The impact of age on the postprandial vascular response to a fish oil-enriched meal

British Journal of Nutrition

Volumn 102, Issue 10, 2009, Pages 1414-1419

  Jackson, Kim G ^a   Armah, Christopher K ^a   Doman, Izzy ^a   James, Lewis ^a   Cheghani, Farah ^a   Minihane, Anne M ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

Age; Fish oil fatty acids; Vascular reactivity

Indexed keywords

ACETYLCHOLINE; CHOLESTEROL; DOCOSAHEXAENOIC ACID; FATTY ACID; FISH OIL; GLUCOSE; ICOSAPENTAENOIC ACID; INSULIN; LIPID; NITRITE; NITROPRUSSIDE SODIUM; TRIACYLGLYCEROL;

ADULT; AGE; ARTICLE; BLOOD SAMPLING; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CONTROLLED STUDY; DIET SUPPLEMENTATION; FOOD COMPOSITION; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; IONTOPHORESIS; LIPID BLOOD LEVEL; MALE; NORMAL HUMAN; POSTPRANDIAL STATE; PREDICTION; TEST MEAL; TIME; VASCULAR ENDOTHELIUM; VASODILATATION;

ACETYLCHOLINE; ADULT; AGED; AGING; ANIMALS; ENDOTHELIUM, VASCULAR; FISH OILS; HUMANS; MALE; MIDDLE AGED; NITROPRUSSIDE; POSTPRANDIAL PERIOD; VASODILATION; VASODILATOR AGENTS;

EID: 73749086658     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114509990742     Document Type: Article

References (25)

1. Thijssen DHJ, de Groot P, Kooijman M, et al. (2006) Sympathetic nervous system contributes to the age-related impairment of flow mediated dilation of the superficial femoral artery. Am J Physiol Heart Circ Physiol 291, H3122-H3129.
2. Egashira K, Inou T, Hirooka Y, et al. (1993) Effects of age on endothelial dependent vasodilation of resistance coronary artery by acetylcholine in humans. Circulation 88, 77-81.
3. Schächinger V, Britten MB & Zeiher AM (2000) Prognostic impact of coronary vasodilator dysfunction on adverse longterm outcome of coronary heart disease. Circulation 101, 1899-1906.
4. Landmesser U, Hornig B & Dexler H (2004) Endothelial function - a critical determinant in atherosclerosis? Circulation 109, 27-33.
5. Franzoni F, Ghiadoni L, Galetta F, et al. (2005) Physical activity, plasma antioxidant capacity, and endotheliumdependent vasodilation in young and older men. Am J Hypertens 18, 510-516.
6. Singh N, Prasad S, Singer DR, et al. (2002) Ageing is associated with impairment in nitric oxide and prostanoid dilator pathways in the human forearm. Clin Sci 102, 595-600.
7. Taddei S, Virdis A, Ghiadoni L, et al. (2001) Age-related reduction of NO availability and oxidative stress in humans. Hypertension 38, 274-279.
8. Skilton MR, Lai NT, Griffiths KA, et al. (2004) Meal-related increases in vascular reactivity are impaired in older and diabetic adults: insights into roles of aging and insulin in vascular flow. Am J Physiol Heart Circ Physiol 288, H1404-H1410.
9. Tagawa H, Shimokawa H, Tagawa T, et al. (1999) Long-term treatment with eicosapentaenoic acid augments both nitric oxide-mediated and non-nitric oxide-mediated endotheliumdependent forearm vasodilatation in patients with coronary artery disease. J Cardiovasc Pharmacol 33, 633-640.
10. Mori TA, Watts GF, Burke V, et al. (2000) Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidaemic, overweight men. Circulation 102, 1264-1269.
11. Nestel P, Shige H, Pomeroy S, et al. (2002) The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. Am J Clin Nutr 76, 326-330.
12. Khan F, Elherik K, Bolton-Smith C, et al. (2003) The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects. Cardiovasc Res 59, 955-962.
13. Vogel RA, Corretti MC & Plotnick GD (2000) The postprandial effect of components of the Mediterranean Diet on endothelial function. J Am Coll Cardiol 36, 455-460.
14. West SG, Hecker KD, Mustad VA, et al. (2005) Acute effects of monounsaturated fatty acids with and without omega-3 fatty acids on vascular reactivity in individuals with type 2 diabetes. Diabetologia 48, 113-122.
15. Armah CK, Jackson KG, James L, et al. (2008) Fish oil fatty acids improve postprandial vascular reactivity in healthy men. Clin Sci 114, 679-686.
16. Jadhav S, Sattar N, Petrie J, et al. (2007) Reproducibility and Repeatability of peripheral microvascular assessment using iontophoresis in conjunction with laser Doppler imaging. J Cardiovasc Pharmacol 50, 343-349.
17. Sax FL, Cannon RO, Hanson C & Epstein SE (1987) Impaired forearm vasodilator reserve in patients with microvascular angina. Evidence of a generalised disorder of vascular function? NEJM 317, 1366-1370.
18. Ramsey JE, Ferrell WR, Greer IA, et al. (2002) Factors critical to iontophoretic assessment of vascular reactivity: implications for clinical studies in endothelial function. J Cardiovasc Pharmacol 9, 9-17.
19. Ferrell WR, Ramsey JE, Brooks N, et al. (2002) Elimination of electrically induced iontophoretic artifacts: implications of noninvasive assessment of peripheral microvascular function. J Vasc Res 39, 447-455.
20. Harris WS, Rambjør GS, Windsor SL, et al. (1997) n-3 fatty acids and urinary excretion of nitric oxide metabolites. Am J Clin Nutr 65, 459-464.
21. Celermajer DS, Sorensen KE, Spiegelhalter DJ, et al. (1994) Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol 24, 471-476.
22. Casey DP, Beck DT & Braith RW (2007) Systemic plasma levels of nitrite/nitrate (NOx) reflect brachial flow-mediated dilatation response in young men and women. Clin Exper Pharmacol Physiol 34, 1291-1293.
23. Gerhard M, Roddy MA, Creager SJ, et al. (1996) Aging progressively impairs endothelium dependent vasodilation in forearm resistance vessels of humans. Hypertension 27, 849-853.
24. Lind L (2006) Impact of ageing on the measurement of endothelium- dependent vasodilation. Pharmacol Rep 58, 41-46.
25. Engler MB & Engler MM (1996) Influence of aging on the relaxant responses to omega-3 fatty acids in Fischer 344 rat aorta. Gerontology 42, 25-35.