Imaging and organelle distribution of fluorescent InGaP/ZnS nanoparticles in glial cells

Nanomedicine

Volumn 4, Issue 7, 2009, Pages 747-761

  Behrendt, Maik ^a,b   Sandros, Marinella G ^a   McKinney, R Anne ^a   McDonald, Ken ^a   Przybytkowski, Ewa ^a   Tabrizian, Maryam ^a   Maysinger, Dusica ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Cell organelles; Imaging; Lipid droplets; Lysosomes; Microglia; Mitochondria; Quantum dots

Indexed keywords

FAT DROPLET; INDIUM GALLIUM PHOSPHIDE; NANOPARTICLE; OLEIC ACID; PHOSPHINE; UNCLASSIFIED DRUG; ZINC SULFIDE;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL ORGANELLE; CELL SELECTION; CELL TRANSPORT; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG COATING; DRUG DELIVERY SYSTEM; LYSOSOME; MICROGLIA; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SPECTROFLUOROMETRY;

ANIMALS; BIOLOGICAL TRANSPORT; CELLS, CULTURED; FLOW CYTOMETRY; GALLIUM; INDIUM; MICE; MICROSCOPY, CONFOCAL; NANOPARTICLES; NANOTECHNOLOGY; NEUROGLIA; OLEIC ACID; PHOSPHINES; SULFIDES; ZINC COMPOUNDS;

EID: 73549086737     PISSN: 17435889     EISSN: None     Source Type: Journal    
DOI: 10.2217/nnm.09.64     Document Type: Article

References (63)

1. Sanhai WR, Sakamoto JH, Canady R, Ferrari M: Seven challenges for nanomedicine. Nat. Nanotechnol. 3(5), 242-244 (2008).
2. Giepmans BNG, Adams SR, Ellisman MH, Tsien RY: The fluorescent toolbox for assessing protein location and function. Science 312(5771), 217-224 (2006).
3. Lovric J, Cho SJ, Winnik FM, Maysinger D: Unmodified cadmium telluride quantum dots induce reactive oxygen species formation leading to multiple organelle damage and cell death. Chem. Biol. 12(11), 1227-1234 (2005).
4. Pathak S, Cao E, Davidson MC, Jin S, Silva GA: Quantum dot applications to neuroscience: new tools for probing neurons and glia. J. Neurosci. 26(7), 1893-1895 (2006).
5. Sundara RS, Vu TQ: Quantum dots monitor trka receptor dynamics in the interior of neural PC12 cells. Nano Lett. 6(9), 2049-2059 (2006).
6. Vu TQ, Maddipati R, Blute TA, Nehilla BJ, Nusblat L, Desai TA: Peptide-conjugated quantum dots activate neuronal receptors and initiate downstream signaling of neurite growth. Nano Lett. 5(4), 603-607 (2005).
7. Stern ST, Zolnik BS, Mcleland CB, Clogston J, Zheng J, Mcneil SE: Induction of autophagy in porcine kidney cells by quantum dots: a common cellular response to nanomaterials? Toxicol. Sci. 106(1), 140-152 (2008)
8. Sandros MG, Behrendt M, Maysinger D, Tabrizian M: Ingap@zns-enriched chitosan nanoparticles: a versatile fluorescent probe for deep-tissue imaging. Adv. Funct. Mater. 17(18), 3724-3730 (2007). •• Describes preparation and characterization of indium gallium phosphide-zinc sulfide-coated nanoparticles and suggests their potential use for CNS imaging.
9. Rodriguez-Rodriguez RA, Tabernero A, Velasco A, Lavado EM, Medina JM: The neurotrophic effect of oleic acid includes dendritic differentiation and the expression of the neuronal basic helix-loop-helix transcription factor neurod2. J. Neurochem. 88(5), 1041-1051 (2004).
10. Medina JM, Tabernero A: Astrocyte-synthesized oleic acid behaves as a neurotrophic factor for neurons. J. Physiol. Paris 96(3-4), 265-271 (2002).
11. Tabernero A, Lavado EM, Granda B, Velasco A, Medina JM: Neuronal differentiation is triggered by oleic acid synthesized and released by astrocytes. J. Neurochem. 79(3), 606-616 (2001).
12. Velasco A, Tabernero A, Medina JM: Role of oleic acid as a neurotrophic factor is supported in vivo by the expression of gap-43 subsequent to the activation of srebp-1 and the up-regulation of stearoylcoa desaturase during postnatal development of the brain. Brain Res. 977(1), 103-111 (2003).
13. Basit H, Pal A, Sen S, Bhattacharya S: Two-component hydrogels comprising fatty acids and amines: structure, properties, and application as a template for the synthesis of metal nanoparticles. Chem. Eur. J. 14(21), 6534-6545 (2008).
14. Young AG, Al-Salim N, Green DP, Mcquillan AJ: Attenuated total reflection infrared studies of oleate and trioctylphosphine oxide ligand adsorption and exchange reactions on cds quantum dot films. Langmuir 24(8), 3841-3849 (2008).
15. Chen M, Ding W, Kong Y, Diao G: Conversion of the surface property of oleic acid stabilized silver nanoparticles from hydrophobic to hydrophilic based on host-guest binding interaction. Langmuir 24(7), 3471-3478 (2008).
16. Li Y, Wong HL, Shuhendler AJ, Rauth AM, Wu XY: Molecular interactions, internal structure and drug release kinetics of rationally developed polymer-lipid hybrid nanoparticles. J. Control. Release 128(1), 60-70 (2008).
17. Kim M, Doh H, Choi M et al.: Skin permeation enhancement of diclofenac by fatty acids. Drug Deliv. 15(6), 373-379 (2008). • Shows how oleic acid is used as a chemical enhancer in transdermal drug delivery.
18. Mittal A, Sara UVS, Ali A, Aqil M: The effect of penetration enhancers on permeation kinetics of nitrendipine in two different skin models. Biol. Pharm. Bull. 31(9), 1766-1772 (2008).
19. Sato K, Sugibayashi K, Morimoto Y: Effect and mode of action of aliphatic esters on the in vitro skin permeation of nicorandil. Int. J. Pharm. 43(1-2), 31-40 (1988).
20. Green PG, Hadgraft J: Facilitated transfer of cationic drugs across a lipoidal membrane by oleic acid and lauric acid. Int. J. Pharm. 37(3), 251-255 (1987).
21. Aungst BJ, Blake JA, Hussain MA: Contributions of drug solubilization, partitioning, barrier disruption, and solvent permeation to the enhancement of skin permeation of various compounds with fatty acids and amines. Pharm. Res. 7(7), 712-718 (1990).
22. Fujimoto Y, Onoduka J, Homma KJ et al.: Long-chain fatty acids induce lipid droplet formation in a cultured human hepatocyte in a manner dependent of acyl-CoAsynthetase. Biol. Pharm. Bull. 29(11), 2174-2180 (2006). •• Shows that oleic acid induces lipid droplet formation in human hepatocytes.
23. Zoula S, Rijken PFJW, Peters JPW et al.: Pimonidazole binding in c6 rat brain glioma: relation with lipid droplet detection. Br. J. Cancer 88(9), 1439 (2003).
24. Wolins NE, Brasaemle DL, Bickel PE: A proposed model of fat packaging by exchangeable lipid droplet proteins. FEBS Letters 580(23), 5484-5491 (2006).
25. Goodman JM: The gregarious lipid droplet. J. Biol. Chem. 283(42), 28005-28009 (2008).
26. Au C, Mutkus L, Dobson A, Riffle J, Lalli J, Aschner M: Effects of nanoparticles on the adhesion and cell viability on astrocytes. Biol. Trace Elem. Res. 120(1), 248-256 (2007). •• Suggests that microglia play a role in delivering nanoparticles to the CNS.
27. Jackson H, Muhammad O, Daneshvar H et al.: Quantum dots are phagocytized by macrophages and colocalize with experimental gliomas. Neurosurgery 60, 524-529 (2007).
28. Neuwelt E, Abbott NJ, Abrey L et al.: Strategies to advance translational research into brain barriers. Lancet Neurol. 7(1), 84-96 (2008).
29. Varallyay CG, Muldoon LL, Gahramanov S et al.: Dynamic MRI using iron oxide nanoparticles to assess early vascular effects of antiangiogenic versus corticosteroid treatment in a glioma model. J. Cereb. Blood Flow Metab. 29(4), 853-860 (2009).
30. Pardridge WM: Re-engineering biopharmaceuticals for delivery to brain with molecular trojan horses. Bioconjug. Chem. 19(7), 1327-1338 (2008).
31. Maysinger D, Behrendt M, Lalancette-Hebert M, Kriz J: Real-time imaging of astrocyte response to quantum dots: in vivo screening model system for biocompatibility of nanoparticles. Nano Lett. 7(8), 2513-2520 (2007). • Shows that polyethylene glycolylated nanoparticles are largely taken up by microglia. It provides evidence for transient activation of astrocytes in the CNS of glial fibrillary acidic protein-luciferase transgenic mice.
32. Hanisch UK, Kettenmann H: Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat. Neurosci. 10(11), 1387-1394 (2007).
33. Block ML, Hong JS: Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog. Neurobiol. 76(2), 77-98 (2005).
34. Pekny M, Nilsson M: Astrocyte activation and reactive gliosis. Glia 50, 427-434 (2005).
35. Nakanishi H: Microglial functions and proteases. Mol. Neurobiol. 27, 163-176 (2003).
36. Nimmerjahn A, Kirchhoff F, Helmchen F: Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308(5726), 1314-1318 (2005).
37. Marvizón JCG, Wang X, Matsuka Y, Neubert JK, Spigelman I: Relationship between capsaicin-evoked substance p release and neurokinin 1 receptor internalization in the rat spinal cord. Neuroscience 118(2), 535-545 (2003).
38. Costes SV, Daelemans D, Cho EH, Dobbin Z, Pavlakis G, Lockett S: Automatic and quantitative measurement of protein-protein colocalization in live cells. Biophys. J. 86(6), 3993-4003 (2004). • Describes how to determine intensity thresholds from multicolor fluoresence confocal images.
39. Lewinski N, Colvin V, Drezek R: Cytotoxicity of nanoparticles. Small 4(1), 26-49 (2008).
40. Lovric J, Bazzi HS, Cuie Y, Fortin GR, Winnik FM, Maysinger D: Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots. J. Mol. Med. 83(5), 377-385 (2005).
41. Zhang LW, Monteiro-Riviere NA: Mechanisms of quantum dot nanoparticle cellular uptake. Toxicol. Sci. 110(1), 138-155 (2009).
42. Khatchadourian A, Maysinger D: Lipid droplets: their role in nanoparticle-induced oxidative stress. Mol. Pharm. 6(4), 1125-1137 (2009).
43. Ma J, Chen JY, Zhang Y et al.: Photochemical instability of thiol-capped CdTe quantum dots in aqueous solution and living cells: process and mechanism. J. Phys. Chem. B 111(41), 12012-12066 (2007).
44. Ki HA, Naoghare PK, Oh B-K, Choi J-W, Song JM: Nondestructive quantum dot-based intracellular serotonin imaging in intact cells. Anal. Biochem. 388(1), 23-27 (2009).
45. Maysinger D, Lovric J: Quantum dots and other fluorescent nanoparticles: quo vadis in the cell? Adv. Exp. Med. Biol. 620, 156-167 (2007).
46. Fujimoto T, Kogo H, Ishiguro K, Tauchi K, Nomura R: Caveolin-2 is targeted to lipid droplets, a new "membrane domain" in the cell. J. Cell Biol. 152(5), 1079-1086 (2001).
47. Lavado E, Sanchez-Abarca L, Tabernero A, Bolaños J, Medina J: Oleic acid inhibits gap junction permeability and increases glucose uptake in cultured rat astrocytes. J. Neurochem. 69(2), 721-728 (1997).
48. Harrison JE, Watkinson AC, Green DM, Hadgraft J, Brain K: The relative effect of azone® and transcutol® on permeant diffusivity and solubility in human stratum corneum. Pharm. Res. 13(4), 542-546 (1996).
49. Liu YY, Yu JY, Yin D et al.: A role for ceramide in driving cancer cell resistance to doxorubicin. FASEB J. 22(7), 2541-2551 (2008).
50. Potter W, Kalil RE, Kao WJ: Biomimetic material systems for neural progenitor cell-based therapy. Front. Biosci. 13, 806-821 (2008).
51. Tsutsui Y, Tomizawa K, Nagita M et al.: Development of bionanocapsules targeting brain tumors. J. Control. Release 122(2), 159-164 (2007).
52. Park IK, Lasiene J, Chou SH, Horner PJ, Pun SH: Neuron-specific delivery of nucleic acids mediated by tet1-modified poly(ethylenimine). J. Gene Med. 9(8), 691-702 (2007).
53. Ribot E, Bouzier-Sore AK, Bouchaud V et al.: Microglia used as vehicles for both inducible thymidine kinase gene therapy and MRI contrast agents for glioma therapy. Cancer Gene Ther. 14(8), 724-737 (2007).
54. Long TC, Saleh N, Tilton RD, Lowry GV, Veronesi B: Titanium dioxide (p25) produces reactive oxygen species in immortalized brain microglia (bv2): implications for nanoparticle neurotoxicity. Environ. Sci. Technol. 40(14), 4346-4352 (2006).
55. Chithrani BD, Ghazani AA, Chan WCW: Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett. 6(4), 662-668 (2006).
56. Chou LYT, Fischer HC, Perrault SD, Chan WCW: Visualizing quantum dots in biological samples using silver staining. Anal. Chem. 81(11), 4560-4565 (2009).
57. Cury-Boaventura MF, Pompéia C, Curi R: Comparative toxicity of oleic acid and linoleic acid on raji cells. Nutrition 21(3), 395-405 (2005).
58. Zhu Y, Schwarz S, Ahlemeyer B, Grzeschik S, Klumpp S, Krieglstein J: Oleic acid causes apoptosis and dephosphorylates Bad. Neurochem. Int. 46(2), 127-135 (2005).
59. 2-cell dysfunction. Eur. J. Clin. Invest. 32, 14 (2002).
60. Murphy S, Martin S, Parton RG: Lipid droplet-organelle interactions; sharing the fats. Biochim. Biophys. Acta 1791(6), 441-447 (2008).
61. Sturmey RG, O'Toole PJ, Leese HJ: Fluorescence resonance energy transfer ana lysis of mitochondrial: lipid association in the porcine oocyte. Reproduction 132(6), 829-837 (2006).
62. Piomelli D, Astarita G, Rapaka R: A neuroscientist's guide to lipidomics. Nat. Rev. Neurosci. 8(10), 743-754 (2007).
63. Bitplane. www.bitplane.com