Clinical impact of radiotherapy for locally advanced pancreatic cancer

Journal of Gastroenterology

Volumn 44, Issue 12, 2009, Pages 1209-1214

  Sawaki, Akira ^a   Hoki, Noriyuki ^b   Ito, Satoko ^c   Matsumoto, Kazuya ^a   Mizuno, Nobumasa ^a   Hara, Kazuo ^a   Takagi, Tadayuki ^a   Kobayashi, Yuji ^a   Sawai, Yugo ^a   Kawai, Hiroki ^a   Tajika, Masahiro ^a   Nakamura, Tsuneya ^a   Yamao, Kenji ^a  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

^b Bell Land General Hospital   (Japan)

^c SHIMANE UNIVERSITY   (Japan)

Author keywords

Chemoradiotherapy; Chemotherapy; Locally advanced pancreatic cancer

Indexed keywords

FLUOROURACIL; GEMCITABINE;

ADULT; ADVANCED CANCER; AGED; ANOREXIA; ARTICLE; BLEEDING; BLOOD TOXICITY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CONTINUOUS INFUSION; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG ERUPTION; FEMALE; HEALTH STATUS; HISTOPATHOLOGY; HUMAN; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; NAUSEA AND VOMITING; NEUTROPENIA; OVERALL SURVIVAL; PANCREAS CANCER; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RADIATION DOSE; RASH; RETROSPECTIVE STUDY; STOMATITIS; THROMBOCYTOPENIA; TREATMENT RESPONSE;

ADULT; AGED; ANTIMETABOLITES, ANTINEOPLASTIC; COMBINED MODALITY THERAPY; DEOXYCYTIDINE; FEMALE; HUMANS; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; RADIOTHERAPY; TREATMENT OUTCOME;

EID: 73449128653     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-009-0116-9     Document Type: Article

References (20)

1. V Heinemann 2002 Present and future treatment of pancreatic cancer Semin Oncol 29 23 31 10.1053/sonc.2002.34269 1:CAS:528:DC%2BD38XlslKqtLk%3D 12094335 (Pubitemid 34753280)
2. M Goggins 2005 Molecular markers of early pancreatic cancer J Clin Oncol 23 4524 4531 10.1200/JCO.2005.19.711 1:CAS:528:DC%2BD2MXnsl2ksL4%3D 16002843 (Pubitemid 46196582)
3. YJ Chua D Cunningham 2005 Adjuvant treatment for resectable pancreatic cancer J Clin Oncol 23 4532 4537 10.1200/JCO.2005.17.954 1:CAS:528: DC%2BD2MXnsl2ksL8%3D 16002844 (Pubitemid 46196583)
4. V Heinemann 2002 Gemcitabine in the treatment of advanced pancreatic cancer a comparison analysis of randomized trials Semin Oncol 29 9 16 1:CAS:528:DC%2BD3sXhslehtL8%3D 12577228
5. G Schneider JT Siveke F Eckel RM Schmid 2005 Pancreatic cancer; basic and clinical aspects Gastroenterology 128 1606 1625 10.1053/j.gastro.2005.04.001 1:CAS:528:DC%2BD2MXltlOgtbw%3D 15887154 (Pubitemid 40692555)
6. JL Abbruzzese 2002 Past and present treatment of pancreatic adenocarcinoma: chemotherapy as a standard treatment modality Semin Oncol 29 2 8 1:CAS:528:DC%2BD3sXhslehtL4%3D 12577227
7. CG Willent BG Czito JC Bendell DP Ryan 2005 Locally advanced pancreatic cancer J Clin Oncol 23 4538 4544 10.1200/JCO.2005.23.911 (Pubitemid 46196584)
8. AC Lockhart ML Rothenberg JD Berlin 2005 Treatment for pancreatic cancer; current therapy and continued progress Gastroenterology 128 1642 1654 10.1053/j.gastro.2005.03.039 1:CAS:528:DC%2BD2MXltlOgtb0%3D 15887156 (Pubitemid 40692557)
9. CG Moertel DS Childs Jr RJ Reitemeier MY Colby Jr MA Holbrook 1969 Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer Lancet 2 865 867 10.1016/S0140-6736(69) 92326-5 1:STN:280:DyaE3c%2FgsFyjsQ%3D%3D 4186452
10. CG Moertel S Frytak RG Hahn MJ O'Connell RJ Reitemeier J Rubin, et al. 1981 Therapy of locally unresectable pancreatic carcinoma a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation + 5-fluorouracil Cancer 48 1705 1710 10.1002/1097-0142(19811015)48:8<1705::AID-CNCR2820480803>3.0. CO;2-4 1:STN:280:DyaL38%2FisFaqtg%3D%3D 7284971 (Pubitemid 11022870)
11. Gastrointestinal Tumor Study Group 1988 Treatment of locally unresectable carcinoma of the pancreas: comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone J Natl Cancer Inst 80 751 755 10.1093/jnci/80.10.751
12. DJ Klaassen JM MacIntyre GE Catton PF Engstrom CG Moertel 1985 Treatment of locally unresectable caner of the stomach and pancreas: a randomized comparison of 5-fluorouracil alone with radiation plus concurrent and maintenance 5-fluorouracil-an Eastern Cooperative Oncology Group study J Clin Oncol 3 373 378 1:STN:280:DyaL2M7jtlOktA%3D%3D 3973648
13. HA Burris 3rd MJ Moore J Andersen MR Green ML Rothenberg MR Modiano, et al. 1997 Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial J Clin Oncol 15 2403 2413 1:CAS:528:DyaK2sXlsFKksLY%3D 9196156
14. Chauffert B, Mornex F, Bonnetain F, Rougier P, Mariette C, Bouché O, et al. Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Definitive results of the 2000-01 FFCD/SFRO study. Ann Oncol. 2008;19:1592-9.
15. Sobin LH, Wittekind C, editors. UICC-TNM classification of malignant tumours, 6th ed. New York: Wiley-Liss; 2002.
16. P Therasse SG Arbuck EA Eisenhauer J Wanders RS Kaplan L Rubinstein, et al. 2000 New guidelines to evaluate the response to treatment in solid tumors European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada J Natl Cancer Inst 92 205 216 10.1093/jnci/92.3.205 1:STN:280:DC%2BD3c7it1Gitg%3D%3D 10655437
17. National Cancer Institute Common Toxicity Criteria. Version3.0, 9 August 2006. < http://ctep.cancer.gov/forms/CTCAEv3.pdf >.
18. E Ben-Josef TS Lawrence 2008 Chemoradiotherapy for unresectable pancreatic cancer Int J Clin Oncol 13 121 126 10.1007/s10147-007-0763-x 18463955 (Pubitemid 351668178)
19. T Okusaka Y Ito H Ueno M Ikeda Y Takezako C Morizane, et al. 2004 Phase II study of radiotherapy combined with gemcitabine for locally advanced pancreatic cancer Br J Cancer 91 673 677 1:CAS:528:DC%2BD2cXmsVCgsLk%3D 15226765
20. K Asanuma R Moriai T Yajima A Yagihashi M Yamada D Kobayashi, et al. 2000 Survivin as a radioresistance factor in pancreatic cancer Jpn J Cancer Res 91 1204 1209 1:CAS:528:DC%2BD3cXosVGrsbo%3D 11092988