Pharmacokinetic interaction between liquiritigenin (LQ) and DDB: Increased glucuronidation of LQ in the liver possibly due to increased hepatic blood flow rate by DDB

European Journal of Pharmaceutical Sciences

Volumn 39, Issue 1-3, 2010, Pages 181-189

  Kang, Hee E ^a   Chung, Hye J ^b   Kim, Hyung S ^c   Lee, Jee W ^a   Lee, Myung G ^a  

^a Seoul National University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

^c Daewoong Pharmaceutical Co Ltd   (South Korea)

Author keywords

Hepatic blood flow rate; LQ and DDB; Pharmacokinetic interaction; Rats; UDPGA; UGT

Indexed keywords

4,4' DIMETHOXY 5,6:5',6' BIS(METHYLENEDIOXY)BIPHENYL 2,2' DICARBOXYLIC ACID DIMETHYL ESTER; LIQUIRITIGENIN; LIVER PROTECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG GLUCURONIDATION; DRUG POTENTIATION; LIVER BLOOD FLOW; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; BIPHENYL COMPOUNDS; DICARBOXYLIC ACIDS; DRUG INTERACTIONS; FLAVANONES; INJECTIONS, INTRAVENOUS; LIVER; METABOLIC CLEARANCE RATE; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW;

EID: 73749087156     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2009.11.014     Document Type: Article

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