Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1791, Issue 12, 2009, Pages 1114-1124

  Uyama, Toru ^a   Jin, Xing Hua ^a   Tsuboi, Kazuhito ^a   Tonai, Takeharu ^b   Ueda, Natsuo ^a  

^a KAGAWA UNIVERSITY   (Japan)

^b National Hospital Organization   (Japan)

Author keywords

Acyltransferase; LRAT family; N acylphosphatidylethanolamine; Phospholipase A1; Phospholipase A2; Tumor suppressor

Indexed keywords

CALCIUM; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LECITHIN RETINOL ACYLTRANSFERASE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPASE A1; PHOSPHOLIPASE A2; PHOSPHOLIPID; PROTEIN HRASLS2; PROTEIN HREV107; PROTEIN TIG3; RECOMBINANT PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; HRASLS2 PROTEIN, HUMAN; HRASLS3 PROTEIN, HUMAN; LYSOPHOSPHATIDYLCHOLINE; RARRES3 PROTEIN, HUMAN; RETINOIC ACID RECEPTOR; SIGNAL PEPTIDE;

ACYLATION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SUBSTRATE; HUMAN; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; AMINO ACID SEQUENCE; ANIMAL; BIOCATALYSIS; BIOLOGICAL MODEL; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; ENZYME SPECIFICITY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HUMAN GENOME; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; STEREOISOMERISM; TUMOR CELL LINE;

ACYLATION; AMINO ACID SEQUENCE; ANIMALS; BIOCATALYSIS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME, HUMAN; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYSOPHOSPHATIDYLCHOLINES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PHOSPHATIDYLETHANOLAMINES; PHOSPHOLIPASES A2; PHOSPHOLIPIDS; RECEPTORS, RETINOIC ACID; RECOMBINANT PROTEINS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TUMOR SUPPRESSOR PROTEINS;

EID: 73949097337     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2009.07.001     Document Type: Article

References (46)

1. Prescott S.M., Zimmerman G.A., Stafforini D.M., and McIntyre T.M. Platelet-activating factor and related lipid mediators. Annu. Rev. Biochem. 69 (2000) 419-445
2. Funk C.D. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294 (2001) 1871-1875
3. 2 enzymes. Prostaglandins Other Lipid Mediat. 68-69 (2002) 3-58
4. 1. Biochim. Biophys. Acta 1582 (2002) 26-32
5. Moolenaar W.H., van Meeteren L.A., and Giepmans B.N.G. The ins and outs of lysophosphatidic acid signaling. BioEssays 26 (2004) 870-881
6. 2 superfamily and its group numbering system. Biochim. Biophys. Acta 1761 (2006) 1246-1259
7. Sugo T., Tachimoto H., Chikatsu T., Murakami Y., Kikukawa Y., Sato S., Kikuchi K., Nagi T., Harada M., Ogi K., Ebisawa M., and Mori M. Identification of a lysophosphatidylserine receptor on mast cells. Biochem. Biophys. Res. Commun. 341 (2006) 1078-1087
8. 1 belonging to the pancreatic lipase gene family. Biochimie 89 (2007) 197-204
9. Oka S., Nakajima K., Yamashita A., Kishimoto S., and Sugiura T. Identification of GPR55 as a lysophosphatidylinositol receptor. Biochem. Biophys. Res. Commun. 362 (2007) 928-934
10. Meyer zu Heringdorf D., and Jakobs K.H. Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism. Biochim. Biophys. Acta 1768 (2007) 923-940
11. 2. Annu. Rev. Biochem. 77 (2008) 495-520
12. Shimizu T. Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation. Annu. Rev. Pharmacol. Toxicol. 49 (2009) 125-150
13. Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., and Shimizu T. Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production. J. Biol. Chem. 281 (2006) 20140-20147
14. Hishikawa D., Shindou H., Kobayashi S., Nakanishi H., Taguchi R., and Shimizu T. Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Proc. Natl. Acad. Sci. U. S. A. 105 (2007) 2830-2835
15. Shindou H., and Shimizu T. Acyl-CoA:lysophospholipid acyltransferases. J. Biol. Chem. 284 (2009) 1-5
16. Shindou H., Hishikawa D., Harayama T., Yuki K., and Shimizu T. Recent progress on acyl CoA:lysophospholipid acyltransferase research. J. Lipid Res. 50 (2009) S46-S51
17. Jonas A. Lecithin cholesterol acyltransferase. Biochim. Biophys. Acta 1529 (2000) 245-256
18. Ruiz A., Winston A., Lim Y.-H., Gilbert B.A., Rando R.R., and Bok D. Molecular and biochemical characterization of lecithin retinol acyltransferase. J. Biol. Chem. 274 (1999) 3834-3841
19. 2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. J. Biol. Chem. 282 (2007) 3614-3623
20. 2+-independent phosphatidylethanolamine N-acyltransferases. Biochim. Biophys. Acta 1791 (2009) 32-38
21. Wang J., and Ueda N. Biology of endocannabinoid synthesis system. Prostaglandins Other Lipid Mediat. 89 (2009) 112-119
22. Hughes P.J., and Stanway G. The 2A proteins of three diverse picornaviruses are related to each other and to the H-rev107 family of proteins involved in the control of cell proliferation. J. Gen. Virol. 81 (2000) 201-207
23. Anantharaman V., and Aravind L. Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes. Genome Biol. 4 (2003) R11
24. Hajnal A., Klemenz R., and Schäfer R. Subtraction cloning of H-rev107, a gene specifically expressed in H-ras resistant fibroblasts. Oncogene 9 (1994) 479-490
25. Sers C., Emmenegger U., Husmann K., Bucher K., Andres A.C., and Schäfer R. Growth-inhibitory activity and downregulation of the class II tumor-suppressor gene H-rev107 in tumor cell lines and experimental tumors. J. Cell Biol. 136 (1997) 935-944
26. Nazarenko I., Schäfer R., and Sers C. Mechanisms of the HRSL3 tumor suppressor function in ovarian carcinoma cells. J. Cell Sci. 120 (2007) 1393-1404
27. 1/2 of the thiol hydrolase type. J. Lipid Res. 50 (2009) 685-693
28. 2 (AdPLA). J. Biol. Chem. 283 (2008) 25428-25436
29. Disepio D., Ghosn C., Eckert R.L., Deucher A., Robinson N., Duvic M., Chandraratna R.A.S., and Nagpal S. Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 14811-14815
30. Tsai F.-M., Shyu R.-Y., and Jiang S.-Y. RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus. Cell. Signal. 19 (2007) 989-999
31. Shyu R.-Y., Hsieh Y.-C., Tsai F.-M., Wu C.-C., and Jiang S.-Y. Cloning and functional characterization of the HRASLS2 gene. Amino acids 35 (2008) 129-137
32. Schmid P.C., Reddy P.V., Natarajan V., and Schmid H.H.O. Metabolism of N-acylethanolamine phospholipids by a mammalian phosphodiesterase of the phospholipase D type. J. Biol. Chem. 258 (1983) 9302-9306
33. Zimmermann R., Strauss J.G., Haemmerle G., Schoiswohl G., Birner-Gruenberger R., Riederer M., Lass A., Neuberger G., Eisenhaber F., Hermetter A., and Zechner R. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306 (2004) 1383-1386
34. Bligh E.G., and Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Med. Sci. 37 (1959) 911-917
35. Breathnach R., and Chambon P. Organization and expression of eucaryotic split genes coding for proteins. Annu. Rev. Biochem. 50 (1981) 349-383
36. Hummasti S., Hong C., Bensinger S.J., and Tontonoz P. HRASLS3 is a PPARγ-selective target gene that promotes adipocyte differentiation. J. Lipid Res. 49 (2008) 2535-2544
37. Jahng W.J., Xue L., and Rando R.R. Lecithin retinol acyltransferase is a founder member of a novel family of enzymes. Biochemistry 42 (2003) 12805-12812
38. Jaworski K., Ahmadian M., Duncan R.E., Sarkadi-Nagy E., Varady K.A., Hellerstein M.K., Lee H.-Y., Samuel V.T., Shulman G.I., Kim K.-H., de Val S., Kang C., and Sul H.S. AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. Nat. Med. 15 (2009) 159-168
39. Sturniolo M.T., Dashti S.R., Deucher A., Rorke E.A., Broome A.-M., Chandraratna R.A., Keepers T., and Eckert R.L. A novel tumor suppressor protein promotes keratinocyte terminal differentiation via activation of type I transglutaminase. J. Biol. Chem. 278 (2003) 48066-48073
40. Huang S.-L., Shyu R.-Y., Yeh M.-Y., and Jiang S.-Y. Cloning and characterization of a novel retinoid-inducible gene 1 (RIG1) deriving from human gastric cancer cells. Mol. Cell Endocrinol. 159 (2000) 15-24
41. Huang S.-L., Shyu R.-Y., Yeh M.-Y., and Jiang S.-Y. The retinoid-inducible gene I: effect on apoptosis and mitogen-activated kinase signal pathways. Anticancer Res. 22 (2002) 799-804
42. Tsai F.-M., Shyu R.-Y., and Jiang S.-Y. RIG1 inhibits the Ras/mitogen-activated protein kinase pathway by suppressing the activation of Ras. Cell. Signal. 18 (2006) 349-358
43. Schmid H.H.O. Pathways and mechanisms of N-acylethanolamine biosynthesis: can anandamide be generated selectively. Chem. Phys. Lipids 108 (2000) 71-87
44. Hansen H.S., Moesgaard B., Hansen H.H., and Petersen G. N-Acylethanolamines and precursor phospholipids-relation to cell injury. Chem. Phys. Lipids 108 (2000) 135-150
45. Simon G.M., and Cravatt B.F. Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for α/β-hydrolase 4 in this pathway. J. Biol. Chem. 281 (2006) 26465-26472
46. 1 and retrograde traffic in C. elegans stem cell divisions. EMBO J. 27 (2008) 1647-1657