus 로고    scopus 로고
    • Clonal evolution in chronic lymphocytic leukemia: Acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival
    • Stilgenbauer S, Sander S, Bullinger L, Wildenberger K, Bentz M, Döhner K, et al. Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival. Haematologica. 2007;92(9):1242-5.
    • (2007) Haematologica , vol.92 , Issue.9 , pp. 1242-1245
    • Stilgenbauer, S.1    Sander, S.2    Bullinger, L.3    Wildenberger, K.4    Bentz, M.5    Döhner, K.6
  • 19
    • 33750577939 scopus 로고    scopus 로고
    • Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia
    • Shanafelt TD, Witzig TE, Fink SR, Jenkins RB, Paternoster SF, Smoley SA, et al. Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia. J Clin Oncol. 2006;24(28):4634-41.
    • (2006) J Clin Oncol , vol.24 , Issue.28 , pp. 4634-4641
    • Shanafelt, T.D.1    Witzig, T.E.2    Fink, S.R.3    Jenkins, R.B.4    Paternoster, S.F.5    Smoley, S.A.6
  • 20
    • 54049141334 scopus 로고    scopus 로고
    • Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: Results from a detailed genetic characterization with long-term follow-up
    • Zenz T, Kröber A, Scherer K, Häbe S, Bühler A, Benner A, et al. Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up. Blood. 2008;112(8):3322-9.
    • (2008) Blood , vol.112 , Issue.8 , pp. 3322-3329
    • Zenz, T.1    Kröber, A.2    Scherer, K.3    Häbe, S.4    Bühler, A.5    Benner, A.6
  • 21
    • 61549089361 scopus 로고    scopus 로고
    • The prognostic value of TP53 in chronic lymphocytic leukemia is independent of del17p13: Implications for overall survival and chemorefractoriness
    • Rossi D, Cerri M, Deambrogi C Sozzi E, Cresta S, Rasi S, et al. The prognostic value of TP53 in chronic lymphocytic leukemia is independent of del17p13: implications for overall survival and chemorefractoriness. Clin Cancer Res. 2009 15(3):995-1004.
    • (2009) Clin Cancer Res , vol.15 , Issue.3 , pp. 995-1004
    • Rossi, D.1    Cerri, M.2    Deambrogi, C.3    Sozzi, E.4    Cresta, S.5    Rasi, S.6
  • 22
    • 65349160420 scopus 로고    scopus 로고
    • Relevance of the immunoglobulin VH somatic mutation status in patients with chronic lymphocytic leukemia treated with fludarabine, cyclophosphamide, and rituximab (FCR) or related chemoimmunotherapy regimens
    • Lin KI, Tam CS, Keating MJ, Wierda WG, O'Brien S, Lerner S, et al. Relevance of the immunoglobulin VH somatic mutation status in patients with chronic lymphocytic leukemia treated with fludarabine, cyclophosphamide, and rituximab (FCR) or related chemoimmunotherapy regimens. Blood. 2009;113(14):3168-71.
    • (2009) Blood , vol.113 , Issue.14 , pp. 3168-3171
    • Lin, K.I.1    Tam, C.S.2    Keating, M.J.3    Wierda, W.G.4    O'Brien, S.5    Lerner, S.6
  • 23
    • 70349231440 scopus 로고    scopus 로고
    • De novo deletion 17p13.1 chronic lymphocytic leukemia shows significant clinical heterogeneity: The MD Anderson and Mayo Clinic experience
    • Tam CS, Shanafelt TD, Wierda WG, Abruzzo LV, Van Dyke DL, O'Brien S, et al. De novo deletion 17p13.1 chronic lymphocytic leukemia shows significant clinical heterogeneity: the MD Anderson and Mayo Clinic experience. Blood. 2009;114(5):957-64.
    • (2009) Blood , vol.114 , Issue.5 , pp. 957-964
    • Tam, C.S.1    Shanafelt, T.D.2    Wierda, W.G.3    Abruzzo, L.V.4    Van Dyke, D.L.5    O'Brien, S.6
  • 24
  • 25
    • 27244434788 scopus 로고    scopus 로고
    • A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
    • Calin GA, Ferracin M, Cimmino A, Di Leva G, Shimizu M, Wojcik SE, et al. A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med. 2005;353(17):1793-801.
    • (2005) N Engl J Med , vol.353 , Issue.17 , pp. 1793-1801
    • Calin, G.A.1    Ferracin, M.2    Cimmino, A.3    Di Leva, G.4    Shimizu, M.5    Wojcik, S.E.6
  • 26
  • 27
    • 67349277730 scopus 로고    scopus 로고
    • Atypical 11q deletions identified by array CGH may be missed by FISH panels for prognostic markers in chronic lymphocytic leukemia
    • Gunn SR, Hibbard MK, Ismail SH, Lowery-Nordberg M, Mellink CH, Bahler DW, et al. Atypical 11q deletions identified by array CGH may be missed by FISH panels for prognostic markers in chronic lymphocytic leukemia. Leukemia. 2009; 23(5):1011-7.
    • (2009) Leukemia , vol.23 , Issue.5 , pp. 1011-1017
    • Gunn, S.R.1    Hibbard, M.K.2    Ismail, S.H.3    Lowery-Nordberg, M.4    Mellink, C.H.5    Bahler, D.W.6
  • 28
    • 70350452269 scopus 로고    scopus 로고
    • miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia
    • Pallasch CP, Patz M, Park YJ, Hagist S, Eggle D, Claus R, et al. miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia. Blood. 2009; 114(15); 3255-65.
    • (2009) Blood , vol.114 , Issue.15 , pp. 3255-3265
    • Pallasch, C.P.1    Patz, M.2    Park, Y.J.3    Hagist, S.4    Eggle, D.5    Claus, R.6
  • 29
    • 72549108614 scopus 로고    scopus 로고
    • A genomic approach to improve prognosis and predict therapeutic response in chronic lymphocytic leukemia
    • Friedman DR, Weinberg JB, Barry WT, Goodman BK, Volkheimer AD, Bond KM et al. A genomic approach to improve prognosis and predict therapeutic response in chronic lymphocytic leukemia. Clin Cancer Res. 2009;15(22):6947-55.
    • (2009) Clin Cancer Res , vol.15 , Issue.22 , pp. 6947-6955
    • Friedman, D.R.1    Weinberg, J.B.2    Barry, W.T.3    Goodman, B.K.4    Volkheimer, A.D.5    Bond, K.M.6
  • 31
    • 65949124249 scopus 로고    scopus 로고
    • Genomewide association studies - illuminating biologic pathways
    • Hirschhorn JN. Genomewide association studies - illuminating biologic pathways. N Engl J Med. 2009;360(17):1699-701.
    • (2009) N Engl J Med , vol.360 , Issue.17 , pp. 1699-1701
    • Hirschhorn, J.N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.