Cigarette filter-based assays as proxies for toxicant exposure and smoking behavior - A literature review

Cancer Epidemiology Biomarkers and Prevention

Volumn 18, Issue 12, 2009, Pages 3321-3333

  Pauly, John L ^a   O'Connor, Richard J ^a   Paszkiewicz, Geraldine M ^a   Cummings, K Michael ^a   Djordjevic, Mirjana V ^b   Shields, Peter G ^c  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED CARBON; CIGARETTE SMOKE; NICOTINE; TAR; TOBACCO SMOKE;

CIGARETTE FILTER; CIGARETTE SMOKING; DIGITAL IMAGING; ELUTION; FILTER; HUMAN; PARTICULATE MATTER; PRIORITY JOURNAL; REVIEW; SCIENTIFIC LITERATURE; TOBACCO INDUSTRY;

BEHAVIOR, ADDICTIVE; BIOLOGICAL ASSAY; ENVIRONMENTAL EXPOSURE; FILTRATION; HUMANS; SMOKING; TOBACCO USE DISORDER;

EID: 73649147027     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-09-0925     Document Type: Review

References (139)

1. Stratton K, Shetty P, Wallace R, Bondurant S. Clearing the smoke: the science base for tobacco harm reduction. p. 636Washington (DC): National Academy Press, Institute of Medicine; 2001.
2. False and misleading advertising (filter-tip cigarettes) hearings before a subcommittee of the committee on government operations. 1957, p. 799.
3. Federal Trade Commission. Cigarette report for 2004 and 2005. p. 30 Washington (DC): Federal Trade Commission; 2007.
4. Fairchild A, Colgrove J. Out of the ashes: the life, death and rebirth of the "safer" cigarette in the United States. Am J Public Health 2004;94: 192-204.
5. Rees VW, Wayne GF, Thomas BF, Connolly GN. Physical design analysis and mainstream smoke constituent yields of the new potential reduced exposure product, Marlboro UltraSmooth. Nicotine Tob Res 2007;9:1197-206.
6. Norman A. Cigarette design and materials. Chapter 11B. In: Davis DL, Nielsen MT, editors. Tobacco - production, chemistry and technology. Oxford: Blackwell Science Ltd.; 1999, p. 353-87.
7. Hatsukami DK, Giovino GA, Eissenberg T, Clark PI, Lawrence D, Leischow S. Methods to assess potential reduced exposure products. Nicotine Tob Res 2005;7:827-44.
8. Hatsukami DK, Benowitz NL, Rennard SI, Oncken C, Hecht SS. Biomarkers to assess the utility of potential reduced exposure tobacco products. Nicotine Tob Res 2006;8:169-91.
9. National Cancer Institute. Risks associated with smoking cigarettes with low machine-measured yields of tar and nicotine. Smoking and Tobacco Control Monograph 13. Bethesda (MD): NCI; 2001. p. 236
10. Hecht SS, Murphy SE, Carmella SG, et al. Similar uptake of lung carcinogens by smokers of regular, light, and ultralight cigarettes. Cancer Epidemiol Biomarkers Prev 2005;14:693-8.
11. Bernert JT, Jain RB, Pirkle JL, Wang L, Miller BB, Sampson EJ. Urinary tobacco-specific nitrosamines and 4-aminobiphenyl hemoglobin adducts measured in smokers of either regular or light cigarettes. Nicotine Tob Res 2005;7:729-38.
12. Benowitz NL, Jacob P III, Bernert JT, et al. Carcinogen exposure during short-term switching from regular to "light" cigarettes. Cancer Epidemiol Biomarkers Prev 2005;14:1376-83.
13. Scherer G, Engl J, Urban M, Gilch G, Janket D, Riedel K. Relationship between machine-derived smoke yields and biomarkers in cigarette smokers in Germany. Regul Toxicol Pharmacol 2007;47:171-83.
14. Burns DM, Dybing E, Gray N, et al. Mandated lowering of toxicants in cigarette smoke: a description of the World Health Organization. TobReg proposal. Tob Control 2008;17:132-41.
15. Hammond D, Fong GT, Cummings KM, O'Connor RJ, Giovino GA, McNeill A. Cigarettes yields and human exposure: a comparison of alternative testing regimens. Cancer Epidemiol Biomarkers Prev 2006;15:1495-501.
16. Andersson G, Vala EK, Curvall M. The influence of cigarette consumption and smoking machine yields of tar and nicotine on the nicotine uptake and oral mucosal lesions in smokers. J Oral Pathol Med 1997;26:117-23.
17. Webb EJ, Campbell DT, Schwartz RD, Sechrest L. Unobtrusive measures: nonreactive research in the social sciences. Chicago: Rand McNally; 1966. p. 219
18. Bentley HR, Burgan JG. Polynuclear hydrocarbons in tobacco and tobacco smoke. Analyst 1958;83:442-47.
19. McConnell WV, Mumpower RC II, Touey GP. Evaluation of cigarette filter efficiency by photofluorometry. Tob Sci 1960;4:56-61.
20. Service d'Exploitation Industrielle des Tabacs et des Allumettes (SEITA). Comparative investigation on the measurement of filter efficiency results of an international collaborative investigation carried out by the Coresta Smoke Technology group. Beitr Tabakforsch Int 1963; 2/1:1-35.
21. Lipp G. The selective effect of cigarette filters on the nicotine and phenol retention in different tobacco types. Beitr Tabakforsch Int 1965;3/2: 109-27, [Article in German].
22. Pillsbury HC, Bright CC, O'Connor KJ, Irish FW. Tar and nicotine in cigarette smoke. J Assoc Offic Anal Chem 1969;52:458-62.
23. Curran JG, Kiefer JE. A method for measuring the elution of nicotine and total particulate matter from a cigarette filter. Beitr Tabakforsch Int 1973;7:29-35.
24. Forbes WF, Robinson JC, Hanley JA, Colburn NH. Studies on the nicotine exposure of individual smokers changes in mouth-level exposure to nicotine on switching to lower nicotine cigarettes. Int J Addict 1976;11:933-50.
25. Thomas CE. Automated method for FTC tar of low delivery cigarettes based upon fluorescence of TPM extracts. Tob Sci 1980;24:64-8.
26. Sloan CH, Curran JG. Spectrophotometric determination of filtration efficiency of cigarette filters. Tob Sci 1980;26:57-60.
27. Robinson JC, Young JC. Temporal patterns in smoking rate and mouth-level nicotine exposure. Addict Behav 1980;5:91-5.
28. Kozlowski LT, Frecker RC, Khouw V, Pope MA. The misuse of "lesshazardous" cigarettes and its detection: hole-blocking of ventilated filters. Am J Public Health 1980;70:1202-3.
29. Kozlowski LT, Rickert WS, Pope MA, Robinson JC. A color-matching technique for monitoring tar/nicotine yields to smokers. Am J Public Health 1982;72:597-9.
30. Lombardo T, Davis CJ, Prue DM. When low tar cigarettes yield high tar: cigarette filter ventilation hole blocking and its detection. Addict Behav 1983;8:67-9.
31. Norman V, Ihrig AM, Shoffner RA, Ireland MS. The effect of tip dilution on the filtration efficiency of upstream and downstream segments of cigarette filters. Beitr Tabakforsch Int 1984;12/4:178-85.
32. Devitt G, West RJ, Jarvis M. Test for assessing tar/nicotine yields [letter to the editor]. Am J Public Health 1984;74:391.
33. Green CR, Conrad FW, Bridle JKA, Borgerding MF. A liquid chromatography procedure for analysis of nicotine on cellulose acetate filters. Beitr Tabakforsch Int 1985;13:11-6.
34. Zacny JP, Stitzer ML, Yingling JE. Cigarette filter vent blocking: effects on smoking topography and carbon monoxide exposure. Pharmacol Biochem Behav 1986;25:1245-52.
35. Kozlowski LT, Pope MA, Lux JE. Prevalence of the misuse of ultralow-tar cigarettes by blocking filter vents. Am J Public Health 1988; 78:694-5.
36. Kozlowski LT, Pillitteri JL, Sweeney CT. Misuse of "light" cigarettes by means of vent blocking. J Subst Abuse 1994;6:333-6.
37. Pillitteri JL, Morse AC, Kozlowski LT. Detection of vent-blocking on light and ultralight cigarettes. Pharmacol Biochem Behav 1994;48: 539-42.
38. Kozlowski LT, Sweeney CT, Pillitteri JL. Blocking cigarette filter vents with lips more than doubles carbon monoxide intake from ultra-low tar cigarettes. Exp Clin Psychopharmacol 1996;4:404-8.
39. Porter A, Dunn P. Mouth insertion depths in Canadian smokers. Beitr Tabakforsch Int 1998;18:85-91.
40. Baker RR, Dixon M, Hill CA. The incidence and consequences of filter vent blocking among British smokers. Beitr Tabakforsch Int 1998;18: 71-83.
41. Husset M, Chaouat V, Lethu T, Victoria R. Ne premiere: le nuancier guodrons. [Premier: shades of tar] 60 Millions de Consummateurs 2000;358:36-40, [Article in French].
42. Baker RR, Lewis LS. A review of the incidence and consequences of cigarette filter vent blocking among smokers. Beitr Tabakforsch Int 2001;19:209-28.
43. St Charles FK, Kabbani AA, Borgerding MF. Estimating tar and nicotine exposure: human smoking versus machine generated smoke yields. Regul Toxicol Pharmacol, In press 2009. (PMID: 19723554. Accepted manuscript available for viewing; re-visited 10-08-09; citation will be updated when information is available).
44. Hu Q, Liu Z, Ma J, Peng L, Bai H. Cigarette mouth insertion depths among Chinese smokers. Beitr Tabakforsch Int 2003;20/7:476-80.
45. Watson C, McCraw J, Polzin G, Ashley D. Development of a method to assess cigarette smoke intake. Environ Sci Technol 2004;38:248-53.
46. Calafat AM, Polzin GM, Saylor J, Richter P, Ashley DL, Watson CH. Determination of tar, nicotine and carbon monoxide yields in the mainstream smoke of selected international cigarettes. Tob Control 2004;13:45-51.
47. Strasser AA, Ashare RL, Kozlowski LT, Pickworth WB. The effect of filter vent blocking and smoking topography on carbon monoxide levels in smokers. Pharmacol Biochem Behav 2005;82:320-9.
48. Prignot JJ, Jamart J. What can be learnt from tobacco butts? An observational study in a realistic hospital setting. Int J Tuberc Lung Dis 2005;9:210-5.
49. O'Connor RJ, Stitt JP, Kozlowski LT. A digital image analysis system for identifying filter vent blocking on ultralight cigarettes. Cancer Epidemiol Biomarkers Prev 2005;14:533-7.
50. Hammond D, Fong GT, Cummings KM, Hyland A. Smoking topography, brand switching and nicotine delivery: results from an in vivo study. Cancer Epidemiol Biomarkers Prev 2005;14: 1370-5.
51. Strasser AA, O'Connor RJ, Mooney ME, Wileyto EP. Digital image analysis of cigarette filter stains as an indicator of compensatory smoking. Cancer Epidemiol Biomarkers Prev 2006;15:2565-9.
52. St Charles FK, Krautter GR, Dixon M, Mariner DC. A comparison of nicotine dose estimates in smokers between filter analysis, salivary cotinine, and urinary excretion of nicotine metabolites. Psychopharmacology (Berl) 2006;189:345-54.
53. Shepperd CJ, St Charles FK, Lien M, Dixon M. Validation of methods for determining consumer smoked cigarette yields from cigarette filter analysis. Cont Tob Res 2006;22:176-84.
54. Ou B, Huang D. Fluorescent approach to quantitation of reactive oxygen species in mainstream cigarette smoke. Anal Chem 2006;78: 3097-103.
55. Lubin JH, Caporaso NE. Cigarette smoking and lung cancer: modeling total exposure and intensity. Cancer Epidemiol Biomarkers Prev 2006; 15:517-23.
56. Cummings KM, Brown A, Douglas CE. Consumer acceptable risk. How cigarette companies have responded to accusations that their products are defective. Tob Control 2006;15 Suppl 4:iv84-9.
57. O'Connor RJ, Kozlowski LT, Hammond D, Vance TT, Stitt JP, Cummings KM. Digital image analysis of cigarette filter staining to estimate smoke exposure. Nicotine Tob Res 2007;9:865-71.
58. Thomson G,Wilson N, Bushell L, et al. Butt lengths differ by area deprivation level: a field study to explore intensive smoking. Nicotine Tob Res 2008;10:927-31.
59. Paszkiewicz GM, Pauly JL. Spectrofluorometric method for measuring tobacco smoke particulate matter on cigarette filters and Cambridge pads. Tob Control 2008;17 Suppl 1:i53-8.
60. Polzin GM, Wu W, et al. Estimating smokers' mouth-level exposure to select mainstream smoke constituents from discarded cigarette filter butts. Nicotine Tob Res 2009;11:868-74.
61. Blank MD, Disharoon S, Eissenberg T. Comparison of methods for measurement of smoking behavior: mouthpiece-based computerized devices versus direct observation. Nicotine Tob Res 2009;7: 896-903.
62. Mellors RC, Hlinka J, Stoholski A. In vivo cellular localization of fluorescent materials derived from cigarette smoke [abstract]. Amer Assoc Cancer Res 1957.
63. Vilcins G, Varsel CJ, Resnik FE. Infrared method for evaluation of cigarette filter efficiency [abstract]. Tob Sci 1964;8:49-52.
64. Burton FG, Veal JT, Phelps DW. Quantitative analysis of cigarette tars using fluorescent spectroscopy [Paper #51]. 1977.
65. Rickert WS, Robinson JC, Kaiserman MJ. Quantitation of "tar" colour with specific reference to estimating yields, quantifying ETS and the production of colour scales [abstract]. 1994.
66. Pauly JL. The third phase of mainstream cigarette smoke identified as fibers and particles released from cigarette filters [Abstract and Slide presentation]. 2000.
67. St Charles FK, Kabbani AA, Cowart ML. Estimation of consumersmoked cigarette yields for a wide range of cigarette designs. 2002, p. 35, [Color prints of a slide presentation].
68. Rickert WS, Wright WG, Kaiserman MJ. Measured cigarette filter colour (CIELab) after smoking as a predictor of mouth level exposure to selected Hoffmann analytes [Slide presentation and Paper No. SS 5; 2004. 2004.
69. St Charles K, Krautter G, Mariner D. A comparison of human nicotine dose estimates from filter analysis with nicotine metabolites analysis [Poster - POS1-005]. 2005.
70. Slide: (Benzo[a]pyrene Yields with Massachusetts Tar Yields (Machine Smoking). PM USA Brand Styles and Non-PM USA Brand Styles. 2005, PM USA - [Slide #21].
71. Mariner DC, McEwan M, St Charles FK, Krautter G, Appleton S. Dose-response relationships for urinary biomarkers of selected tobacco smoke constituents [Poster POS1-001]. 2005.
72. Kozlowski LT. Puff Topography - What is it good for? [Slide Presentation]. 2005.
73. Estimation of human smoke nicotine and NFDPM yield by analysis of subjects' part filters post smoking. DRAFT. E-mail to Dr. Pauly from Mike-Dixon@bat.com. Subject: Filter analysis details. May 19, 2005 Attached Word document: Draft Part Filter Method.doc (241 MB) and PDF file 28-St. Charles, F.K. PDF (480 MB).Presented at 2005 Society for Research on Nicotine and Tobacco (SRNT) meeting in Prague.
74. Dixon M, Shepperd J, St Charles K. Validation of cigarette filter analysis methods for estimating tar and nicotine yields to smokers [Poster POS1-008]. 2005.
75. Rennard . Lung Disease Caused by Cigarette Smoke. University of Nebraska. [Slide presentation]. 2006.
76. Ashley DL. Analysis of Product, Smoke and Biomarkers in Evaluating the Health Impact of Tobacco Use. [Slide presentation]. 2006.
77. Shepperd CJ, McEwan M. A study design to investigate the influence of FTC/ISO tar yield and tar brand switching on cigarette smoke dose as determined by filter analysis and biomarkers of exposure. [Poster RPOS3-115]. 2007.
78. Strasser AA, Sanborn PM, Tang KZ, Zhou JY. The effect of filter vent blocking, smoking topography and filter tar stain scoring on carbon monoxide boost. [Poster POS1-123]. 2007.
79. Morton MJ,Williams DL, Hjorth HB, Smith JH. Philip Morris USA Inc. Cigarette filter color as an estimator of cigarette tar yield. [Poster POS1-124]. 2007.
80. Mariner DC, Booty M, Mullard G, Shepperd CJ. A comparison of German smokers' exposure to tar and nicotine using analysis of smoked cigarette filters with yields from a range of machine smoking regimes [Poster #34]. 2007.
81. Shepperd CJ, Mariner DC, McEwan M, O'Reilly D, Eldridge A. A study to estimate and correlate cigarette smoke exposure as determined by filter analysis and biomarkers of exposure. [Poster]. 2008.
82. Mariner DC, Slayford SJ, Nother K, Shepperd CJ. A comparison of the plowshare CRESSMICRO™ smoking topography analyser with a proprietary smoking analyser. 2008.
83. Pillsbury HC, Bright CC, O'Connor KJ, Irish FW. Tar and nicotine in cigarette smoke. 1968.
84. CORESTA (Centre de Coopération pour les Recherches Scientifiques Relatives au Taba). Recommended Method No. 13. Determination of alkaloid retention by cigarette filters. 1968.
85. CORESTA (Centre de Coopération pour les Recherches Scientifiques Relatives au Taba). Recommended Method No. 9. Determination of nicotine in cigarette filters by gas chromatographic analysis. 1989.
86. Determination of filter efficiency in mainstream tobacco smoke. Health Canada 1999.
87. Pickworth W, Houlgate P, Schorp M, Dixon M, Borgerding M, Zaatari G. A review of human smoking behaviour data and recommendations for a new ISO standard for the machine smoking of cigarettes. August 10, 2005. A Report of the Ad Hoc WG9 Smoking behaviour Review Team to ISO/TC 126 WG 9.
88. Tar, nicotine and carbon monoxide values for most market cigarette brands. Tobacco Industry Testing Laboratory, Market Sample #47. Kindly provided to Dr. Pauly by Dr. Richard O'Connor, e-mail communication of 01-09-06. Information obtained by Dr. O'Connor via Freedom of Information Act (FOIA).
89. Tar, nicotine and carbon monoxide values for most market cigarette brands. Tobacco Industry Testing Laboratory. Market Sample #46. Kindly provided to Dr. Pauly by Dr. Richard O'Connor. E-mail communication of 01-09-06. Information obtained by Dr. O'Connor via Freedom of Information Act (FOIA).
90. Lesser CA, Von Borstel RW. Tobacco smoke filter. Assigned to Filligent Limited, Central (Hong Kong Special Administrative Reg). PCT Pub. United States Patent 6,792,953 B2. Issued 2002 Mar 21.
91. Sweeney CT. Experimental research on the behavioral blocking of filter vents on low-yield cigarettes [Dissertation]. Pennsylvania State University; 1998.
92. US Patent 258,255. Cigarette. Issued 1882 May 23. Awarded to Henry H. Schleber, Rochester, NY. Retrieved on 10/01/2009 from http:// www.google.com/patents?id=YiBgAAAAEBAJ&dq=258,255.
93. "The History of Filters." Retrieved on 10/01/2009 from http://www. tobaccoasia.com/news.asp?id=534.
94. CHAPTER 2 - Cigarette Components Ltd and the Bunzl and Filtrona Groups Historical Development. Retrieved on 10/01/2009 from http://www.google.com/ search?hl=en&q=CHAPTER +2+-+Cigarette+Components+Filtrona+Groups+Historical +Development&btnG=Search&aq=f&oq=&aqi=.
95. Parliament (cigarette). Retrieved on 10/01/2009 from http://en.wikipedia. org/wiki/Parliament-(cigarette).
96. Viceroy (cigarette). Retrieved on 10/01/2009 from http://en.wikipedia. org/wiki/Viceroy-(cigarette).
97. History of cigarettes and smoking. Retrieved on 10/01/2009 from http://www.cigarettes-below-cost.com/history-of-cigarettes.html.
98. Browne CL. The design of cigarettes. 3rd ed. p. 43Charlotte (NC): Hoechst Celanese Corporation; 1990.
99. Borio G. The tobacco timeline. Retrieved on 10/01/2009 from http://www.tobacco.org/History/Tobacco-History.html.
100. Longo WE, Rigler MW, Slade J. Crocidolite asbestos fibers in smoke from original Kent cigarettes. Cancer Res 1995;55:2232-35.
101. Miller L, Monahan J. The facts behind the cigarette controversy. Reports to consumers on American cigarettes. Pleasantville (NY): Reader's Digest; 1954. pp. 37-45
102. Lark (cigarette). Retrieved on 10/01/2009 from http://en.wikipedia.org/ wiki/Lark-(cigarette).
103. Dunn WL, Jr. A study of the effect of lip occlusion of air holes on main stream delivery in air diluted cigarettes. Bates Number 1001892531-1001892534. Retrieved on 10/01/09 from http://tobaccodocuments.org/filters/1001892531-2534. html.
104. Correspondence. To: W.L. Dunn. From: L. Wilson, Subject: Cigarette Measurements. Purpose: Study designed to determine the extent to which a smoker places the filter in hismouth. BatesNumber 1003295399.
105. O'Connor RJ, Hammond D, McNeill A, et al. How do different cigarette design features influence the standard tar yields of popular cigarette brands sold in different countries? Tob Control 2008;17 Suppl 1:i1-5.
106. Kozlowski LT, O'Connor RJ. Cigarette filter ventilation is a defective design because of misleading taste, bigger puffs, and blocked vents. Tob Control 2002;11:i40-50.
107. Pauly JL, Mepani AB, Lesses JD, Cummings KM, Streck RJ. Cigarettes with defective filters marketed for 40 years: what Philip Morris never told smokers. Tob Control 2002;11 Suppl 1:i51-61.
108. Pauly JL, Waight JD, Paszkiewicz GM. Tobacco flakes on cigarette filters grow bacteria: a potential health risk to the smoker? Tob Control 2008;17:i49-52.
109. Pauly JL, Smith LA, Rickert MH, Hutson A, Paszkiewicz GM. Review: Is lung inflammation associated with microbes and microbial toxins in cigarette tobacco smoke? Immunol Res DOI.10.107/s1206-009-8117-6 11 Published online: September 2009.
110. Carpenter CM, Wayne GF, Pauly JL, Koh HK, Connolly GN. New cigarette brands with flavors that appeal to youth: tobacco marketing strategies. Health Aff (Millwood) 2005;24:1601-10.
111. Richard C. New Camel brand contains crushable capsule. Winston-Salem Journal 2008.
112. Shepperd CJ, Eldridge AC, Mariner DC, McEwan M, Errington G, Dixon M. A study to estimate and correlate cigarette smoke exposure in smokers in Germany as determined by filter analysis and biomarkers of exposure. Reg Toxicol Pharm 2009;55:97-109.
113. Djordjevic MV, Stellman SD, Zang E. Doses of nicotine and lung carcinogens delivered to cigarette smokers. J Natl Cancer Inst 2000;92: 106-11.
114. Melikian AA, Djordjevic MV, Chen S, Richie J, Jr., Stellman SD. Effect of delivered dosage of cigarette smoke toxins on the levels of urinary biomarkers of exposure. Cancer Epidemiol Biomarkers Prev 2007;16: 1408-15.
115. Philip Morris, Dictionary of tobacco terminology. Retrieved on 10-08-09 from: http://openlibrary.org/b/OL3819962M/Dictionary-of-tobacco-terminology.
116. Gaworski CL, Schramke H, Diekmann J, et al. Effect of filtration by activated charcoal on the toxicological activity of mainstream smoke from experimental cigarettes. Inhal Toxicol 2009;21:688-704, (ahead of print; viewed on 10-09-09. will be updatedwhen information is available).
117. Coggins CRE, Gaworski CL. Could charcoal filtration of cigarette smoke reduce smoking-induced disease? A review of the literature. Regul Toxicol Pharmacol 2008;50:359-65.
118. Laugesen M, Fowles J. Marlboro UltraSmooth: a potentially reduced exposure cigarette? Tob Control 2006;15:430-5.
119. Mola M, Hallum M, Branton P. The characterization and evaluation of activated carbon in a cigarette filter. Adsorption 2008;14:335-41.
120. Polzin GM, Zhang L, Hearn BA, et al. Effect of charcoal-containing cigarette filters on gas phase volatile organic compounds in mainstream cigarette smoke. Tob Control 2008;17 Suppl 1:i10-6.
121. Sarkar M, Kapur S, Frost-Pineda K, et al. Evaluation of biomarkers of exposure to selected cigarette smoke constituents in adult smokers switched to carbon-filtered cigarettes in short-term and long-term clinical studies. Nicotine Tob Res 2008;10:1761-72.
122. Xue L, Thomas CE, Koller KB. Mainstream smoke gas phase filtration performance of adsorption materials evaluated with a puff-by-puff machine GC-MS method. Beitr Tabakforsch Int 2002;20:251-6.
123. British American Tobacco Company. Active charcoal as a constituent of cigarette filters. Bates: 402368992-402369045. Retrieved from Tobacco Documents Online on 09-09-09. p. 541965.
124. British American Tobacco Company Limited. R&D-B09-94 Charcoal filter development - Evaluation of commercial filter designs. Research & Development. Bates 402382486-402382511. Retrieved from the Legacy Tobacco Documents Library on 09-09-09.
125. CORESTA (Centre de Coopération pour les Recherches Scientifiques Relatives au Taba). Determination of alkaloid retention by cigarette filters (September 1968). Recommended Method No.12. Confidential.
126. Schori TR, Jones BW. Smoker Psychology 1600 Does the smoker compensate for the changes in delivery in order to regulate intake (TNT-4). Philip Morris USA; 1974, Bates 2062951144-2062951168. Retrieved from Tobacco Documents Online on 09-09-09. p. 25.
127. Duggins J, Dunn WL, Shori T, Thomson R. 1600 Smoker psychology smoking behavior: real world observations. Confidential. p. 56: Philip Morris USA; 1973, Bates 1000353355-1000353357. Retrieved from Tobacco Documents Online on 09-09-09.
128. Ryan F. Project 1600 SEX II. Evaluation Report #415 Changes in FTC intake produced by changes in FTC delivery. Confidential. Philip Morris USA; 1970, Bates 1003286591-1003286612. Retrieved from Tobacco Documents Online on 09-09-09. p. 22.
129. LaKind JS, Jenkins RA, Naiman DQ, Ginevan ME, Graves CG, Tardiff RG. Use of environmental tobacco smoke constituents as markers for exposure. Risk Anal 1999;19:359-73.
130. National Research Co. Environmental tobacco smoke. Measuring exposure and assessing health Effects.Washington (DC): National Academy Press; 1986.
131. Tang H, Richards G, Benner CL, et al. Solanesol: a tracer for environmental tobacco smoke particles. Environ Sci Technol 1990;24:848-52.
132. Seeman JI. Possible role of ammonia on the deposition, retention, and absorption of nicotine in humans while smoking. Chem Res Toxicol 2007;20:326-43.
133. Tucker SP, Pretty JR. Identification of oxidation products of solanesol produced during air sampling for smoke by electrospray mass spectrometry and HPLC. Analyst 2005;130:1414-24.
134. Cancer biomarkers - the promises and challenges of improving detection and treatment. Institutes of Medicine, of the National Academies. Washington (DC): The National Academies Press; 2007. p. 236.
135. Hecht SS. Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat Rev Cancer 2003;3:733-44.
136. Shin HJ, Sohn HO, Han JH, et al. Effect of cigarette filters on the chemical composition and in vitro biological activity of cigarette mainstream smoke. Food Chem Toxicol 2009;47:192-7.
137. Hatsukami DK, Joseph AM, Lesage M, et al. Developing the science base for reducing tobacco harm. Nicotine Tob Res 2007;9 Suppl 4: S537-53, Review.
138. Church TR, Anderson KE, Caporaso NE, et al. A prospectively measured serum biomarker for a tobacco-specific carcinogen and lung cancer in smokers. Cancer Epidemiol Biomarkers Prev 2009;18:260-6.
139. Lowe FJ, Gregg EO, McEwan M. Evaluation of biomarkers of exposure and potential harm in smokers, former smokers and never-smokers. Clin Chem Lab Med 2009;47:310-20.