Safety of binodenoson, a selective adenosine A2A receptor agonist vasodilator pharmacological stress agent, in: Healthy subjects with mild intermittent asthma

Circulation: Cardiovascular Imaging

Volumn 2, Issue 6, 2009, Pages 492-498

  Murray, John J ^a   Weiler, John M ^b   Schwartz, Lawrence B ^c   Busse, William W ^d   Katial, Rohit K ^e   Lockey, Richard F ^f   McFadden Jr , E R ^g   Pixton, Glenn C ^h   Barrett, Richard J ^h  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b Iowa Clinical Research Corporation   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^e NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^f UNIVERSITY OF SOUTH FLORIDA   (United States)

^g METROHEALTH MEDICAL CENTER   (United States)

^h King Pharmaceuticals Research and Development Inc   (United States)

Author keywords

Asthma; Binodenoson; Bronchoconstriction; Pharmacological stress

Indexed keywords

ADENOSINE A2A RECEPTOR AGONIST; BINODENOSON; PLACEBO; 2 (CYCLOHEXYLMETHYLIDENEHYDRAZINO)ADENOSINE; 2-(CYCLOHEXYLMETHYLIDENEHYDRAZINO)ADENOSINE; ADENOSINE; DRUG DERIVATIVE; VASODILATOR AGENT;

ABDOMINAL DISCOMFORT; ADULT; ARTICLE; ASTHMA; BRONCHOSPASM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DOSE ESCALATION; DRUG SAFETY; FEMALE; FLUSHING; FORCED EXPIRATORY FLOW; FORCED EXPIRATORY VOLUME; HEADACHE; HUMAN; HYPERTENSION; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; PRIORITY JOURNAL; PULSE OXIMETRY; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINGLE BLIND PROCEDURE; TACHYCARDIA; ADOLESCENT; ANALYSIS OF VARIANCE; DOSE RESPONSE; EXERCISE TEST; LUNG FUNCTION TEST; MIDDLE AGED; PATHOPHYSIOLOGY; PHASE 2 CLINICAL TRIAL; TREATMENT OUTCOME;

ADENOSINE; ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ASTHMA; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; EXERCISE TEST; FEMALE; HUMANS; MALE; MIDDLE AGED; PLACEBOS; RESPIRATORY FUNCTION TESTS; SINGLE-BLIND METHOD; TREATMENT OUTCOME; VASODILATOR AGENTS;

EID: 73449123101     PISSN: 19419651     EISSN: 19420080     Source Type: Journal    
DOI: 10.1161/CIRCIMAGING.108.817932     Document Type: Article

References (25)

1. IMV. 2005 Nuclear Medicine Census Market Summary Report. Des Plaines, IL: IMV Medical Information Division, 2006.
2. Travin MI, Wexler JP. Pharmacological stress testing. Semin Nucl Med. 1999;29:298-318.
3. Adenoscan [package insert]. Deerfield, IL: Astellas Pharma US, Inc; 2005.
4. Persantine [package insert]. Bedford, OH: Bedford Laboratories; 2006.
5. Anderson SD. How does exercise cause asthma attacks?. Curr Opin Allergy Clin Immunol. 2006;6:37-42.
6. Polosa R. Adenosine-receptor subtypes: their relevance to adenosinemediated responses in asthma and chronic obstructive pulmonary disease. Eur Respir J. 2002;20:488-496.
7. Belardinelli L, Shryock JC, Snowdy S, Zhang Y, Monopoli A, Lozza G, Ongini E, Olsson RA, Dennis DM. The A2A adenosine receptor mediates coronary vasodilation. J Pharmacol Exp Ther. 1998;284:1066-1073. (Pubitemid 28130836)
8. Cerqueira MD, Verani MS, Schwaiger M, Heo J, Iskandrian AS. Safety profile of adenosine stress perfusion imaging: results from the Adenoscan Multicenter Trial Registry. J Am Coll Cardiol. 1994;23:384-389.
9. Johnston DL, Daley JR, Hodge DO, Hopfenspirger MR, Gibbons RJ. Hemodynamic responses and adverse effects associated with adenosine and dipyridamole pharmacologic stress testing: a comparison in 2,000 patients. Mayo Clin Proc. 1995;70:331-336.
10. Ranhosky A, Kempthorne-Rawson J. The safety of intravenous dipyridamole thallium myocardial perfusion imaging: Intravenous Dipyridamole Thallium Imaging Study Group. Circulation. 1990;81:1205-1209.
11. Dakik HA, Vempathy H, Verani MS. Tolerance, hemodynamic changes, and safety of dobutamine stress perfusion imaging. J Nucl Cardiol. 1996;3:410-414.
12. Holgate ST. The Quintiles Prize Lecture 2004: The identification of the adenosine A2B receptor as a novel therapeutic target in asthma. Br J Pharmacol. 2005;145:1009-1015.
13. Martin PL, Barrett RJ, Linden J, Abraham WM. Pharmacology of 2-cyclohexylmethylidenehydrazinoadenosine (WRC-0470), a novel, short-acting adenosine A2A receptor agonist that produces selective coronary vasodilation. Drug Dev Res. 1997;40:313-324.
14. Udelson JE, Heller GV, Wackers FJTh, Chai A, Hinchman D, Coleman PS, Dilsizian V, DiCarli M, Hachamovitch R, Johnson JR, Barrett RJ, Gibbons RJ. Randomized, controlled dose-ranging study of the selective adenosine A2A receptor agonist binodenoson for pharmacological stress as an adjunct to myocardial perfusion imaging. Circulation. 2004;109:457-464.
15. Hodgson JM, Dib N, Kern MJ, Bach RG, Barrett RJ. Coronary circulation responses to binodenoson, a selective adenosine A2A receptor agonist. Am J Cardiol. 2007;99:1507-1512.
16. American Thoracic Society. Guidelines for methacholine and exercise challenge testing, 1999. Am J Respir Crit Care Med. 2000;161:309-329.
17. National Asthma Education and Prevention Program. Expert Panel Report: Guidelines for the Diagnosis and Management of Asthma Update on Selected Topics, 2002. J Allergy Clin Immunol. 2002;110(suppl): S141-S219.
18. Gibbons RJ, Balady GJ, Bricker JT, Chaitman BR, Fletcher GF, Froelicher VF, Mark DB, McCallister BD, Mooss AN, OReilly MG, Winters WL. ACC/AHA 2002 guideline update for exercise testing: summary article: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines). Circulation. 2002;106:1883-1892.
19. Drake I, Routledge PA, Richards R. Bronchospasm induced by intravenous adenosine. Hum Exp Toxicol. 1994;13:263-265.
20. Johnston DL, Scanlon PD, Hodge DO, Glynn RB, Hung JCY, Gibbons RJ. Pulmonary function monitoring during adenosine myocardial perfusion scintigraphy in patients with chronic obstructive pulmonary disease. Mayo Clin Proc. 1999;74, 339-346.
21. van Gaal WJ, Couthino B, Chan M, Allman KC. The safety and tolerability of adenosine in patients with obstructive airways disease. Int J Cardiol. 2007;128:436-438.
22. Reyes E, Loong CY, Wechalekar K, Latus K, Anagnostopoulos C, Underwood SR. Side effect profile and tolerability of adenosine myocardial perfusion scintigraphy in patients with mild asthma or chronic obstructive pulmonary disease. J Nucl Cardiol. 2007;14:827-834.
23. Verani MS. Dobutamine myocardial perfusion imaging. J Nucl Med. 1994;35:737-739.
24. Dhalla AK, Wong M-Y, Wang W-Q, Biaggioni I, Belardinelli L. Tachycardia caused by A2A adenosine receptor agonists is mediated by direct sympathoexcitation in awake rats. J Pharmacol Exp Ther. 2006; 316:695-702.
25. Lappe RW, Sheldon JH, Cox BF. Selective adenosine-2 agonist produces both direct and reflex tachycardia in normotensive rats. J Cardiovasc Pharmacol. 1992;19:460-463.