The Paracoccidioides brasiliensis gp70 antigen is encoded by a putative member of the flavoproteins monooxygenase family

Fungal Genetics and Biology

Volumn 47, Issue 2, 2010, Pages 179-189

  Maricato, Juliana T ^a   Batista, Wagner L ^a   Kioshima, Érika S ^a   Feitosa, Luciano S ^a   Brito, Ronni R Novaes e ^a   Goldman, Gustavo H ^b   Mariano, Mário ^a,c   Puccia, Rosana ^a   Lopes, José D ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c PAULISTA UNIVERSITY   (Brazil)

Author keywords

Antigen; Flavoprotein; Oxidative stress; Paracoccidioides brasiliensis

Indexed keywords

EPITOPE; GLYCOPROTEIN GP 70; HYDROGEN PEROXIDE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELLULAR IMMUNITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; FUNGUS GROWTH; FUNGUS IMMUNITY; GLYCOSYLATION; HETEROLOGOUS EXPRESSION; HUMORAL IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARACOCCIDIOIDES BRASILIENSIS; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SOUTH AMERICAN BLASTOMYCOSIS;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, SOUTHERN; CELLS, CULTURED; FLAVOPROTEINS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GLYCOPROTEINS; HYDROGEN PEROXIDE; MACROPHAGES; MICE; MICE, INBRED BALB C; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; OXIDATIVE STRESS; PARACOCCIDIOIDES; SEQUENCE HOMOLOGY, AMINO ACID;

FUNGI; PARACOCCIDIOIDES BRASILIENSIS;

EID: 73749087668     PISSN: 10871845     EISSN: 10960937     Source Type: Journal    
DOI: 10.1016/j.fgb.2009.10.002     Document Type: Article

References (55)

1. Akileswaran L., Brock B.J., Cereghino J.L., and Gold M.H. 1,4-benzoquinone reductase from Phanerochaete chrysosporium: cDNA cloning and regulation of expression. Appl. Environ. Microbiol. 65 (1999) 415-421
2. Batista W.L., Matsuo A.L., Ganiko L., Barros T.F., Veiga T.R., Freymuller E., and Puccia R. The PbMDJ1 gene belongs to a conserved MDJ1/LON locus in thermodimorphic pathogenic fungi and encodes a heat shock protein that localizes to both the mitochondria and cell wall of Paracoccidioides brasiliensis. Eukaryot. Cell 5 (2006) 379-390
3. Batista W.L., Barros T.F., Goldman G.H., Morais F.V., and Puccia R. Identification of transcription elements in the 5′ intergenic region shared by LON and MDJ1 heat shock genes from the human pathogen Paracoccidioides brasiliensis. Evaluation of gene expression. Fungal Genet. Biol. 44 (2007) 347-356
4. Benard G., Mendes-Giannini M.J.S., Juvenale M., Miranda E.T., and Duarte A.J.S. Immunosuppression in paracoccidioidomycosis: T cell hyporesponsiveness to two Paracoccidioides brasiliensis glycoproteins that elicit strong humoral immune response. J. Infect. Dis. 175 (1997) 1263-1267
5. Braga C.J., Rittner G.M., Muñoz-Henao J.E., Teixeira A.F., Massis L.M., Sbrogio-Almeida M.E., Taborda C.P., Travassos L.R., and Ferreira L.C. Paracoccidioides brasiliensis vaccine formulations based on the gp43-derived P10 sequence and the Salmonella enterica FliC flagellin. Infect. Immun. 77 (2009) 1700-1707
6. Brummer E., Hanson L.H., Restrepo A., and Stevens D.A. Intracellular multiplication of Paracoccidioides brasiliensis in macrophages: killing and restriction of multiplication by activated macrophages. Infect. Immun. 57 (1989) 2289-2294
7. Brummer E., Castañeda E., and Restrepo A. Paracoccidioidomycosis - An update. Clin. Microbiol. Rev. 6 (1993) 89-117
8. Calich V.L., Singer-Vermes L.M., Siqueira A.M., and Burger E. Susceptibility and resistance of inbred mice to Paracoccidioides brasiliensis. Br. J. Experiment. Pathol. 66 (1985) 585-594
9. Calich V.L., Vaz C.A., and Burger E. Immunity to Paracoccidioides brasiliensis infection. Res. Immunol. 149 (1998) 407-417
10. Camargo Z.P., Unterkircher C., and Travassos L.R. Identification of antigenic polypeptides of Paracoccidioides brasiliensis by immunoblotting. J. Med. Vet. Mycol. 27 (1989) 407-412
11. Cano L.E., Singer-Vermes L.M., Vaz C.A.C., Russo M., and Calich V.L.G. Pulmonary Paracoccidioidomycosis in resistant and susceptible mice - Relationship among progression of infection, bronchoalveolar cell activation, cellular immune-response, and specific isotype patterns. Infect. Immun. 63 (1995) 1777-1783
12. Castañeda E., Brummer E., Pappagianis D., and Stevens D.A. Impairment of cellular but, not humoral response in chronic pulmonary and disseminated paracoccidioidomycosis in mice. Infct. Immun. 56 (1988) 1771-1777
13. Cisalpino P.S., Puccia R., Yamauchi L.M., Cano M.I.N., da Silveira J.F., and Travassos L.R. Cloning, characterization, and epitope expression of the major diagnostic antigen of Paracoccidioides brasiliensis. J. Biol. Chem. 271 (1996) 4553-4560
14. Daher B.S., Venancio E.J., de Freitas S.M., Báo S.N., Vianney P.V., Andrade R.V., Dantas A.S., Soares C.M., Silva-Pereira I., and Felipe M.S. The highly expressed yeast gene PbY20 from Paracoccidioides brasiliensis encodes a flavodoxin-like protein. Fungal Genet. Biol. 42 (2005) 434-443
15. Feitosa L.S., Soares C.M.A., dos Santos M.R.M., Bailão A.M., Xander P., Mortara R.A., and Lopes J.D. Cloning, characterization and expression of a calnexin homologue from pathogenic fungus Paracoccidioides brasiliensis. Yeast 24 (2007) 79-87
16. Felipe M.S., Andrade R.V., Arraes F.B., Nicola A.M., Maranhao A.Q., Torres F.A., Silva-Pereira I., Pocas-Fonseca M.J., Campos E.G., Moraes L.M., Andrade P.A., Tavares A.H., Silva S.S., Kyaw C.M., Souza D.P., Network P., Pereira M., Jesuino R.S., Andrade E.V., Parente J.A., Oliveira G.S., Barbosa M.S., Martins N.F., Fachin A.L., Cardoso R.S., Passos G.A., Almeida N.F., Walter M.E., Soares C.M., Carvalho M.J., and Brigido M.M. Transcriptional profiles of the human pathogenic fungus Paracoccidioides brasiliensis in mycelium and yeast cells. J. Biol. Chem. 280 (2005) 24706-24714
17. Fitzpatrick T.B., Amrhein N., and Marcheroux P. Characterization of YqjM, an old yellow enzyme homolog from Bacillus subtilis involved in the oxidative stress response. J. Biol. Chem. 278 (2003) 19891-19897
18. Franco M., Peracoli M.T., Soares A., Montenegro R., Mendes R.P., and Meira D.A. Host-parasite relationship in paracoccidioidomycosis. Curr. Top. Med. Mycol. 5 (1993) 115-149
19. Franco M., Montenegro M.R., Mendes R.P., Marques S.A., Dillon N.L., and Mota N.G.S. Paracoccidioidomycosis: a recent proposed classification of its clinical forms. Rev. Soc. Bras. Med. Trop. 20 (1987) 129
20. Gasch A.P., Spellman P.T., Kao C.M., Carmel-Harel O., Eisen M.B., Storz G., Botstein D., and Brown P.O. Genomic expression programs in the response of yeast cells to environmental changes. Mol. Biol. Cell. 11 (2000) 4241-4257
21. Goldman G.H., Marques E.D., Ribeiro D.C.D., Bernardes L.A.D., Quiapin A.C., Vitorelli P.M., Savoldi M., Semighini C.P., de Oliveira R.C., Nunes L.R., Travassos L.R., Puccia R., Batista W.L., Ferreira L.E., Moreira J.C., Bogossian A.P., Tekaia F., Nobrega M.P., Nobrega F.G., and Goldman M.H.S. Expressed sequence tag analysis of the human pathogen Paracoccidioides brasiliensis yeast phase: identification of putative homologues of Candida albicans virulence and pathogenicity genes. Eukaryot. Cell 2 (2003) 34-48
22. Grosso D.d.M., de Almeida S.R., Mariano M., and Lopes J.D. Characterization of gp70 and anti-gp70 monoclonal antibodies in Paracoccidioides brasiliensis pathogenesis. Infect. Immun. 71 (2003) 6534-6542
23. Haarer B.K., and Amberg D.C. Old yellow enzyme protects the actin cytoskeleton from oxidative stress. Mol. Biol. Cell 15 (2004) 4522-4531
24. Laemmili U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
25. Leclerc M.C., Philippe H., and Guého E. Phylogeny of dermatophytes and dimorphic fungi based on large subunit ribosomal RNA sequence comparisons. J. Med. Vet. Mycol. 32 (1994) 331-341
26. Marques A.F., da Silva M.B., Juliano M.A., Munhõz J.E., Travassos L.R., and Taborda C.P. Additive effect of P10 immunization and chemotherapy in anergic mice challenged intratracheally with virulent yeasts of Paracoccidioides brasiliensis. Microbes Infect. 10 (2008) 1251-1258
27. Marzluf G.A. Genetic regulation of nitrogen metabolism in the fungi. Microbiol. Mol. Biol. Rev. 61 (1997) 17-32
28. Massey V. The chemical and biological versatility of riboflavin. Biochem. Soc. Trans. 28 (2000) 283-296
29. Matute D.R., McEwen J.G., Puccia R., Montes B.A., San-Blas G., Bagagli E., Rauscher J.T., Restrepo A., Morais F., Niño-Vega G., and Taylor J.W. Cryptic speciation and recombination in the fungus Paracoccidioides brasiliensis as revealed by gene genealogies. Mol. Biol. Evol. 23 (2006) 65-73
30. McEwen J.G., Bedoya V., Patino M.M., Salazar M.E., and Restrepo A. Experimental murine Paracoccidioidomycosis induced by the inhalation of conidia. J. Med. Vet. Mycol. 25 (1987) 165-175
31. Morais F.V., Barros T.F., Fukada M.K., Cisalpino P.S., and Puccia R. Polymorphism in the gene coding for the immunodominant antigen gp43 from the pathogenic fungus Paracoccidioides brasiliensis. J. Clin. Microbiol. 38 (2000) 3960-3966
32. Musatti, C. C., Peraçoli, M. T. S., Soares, A. M. V., C., Rezkallah-Iwasso, M. T., 1994. Cell-mediated immunity in patients with paracoccidiodomycosis, In: Franco, M., Lacaz, C. S., Restrepo, A., Del Negro, G. Paracoccidioidomycosis, Boca Raton, London, pp. 175-186.
33. Peterson S.W., and Sigler L. Molecular genetic variation in Emmonsia crescens and Emmonsia parva, etiologic agents of adiaspiromycosis, and their phylogenetic relationship to Blastomyces dermatitidis (Ajellomyces dermatitidis) and other systemic fungal pathogens. J. Clin. Microbiol. 36 (1998) 2918-2925
34. Prado M., da Silva M.B., Laurenti R., Travassos L.R., and Tadorda C.P. Mortality due to systemic mycoses as a primary cause of death or in association with AIDS in Brazil: a review from 1996 to 2006. Mem. Inst. Oswaldo Cruz 104 (2009) 513-521
35. Puccia R., Schenkman S., Gorin P.A., and Travassos L.R. Exocellular components of Paracoccidioides brasiliensis: identification of a specific antigen. Infect. Immun. 53 (1986) 199-206
36. Ruis H., and Schüller C. Stress signaling in yeast. BioEssays 17 (1995) 959-965
37. Sambrook J., Fritsch E.F., and Maniatis T. Molecular Cloning: A Laboratory Manual. 2nd ed. (1989), Cold Spring Harbor laboratory Press, New York
38. San-Blas G. Paracoccidioidomycosis and its etiologic agent Paracoccidioides brasiliensis. J. Med. Vet. Mycol. 31 (1993) 99-113
39. Scazzocchio C. The fungal GATA factors. Curr. Opin. Microbiol. 3 (2000) 126-131
40. Semighini C.P., de Camargo Z.P., Puccia R., Goldman M.H., and Goldman G.H. Molecular identification of Paracoccidioides brasiliensis by 5′ nuclease assay. Diagn. Microbiol. Infect. Dis. 44 (2002) 383-386
41. Sheffield P., Garrard S., and Derewenda Z. Overcoming expression and purification problems of RhoGDI using a family of "parallel" expression vectors. Protein Expr. Purif. 15 (1999) 34-39
42. Silva S.H., Grosso D.d.M., Lopes J.D., Colombo A.L., Blotta M.H., Queiroz-Telles F., and de Camargo Z.P. Detection of Paracoccidioides brasiliensis gp70 circulating antigen and follow-up of patients undergoing antimycotic therapy. J. Clin. Microbiol. 42 (2004) 4480-4486
43. Taborda C.P., Nakaie C.R., Cilli E.M., Rodrigues E.G., Silva L.S., Franco M.F., and Travassos L.R. Synthesis and immunological activity of a branched peptide carrying the T-cell epitope of gp43, the major exocellular antigen of Paracoccidioides brasiliensis. Scand. J. Immunol. 59 (2004) 58-65
44. Tavares A.H., Silva S.S., Dantas A., Campos E.G., Andrade R.V., Maranhão A.Q., Brígido M.M., Passos-Silva D.G., Fachin A.L., Teixeira S.M., Passos G.A., Soares C.M., Bocca A.L., Carvalho M.J., Silva-Pereira I., and Felipe M.S. Early transcriptional response of Paracoccidioides brasiliensis upon internalization by murine macrophages. Microbes Infect. 9 (2007) 583-590
45. Teixeira M.M., Theodoro R.C., de Carvalho M.J., Fernandes L., Paes H.C., Hahn R.C., Mendoza L., Bagagli E., San-Blas G., and Felipe M.S. Phylogenetic analysis reveals a high level of speciation in the Paracoccidioides genus. Mol. Phylogenet. Evol. 52 (2009) 273-283
46. Torres F.A., Vilaça R., Pepe de Moraes L.M., Reis V.C., and Felipe M.S. Expression of a kexin-like gene from the human pathogenic fungus Paracoccidioides brasiliensis in Saccharomyces cerevisiae. Med. Mycol. 46 (2008) 385-388
47. Travassos L.R., Taborda C.P., Iwai L.K., Cunha-Neto E., and Puccia R. The gp43 from Paracoccidioides brasiliensis: a major diagnostic antigen and vaccine candidate. In: Domer J.E., and Kobayashi G.S. (Eds). Mycota XII - Human Fungal Pathogens (2004), Springer-Verlag, Berlin-Heidelberg 279-296
48. Travassos L.R., Casadevall A., and Taborda C.P. Immunomodulation and immunoprotection in fungal infections: humoral and cellular immune responses. In: San-Blas G., and Calderoni R.A. (Eds). Pathogenic Fungi: Host Interactions and Emerging Strategies for Control (2004), Caister Academic Press, Norfolk, England 241-283
49. Travassos L.R., Rodrigues E.G., Iwai L.K., and Taborda C.P. Attempts at a peptide vaccine against paracoccidioidomycosis, adjuvant to chemotherapy. Mycopathologia 165 (2008) 341-352
50. Untereiner W.A., Scott J.A., Naveaus F.A., Sigler L., Bachewich J., and Angus A. The Ajellomycetaceae, a new family of vertebrate-associated Onygenales. Mycology 96 (2004) 812-861
51. Van Berkel W.J., Kamerbeek N.M., and Fraaije M.W. Flavoprotein monooxygenases, a diverse class of oxidative biocatalysts. J. Biotechnol. 124 (2006) 670-689
52. Van de Ven W.J., Roebroek A.J., and Van Duijnhoven H.L. Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases. Crit. Rev. Oncog. 4 (1993) 115-136
53. Yamamoto A., Mizukami Y., and Sakurai H. Identification of a novel class of target genes and a novel type of binding sequence of heat shock transcription factor in Saccharomyces cerevisiae. J. Biol. Chem. 280 (2005) 11911-11919
54. Yan W., Shen F., Dillon B., and Ratnam M.J. The hydrophobic domains in the carboxyl-terminal signal for GPI modification and in the amino-terminal leader peptide have similar structural requirements. Mol. Biol. 275 (1998) 25-33
55. Zamboni D.S., and Rabinovitch M. Nitric oxide partially controls Coxiella burnetti phase II infection in mouse primary macrophages. Infect. Immun. 71 (2003) 122