The serotonin transporter gene polymorphism (5-HTTLPR) and affective symptoms among women diagnosed with borderline personality disorder

European Psychiatry

Volumn 25, Issue 1, 2010, Pages 19-25

  Maurex, L ^a   Zaboli, G ^b   Ohman A ^a,c,d   Asberg M ^a   Leopardi, R ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c Stockholm Brain Institute   (Sweden)

^d UNIVERSITY OF FLORIDA   (United States)

Author keywords

Anxiety; Borderline personality disorder; Depression; Obsession compulsion; Serotonin transporter gene polymorphism (5 HTTLPR); Suicide

Indexed keywords

SEROTONIN; SEROTONIN TRANSPORTER;

ADULT; ALLELE; ANXIETY; ARTICLE; BORDERLINE STATE; CLINICAL FEATURE; DEPRESSION; DISEASE SEVERITY; FEMALE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MENTAL DISEASE; MOOD DISORDER; OBSESSIVE COMPULSIVE DISORDER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN POLYMORPHISM; SUICIDE ATTEMPT;

ADOLESCENT; ADULT; BORDERLINE PERSONALITY DISORDER; DEPRESSIVE DISORDER; FEMALE; GENOTYPE; HUMANS; MIDDLE AGED; MOOD DISORDERS; OBSESSIVE-COMPULSIVE DISORDER; POLYMORPHISM, GENETIC; PREVALENCE; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; YOUNG ADULT;

EID: 73649128573     PISSN: 09249338     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eurpsy.2009.05.001     Document Type: Article

References (79)

1. Andersson EE, Forslund K, Gustavsson JP, Asberg M. Symptoms in borderline personality disorder - a new self rating scale (unpublished manuscript).
2. APA. Diagnostic and statistical manual of mental disorders. 4th ed: Washington DC: American Psychiatric Association; 1994.
3. Asberg M., Montgomery S.A., Perris C., Schalling D., and Sedvall G. A comprehensive psychopathological rating scale. Acta Psychiatr Scand Suppl 271 (1978) 5-27
4. Barkeling B., Linne Y., Lindroos A.K., Birkhed D., Rooth P., and Rossner S. Intake of sweet foods and counts of cariogenic microorganisms in relation to body mass index and psychometric variables in women. Int J Obes Relat Metab Disord 26 (2002) 1239-1244
5. Bellino S., Patria L., Paradiso E., Di Lorenzo R., Zanon C., Zizza M., et al. Major depression in patients with borderline personality disorder: a clinical investigation. Can J Psychiatry 50 (2005) 234-238
6. Bennett A.J., Lesch K.P., Heils A., Long J.C., Lorenz J.G., Shoaf S.E., et al. Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry 7 (2002) 118-122
7. Black D.W., Noyes Jr. R., Pfohl B., Goldstein R.B., and Blum N. Personality disorder in obsessive-compulsive volunteers, well comparison subjects, and their first-degree relatives. Am J Psychiatry 150 (1993) 1226-1232
8. Bloch M.H., Landeros-Weisenberger A., Sen S., Dombrowski P., Kelmendi B., Coric V., et al. Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic review. Am J Med Genet B Neuropsychiatr Genet 147B (2008) 850-858
9. Bondy B., Erfurth A., de Jonge S., Kruger M., and Meyer H. Possible association of the short allele of the serotonin transporter promoter gene polymorphism (5-HTTLPR) with violent suicide. Mol Psychiatry 5 (2000) 193-195
10. Brown M.Z., Comtois K.A., and Linehan M.M. Reasons for suicide attempts and nonsuicidal self-injury in women with borderline personality disorder. J Abnorm Psychol 111 (2002) 198-202
11. Brown S.M., and Hariri A.R. Neuroimaging studies of serotonin gene polymorphisms: exploring the interplay of genes, brain, and behavior. Cogn Affect Behav Neurosci 6 (2006) 44-52
12. Canli T., and Lesch K.P. Long story short: the serotonin transporter in emotion regulation and social cognition. Nat Neurosci 10 (2007) 1103-1109
13. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301 (2003) 386-389
14. Cohen D. A power primer. Psychol Bull 112 (1992) 155-159
15. Dickel D.E., Veenstra-VanderWeele J., Bivens N.C., Wu X., Fischer D.J., Van Etten-Lee M., et al. Association studies of serotonin system candidate genes in early-onset obsessive-compulsive disorder. Biol Psychiatry 61 (2007) 322-329
16. Distel M.A., Trull T.J., Derom C.A., Thiery E.W., Grimmer M.A., Martin N.G., et al. Heritability of borderline personality disorder features is similar across three countries. Psychol Med 8 (2007) 1-11
17. Driessen M., Herrmann J., Stahl K., Zwaan M., Meier S., Hill A., et al. Magnetic resonance imaging volumes of the hippocampus and the amygdala in women with borderline personality disorder and early traumatization. Arch Gen Psychiatry 57 (2000) 1115-1122
18. Ebner-Priemer U.W., Welch S.S., Grossman P., Reisch T., Linehan M.M., and Bohus M. Psychophysiological ambulatory assessment of affective dysregulation in borderline personality disorder. Psychiatry Res 150 (2007) 265-275
19. Esau L., Kaur M., Adonis L., and Arieff Z. The 5-HTTLPR polymorphism in South African healthy populations: a global comparison. J Neural Transm 115 (2008) 755-760
20. Geijer T., Frisch A., Persson M.L., Wasserman D., Rockah R., Michaelovsky E., et al. Search for association between suicide attempt and serotonergic polymorphisms. Psychiatr Genet 10 (2000) 19-26
21. Goodman M., New A., and Siever L. Trauma, genes, and the neurobiology of personality disorders. Ann N Y Acad Sci 1032 (2004) 104-116
22. Gorman J.M. Gender differences in depression and response to psychotropic medication. Gend Med 3 (2006) 93-109
23. Gotlib I.H., Joormann J., Minor K.L., and Hallmayer J. HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biol Psychiatry 63 (2008) 847-851
24. Grant B.F., Chou S.P., Goldstein R.B., Huang B., Stinson F.S., Saha T.D., et al. Prevalence, correlates, disability, and comorbidity of DSM-IV borderline personality disorder: results from the wave 2 national epidemiologic survey on alcohol and related conditions. J Clin Psychiatry 11 (2008) e1-e13
25. Hansenne M., Pitchot W., Pinto E., Reggers J., Scantamburlo G., Fuchs S., et al. 5-HT1A dysfunction in borderline personality disorder. Psychol Med 32 (2002) 935-941
26. Hariri A.R., Mattay V.S., Tessitore A., Kolachana B., Fera F., Goldman D., et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 297 (2002) 400-403
27. Hariri A.R., and Weinberger D.R. Functional neuroimaging of genetic variation in serotonergic neurotransmission. Genes Brain Behav 2 (2003) 341-349
28. Hasler G., Kazuba D., and Murphy D.L. Factor analysis of obsessive-compulsive disorder YBOCS-SC symptoms and association with 5-HTTLPR SERT polymorphism. Am J Med Genet B Neuropsychiatr Genet 141 (2006) 403-408
29. Hayashi N. Obsessive-compulsive disorder comorbid with borderline personality disorder: a long-term case study. Psychiatry Clin Neurosci 50 (1996) 51-54
30. Helbecque N., Sparks D.L., Hunsaker III J.C., and Amouyel P. The serotonin transporter promoter polymorphism and suicide. Neurosci Lett 400 (2006) 13-15
31. Hranilovic D., Stefulj J., Furac I., Kubat M., Balija M., and Jernej B. Serotonin transporter gene promoter (5-HTTLPR) and intron 2 (VNTR) polymorphisms in Croatian suicide victims. Biol Psychiatry 54 (2003) 884-889
32. Johnson P.A., Hurley R.A., Benkelfat C., Herpertz S.C., and Taber K.H. Understanding emotion regulation in borderline personality disorder: contributions of neuroimaging. J Neuropsychiatry Clin Neurosci 15 (2003) 397-402
33. Jovanovic H., Lundberg J., Karlsson P., Cerin A., Saijo T., Varrone A., et al. Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET. Neuroimage 39 (2008) 1408-1419
34. Kendler K.S., Kuhn J.W., Vittum J., Prescott C.A., and Riley B. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch Gen Psychiatry 62 (2005) 529-535
35. Koenigsberg H.W., Anwunah I., New A.S., Mitropoulou V., Schopick F., and Siever L.J. Relationship between depression and borderline personality disorder. Depress Anxiety 10 (1999) 158-167
36. Korzekwa M.I., Dell P.F., Links P.S., Thabane L., and Webb S.P. Estimating the prevalence of borderline personality disorder in psychiatric outpatients using a two-phase procedure. Compr Psychiatry 49 (2008) 380-386
37. Lewinsohn P.M., Rohde P., Seeley J.R., and Baldwin C.L. Gender differences in suicide attempts from adolescence to young adulthood. J Am Acad Child Adolesc Psychiatry 40 (2001) 427-434
38. Li D., and He L. Further clarification of the contribution of the tryptophan hydroxylase (TPH) gene to suicidal behavior using systematic allelic and genotypic meta-analyses. Hum Genet 119 (2006) 233-240
39. Li D., and He L. Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior. Mol Psychiatry 12 (2007) 47-54
40. Lieb K., Zanarini M.C., Schmahl C., Linehan M.M., and Bohus M. Borderline personality disorder. Lancet 364 (2004) 453-461
41. Lin P.Y., and Tsai G. Association between serotonin transporter gene promoter polymorphism and suicide: results of a meta-analysis. Biol Psychiatry 55 (2004) 1023-1030
42. Lin P.Y. Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 31 (2007) 683-689
43. Linehan M.M., Comtois K.A., Brown M.Z., Heard H.L., and Wagner A. Suicide Attempt Self-Injury Interview (SASII): development, reliability, and validity of a scale to assess suicide attempts and intentional self-injury. Psychol Assess 18 (2006) 303-312
44. Lis E., Greenfield B., Henry M., Guile J.M., and Dougherty G. Neuroimaging and genetics of borderline personality disorder: a review. J Psychiatry Neurosci 32 (2007) 162-173
45. Lyons-Ruth K., Holmes B.M., Sasvari-Szekely M., Ronai Z., Nemoda Z., and Pauls D. Serotonin transporter polymorphism and borderline or antisocial traits among low-income young adults. Psychiatr Genet 17 (2007) 339-343
46. Mattila-Evenden M., Svanborg P., Gustavsson P., and Asberg M. Determinants of self-rating and expert rating concordance in psychiatric out-patients, using the affective subscales of the CPRS. Acta Psychiatr Scand 94 (1996) 386-396
47. Maurex L., Zaboli G., Wiens S., Asberg M., Leopardi R., and Ohman A. Emotionally controlled decision-making and a gene variant related to serotonin synthesis in women with borderline personality disorder. Scand J Psychol 50 (2009) 5-10
48. McKay D., Kulchycky S., and Danyko S. Borderline personality and obsessive-compulsive symptoms. J Personal Disord 14 (2000) 57-63
49. Munafo M.R., Freimer N.B., Ng W., Ophoff R., Veijola J., Miettunen J., et al. 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data. Am J Med Genet B Neuropsychiatr Genet 150B (2009) 271-281
50. Murphy D.L., and Lesch K.P. Targeting the murine serotonin transporter: insights into human neurobiology. Nat Rev Neurosci 9 (2008) 85-96
51. Neves F.S., Silveira G., Romano-Silva M.A., Malloy-Diniz L., Ferreira A.A., De Marco L., et al. Is the 5-HTTLPR polymorphism associated with bipolar disorder or with suicidal behavior of bipolar disorder patients?. Am J Med Genet B Neuropsychiatr Genet 147B (2008) 114-116
52. Parsey R.V., Hastings R.S., Oquendo M.A., Hu X., Goldman D., Huang Y.Y., et al. Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. Am J Psychiatry 163 (2006) 48-51
53. Pascual J.C., Soler J., Barrachina J., Campins M.J., Alvarez E., Perez V., et al. Failure to detect an association between the serotonin transporter gene and borderline personality disorder. J Psychiatr Res 42 (2008) 87-88
54. Pascual J.C., Soler J., Cortes A., Menoyo A., Barrachina J., Ropero M., et al. Association between the serotonin transporter gene and personality traits in bordeline personality disorder patients evaluated with Zuckerman-Kuhlman Personality Questionnaire (ZKPQ). Actas Esp Psiquiatr 35 (2007) 382-386
55. Pezawas L., Meyer-Lindenberg A., Drabant E.M., Verchinski B.A., Munoz K.E., Kolachana B.S., et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 8 (2005) 828-834
56. Pohl A., and Nordin C. Clinical and biochemical observations during treatment of depression with electroacupuncture: a pilot study. Hum Psychopharmacol 17 (2002) 345-348
57. Pooley E.C., Houston K., Hawton K., and Harrison P.J. Deliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene (TPH A779C), but not with polymorphisms in five other serotonergic genes. Psychol Med 33 (2003) 775-783
58. Saiz P.A., Garcia-Portilla M.P., Arango C., Morales B., Bascaran M.T., Martinez-Barrondo S., et al. Association study between obsessive-compulsive disorder and serotonergic candidate genes. Prog Neuropsychopharmacol Biol Psychiatry 32 (2008) 765-770
59. Sakai Y., Nishikawa M., Leyton M., Benkelfat C., Young S.N., and Diksic M. Cortical trapping of alpha-[(11)C]methyl-l-tryptophan, an index of serotonin synthesis, is lower in females than males. Neuroimage 33 (2006) 815-824
60. Schinka J.A., Busch R.M., and Robichaux-Keene N. A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Mol Psychiatry 9 (2004) 197-202
61. Sen S., Villafuerte S., Nesse R., Stoltenberg S.F., Hopcian J., Gleiberman L., et al. Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism. Biol Psychiatry 55 (2004) 244-249
62. Serretti A., Calati R., Mandelli L., and De Ronchi D. Serotonin transporter gene variants and behavior: a comprehensive review. Curr Drug Targets 7 (2006) 1659-1669
63. Siever L.J., Buchsbaum M.S., New A.S., Spiegel-Cohen J., Wei T., Hazlett E.A., et al. d,l-fenfluramine response in impulsive personality disorder assessed with [F-18]fluorodeoxyglucose positron emission tomography. Neuropsychopharmacology 20 (1999) 413-423
64. Skodol A.E., Gunderson J.G., Pfohl B., Widiger T.A., Livesley W.J., and Siever L.J. The borderline diagnosis I: psychopathology, comorbidity, and personality structure. Biol Psychiatry 51 (2002) 936-950
65. Skodol A.E., Siever L.J., Livesley W.J., Gunderson J.G., Pfohl B., and Widiger T.A. The borderline diagnosis II: biology, genetics, and clinical course. Biol Psychiatry 51 (2002) 951-963
66. Soloff P.H., Meltzer C.C., Greer P.J., Constantine D., and Kelly T.M. A fenfluramine-activated FDG-PET study of borderline personality disorder. Biol Psychiatry 47 (2000) 540-547
67. Stanley B., and Wilson S.T. Heightened subjective experience of depression in borderline personality disorder. J Personal Disord 20 (2006) 307-318
68. Steiger H., Richardson J., Joober R., Gauvin L., Israel M., Bruce K.R., et al. The 5HTTLPR polymorphism, prior maltreatment and dramatic-erratic personality manifestations in women with bulimic syndromes. J Psychiatry Neurosci 32 (2007) 354-362
69. Stein M.B., Schork N.J., and Gelernter J. Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders. Neuropsychopharmacology 33 (2008) 312-319
70. Svanborg P., and Asberg M. A new self-rating scale for depression and anxiety states based on the Comprehensive Psychopathological Rating Scale. Acta Psychiatr Scand 89 (1994) 21-28
71. Tadic A., Victor A., Baskaya O., von Cube R., Hoch J., Kouti I., et al. Interaction between gene variants of the serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT) in borderline personality disorder. Am J Med Genet B Neuropsychiatr Genet 150B 4 (2008) 1487-1495
72. Tebartz van Elst L., Hesslinger B., Thiel T., Geiger E., Haegele K., Lemieux L., et al. Frontolimbic brain abnormalities in patients with borderline personality disorder: a volumetric magnetic resonance imaging study. Biol Psychiatry 54 (2003) 163-171
73. Torgersen S., Lygren S., Oien P.A., Skre I., Onstad S., Edvardsen J., et al. A twin study of personality disorders. Compr Psychiatry 41 (2000) 416-425
74. Wagner S., Baskaya O., Lieb K., Dahmen N., and Tadic A. The 5-HTTLPR Polymorphism modulates the association of serious life events (SLE) and impulsivity in patients with Borderline Personality Disorder. J Psychiatr Res (2009) doi:10.1016/j.psychres.2009.03.004
75. Zaboli G., Gizatullin R., Nilsonne A., Wilczek A., Jonsson E.G., Ahnemark E., et al. Tryptophan hydroxylase-1 gene variants associate with a group of suicidal borderline women. Neuropsychopharmacology 31 (2006) 1982-1990
76. Zalsman G., Huang Y.Y., Oquendo M.A., Burke A.K., Hu X.Z., Brent D.A., et al. Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry 163 (2006) 1588-1593
77. Zanarini M.C., Frankenburg F.R., Hennen J., and Silk K.R. The longitudinal course of borderline psychopathology: 6-year prospective follow-up of the phenomenology of borderline personality disorder. Am J Psychiatry 160 (2003) 274-283
78. Zanarini M.C., Frankenburg F.R., Reich D.B., Silk K.R., Hudson J.I., and McSweeney L.B. The subsyndromal phenomenology of borderline personality disorder: a 10-year follow-up study. Am J Psychiatry 164 (2007) 929-935
79. Zoger S., Svedlund J., and Holgers K.M. Relationship between tinnitus severity and psychiatric disorders. Psychosomatics 47 (2006) 282-288