Reduction in low-density lipoprotein cholesterol levels during statin therapy is associated with a reduced incidence of advanced colon polyps

American Journal of the Medical Sciences

Volumn 338, Issue 5, 2009, Pages 378-381

  Siddiqui, Ali ^a   Nazario, Hector E ^b   Patel, Mahir ^b   Mahgoub, Amar ^b   Spechler, Stuart J ^b  

^a VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

3 Hydroxy 3 methyl glutaryl coenzyme A; Adenomatous polyps; Body mass index; Colorectal cancer; Low density lipoproteins

Indexed keywords

ACETYLSALICYLIC ACID; ATORVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NONSTEROID ANTIINFLAMMATORY AGENT; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN;

ADULT; AGED; ARTICLE; CHOLESTEROL BLOOD LEVEL; COLON POLYP; COLONOSCOPY; CORRELATION ANALYSIS; DISEASE SEVERITY; DRUG MECHANISM; FOLLOW UP; HUMAN; HYPERCHOLESTEROLEMIA; INCIDENCE; MAJOR CLINICAL STUDY; MALE; RETROSPECTIVE STUDY; RISK FACTOR; RISK REDUCTION;

EID: 73649106584     PISSN: 00029629     EISSN: None     Source Type: Journal    
DOI: 10.1097/MAJ.0b013e3181b4c496     Document Type: Article

References (25)

1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin 2008;58:71-96.
2. Kronborg O, Fenger C. Prognostic evaluation of planned follow-up in patients with colorectal adenomas. An interim report. Int J Colorectal Dis 1987;2:203-207
3. Thiis-Evensen E, Hoff GS, Sauar J, et al. Population-based surveillance by colonoscopy: Effect on the incidence of colorectal cancer. Telemark Polyp Study I. Scand J Gastroenterol 1999;34:414-420
4. Atkin WS, Morson BC, Cuzick J. Long-term risk of colorectal cancer after excision of rectosigmoid adenomas. N Engl J Med 1992;326:658-662
5. Wong WW, Dimitroulakos J, Minden MD, et al. HMG-CoA reductase inhibitors and the malignant cell: The statin family of drugs as triggers of tumor-specific apoptosis. Leukemia 2002;16:508-519
6. Jakobisiak M, Golab J. Potential antitumor effects of statins (Review). Int J Oncol 2003;23:1055-1069
7. Carlberg M, Dricu A, Blegen H, et al. Mevalonic acid is limiting for N-linked glycosylation and translocation of the insulin-like growth factor-1 receptor to the cell surface. Evidence for a new link between 3-hydroxy-3-methylglutaryl-coenzyme a reductase and cell growth. J Biol Chem 1996;271:17453-17462
8. Keyomarsi K, Sandoval L, Band V, et al. Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin. Cancer Res 1991;51:3602-3609
9. Wachtershauser A, Akoglu B, Stein J. HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2. Carcinogenesis 2001;22:1061-1067
10. Reddy BS, Wang CX, Kong AN, et al. Prevention of azoxymethaneinduced colon cancer by combination of low doses of atorvastatin, aspirin, and celecoxib in F 344 rats. Cancer Res 2006;66:4542-4546
11. Narisawa T, Morotomi M, Fukaura Y, et al. Chemoprevention by pravastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, of N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats. Jpn J Cancer Res 1996;87:798-804.
12. Poynter JN, Gruber SB, Higgins PD, et al. Statins and the risk of colorectal cancer. N Engl J Med 2005;352:2184-2192
13. Houghton J, Lardieri GG, Zauber NP, et al. Effect of cholesterol levels on villous histology in colonic adenomas. Dig Dis Sci 2000;45: 896-899
14. Bayerdorffer E, Mannes GA, Richter WO, et al. Decreased highdensity lipoprotein cholesterol and increased low-density cholesterol levels in patients with colorectal adenomas. Ann Intern Med 1993;118: 481-487
15. Demers RY, Neale AV, Demers P, et al. Serum cholesterol and colorectal polyps. J Clin Epidemiol 1988;41:9-13.
16. Kono S, Ikeda N, Yanai F, et al. Serum lipids and colorectal adenoma among male self-defence officials in northern Kyushu, Japan. Int J Epidemiol 1990;19:274-278
17. Winawer SJ, Zauber AG, Ho MN, et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med 1993;329:1977-1981
18. Fazio S, Linton MF. Debate: "How low should LDL cholesterol be lowered?" Viewpoint: "It doesn't need to be very low". Curr Control Trials Cardiovasc Med 2001;2:8-11.
19. Mannes GA, Maier A, Thieme C, et al. Relation between the frequency of colorectal adenoma and the serum cholesterol level. N Engl J Med 1986;315:1634-1638
20. Pappalardo G, Guadalaxara A, Maiani G, et al. Antioxidant agents and colorectal carcinogenesis: Role of beta-carotene, vitamin E and vitamin C. Tumori 1996;82:6-11.
21. Tseng TH, Hsu JD, Chu CY, et al. Promotion of colon carcinogenesis through increasing lipid peroxidation induced in rats by a high cholesterol diet. Cancer Lett 1996;100:81-87
22. Cruse P, Lewin M, Clark CG. Dietary cholesterol is co-carcinogenic for human colon cancer. Lancet 1979;1:752-755
23. Cummings JH, Wiggins HS, Jenkins DJ, et al. Influence of diets high and low in animal fat on bowel habit, gastrointestinal transit time, fecal microflora, bile acid, and fat excretion. J Clin Invest 1978;61:953-963
24. Deschner EE, Cohen BI, Raicht RF. Acute and chronic effect of dietary cholic acid on colonic epithelial cell proliferation. Digestion 1981;21:290-296
25. Siddiqui AA, Nazario H, Mahgoub A, et al. The long-term use of statins is associated with a decreased incidence of adenomatous colon polyps. Digestion 2009;79:17-22.