Antioxidant agents and colorectal carcinogenesis: Role of β-carotene, vitamin E and vitamin C

Tumori

Volumn 82, Issue 1, 1996, Pages 6-11

  Pappalardo, Giuseppe ^a,d   Guadalaxara, Antonio ^a   Maiani, Giuseppe ^b   Illomei, Giovanni ^a   Trifero, Mauro ^a   Frattaroli, Fabrizio Maria ^a   Mobarhan, Sohrab ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

^c LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^d NONE   (Italy)

Author keywords

antioxidant agents; colorectal cancer; vitamin C; vitamin E; carotene

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE;

COLORECTAL CANCER; HUMAN; REVIEW;

EID: 0029984445     PISSN: 03008916     EISSN: None     Source Type: Journal    
DOI: 10.1177/030089169608200102     Document Type: Review

References (88)

1. Alam B.S., Alam S.Q., Weir J.C., Gibson W.A.: Chemopreventive effects of beta-carotene and 13-cis-retinoic acid on salivary gland tumors. Nutr. Cancer, 6: 4-11, 1984.
2. American Cancer Society: Cancer Facts and Figures 1990. American Cancer Society, 1990.
3. Belisario M.A., Pecce R., Battista C., Panza N., Pacilio G.: Inhibition of cyclophosphamide mutagenicity by beta-carotene. Biomed. Pharmacother., 39: 445-448, 1985.
4. Bendich A., Shapiro S.S.: Effect of beta-carotene and canthaxanthin on the immune response of the rat. J. Nutr., 116: 2254-2262, 1986.
5. Bendich A.: The safety of beta-carotene. Nutr. Cancer, 11: 207-214, 1988.
6. Berrino F., Sant M., Verdecchia A., Capocaccia R., Hakulinen T., Esteve J.: The Eurocare Study. In: Survival of Cancer Patients in Europe. IARC Scientific Publications, 192, 205; no 132; Lyon 1995.
7. Bleiberg H., Buyse M., Galand P.: Cell kinetic indicators of premalignant stages of colorectal cancer. Cancer, 56: 124-129, 1985.
8. Bostick R.M., Potter J.D., McKenzie D.R., Sellers T.A., Kushi L.H., Steinmetz K.A., Folsom A.R.: Reduced risk of colon cancer with high intake of vitamin E: the Iowa women's health study. Cancer Res, 53: 4230-4237, 1993.
9. Bowen P.E., Mobarhan S., Smith J.C. Jr.: Carotenoid absorption in humans. Meth. Enzymol., 214: 3-17, 1993.
10. Brevard P.B., Anderton L.G., Magee A.C.: In vivo effects of retinoids on the histological changes in colorectal tissue. Nutr. Rep. Int., 31: 1130-1135, 1985.
11. Brown E.D., Micozzi M.S., Craft N.B., Bicri J.G., Beecher G., Edwards B.K., Rose A., Taylor P.R., Smith J.C.: Plasma carotenoids in normal men after a single ingestion of vegetables or purified beta-carotene. Am. J. Clin. Nutr., 49: 1258-1265, 1989.
12. Burton G.W., Ingold K.U.: Beta-carotene: an unusual type of lipid antioxidant. Science, 224: 569-573, 1984.
13. Bussey H.J.R., De Cosse J.J., Deschner E.E., Eyers A.A., Lesser M.L., Morson B.C., Ritchie S.M., Thomson J.P.S., Wadsworth J.: A randomized trial of ascorbic acid in polyposis coli. Cancer, 50: 1434-1439, 1982.
14. Cahill R.J., O'Sullivan K.R., Mathias P.M., Beattie S., Hamilton H., O'Morain C.: Effects of vitamin antioxidant supplementation on cell kinetics of patients with adenomatous polyps. Gut, 34: 963-967, 1993.
15. Comstock G.W., Helzlsouer K.J., Bush T.J.: Prediagnostic serum levels of carotenoids and vitamin E as related to subsequent cancer in Washington County, Maryland. Am. J. Clin. Nutr., 53: 260S-264S, 1991.
16. Craven P.A., Pfanshel J., De Rubertis F.: Role of reactive oxygen in bile salt stimulation of colonie epithelial proliferation. J. Clin. Invest., 77: 850-859, 1986.
17. De Cosse J.J., Miller H.H., Lesser M.L.: Effect of wheat fiber and vitamins C and E on rectal polyps in patients with familial adenomatous polyposis. J. Natl. Cancer Inst., 81: 1290-1297, 1989.
18. De Cosse J.J., Tsioulias G.J., Jacobson J.S.: Colorectal cancer: detection, treatment and rehabilitation. Cancer J. Clin., 44: 27-42, 1994.
19. Doll R., Peto R.: The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J. Natl. Cancer Inst., 66: 1191-1308, 1981.
20. Dorgan J.F., Schatzkin A.: Antioxidant micronutrients in cancer prevention. Hematol. Oncol. Clin. N. Am., 5: 43-68, 1991.
21. Friedman E.A.: A multistage model for human colon carcinoma development integrating cell culture studies with pathology. Cancer Invest., 5:453-461, 1985.
22. Garewel H., Sloan D., Sampliner R., Fennerty M.B., Hixson L.G.: The ornithine decarboxylase assay in human colorectal tissues: marked variability in measured activity due to "minor" methodologic differences. Int. J. Cancer, 52: 355-358, 1992.
23. Greenwald P., Nixon D.W., Malone W.F., Kelloff G.J., Stern H.R., Witkin K.M.: Concepts in cancer chemoprevention research. Cancer, 65: 1483-1490, 1990.
24. Haenszel W., Kurihara M.: Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States. J. Natl. Cancer Inst., 40: 43-68, 1968.
25. Henderson C.T., Mobarhan S., Bowen P.E., Stacewicz-Sapuntzakis M., Friedman H., Langenberg P.: Normal serum response to oral beta-carotene in humans. J. Am. Coll. Nutr., 8: 625-635, 1989.
26. Hill M.J., Drasar B.S.: Bacteria and the aetiology of human cancer. Br. J. Cancer, 28:94, 1973.
27. Hixson L.J., Garewal H.S., McGee D.L., Sloan D., Fennerty M.B., Sampliner R.E., Gerner E.W.: Ornithine decarboxylase and polyamines in colorectal neoplasia and mucosa. Cancer Epidemiol. Biol. Prev., 2: 369-374, 1993.
28. Index of welfare: overview of national hygiene (in Japanese). Tokyo, Japan: Health and Welfare Statistics Association, 54, 1987.
29. Keshavarzian A., Olyaee M., Sontang S., Mobarhan S.: Increased levels of luminol-enhanced chemiluminescence by rectal mucosa of patients with colonic neoplasia: a possible marker for colonic neoplasia. Nutr. Cancer, 19: 201-206, 1993.
30. Keshavarzian A., Zapeda D., List T., Mobarhan S.: High levels of reactive oxygen metabolites in colon cancer tissue: analysis by chemiluminescence probe. Nutr. Cancer, 17: 243-249, 1992.
31. Knekt P., Aromaa A., Maatela J., Aaran R., Nikkari T., Hakama M., Hakulinen T., Peto R., Saxen E., Teppo L.: Serum vitamin E, serum selenium and the risk of gastrointestinal cancer. Int. J. Cancer, 42: 846-850, 1988.
32. Knutila S.: Role of free radicals in genetic damage (mutation). Med. Biol., 62: 110-114, 1984.
33. Krinsky N.I.: Antioxidant functions of β-carotene. Free Radical Biol. Med., 7: 617-635, 1989.
34. Krinsky N.I.: Effects of carotenoids in cellular and animal systems. Am. J. Clin. Nutr., 53(suppl): 238S-246S, 1991.
35. Lambert L.A., Warner W.O., Wei R.R., Sukadev L., Chirtel S.J., Kornhauser A.: The protective but nonsynergistic effect of dietary beta-carotene and vitamin E on skin tumorigenesis in Skh mice. Nutr. Cancer, 21: 1-12, 1994.
36. Leitner Z.A., Moore T., Sharman I.M.: Vitamin A and vitamin E in human blood. Br. J. Nutr., 14: 281-287, 1986.
37. Lipkin M.: Biomarkers of increased susceptibility to gastrointestinal cancer: new application to studies of cancer prevention in human subjects. Cancer Res., 48: 235-245, 1988.
38. Machlin L.J., Bendich A.: Free radical tissue damage: protective role of antioxidant nutrients. FASEB J., 1: 441-445, 1987.
39. Maiani G., Mobarhan S., Ceccanti M., Ranaldi L., Gettner S., Bowen P., Friedman H., De Lorenzo A., Ferro-Luzzi A.: Beta-carotene serum response in young and elderly females. Eur. J. Clin. Nutr., 43: 749-761, 1989.
40. Maiani G., Pappalardo G., Ferro-Luzzi A., Raguzzini A., Azzini E., Guadalaxara A., Trifero M., Frommel T., Mobarhan S.: Accumulation of beta-carotene in normal colorectal mucosa and colonic neoplastic lesions in humans. Nutr. Cancer, 24: 23-31, 1995.
41. Maiani G., Pappalardo G., Mobarhan S., Guadalaxara G., Stucchi C., Azzini E., Trifero M., Ferro-Luzzi A.: Beta-carotene supplementation results in a significant increase in normal colonic mucosa beta-carotene concentration and accumulation of beta-carotene in colonic neoplastic lesions. Atti Riunione Congiunta Soc. Ital. Biol. Sperimental, Ischia, 25-28 September 1994.
42. Mayne Taylor S., Janerich D.T., Greenwald P., Chorost S., Tucci C., Zaman M.B., Melamed M.R., Kiely M., McKneally M.F.: Dietary beta-carotene and lung cancer risk in US non-smokers. J. Natl. Cancer. Inst., 86: 33-38, 1994.
43. Mergens W.J., Bhagavan H.N.: α-Tocopherols (vitamin E). In: Nutrition and Cancer Prevention. Investigating the Role of Micronutrients. Moon T.E., Micozzis M.S. (Eds.), pp. 305-340, Marcel Dekker, New York, 1990.
44. Micheli A., Sant M., Gatta G., Dell'Era L., Capocaccia R.: Incidenza e sopravvivenza dei tumori del colon in Italia. Quad. Oncol., 2: 89-92, 1992.
45. Mirvish S.S.: Effects of vitamin C and E on N-nitroso compound formation, carcinogenesis and cancer. Cancer, 58: 1842-1850, 1986.
46. Mobarhan S., Bowen P., Andersen B., Evans M., Stacewicz-Sapuntzakis M., Sugerman S., Simms P., Lucchesi D., Friedman H.: Effects of beta-carotene supplementation on beta-carotene absorption, lipid peroxidation, and neutrophil superoxide formation in young men. Nutr. Cancer, 14: 195-206, 1990.
47. Mobarhan S., Hupert J., Friedman H.: Effects of aging on beta-carotene and vitamin A status. Age, 14: 13-16, 1991.
48. Mobarhan S., Shiau A., Grande A., Kolli S., Stacewicz-Sapuntzakis M., Oldham T., Liao Y., Bowen P., Dyavanapalli M., Kazi N., McNeal K., Frommel T.: β-carotene supplementation results in an increased serum and colonie mucosal concentration of β-carotene and a decrease in α-tocopherol concentration in patients with colonic neoplasia. Cancer Epidemiol. Biomarkers Preven., 3: 501-503, 1994.
49. Mute J., Moriawaki H.: Anti-tumor activity of vitamin A and its derivates. J. Natl. Cancer Inst., 73: 1389-1393, 1984.
50. Muto T., Bussey J.H., Morson B.C.: The evolution of cancer of the colon and rectum. Cancer, 36: 2251-2270, 1975.
51. National Cancer Institute, Division of Cancer Prevention and Control Surveillance Program. Cancer statistics review 1973-1988. US Department of Health and Human Services, National Institutes of Health, February 1991. NIH publication, 91-2789.
52. Nomura A.M., Stemmermann G.N., Heilbrun L.K., Salkeld R.M., Vuilleumier J.P.: Serum vitamin levels and the risk of cancer of specific sites in men of Japanese ancestry in Hawaii. Cancer Res., 45: 2369-2372, 1985.
53. O'Sullivan K.R., Mathias P.M., Tobin A., O'Morain C.: Risk of adenomatous polyps and colorectal cancer in relation to serum antioxidants and cholesterol status. Eur. J. Gastroenterol. Hepatol., 3: 775-779, 1991.
54. Olson J.A.: Carotenoids, vitamin A and cancer. J. Nutr., 116: 1127-1130, 1986.
55. Palozza P., Krinsky N.I.: The inhibition of radical-initiated peroxidation of microsomal lipids by both alpha-tocopherol and beta-carotene. Free radical Biol. Med., 11: 407-414, 1991.
56. Palozza P., Krinsky N.I.: Beta-carotene and alpha-tocopherol are synergistic antioxidants. Arch. Biochem. Biophys., 297: 184-187, 1992.
57. Parker R.S.: Carotenoids in human blood and tissues. Am. J. Clin. Nutr., 119: 101-104, 1989.
58. Peto R., Doll R., Buckley J.D., Sporn M.B.: Can beta-carotene materially reduce the risk of human cancer rates? Nature, 290: 201-208, 1981.
59. Phillips R.W., Kikendall J.W., Luk G.D., Willis S.M., Murphy J.R., Maydonovitch C., Bowen P.E., Stacewicz Sapuntzakis M., Wong R.K.H.: Beta-carotene inhibits rectal mucosa ornithine decarboxylase activity in colon cancer patients. Cancer Res., 53: 3723-3725, 1993.
60. Raj A.S., Katz M.: Beta-carotene as an inhibitor of benzo(a)pyrene and mitomycin C-induced chromosomal breaks in the bone marrow of mice. Can. J. Genet. Cytol, 27: 598-602, 1985.
61. Rettura G., Stratford F., Levenson S.M., Steifter E.: Prophylactic and therapeutic actions of supplemental beta-carotene in mice inoculated with C3HBA adenocarcinoma cells: lack of therapeutic action of supplemental ascorbic acid. J. Natl. Cancer Inst., 69: 73-77, 1982.
62. Risio M., Coverlizza S., Ferrari A., Cantelaresi I., Rossini F.P.: Immunohistochemical study of epithelial cell proliferation in hyperplastic polyps, adenomas, and adenocarcinomas of the large bowel. Gastroenterology, 94: 899-906, 1988.
63. Robins S.L., Cotran R.S., Kumar V: Apparato gastroenterico: colon. In: Le Basi Patologiche delle Malattie, Robins S.L., Cotran R.S., Kumar V. (Eds.), III ediz. italiana, p. 1068, Piccin, Padova, 1987.
64. Roncucci L., Di Donato P., Carati L., Ferrari A., Perini M., Bertoni G., Bedogni G., Paris B., Svanoni F., Girola M., Ponz de Leon M.: Antioxidant vitamins or lactulose for the prevention of the recurrence of colorectal adenomas. Dis. Colon Rectum, 36: 227-234, 1993.
65. Roncucci L., Scalmati A., Ponz de Leon M.: Pattern of cell kinetics in colorectal mucosa of patients with different types of adenomatous polyps of the large bowel. Cancer, 68: 873-78, 1991.
66. Salonen J.T., Salonen R., Lappctelainen R., Maenpaa P.H., Alfthan G., Puska P.: Risk of cancer in relation to serum concentrations of selenium and vitamin A and E: matched case-control analysis of prospective data. Br. Med. J., 290: 417-420, 1985.
67. Santamaria L., Bianchi A., Arnaboldi A., Andreoni L., Bermond P.: Serum protein depletion by cultured post-implantation rat embryos. Experientia, 39: 1042-1044, 1983.
68. Schrober S.E., Comstock G.W., Helsing K.J., Salkeld R.M., Morris J.S., Rider A.A., Brookmeyer R.: Serologic precursor of cancer: I. Prediagnostic serum nutrients and colon cancer risk. Am. J. Epidemiol., 126: 1033-1041, 1987.
69. Schwartz J., Suda D., Light G.: Beta-carotene is associated with the regression of hamster buccal pouch carcinoma and the induction of tumor necrosis factor in macrophages. Biochem. Biophys. Res. Commun., 136: 1130-1135, 1986.
70. Schwartz J.L., Antoniades D.Z., Zhao S.: Molecular and biochemical reprogramming of oncogenesis through the activity of prooxidants and antioxidants. Ann. N.Y. Acad. Sci., 686: 262-279, 1993.
71. Schwartz J.L., Tanaka J., Khandekar V., Herman T., Teicher B.A.: Beta-carotene and/or vitamin E as modulators of alkylating agents in SCC-25 human squamous carcinoma cells. Cancer Chemother. Pharmacol., 29: 207-213, 1992.
72. Shklar G., Schwartz J., Trickler D., Cheverise S.R.: The effectiveness of a mixture of beta-carotene, alpha-tocopherol, glutathione, and ascorbic acid for cancer prevention. Nutr. Cancer, 20: 145-151, 1993.
73. Stahelin H.B., Rosel F., Buess E., Brubecher G.: Cancer vitamins and plasma lipids prospective basel study. J. Natl. Cancer Inst., 73: 1463-1468, 1984.
74. Staszewski J., Haenszel W.: Cancer mortality among the Polish-born in the United States. J. Natl. Cancer Inst., 35: 291-297, 1965.
75. Steifter E., Rettura G., Padawer J., Goodwin P., Levenson S.: Regression of C3HBA mouse tumor due to X-ray therapy combined with supplemental beta-carotene or vitamin A. J. Natl. Cancer Inst, 71: 409-417, 1983.
76. Suda D., Schwartz J., Shklar G.: GGT reduction in beta-carotene - inhibition of hamster buccal pouch carcinogenesis. Eur. J. Cancer Clin. Oncol., 1: 43-46, 1987.
77. Suda D., Schwartz J., Shklar G.: Inhibition of experimental oral carcinogenesis by topical beta-carotene. Carcinogenesis, 7: 711-715, 1986.
78. Temple N.J., Basu T.K.: Protective effects of β-carotene against colon tumor in mice. J. Natl. Cancer Inst., 78: 1211-1214, 1987.
79. Terpstra O.T., Van Blankenstain M., Dees J., Eilers G.A.M.: Abnormal pattern of cell proliferation in the entire colonic mucosa of patients with colon adenoma or cancer. Gastroenterology, 92: 704-708, 1987.
80. Tomkin G.H., Scott L., Ogbuah C., O'Shaughnessy M.: Carcinoma of the colon: association with low dietary vitamin A in females: preliminary comunications. J. R. Irish Soc. Med., 79: 642-644, 1986.
81. Wald N.J., Thomas S.G., Densem J.W., Borcham J., Bailey A.: Serum vitamin E and subsequent risk of cancer. Br. J. Cancer, 56: 69-72, 1987.
82. Willet C.H., Stampfer M.J., Underwood B.A., Taylor J.O., Hennekens C.H.: Vitamins A, E, and carotene: effects of supplementation on their plasma levels. Am. J. Clin. Nutr., 38: 559-566, 1983.
83. Willet W., Stampfer M.J., Colditz G.A., Rosner B., Speizer F.E.: Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women. N. Engl. J. Med., 3: 1664-1672, 1990.
84. Willet W.: Diet and health: what should we eat? Science, 264: 532, 1994.
85. Willet W.: The search for the causes of breast and colon cancer. Nature, 338: 389-394, 1983.
86. Willet W.C., Polk B.F., Morris J.S., Stampfer M.J., Pressel S., Rosner B., Taylor J.O., Schneider K., Hames G.G.: Prediagnostic serum selenium and risk of cancer. Lancet, 2: 130-134, 1983.
87. Xu M.J., Plezia M., Alberts D.S., Hemerson S.S., Peng Y.M., Sayers S.M., Liu Y., Rittenbaugh C., Gensler H.L.: Reduction in plasma or skin alpha-tocopherol concentration with long term oral administration of beta-carotene in humans and mice. J. Natl. Cancer Inst., 84:1559-1565, 1992.
88. Ziegler R.G.: Vegetables, fruits and carotenoids and the risk of cancer. Am. J. Clin. Nutr., 53(suppl): 251S-259S, 1991.