Antifibrotic effects of green tea on in vitro and in vivo models of liver fibrosis

World Journal of Gastroenterology

Volumn 15, Issue 41, 2009, Pages 5200-5205

  Kim, Hye Kyung ^a   Yang, Taik Hoon ^b   Cho, Hong Yon ^b  

^a Hanseo University   (South Korea)

^b Korea University   (South Korea)

Author keywords

Dimethylnitrosamine; Green tea extract; HSC T6 cell; Liver fibrosis; Rat model; Type 1 collagen

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; COLLAGEN; COLLAGEN TYPE 1; DIMETHYLNITROSAMINE; EOSIN; GREEN TEA EXTRACT; HEMATOXYLIN; HYDROXYPROLINE; LIPID PEROXIDE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIFIBROTIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; LIVER FIBROSIS; LIVER HISTOLOGY; MALE; NONHUMAN; PROTEIN CONTENT; QUANTITATIVE ANALYSIS; RAT; STAINING; STELLATE CELL;

EID: 73449123006     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.15.5200     Document Type: Article

References (26)

1. Bissell DM. Hepatic fibrosis as wound repair: a progress report. J Gastroenterol 1998; 33: 295-302
2. Wu J, Zern MA. Hepatic stellate cells: a target for the treatment of liver fibrosis. J Gastroenterol 2000; 35: 665-672
3. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest 2005; 115: 209-218
4. Lotersztajn S, Julien B, Teixeira-Clerc F, Grenard P, Mallat A. Hepatic fibrosis: molecular mechanisms and drug targets. Annu Rev Pharmacol Toxicol 2005; 45: 605-628
5. Casini A, Cunningham M, Rojkind M, Lieber CS. Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesisdependent mechanism. Hepatology 1991; 13: 758-765
6. Savolainen ER, Leo MA, Timpl R, Lieber CS. Acetaldehyde and lactate stimulate collagen synthesis of cultured baboon liver myofibroblasts. Gastroenterology 1984; 87: 777-787
7. Parola M, Pinzani M, Casini A, Albano E, Poli G, Gentilini A, Gentilini P, Dianzani MU. Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen alpha 1 (I) gene expression in human liver fat-storing cells. Biochem Biophys Res Commun 1993; 194: 1044-1050
8. Lyons BL, Schwarz RI. Ascorbate stimulation of PAT cells causes an increase in transcription rates and a decrease in degradation rates of procollagen mRNA. Nucleic Acids Res 1984; 12: 2569-2579
9. Lee KS, Buck M, Houglum K, Chojkier M. Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 1995; 96: 2461-2468
10. Erba D, Riso P, Bordoni A, Foti P, Biagi PL, Testolin G. Effectiveness of moderate green tea consumption on antioxidative status and plasma lipid profile in humans. J Nutr Biochem 2005; 16: 144-149
11. Shiozaki T, Sugiyama K, Nakazato K, Takeo T. [Effect of tea extracts, catechin and caffeine against type-I allergic reaction] Yakugaku Zasshi 1997; 117: 448-454
12. Cabrera C, Artacho R, Giménez R. Beneficial effects of green tea - a review. J Am Coll Nutr 2006; 25: 79-99
13. Zhong Z, Froh M, Lehnert M, Schoonhoven R, Yang L, Lind H, Lemasters JJ, Thurman RG. Polyphenols from Camellia sinenesis attenuate experimental cholestasis-induced liver fibrosis in rats. Am J Physiol Gastrointest Liver Physiol 2003; 285: G1004-G1013
14. Sakata R, Ueno T, Nakamura T, Sakamoto M, Torimura T, Sata M. Green tea polyphenol epigallocatechin-3-gallate inhibits platelet-derived growth factor-induced proliferation of human hepatic stellate cell line LI90. J Hepatol 2004; 40: 52-59
15. Xiao J, Lu R, Shen X, Wu M. [Green tea extracts protected against carbon tetrachloride-induced chronic liver damage and cirrhosis] Zhonghua Yufang Yixue Zazhi 2002; 36: 243-246
16. Arteel GE, Uesugi T, Bevan LN, Gäbele E, Wheeler MD, McKim SE, Thurman RG. Green tea extract protects against early alcohol-induced liver injury in rats. Biol Chem 2002; 383: 663-670
17. Wasser S, Tan CE. Experimental models of hepatic fibrosis in the rat. Ann Acad Med Singapore 1999; 28: 109-111
18. Jézéquel AM, Mancini R, Rinaldesi ML, Ballardini G, Fallani M, Bianchi F, Orlandi F. Dimethylnitrosamine-induced cirrhosis. Evidence for an immunological mechanism. J Hepatol 1989; 8: 42-52
19. George J, Rao KR, Stern R, Chandrakasan G. Dimethylnitrosamine- induced liver injury in rats: the early deposition of collagen. Toxicology 2001; 156: 129-138
20. Gressner AM. The cell biology of liver fibrogenesis - an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts. Cell Tissue Res 1998; 292: 447-452
21. Friedman SL. Cellular sources of collagen and regulation of collagen production in liver. Semin Liver Dis 1990; 10: 20-29
22. Alcolado R, Arthur MJ, Iredale JP. Pathogenesis of liver fibrosis. Clin Sci (Lond) 1997; 92: 103-112
23. Nakamuta M, Higashi N, Kohjima M, Fukushima M, Ohta S, Kotoh K, Kobayashi N, Enjoji M. Epigallocatechin-3-gallate, a polyphenol component of green tea, suppresses both collagen production and collagenase activity in hepatic stellate cells. Int J Mol Med 2005; 16: 677-681
24. Chen A, Zhang L. The antioxidant (-)-epigallocatechin-3-gallate inhibits rat hepatic stellate cell proliferation in vitro by blocking the tyrosine phosphorylation and reducing the gene expression of platelet-derived growth factor-beta receptor. J Biol Chem 2003; 278: 23381-23389
25. Svegliati Baroni G, D'Ambrosio L, Ferretti G, Casini A, Di Sario A, Salzano R, Ridolfi F, Saccomanno S, Jezequel AM, Benedetti A. Fibrogenic effect of oxidative stress on rat hepatic stellate cells. Hepatology 1998; 27: 720-726
26. Chen JH, Tipoe GL, Liong EC, So HS, Leung KM, Tom WM, Fung PC, Nanji AA. Green tea polyphenols prevent toxininduced hepatotoxicity in mice by down-regulating inducible nitric oxide-derived prooxidants. Am J Clin Nutr 2004; 80: 742-751