Conjunctival interleukin-13 expression in mucous membrane pemphigoid and functional effects of interleukin-13 on conjunctival fibroblasts in vitro

American Journal of Pathology

Volumn 175, Issue 6, 2009, Pages 2406-2415

  Saw, Valerie P J ^a,b   Offiah, Ifeoma ^a   Dart, Robin J ^b   Galatowicz, Grazyna ^a   Dart, John K G ^b   Daniels, Julie T ^a   Calder, Virginia L ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MOORFIELDS EYE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; HLA DR ANTIGEN; INTERLEUKIN 13; STROMELYSIN; STROMELYSIN 2;

ADULT; AGED; ARTICLE; CD3+ T LYMPHOCYTE; CELL MIGRATION; CHEMOTAXIS; CHRONIC INFLAMMATION; CLINICAL ARTICLE; CONJUNCTIVA; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FIBROBLAST; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; LYMPHOCYTE CULTURE; MALE; MUCOUS MEMBRANE PEMPHIGOID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STROMA CELL; T LYMPHOCYTE; UPREGULATION;

EID: 73549093147     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2009.090579     Document Type: Article

References (44)

1. Chan LS, Ahmed AR, Anhalt GJ, Bernauer W, Cooper KD, Elder MJ, Fine JD, Foster CS, Ghohestani R, Hashimoto T, Hoang-Xuan T, Kirtschig G, Korman NJ, Lightman S, Lozada-Nur F, Marinkovich MP, Mondino BJ, Prost-Squarcioni C, Rogers RS, III, Setterfield JF, West DP, Wojnarowska F, Woodley DT, Yancey KB, Zillikens D, Zone JJ: The first international consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators. Arch Dermatol 2002, 138:370-379
2. Black AP, Wojnarowska F, Ogg GS: Role of T cells in the pathogenesis of mucous membrane pemphigoid. Expert Rev Dermatol 2006, 1:25-30
3. Hardy KM, Perry HO, Pingree GC, Kirby TJ, Jr.: Benign mucous membrane pemphigoid. Arch Dermatol 1971, 104:467-475
4. Miserocchi E, Baltatzis S, Roque MR, Ahmed AR, Foster CS: The effect of treatment and its related side effects in patients with severe ocular cicatricial pemphigoid. Ophthalmology 2002, 109:111-118
5. Saw VP, Dart JK, Rauz S, Ramsay A, Bunce C, Xing W, Maddison PG, Phillips M: Immunosuppressive therapy for ocular mucous membrane pemphigoid strategies and outcomes. Ophthalmology 2008, 115:253-261
6. Aliprantis AO, Wang J, Fathman JW, Lemaire R, Dorfman DM, Lafyatis R, Glimcher LH: Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13. Proc Natl Acad Sci USA 2007, 104:2827-2830
7. Chiaramonte MG, Donaldson DD, Cheever AW, Wynn TA: An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest 1999, 104:777-785
8. Keane MP, Gomperts BN, Weigt S, Xue YY, Burdick MD, Nakamura H, Zisman DA, Ardehali A, Saggar R, Lynch JP, III, Hogaboam C, Kunkel SL, Lukacs NW, Ross DJ, Grusby MJ, Strieter RM, Belperio JA: IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome. J Immunol 2007, 178:511-519
9. Kumar RK, Herbert C, Yang M, Koskinen AM, McKenzie AN, Foster PS: Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma. Clin Exp Allergy 2002, 32:1104-1111
10. Hershey GK: IL-13 receptors and signaling pathways: an evolving web. J Allergy Clin Immunol 2003, 111:677-690
11. Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, Zhang Y, Elias JA: Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999, 103:779-788
12. Wynn TA: Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat Rev Immunol 2004, 4:583-594
13. Bernauer W, Wright P, Dart JK, Leonard JN, Lightman S: The conjunctiva in acute and chronic mucous membrane pemphigoid. An immunohistochemical analysis. Ophthalmology 1993, 100:339-346
14. Rice BA, Foster CS: Immunopathology of cicatricial pemphigoid affecting the conjunctiva. Ophthalmology 1990, 97:1476-1483
15. Sacks EH, Jakobiec FA, Wieczorek R, Donnenfeld E, Perry H, Knowles DM, Jr.: Immunophenotypic analysis of the inflammatory infiltrate in ocular cicatricial pemphigoid. Further evidence for a T cell-mediated disease. Ophthalmology 1989, 96:236-243
16. Azouz A, Razzaque MS, El Hallak M, Taguchi T: Immunoinflammatory responses and fibrogenesis. Med Electron Microsc 2004, 37:141-148
17. Bernauer W, Wright P, Dart JK, Leonard JN, Lightman S: Cytokines in the conjunctiva of acute and chronic mucous membrane pemphigoid: an immunohistochemical analysis. Graefes Arch Clin Exp Ophthalmol 1993, 231:563-570
18. Caproni M, Calzolari A, Salvatore E, Giomi B, Volpi W, D'Agata A, Santucci M, Fabbri P: Cytokine profile and supposed contribution to scarring in cicatricial pemphigoid. J Oral Pathol Med 2003, 32:34-40
19. Elder MJ, Dart JK, Lightman S: Conjunctival fibrosis in ocular cicatricial pemphigoid-the role of cytokines. Exp Eye Res 1997, 65:165-176
20. Razzaque MS, Ahmed BS, Foster CS, Ahmed AR: Effects of IL-4 on conjunctival fibroblasts: possible role in ocular cicatricial pemphigoid. Invest Ophthalmol Vis Sci 2003, 44:3417-3423
21. Ingram JL, Rice A, Geisenhoffer K, Madtes DK, Bonner JC: Interleukin-13 stimulates the proliferation of lung myofibroblasts via a signal transducer and activator of transcription-6-dependent mechanism: a possible mechanism for the development of airway fibrosis in asthma. Chest 2003, 123: 422S-424S
22. Kohyama T, Liu X, Wen FQ, Kobayashi T, Abe S, Rennard SI: IL-4 and IL-13 induce chemotaxis of human foreskin fibroblasts, but not human fetal lung fibroblasts. Inflammation 2004, 28:33-37
23. Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI: Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells. Am J Physiol Lung Cell Mol Physiol 2002, 282:L1049-L1056
24. Saito A, Okazaki H, Sugawara I, Yamamoto K, Takizawa H: Potential action of IL-4 and IL-13 as fibrogenic factors on lung fibroblasts in vitro. Int Arch Allergy Immunol 2003, 132:168-176
25. Flavell SJ, Hou TZ, Lax S, Filer AD, Salmon M, Buckley CD: Fibroblasts as novel therapeutic targets in chronic inflammation. Br J Pharmacol 2008, 153 Suppl 1: S241-S246
26. Fujitsu Y, Fukuda K, Kimura K, Seki K, Kumagai N, Nishida T: Protection of human conjunctival fibroblasts from NO-induced apoptosis by interleukin-4 or interleukin-13. Invest Ophthalmol Vis Sci 2005, 46:797-802
27. Fukuda K, Fujitsu Y, Kumagai N, Nishida T: Inhibition of matrix metalloproteinase-3 synthesis in human conjunctival fibroblasts by interleukin-4 or interleukin-13. Invest Ophthalmol Vis Sci 2006, 47:2857-2864
28. Stramer BM, Mori R, Martin P: The inflammation-fibrosis link? A Jekyll and Hyde role for blood cells during wound repair. J Invest Dermatol 2007, 127:1009-1017
29. Filer A, Parsonage G, Smith E, Osborne C, Thomas AM, Curnow SJ, Rainger GE, Raza K, Nash GB, Lord J, Salmon M, Buckley CD: Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils. Arthritis Rheum 2006, 54:2096-2108
30. Tauber J, Jabbur N, Foster CS: Improved detection of disease progression in ocular cicatricial pemphigoid. Cornea 1992, 11:446-451
31. Khaw PT, Ward S, Porter A, Grierson I, Hitchings RA, Rice NS: The long-term effects of 5-fluorouracil and sodium butyrate on human Tenon's fibroblasts. Invest Ophthalmol Vis Sci 1992, 33:2043-2052
32. Leonardi A, Cortivo R, Fregona I, Plebani M, Secchi AG, Abatangelo G: Effects of Th2 cytokines on expression of collagen, MMP-1, and TIMP-1 in conjunctival fibroblasts. Invest Ophthalmol Vis Sci 2003, 44:183-189
33. Leonardi A, Curnow SJ, Zhan H, Calder VL: Multiple cytokines in human tear specimens in seasonal and chronic allergic eye disease and in conjunctival fibroblast cultures. Clin Exp Allergy 2006, 36:777-784
34. Mazure A, Grierson I: In vitro studies of the contractility of cell types involved in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 1992, 33:3407-3416
35. Calder VL, Jolly G, Hingorani M, Adamson P, Leonardi A, Secchi AG, Buckley RJ, Lightman S: Cytokine production and mRNA expression by conjunctival T-cell lines in chronic allergic eye disease. Clin Exp Allergy 1999, 29:1214-1222
36. Sempowski GD, Chess PR, Phipps RP: CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts. J Immunol 1997, 158:4670-4677
37. Wong TT, Sethi C, Daniels JT, Limb GA, Murphy G, Khaw PT: Matrix metalloproteinases in disease and repair processes in the anterior segment. Surv Ophthalmol 2002, 47:239-256
38. Purwar R, Kraus M, Werfel T, Wittmann M: Modulation of keratinocytederived MMP-9 by IL-13: a possible role for the pathogenesis of epidermal inflammation. J Invest Dermatol 2008, 128:59-66
39. Kaufman J, Sime PJ, Phipps RP: Expression of CD154 (CD40 ligand) by human lung fibroblasts: differential regulation by IFN-gamma and IL-13, and implications for fibrosis. J Immunol 2004, 172:1862-1871
40. Bluml G: Microcarrier cell culture technology. Methods in biotechnology Vol 2. Animal cell biotechnology: Methods and protocols. Edited by R Portner. Totowa NJ, Humana Press Inc, 2007, pp. 149-178
41. Bhatia S, Edidin M, Almo SC, Nathenson SG: B7-1 and B7-2: similar costimulatory ligands with different biochemical, oligomeric and signaling properties. Immunol Lett 2006, 104:70-75
42. Tesavibul N, Dorfman D, Sangwan VS, Christen W, Panayotis Z, Rojas B, Foster CS: Costimulatory molecules in ocular cicatricial pemphigoid. Invest Ophthalmol Vis Sci 1998, 39:982-988
43. Crowston JG, Chang LH, Constable PH, Daniels JT, Akbar AN, Khaw PT: Apoptosis gene expression and death receptor signaling in mitomycin-C-treated human tenon capsule fibroblasts. Invest Ophthalmol Vis Sci 2002, 43:692-699
44. Zhou X, Trudeau JB, Schoonover KJ, Lundin JI, Barnes SM, Cundall MJ, Wenzel SE: Interleukin-13 augments transforming growth factor-beta1-induced tissue inhibitor of metalloproteinase-1 expression in primary human airway fibroblasts. Am J Physiol Cell Physiol 2005, 288:C435-C442