Magnesium, calcium and cancer

Magnesium Research

Volumn 22, Issue 4, 2009, Pages 247-255

  Anghileri, Leopoldo J ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

Author keywords

Calcium; Cancer; Carcinogenesis; Magnesium; Magnesium calcium ratio

Indexed keywords

CALCIUM; DIAGNOSTIC AGENT; GALLIUM; MAGNESIUM;

ARTICLE; CELL DIFFERENTIATION; CELL DIVISION; CELL TRANSFORMATION; GENETIC TRANSCRIPTION; HUMAN; NEOPLASM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RADIATION INDUCED NEOPLASM; SIGNAL TRANSDUCTION;

CALCIUM; CELL DIFFERENTIATION; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; GALLIUM; HUMANS; MAGNESIUM; NEOPLASMS; NEOPLASMS, RADIATION-INDUCED; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 73649140938     PISSN: 09531424     EISSN: 19524021     Source Type: Journal    
DOI: 10.1684/mrh.2009.0173     Document Type: Article

References (96)

1. Durlach J. Le Magnésium en pratique clinique. Paris: Éditions Médicales internationales 1985: 7-41.
2. Günther T. Comment on the number of magnesiumactivated enzymes. Magnes Res 2008; 21: 185-7.
3. Vidair C, Rubin H. Magnesium as activator of uridine phosphorylation in coordination with other cellular responses to growth factors. Proc Natl Acad Sci USA 2005; 102: 662-6.
4. Rubin H. Magnesium: the missing element in molecular views of cell proliferation control. Bio Essays 2005; 27: 311-20.
5. Terasaki M, Rubin H. Evidence that intracellular magnesium is present in cells at a regulating concentration for protein synthesis. Proc Natl Acad Sci USA 1985; 82: 7324-6.
6. Rubin H. The logic of membrane, magnesium, mitosis (MMM) model for the regulation of animal cell proliferation. Arch Biochem Biophys 2007; 458: 16-23.
7. Rubin H, Terasaki M, Sanui H. Major intracellular cations and growth control: Correspondence among magnesium content, protein synthesis, and the onset of DNA synthesis in BALB/C3T3 cells. Proc Natl Acad Sci USA 1979; 76: 3917-21.
8. Durham ACH, Walton JM. Calcium ions and the control of proliferation in normal and cancer cells. Biosci Reports 1982; 2: 15-30 (Review).
9. Withfield JF. Cycles and signals. In: Calcium, Cell Cycles and Cancer. CRC Press, 1999: 7-52.
10. Wiercinsky F. Calcium an overview - 1989. Biol Bull 1989; 176: 195-217.
11. Hunger R. Magnesium and the membrane mechanisms. Trace Elem Electrolyt 2004; 2: 99-101.
12. Hartwig A. The role of magnesium in genomic stability. Mutat Res 2001; 475: 113-21.
13. Anghileri LJ. Magnesium concentration during carcinogenesis. Magnes Bull 1979; 1: 46-8.
14. Anghileri LJ, Collery P, Coudoux P, Durlach J. Experimental relations between magnesium and cancer. Magnes Bull 1981; 3: 1-5.
15. Anghileri LJ. Metabolism of calcium and magnesium in liver during acute thioacetamide intoxication. Int J Clin Pharmacol 1976; 14: 101-8.
16. Anghileri LJ, Heidbreder M, Weiler G, Dermietzel R. Hepatocarcinogenesis by thioacetamide: Correlations of histological and biochemical changes, and possible role of cell injury. Expl Cell Biol 1977; 45: 34-47.
17. Anghileri LJ. Calcium, magnesium and phosphorus in experimental tumors: Effects of the age of the tumor. Z Krebsforsch 1974; 81: 109-18.
18. Wolf FI, Maier JA, Nasulewicz A, Feillet-Coudray C, Simonacci M, Mazur A, et al. Magnesium and neoplasia: from carcinogenesis to tumor growth and progression or treatment. Arch Biochim Biophys 2007; 458: 24-32.
19. Nasulewicz A, Wietrzyk J, Wolf FL, Dzimira S, Madej J, Maier JA, Rayssiguier Y, Mazur A, Opolski A. Magnesium deficiency inhibits primary tumor growth but favors metastasis in mice. Biochim Biophys Acta 2004; 1739: 26-32.
20. Berridge MJ. Elementary and global aspects of calcium signalling. J Exp Biol 1997; 200: 315-9.
21. Bootman MD, Collins TJ, Peppiatt CM, et al. Calcium signalling - an overview. Semin Cell Dev Biol 2001; 12: 3-10.
22. Wyse DG. Calcium channels blockers. Cardiac Electrophysiol Rev 2000; 4: 308-10.
23. Singh RB. Calcium channels antagonists modulate calcium by increasing magnesium influx: A hypothesis. Drug Develop Res 2004; 13: 1-9.
24. Anghileri LJ, Thouvenot P. ATP in cellular calcium overload by trivalent metal ions. Biol Trace Elem Res 1996; 62: 115-22.
25. Anghileri LJ. The mechanism of accumulation of radiogallium and radiolanthanides in tumor. J Nucl Biol Med 1973; 17: 177-86.
26. 2+-pump ATPase. Experientia 1983; 39: 311-2.
27. Kass RS, Tsien RW. Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers. J Gen Physiol 1975; 66: 169-73.
28. Loomis CR, Martin DW, McCaslin DR, Tanford C. Phosphorylation of calcium-ATPase by inorganic phosphate reversible inhibition at high magnesium concentration. Biochemistry 1982; 21: 151-6.
29. Anghileri LJ, Plenat F, Thouvenot P. Role of iron in lymphoma-induction by ATP. Oncology Reports 2001; 8: 1153-7.
30. Anghileri LJ, Mayayo E, Domingo JL, Thouvenot P. Toxic and carcinogenic effects of parenteral and percutaneous ATP and its iron complex. Drug Chemical Toxicol 2002; 25: 267-79.
31. Maier JAM, Nasulewicz-Goldeman A, Simonacci M, Boninsegna A, Mazur A. Magnesium-dependent inhibition of primary tumor growth. Nutr Cancer 2007; 59: 192-8.
32. Wolf FI, Trapani V, Simonacci M, Ferrè S, Maier JAM. Magnesium deficiency and endothelial dysfunction: is oxidative stresss involved? Magnes Res 2008; 21: 58-64.
33. Wolf FI, Trapani V. Cell (patho)physiology of magnesium. Clin Sci 2008; 114: 27-35.
34. Wolf FI, Torsello A, Fasanella S, Cittadini A. Cell physiology of magnesium. Molec Aspects Med 2003; 24: 11-26.
35. Ferrè S, Mazur A, Maier JAM. Low magnesium induces senescent features in cultured human endothelial cells. Magnes Res 2007; 20: 60-71.
36. Wolf FI, Trapani V, Cittadini A. Magnesium and the control of cell proliferation: looking for a needle in a haystack. Magnes Res 2008; 21: 83-91.
37. Wolf FI, Trapani V, Simonacci M, Bonsegna A, Mazur A, Maier JAM. Magnesium deficiency affects mammary epithelial cell proliferation: involvement of oxidative stress. Nutr Cancer 2009; 61: 131-6.
38. Gradinaru I, Ghiciuc CM, Popescu E, Nechifor C, Mandrechi I, Nechifor M. Blood plasma and saliva levels of magnesium and other bivalent cations in patients with parotid gland tumors. Magnes Res 2007; 20: 254-8.
39. Touyz RM. Role of magnesium in the pathogenesis of hypertension. Molec Aspects Med 2003; 24: 107-36.
40. Killilea DW, Ames BN. Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts. Proc Natl Acad Sci USA 2008; 105: 5768-73.
41. Tohno S, Tohno Y, Moriwake Y, Azuma C, Ohnishi Y, Minami T. Quantitative changes of calcium, phosphorus and magnesium in common iliac arteries with aging. Biol Trace Elem Res 2001; 84: 57-66.
42. Nielsen FH, Milne DB, Gallagher S, Johnson L, Hoverson B. Moderate magnesium deprivation results in calcium retention and altered potassium and phosphorus excretion by postmenopausal women. Magnes Res 2007; 20: 19-31.
43. Dai Q, Shrubsole MJ, Ness RM, Schlundt D, Cai Q, Smalley WE, et al. The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk. Am J Clin Nutr 2007; 86: 743-51.
44. Kisters K, Wessels F, Küper H, et al. Increased calcium and decreased magnesium concentrations and an increased calcium/magnesium ratio in spontaneously hypertensive rats versus Wistar-Kyoto rats: Relation to arteriosclerosis. Am J Hypertens 2004; 17: 59-62.
45. Altura BM, Zhang A, Cheng TP, Altura BT. Extracellular magnesium regulates nuclear and perinuclear free ionized calcium in cerebral vascular smooth muscle cells: possible relation to alcohol and central nervous system injury. Alcohol 2001; 23: 83-90.
46. Anghileri LJ. Iron, intracellular calcium ion, lipid peroxidation and carcinogenesis. Anticancer Res 1995; 15: 1395-400.
47. Anghileri LJ, Mayayo E, Domingo JL. IronRadiofrequency synergism in lymphomagenesis. Immunopharmacol Immunotoxicol 2006; 28: 175-83.
48. Stevens RG, Graubard BI, Micozzi MS, Neriishi K, Blumberg BS. Moderate elevation of body iron level and increased risk of cancer occurrence and death. Int J Cancer 1994; 56: 364-9.
49. Magnusson G, Flodh H, Malmfors T. Oncological study in rat of Ferastral, an iron-poly(sorbitol-glyconic acid) complex after intramuscular administration. Scand Haematol 1977 (Suppl. 32): 87-99.
50. Ludin PM. The carcinogenic action of complex iron preparations. Brit J Cancer 1961; 15: 838-47.
51. Anghileri LJ, Mayayo E, Domingo JL. Aluminum- Radiofrequency synergism in lymphomagenesis. Immunopharmacology and Immunotoxicology 2009 (in press).
52. Macdonad TL, Martin RB. Aluminum in biological systems. Trends Biochem Sci 1988; 13: 15-9.
53. Martin RB. The chemistry of aluminum as related to biology and medicine. Clin Chem 1986; 32: 1797-806.
54. Ganrot PO. Metabolism and possible health effects of aluminum. Envir Health Perspect 1986; 65: 363-441.
55. Gandolfi L, Stella MP, Zambenedetti P. Aluminum alters intracellular calcium homeostasis. Biochim Biophys Acta 1998; 1406: 315-20.
56. Anghileri LJ, Robert J. Isomorphous ionic replacement: Experimental evidence for the hypothesis proposed to explain 67Gallium accumulation. J Nuclear Med All Sci 1982; 26: 113-5.
57. Anghileri LJ, Thouvenot P, Brunotte F, Marchal C, Robert J. In vitro and in vivo effects of ferric citrate on 67Ga-citrate uptake by DS sarcoma tumors. Eur J Nucl Med 1982; 7: 266-8.
58. Ito Y, Muranaka A. The factors influencing localization of radio tracers in tumors. In: Anghileri LJ, ed. General Processes of Radiotracer Localization, Vol. I. CRC Press, 1982: 95-151.
59. Chen FY, Amara FM, Wright JA. Regulation of mammalian ribonucleotide reductase R1mRNA stability is mediated by a ribonucleotide de reductase R1mRNA3′-untranslated region cis-trans interaction through a protein kinase C-controlled pathway. Biochem J 1994; 302: 126-32.
60. Oblender M, Carpentier V. Effects of iron, copper and zinc on the activity of ribonuclease reductase on normal and leukemic human lymphocytes. Anticancer Res 1990; 10: 123-8.
61. Myette MS, Elford HL, Chitambar CR. Interaction of gallium nitrate with other inhibitors of ribonuclease reductase: effects on the proliferation of human leukemic cells. Cancer Lett 1998; 129: 199-204.
62. Chitambar CR, Narasimhan J, Guy J, Sem DS, O'Brien WJ. Inhibition of ribonucleotide reductase by gallium in murine leukemic L1210 cells. Cancer Res 1991; 51: 6199-201.
63. Chitambar CR, Wereley JP, Matsuyama S. Galliuminduced cell death in lymphoma: role of transferrin receptor cycling, involvement of Bax and the mitochondria, and effects of proteosome inhibition. Mol Cancer Ther 2006; 5: 2834-46.
64. Anghileri LJ, Crone-Escanye MC, Martin JA, Curiem B, Robert J. In vivo changes of ionic composition of tumors treated by hyperthermia. Cancer Biochem Biophys 1988; 10: 149-55.
65. Anghileri LJ, Crone-Escanye MC, Martin JA, Robert J. Modification of the ionic environment in the tumor cell by hyperthermia. Neoplasma 1988; 35: 489-94.
66. Anghileri LJ, Crone-Escanye MC, Marchal C, Robert J. Plasma membrane changes during hyperthermia: Probable role of ionic modification in tumor cell death. In: Overgaard J, ed. Hyperthermia Oncology, Vol. 1. London Philadelphia: Taylor & Francis, 1984: 49-52.
67. Lilly MB, Ng TC, Evanochko WT, Katholi CR, Kumar NG, Elgavish GA, et al. Loss of high energy phosphate following hyperthermia demonstrated by in vivo 31P- nuclear magnetic resonance spectroscopy. Cancer Res 1984; 44: 633-5.
68. Campbell K, Meloni BP, Knuckey NW. Combined magnesium and mild hypothermia (35°C) treatment reduces infarct volume after permanent middle cerebral artery occlusion in the rat at 2, and 4, but not 6 h. Brain Res 2008; 1230: 258-64.
69. Marchal C, Anghileri LJ, Crone-Escanye MC, Robert J. Hyperthermia and cytotoxic drugs: Possible use of lanthanum as a potentiator of hyperthermia. Int J Hyperthermia 1986; 2: 83-92.
70. Altura BM, Altura BT. Magnesium: Forgotten mineral in cardiovascular biology and atherogenesis. In: Nishizawa Y, Morii H, Durlach J, eds. New Perspectives in Magnesium Research. London: Springer Verlag, 2007: 239-60.
71. Adam JK, Odhav B, Bhoola KD. Immune responses in cancer. Pharmacol Ther 2003; 99: 113-32.
72. Agarwal A, Rani M, Saha GK, et al. Disregulated expression of the Th2 cytokine gene in patients with intraoral squamous cell carcinoma. Immunol Invest 2003; 32: 17-30.
73. Antonia SJ, Extermann M, Flavell RA. Immunologic nonresponsiveness to tumors. Crit Rev Oncog 1998; 9: 35-41.
74. Skotnicki AB. The effect of magnesium on immune response and carcinogenesis. J Nutr Immunol 1993; 2: 67-80.
75. Tarn M, Gomez S, Gonzalez-Gross M, Marcos A. Possible roles of magnesium on the immune system. Eur J Clin Nutrition 2003; 57: 1193-7 (Review).
76. Zimowska W, Girardeau JP, Kuryszko J, Bayle D, Rayssiguier Y, Mazur A. Morphological and immune response alterations of the intestinal mucosa of the mouse after short periods on a low-magnesium diet. Brit J Nutr 2002; 88: 515-22.
77. Malpuech-Brugère C, Rock E, Astier C, Nowacki W, Mazur A, Rayssiguier Y. Exacerbated immune stress response during experimental magnesium deficiency results from abnormal calcium homeostasis. Life Sci 1998; 63: 1815-22.
78. Malpuech-Brugère C, Nowacki W, Daveau M, Gueux E, Linard C, Rock E, et al. Inflammatory response following acute magnesium deficiency in the rat. Biochim Biophys Acta 2000; 1501: 91-8.
79. Bussière FI, Gueux E, Rock E, et al. Increased phagocytosis and production of reactive oxygen species by neutrophils during magnesium deficiency in rats and inhibition by high magnesium concentration. Brit J Nutr 2002; 87: 107-13.
80. Petrault I, Zimowska W, Mathieu J, Bayle D, Rock E, Favier A, et al. Changes in gene expression in rat thymocytes identified by cDNA array support the occurrence of oxidative stress in early magnesium deficiency. Biochim Biophys Acta 2000; 1586: 92-8.
81. Buchachenko AL, Kutznetsov DA, Berdinsky VL. New Mechanisms of biological effects of electromagnetic fields. Biophysics 2006; 51: 489-96.
82. Buchachenko AL, Kuznetsov DA. Magnetic field affects enzymatic ATP synthesis. J Am Chem Soc 2008; 130: 12868-9.
83. Feyehting M, Ahlbom A, Kheifets L. EMF and health. Annu Rev Public Health 2005; 26: 165-89.
84. Kheifets L, Shimkhada R. Childhood leukemia and EMF: Review of the epidemiologic evidence. Bioelectromagnetics 2005; 26: S51-9.
85. Lowenthal RM, Tuck DM, Bray IC. Residential exposure to electric power transmission lines and risk of lymphoproliferative and myeloproliferative disorders: a case-control study. Intern Med J 2007; 37: 614-9.
86. Bortoletto E, Mognato M, Ferraro P, et al. Chromosome instability induced in the cell progeny of human T lymphocytes irradiated in G0 with (gamma)-rays. Mutagenesis 2001; 16: 529-37.
87. Tice RR, Hook GG, Donner M, McRee DI, Guy AW. Genotoxicity of radiofrequency signals. I. Investigation of DNA damage and micronuclei induction in cultured blood cells. Bioelectromagnetics 2002; 23: 113-26.
88. 2+ channels and their role in modulation of neuroendocrine cell proliferation and death. Cell Calcium 2004; 35: 307-15.
89. White JA, Blackmore PF, Schoenbach KH, Beebe SJ. Stimulation of capacitative calcium entry in HL-60 cells by nanosecond pulsed electric fields. J Biol Chem 2004; 279: 22964-72.
90. Gapeev AB, Chemeris NK. Modeling of the effect of modulated electromagnetic radiation on animal cell. Biofizika 2000; 45: 299-312.
91. Garaj-Vrhovac V. Micronucleous assay and lymphocyte mitotic activity in risk assessment of occupational exposure to microwave radiation. Chemosphere 1999; 39: 2301-12.
92. Anghileri LJ, Mayayo E, Domingo JL. Radiofrequencyinduced carcinogenesis: cellular calcium homeostasis changes as a triggering factor. Int J Radiat Biol 2005; 81: 205-9.
93. Baureus Koch CL, Sommarin M, Persson BR, Salford LG, Eberhardt JL. Interaction between low frequency magnetic fields and cell membranes. Bioelectromagnetics 2003; 24: 395-402.
94. Praputpittaya C, Pleumsamran J, Duangjai A. Electromagnetic radiation from mobile phone causes no oxidative stress to the brain. Asian Biomed 2008; 2: 507-10.
95. Anghileri LJ, Mayayo E, Domingo JL, Thouvenot P. Evaluation of health risks caused by radio frequency accelerated carcinogenesis: the importance of processes driven by the calcium ion signal. Eur J Cancer Prevention 2006; 15: 191-5.
96. Anghileri LJ, Mayayo E, Domingo JL. Dependence of radiofrequency carcinogenic effects on the preexistent oncogenes. Int J Cancer Prevention 2008; 2: 335-8.