The disruption of the epithelial mesenchymal trophic unit in COPD

COPD: Journal of Chronic Obstructive Pulmonary Disease

Volumn 6, Issue 6, 2009, Pages 421-431

  Behzad, Ali R ^a   McDonough, John E ^a   Seyednejad, Nazgol ^a   Hogg, James C ^a   Walker, David C ^a  

^a ST PAUL S HOSPITAL   (Canada)

Author keywords

Bronchiolar epithelium; Electron microscopy; Fibroblasts; Lamina propria

Indexed keywords

ADULT; ARTICLE; BASEMENT MEMBRANE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; LAMINA PROPRIA; LUNG ALVEOLUS EPITHELIUM; LUNG FUNCTION; MALE; PRIORITY JOURNAL; SMOKING; THREE DIMENSIONAL IMAGING; TRANSMISSION ELECTRON MICROSCOPY;

AGED; BASEMENT MEMBRANE; CASE-CONTROL STUDIES; EPITHELIAL CELLS; FEMALE; FIBROBLASTS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MESODERM; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; PROBABILITY; PULMONARY ALVEOLI; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY MUCOSA; SEVERITY OF ILLNESS INDEX; TISSUE CULTURE TECHNIQUES;

EID: 73549115088     PISSN: 15412555     EISSN: 15412563     Source Type: Journal    
DOI: 10.3109/15412550903341471     Document Type: Article

References (22)

1. Lopez AD, Murray CC. The global burden of disease, 1990-2020. Nat Med 1998; 4:1241-1243.
2. Pauwels RA, Buist AS, Ma P, Jenkins CR, Hurd SS. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: National heart, lung, and blood institute and world health organization global initiative for chronic obstructive lung disease (gold): Executive summary. Respir Care 2001; 46:798-825.
3. Yanai M, Sekizawa K, Ohrui T, Sasaki H, Takishima T. Site of airway obstruction in pulmonary disease: Direct measurement of intrabronchial pressure. J Appl Physiol 1992; 72:1016-1023.
4. Van Brabandt H, Cauberghs M, Verbeken E, Moerman P, Lauweryns JM, Van de Woestijne KP. Partitioning of pulmonary impedance in excised human and canine lungs. J Appl Physiol 1983; 55:1733-1742.
5. Hogg JC, Macklem PT, ThurlbeckWM. Site and nature of airway obstruction in chronic obstructive lung disease. N Engl J Med 1968; 278:1355-1360.
6. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004; 350:2645-2653.
7. Evans MJ, Guha SC, Cox RA, Moller PC. Attenuated fibroblast sheath around the basement membrane zone in the trachea. Am J Respir Cell Mol Biol 1993; 8:188-192.
8. MacDonell SD, Chu F, Walker DC. The role of fibroblast in eosinophil and neutrophil migration through the conducting airway interstitium. FASEB J 1998; 12:A180.
9. Sirianni FE, Chu FS, Walker DC. Human alveolar wall fibroblasts directly link epithelial type 2 cells to capillary endothelium. Am J Respir Crit Care Med 2003; 168:1532-1537.
10. Sirianni FE, Milaninezhad A, Chu FS, Walker DC. Alteration of fibroblast architecture and loss of basal lamina apertures in human emphysematous lung. Am J Respir Crit Care Med 2006; 173:632-638.
11. Behzad AR, Chu F, Walker DC. Fibroblasts are in a position to provide directional information to migrating neutrophils during pneumonia in rabbit lungs. Microvasc Res 1996; 51:303-316.
12. Walker DC, Behzad AR, Chu F. Neutrophil migration through preexisting holes in the basal laminae of alveolar capillaries and epithelium during streptococcal pneumonia. Microvasc Res 1995; 50:397-416.
13. Adamson IY, Hedgecock C, Bowden DH. Epithelial cell-fibroblast interactions in lung injury and repair. Am J Pathol 1990; 137:385-392.
14. Adamson IY, Young L, King GM. Reciprocal epithelial: Fibroblast interactions in the control of fetal and adult rat lung cells in culture. Exp Lung Res 1991; 17:821-835.
15. Damiano VV, Cohen A, Tsang AL, Batra G, Petersen R. A morphologic study of the influx of neutrophils into dog lung alveoli after lavage with sterile saline. Am J Pathol 1980; 100:349-364.
16. McDonough JE, Sanchez PG, Cooper JD, Yuan R, Coxson HO, Elliott WM, Naiman D, Pochettino M, Horng D, GefterWB, et al. The quantification of lung structure in copd using micro-ct. Amer J Respir Crit Care Med 2008; 177:A659.
17. Terzaghi M, Nettesheim P, Williams ML. Repopulation of denuded tracheal grafts with normal, preneoplastic, and neoplastic epithelial cell populations. Cancer Res 1978; 38:4546-4553.
18. Klien JH, Adamson IY. Fibroblast inhibition and prostaglandin secretion by alveolar epithelial cells exposed to silica. Lab Invest 1989; 60:808-813.
19. Ikegami T, Zhang Y, Matsuzaki Y. Liver fibrosis: Possible involvement of emt. Cells Tissues Organs 2007; 185:213-221.
20. Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003; 112:1776-1784.
21. Selman M, Pardo A. The epithelial/fibroblastic pathway in the pathogenesis of idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 2003; 29:S93-97.
22. Zavadil J, Bottinger EP. Tgf-beta and epithelial-to-mesenchymal transitions. Oncogene 2005; 24:5764-5774.