Synthesis of biologically potent new 3-(heteroaryl)aminocoumarin derivatives via Buchwald-Hartwig C-N coupling

Tetrahedron Letters

Volumn 51, Issue 7, 2010, Pages 1099-1102

  Das, Asish R ^a   Medda, Arunima ^a   Singha, Raghunath ^a  

^a UNIVERSITY OF CALCUTTA   (India)

Author keywords

3 Aminocoumarin; BINAP; C N bond coupling reaction; Cesium carbonate; Heteroarylhalides; Palladium acetate

Indexed keywords

AMINOCOUMARIN DERIVATIVE; ARGON; CESIUM; CESIUM CARBONATE; PALLADIUM ACETATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; DRUG SYNTHESIS; HIGH TEMPERATURE;

EID: 73649140958     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.12.089     Document Type: Article

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26. °C) and heating was continued with gentle stirring for 18 h. The reaction mixture was cooled to room temperature and filtered through a pad of Celite eluting with ethyl acetate, and the inorganic salts were removed. The filtrate was concentrated and purification of the residue by silica gel column chromatography gave the desired product 3a-j. Yield: 56-98%.