New conjugated benzothiazole-N-oxides: Synthesis and biological activity

Molecules

Volumn 14, Issue 12, 2009, Pages 5382-5388

  Gajdoš, Peter ^a   Magdolen, Peter ^a   Zahradník, Pavol ^a   Foltínová, Pavlína ^a  

^a Faculty of Natural Sciences   (Slovakia)

Author keywords

Antibacterial; Benzothiazole; Euglena gracilis; N oxides; Push pull systems

Indexed keywords

ANTIINFECTIVE AGENT; ANTIPROTOZOAL AGENT; BENZOTHIAZOLE DERIVATIVE;

ARTICLE; CHEMISTRY; MICROBIOLOGICAL EXAMINATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SYNTHESIS; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTI-BACTERIAL AGENTS; ANTIPROTOZOAL AGENTS; BENZOTHIAZOLES; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 73849110190     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules14125382     Document Type: Article

References (14)

1. Milne, G.W.A. Gardneŕs Commercially Important Chemicals; Wiley Interscience: New York, NY, USA, 2005; pp. 61, 69, 424.
2. Mishra, A.; Behera, R.K.; Behera, P.K.; Mishra, B.K.; Behera, G.B. Cyanines during 1990s: A review. Chem. Rev. 2000, 100, 1973-2012.
3. Michaelidou, A.S.; Hadjipavlou-Litina, D. Nonsteroidal anti-inflammatory drugs (NSAIDs): A comparative QSAR study. Chem. Rev. 2005, 105, 3235-3271.
4. Aiello, S.; Wells, G.; Stone, E.L.; Kadri, H.; Bazzi, R.; Bell, D.R.; Stevens, M.F.G.; Matthews, C.S.; Bradshaw, T.D.; Westwell, A.D. Synthesis and biological properties of benzothiazole, benzoxazole, and chromen-4-one analogues of the potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648). J. Med. Chem. 2008, 51, 5135-5139.
5. Cho, Y.; Ioerger, T.R.; Sacchettini, J.C. Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening. J. Med. Chem. 2008, 51, 5984-5992.
6. Zahradník, P.; Foltínová, P.; Halgaš, J. QSAR Study of the toxicity of benzothiazolium salts against Euglena gracilis: The free-Wilson approach. SAR QSAR Environ. Res. 1996, 5, 51-55.
7. Magdolen, P.; Zahradník, P.; Foltínová, synthesis, antimicrobial testing and QSAR study of new 2-phenylethenylbenzothiazolium salts substituted by cyclic amines. Pharmazie 2000, 55, 803-810.
8. Buffa, R.; Zahradník, P.; Foltínová P. Synthesis and QSAR studies of new conjugated benzothiazole derivatives. Coll. Czech. Chem. Commun. 2002, 67, 1820-1832.
9. Zajac, M.; Hrobárik, P.; Magdolen, P.; Foltínová, P.; Zahradník, P. Donor-acceptor benzothiazole derivatives with extended heteroaryl-containing conjugated system: Synthesis, DFT study and antimicrobial activity. Tetrahedron 2008, 64, 10605-10618.
10. Sigmundová, I.; Zahradník, P.; Loos, D. Synthesis and study of novel benzothiazole derivatives with potential nonlinear optical properties. Collect. Czechoslov. Chem. Commun. 2007, 72, 1069-1093.
11. Hrobárik, P.; Sigmundová, I.; Zahradnik, P. Preparation of novel push-pull benzothiazole derivatives with reverse polarity: The compounds with potential non-linear optic application. Synthesis 2005, 600-604.
12. Takahashi, S.; Kano, K. Studies on heteroaromatic N-oxides. IX. The Synthesis and structure of benzothiazole N-oxides. Chem. Pharm. Bull. 1969, 17, 1598-1604.
13. Magdolen, P.; Mečiarová, M.; Toma, S. Ultrasound effect on the synthesis of 4-alkyl-(aryl)aminobenzaldehydes. Tetrahedron 2001, 57, 4781-4785.
14. Foltínová, P.; Sutoris, V.; Blockinger, G.; Ebringer, L. Antimicrobial effects of some benzothiazole derivatives. Folia Microbiol. (Prague) 1978, 23, 225-228.