Significant association of metabolic syndrome with silent brain infarction in elderly people

Journal of Neurology

Volumn 256, Issue 11, 2009, Pages 1825-1831

  Kwon, Hyung Min ^a   Kim, Beom Joon ^b   Park, Jin Ho ^c   Ryu, Wi Sun ^b   Kim, Chi Kyung ^b   Lee, Su Ho ^b   Ko, Sang Bae ^b   Nam, Hyunwoo ^a   Lee, Seung Hoon ^b   Lee, Yong Seok ^a   Yoon, Byung Woo ^b  

^a Seoul National University   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c Seoul National University Hospital Healthcare System Gangnam Center   (South Korea)

Author keywords

Aged; Cross sectional study; Metabolic syndrome; MRI; Silent brain infarction

Indexed keywords

AGE; AGED; ARTICLE; BRAIN INFARCTION; FEMALE; GERIATRIC ASSESSMENT; HOSPITALIZATION; HUMAN; MALE; METABOLIC SYNDROME X; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; RISK FACTOR;

AGE FACTORS; AGE OF ONSET; AGED; AGED, 80 AND OVER; BRAIN INFARCTION; FEMALE; GERIATRIC ASSESSMENT; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; METABOLIC SYNDROME X; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 73449117254     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-009-5201-8     Document Type: Article

References (30)

1. Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15:539-553. doi:10.1002/(SICI) 1096-9136(199807)15:7\539::AID-DIA668[3.0.CO;2-S (Pubitemid 28319935)
2. Bokura H, Kobayashi S, Yamaguchi S (1998) Distinguishing silent lacunar infarction from enlarged Virchow-Robin spaces: A magnetic resonance imaging and pathological study. J Neurol 245:116-122. doi:10.1007/s004150050189 (Pubitemid 28118876)
3. Bokura H, Yamaguchi S, Iijima K, Nagai A, Oguro H (2008) Metabolic syndrome is associated with silent ischemic brain lesions. Stroke 39:1607-1609. doi:10.1161/STROKEAHA.107. 508630
4. Bonora E, Targher G, Formentini G, Calcaterra F, Lombardi S, Marini F, Zenari L, Saggiani F, Poli M, Perbellini S, Raffaelli A, Gemma L, Santi L, Bonadonna RC, Muggeo M (2004) The metabolic syndrome is an independent predictor of cardiovascular disease in type 2 diabetic subjects. Prospective data from the Verona Diabetes Complications Study. Diabet Med 21:52-58. doi:10.1046/j.1464-5491.2003.01068.x (Pubitemid 38168029)
5. Caplan LR (1996) Diabetes and brain ischemia. Diabetes 45(Suppl 3):S95-S97
6. Carplan L (1994) Silent brain infarcts. Cerebrovasc Dis 4:32S-39S. doi:10.1159/000108559
7. Davis PH, Clarke WR, Bendixen BH, Adams HP Jr, Woolson RF, Culebras A (1996) Silent cerebral infarction in patients enrolled in the TOAST Study. Neurology 46:942-948 (Pubitemid 26134631)
8. Deedwania P (1998) The deadly quartet revisited. Am J Med 105:1S-3S. doi:10.1016/S0002-9343(98)00204-6
9. Fagan TC, Deedwania PC (1998) The cardiovascular dysmetabolic syndrome. Am J Med 105:77S-82S. doi:10.1016/S0002-9343(98)00216-2 (Pubitemid 28364431)
10. Fisher CM (1982) Lacunar strokes and infarcts: A review. Neurology 32:871-876 (Pubitemid 12097674)
11. Groop L, Orho-MelanderM(2001) The dysmetabolic syndrome. J Intern Med 250:105-120. doi:10.1046/j.1365-2796.2001.00864.x (Pubitemid 32868690)
12. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F (2005) Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112:2735-2752. doi:10.1161/CIRCULATIONAHA.105.169404 (Pubitemid 41532612)
13. Hoshi T, Kitagawa K, Yamagami H, Furukado S, Hougaku H, Hori M (2005) Relations of serum high-sensitivity C-reactive protein and interleukin-6 levels with silent brain infarction. Stroke 36:768-772. doi:10.1161/01.STR.0000158915. 28329.51
14. Howard G, Wagenknecht LE, Cai J, Cooper L, Kraut MA, Toole JF (1998) Cigarette smoking and other risk factors for silent cerebral infarction in the general population. Stroke 29:913-917 (Pubitemid 28228148)
15. Kobayashi S, Okada K, Koide H, Bokura H, Yamaguchi S (1997) Subcortical silent brain infarction as a risk factor for clinical stroke. Stroke 28:1932-1939 (Pubitemid 27458998)
16. Kwon HM, Kim BJ, Lee SH, Choi SH, Oh BH, Yoon BW (2006) Metabolic syndrome as an independent risk factor of silent brain infarction in healthy people. Stroke 37:466-470. doi:10.1161/01.STR.0000199081.17935.81 (Pubitemid 43732007)
17. Lee SC, Park SJ, Ki HK, Gwon HC, Chung CS, Byun HS, Shin KJ, Shin MH, Lee WR (2000) Prevalence and risk factors of silent cerebral infarction in apparently normal adults. Hypertension 36:73-77 (Pubitemid 30602155)
18. Longstreth WT Jr, Bernick C, Manolio TA, Bryan N, Jungreis CA, Price TR (1998) Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people: The Cardiovascular Health Study. Arch Neurol 55:1217-1225. doi:10.1001/archneur.55.9.1217 (Pubitemid 28427493)
19. Matsui T, Arai H, Yuzuriha T, Yao H, Miura M, Hashimoto S, Higuchi S, Matsushita S, Morikawa M, Kato A, Sasaki H (2001) Elevated plasma homocysteine levels and risk of silent brain infarction in elderly people. Stroke 32:1116-1119 (Pubitemid 32825794)
20. Miranda PJ, DeFronzo RA, Califf RM, Guyton JR (2005) Metabolic syndrome: Definition, pathophysiology, and mechanisms. Am Heart J 149:33-45. doi:10.1016/j.ahj.2004.07.013 (Pubitemid 40126488)
21. Park K, Yasuda N, Toyonaga S, Tsubosaki E, Nakabayashi H, Shimizu K (2008) Significant associations of metabolic syndrome and its components with silent lacunar infarction in middle aged subjects. J Neurol Neurosurg Psychiatry 79:719-721. doi: 10.1136/jnnp.2007.134809 (Pubitemid 351829449)
22. Price TR, Manolio TA, Kronmal RA, Kittner SJ, Yue NC, Robbins J, Anton-Culver H, O'Leary DH (1997) Silent brain infarction on magnetic resonance imaging and neurological abnormalities in community-dwelling older adults. The Cardiovascular Health Study. CHS Collaborative Research Group. Stroke 28:1158-1164 (Pubitemid 27248888)
23. Reaven GM (1988) Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 37:1595-1607. doi:10.2337/diabetes.37.12.1595 (Pubitemid 19004941)
24. Shinkawa A, Ueda K, Kiyohara Y, Kato I, Sueishi K, Tsuneyoshi M, Fujishima M (1995) Silent cerebral infarction in a community-based autopsy series in Japan. The Hisayama Study. Stroke 26:380-385
25. Shintani S, Shiigai T, Arinami T (1998) Silent lacunar infarction on magnetic resonance imaging (MRI): Risk factors. J Neurol Sci 160:82-86. doi:10.1016/S0022-510X(98)00182-8 (Pubitemid 28473890)
26. Stamler J, Vaccaro O, Neaton JD, Wentworth D (1993) Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 16:434-444. doi:10.2337/diacare. 16.2.434 (Pubitemid 23046633)
27. Uehara T, Tabuchi M, Mori E (1999) Risk factors for silent cerebral infarcts in subcortical white matter and basal ganglia. Stroke 30:378-382 (Pubitemid 29071804)
28. Vermeer SE, Koudstaal PJ, Oudkerk M, Hofman A, Breteler MM (2002) Prevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke 33:21-25. doi: 10.1161/hs0102.101629 (Pubitemid 34052178)
29. Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MM (2003) Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med 348:1215-1222. doi: 10.1056/NEJMoa022066 (Pubitemid 36359297)
30. Western Pacific Regional Office of the World Health Organization (2000) The Asia-Pacific perspective: Redefining obesity and its treatment. Health Communications Australia, Sydney