The number of Foxp3-positive regulatory T cells is increased in Helicobacter pylori gastritis and gastric cancer

Pathology Research and Practice

Volumn 206, Issue 1, 2010, Pages 34-38

  Jang, Tae Jung ^a  

^a Dongguk University College of Medicine   (South Korea)

Author keywords

Foxp3 positive regulatory T cells; Gastric cancer; Helicobacter pylori

Indexed keywords

TRANSCRIPTION FACTOR FOXP3;

ADOLESCENT; ADULT; AGED; ARTICLE; BACTERIAL COLONIZATION; CELLULAR IMMUNITY; CHILD; CHRONIC GASTRITIS; CHRONIC INFLAMMATION; DISEASE SEVERITY; DYSPLASIA; FEMALE; HELICOBACTER INFECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH FOLLICLE; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; REGULATORY T LYMPHOCYTE; STOMACH ADENOCARCINOMA; STOMACH BIOPSY; STOMACH CANCER;

ADENOCARCINOMA; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; CELL COUNT; CHILD; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GASTRIC MUCOSA; GASTRITIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; STOMACH NEOPLASMS; T-LYMPHOCYTES, REGULATORY;

EID: 73849090915     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2009.07.019     Document Type: Article

References (30)

1. Chen Y.L., Fang J.H., Lai M.D., and Shan Y.S. Depletion of CD4(+)CD25(+) regulatory T cells can promote local immunity to suppress tumor growth in benzo[a]pyrene-induced forestomach carcinoma. World J. Gastroenterol. 14 (2008) 5797-5809
2. Chen X.Y., Liu W.Z., Shi Y., Zhang D.Z., Xiao S.D., and Tytgat G.N. Helicobacter pylori associated gastric diseases and lymphoid tissue hyperplasia in gastric antral mucosa. J. Clin. Pathol. 55 (2002) 133-137
3. + regulatory T cells via a TGF-β- and retinoic acid-dependent mechanism. J. Exp. Med. 204 (2007) 1757-1764
4. Dixon M.F., Genta R.M., Yardley J.H., and Correa P. Classification and grading of gastritis. The updated Sydney system. Am. J. Surg. Pathol. 20 (1996) 1161-1181
5. Enarsson K., Lundgren A., Kindlund B., Hermansson M., Roncador G., Banham A.H., Lundin B.S., and Quiding-Järbrink M. Function and recruitment of mucosal regulatory T cells in human chronic Helicobacter pylori infection and gastric adenocarcinoma. Clin. Immunol. 121 (2006) 358-368
6. Ernst P.B., and Gold B.D. The disease spectrum of Helicobacter pylori: the immunopathogenesis of gastroduodenal ulcer and gastric cancer. Annu. Rev. Microbiol. 54 (2000) 615-640
7. Fontenot J.D., Rasmussen J.P., Williams L.M., Dooley J.L., Farr A.G., and Rudensky A.Y. Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity 22 (2005) 329-341
8. Fontenot J.D., and Rudensky A.Y. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol. 6 (2005) 331-337
9. Harris P.R., Wright S.W., Serrano C., Riera F., Duarte I., Torres J., Peña A., Rollán A., Viviani P., Guiraldes E., Schmitz J.M., Lorenz R.G., Novak L., Smythies L.E., and Smith P.D. Helicobacter pylori gastritis in children is associated with a regulatory T-cell response. Gastroenterology 134 (2008) 491-499
10. Hiraoka N., Onozato K., Kosuge T., and Hirohashi S. Prevalence of foxp3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions. Clin. Cancer Res. 12 (2006) 5423-5434
11. Jang T.J. Prevalence of Foxp3 positive T regulatory cells is increased during progression of cutaneous squamous tumors. Yonsei Med. J. 31 (2008) 942-948
12. Joneleit H., Schmitt E., Stassen M., Tuettenberg A., Knop J., and Enk A.H. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 193 (2001) 1285-1294
13. Kandulski A., Wex T., Kuester D., Peitz U., Gebert I., Roessner A., and Malfertheiner P. Naturally occurring regulatory T cells (CD4+, CD25high, FOXP3+) in the antrum and cardia are associated with higher H. pylori colonization and increased gene expression of TGF-beta 1. Helicobacter 13 (2008) 295-303
14. Knipp U., Birkholz S., Kaup W., Mahnke K., and Opferkuch W. Suppression of human mononuclear cell response by Helicobacter pylori: effects on isolated monocytes and lymphocytes. FEMS. Immunol. Med. Microbiol. 8 (1994) 157-166
15. Li Z., and Li J. Local expressions of TGF-β1, TGF-β1RI, CTGF, and Smad-7 in Helicobacter pylori associated gastritis. Scand. J. Gastroenterol. 41 (2006) 1007-10012
16. Lindholm C., Quiding-Jarbrink M., Lonroth H., Hamlet A., and Svennerholm A.M. Local cytokine response in Helicobacter pylori-infected subjects. Infect. Immun. 66 (1998) 5964-5971
17. Liyanage U.K., Moore T.T., Joo H.G., Tanaka Y., Herrmann V., Doherty G., Drebin J.A., Strasberg S.M., Eberlein T.J., Goedegebuure P.S., and Linehan D.C. Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J. Immunol. 169 (2002) 2756-2761
18. Lundgren A., Suri-Payer E., Enarsson K., Svennerholm A.M., and Lundin B.S. Helicobacter pylori-specific CD4+ CD25high regulatory T cells suppress memory T-cell responses to H. pylori in infected individuals. Infect. Immun. 71 (2003) 1755-1762
19. Mizukami Y., Kono K., Kawaguchi Y., Akaike H., Kamimura K., Sugai H., and Fujii H. Localization pattern of foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer. Br. J. Cancer 98 (2008) 148-153
20. Ng W.F., Duggan P.J., Ponchel F., Matarese G., Lombardi G., Edwards A.D., Isaacs J.D., and Lechler R.I. Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood 98 (2001) 2736-2744
21. Ormandy L.A., Hillemann T., Wedemeyer H., Manns M.P., Greten T.F., and Korangy F. Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. Cancer Res. 65 (2005) 2457-2464
22. Perrone G., Ruffini P.A., Catalano V., Spino C., Santini D., Muretto P., Spoto C., Zingaretti C., Sisti V., Alessandroni P., Giordani P., Cicetti A., D'Emidio S., Morini S., Ruzzo A., Magnani M., Tonini G., Rabitti C., and Graziano F. Intratumoural FOXP3-positive regulatory T cells are associated with adverse prognosis in radically resected gastric cancer. Eur. J. Cancer 44 (2008) 1875-1882
23. + T cells regulate gastric inflammation and Helicobacter pylori colonization in vivo. Gastroenterology 131 (2006) 525-537
24. Raghavan S., Suri-Payer E., and Holmgren J. Antigen-specific in vitro suppression of murine Helicobacter pylori-reactive immunopathological T cells by CD4CD25 regulatory T cells. Scand. J. Immunol. 60 (2004) 82-88
25. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., and Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155 (1995) 1151-1164
26. Shen L.S., Wang J., Shen D.F., Yuan X.L., Dong P., Li M.X., Xue J., Zhang F.M., Ge H.L., and Xu D. CD4(+)CD25(+)CD127(low/-) regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression. Clin. Immunol. 13 (2009) 109-118
27. Suerbaum S., and Michetti P. Helicobacter pylori infection. N. Engl. J. Med. 347 (2002) 1175-1186
28. Sun C.M., Hall J.A., Blank R.B., Bouladoux N., Oukka M., Mora J.R., and Belkaid Y. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3T reg cells via retinoic acid. J. Exp. Med. 204 (2007) 1775-1785
29. Woo E.Y., Chu C.S., Goletz T.J., Schlienger K., Yeh H., Coukos G., Rubin S.C., Kaiser L.R., and June C.H. Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res. 61 (2001) 4766-4772
30. Ziegler S.F. FOXP3: of mice and men. Annu. Rev. Immunol. 24 (2006) 209-226